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Protein

Glycine cleavage system H protein, mitochondrial

Gene

Gcsh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity).By similarity

Cofactori

(R)-lipoateBy similarityNote: Binds 1 lipoyl cofactor covalently.By similarity

GO - Molecular functioni

  • aminomethyltransferase activity Source: RGD
  • enzyme binding Source: RGD

GO - Biological processi

  • glycine decarboxylation via glycine cleavage system Source: RGD
  • protein lipoylation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-RNO-389661 Glyoxylate metabolism and glycine degradation
R-RNO-6783984 Glycine degradation
SABIO-RKiQ5I0P2

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H protein, mitochondrialCurated
Alternative name(s):
Lipoic acid-containing protein
Gene namesi
Name:GcshImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi619946 Gcsh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000001072646 – 170Glycine cleavage system H protein, mitochondrialAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-lipoyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

PaxDbiQ5I0P2
PRIDEiQ5I0P2

PTM databases

iPTMnetiQ5I0P2
PhosphoSitePlusiQ5I0P2

Expressioni

Gene expression databases

BgeeiENSRNOG00000011535
GenevisibleiQ5I0P2 RN

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH). Interacts with GLDC (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015967

Structurei

3D structure databases

ProteinModelPortaliQ5I0P2
SMRiQ5I0P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 145Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the GcvH family.Curated

Keywords - Domaini

Lipoyl, Transit peptide

Phylogenomic databases

eggNOGiKOG3373 Eukaryota
COG0509 LUCA
GeneTreeiENSGT00390000011666
HOGENOMiHOG000239392
HOVERGENiHBG001129
InParanoidiQ5I0P2
KOiK02437
OMAiWLFKVRV
OrthoDBiEOG091G14BI
PhylomeDBiQ5I0P2
TreeFamiTF300258

Family and domain databases

CDDicd06848 GCS_H, 1 hit
HAMAPiMF_00272 GcvH, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR000089 Biotin_lipoyl
IPR002930 GCV_H
IPR033753 GCV_H/Fam206
IPR017453 GCV_H_sub
IPR011053 Single_hybrid_motif
PANTHERiPTHR11715 PTHR11715, 1 hit
PfamiView protein in Pfam
PF01597 GCV_H, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00527 gcvH, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRVVRSVR AVACSLRIAL ASCPPRPWAP SAAAVRSLRT GSALLSVRKF
60 70 80 90 100
TEKHEWVTAK DGIGTVGISN FAQEALGDVV YCSLPEVGTK LKKQEEFGAL
110 120 130 140 150
ESVKAASELY SPLSGEVTEV NEALAENPGL VNKSCYEDGW LIKMTLSDPS
160 170
ELDELMSEEA YEKYVKSIEE
Length:170
Mass (Da):18,485
Last modified:February 15, 2005 - v1
Checksum:i6E4CD58F28CD26A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088114 mRNA Translation: AAH88114.1
RefSeqiNP_598282.2, NM_133598.2
UniGeneiRn.98456

Genome annotation databases

EnsembliENSRNOT00000015967; ENSRNOP00000015967; ENSRNOG00000011535
GeneIDi171133
KEGGirno:171133
UCSCiRGD:619946 rat

Similar proteinsi

Entry informationi

Entry nameiGCSH_RAT
AccessioniPrimary (citable) accession number: Q5I0P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome