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Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

Qprt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the catabolism of quinolinic acid (QA).By similarity

Catalytic activityi

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Qprt)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateBy similarity1
Binding sitei161SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei201SubstrateBy similarity1
Binding sitei222SubstrateBy similarity1

GO - Molecular functioni

  • nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: RGD

GO - Biological processi

  • NAD biosynthetic process Source: RGD
  • quinolinate catabolic process Source: GO_Central
  • quinolinate metabolic process Source: RGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-196807 Nicotinate metabolism
UniPathwayiUPA00253; UER00331

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name:
QAPRTase
Short name:
QPRTase
Gene namesi
Name:Qprt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310309 Qprt

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002454641 – 299Nicotinate-nucleotide pyrophosphorylase [carboxylating]Add BLAST299

Proteomic databases

PaxDbiQ5I0M2
PRIDEiQ5I0M2

PTM databases

iPTMnetiQ5I0M2
PhosphoSitePlusiQ5I0M2

Expressioni

Gene expression databases

BgeeiENSRNOG00000016980
GenevisibleiQ5I0M2 RN

Interactioni

Subunit structurei

Hexamer formed by 3 homodimers.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023080

Structurei

3D structure databases

ProteinModelPortaliQ5I0M2
SMRiQ5I0M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 139Substrate bindingBy similarity3
Regioni248 – 250Substrate bindingBy similarity3
Regioni269 – 271Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the NadC/ModD family.Curated

Phylogenomic databases

eggNOGiKOG3008 Eukaryota
COG0157 LUCA
GeneTreeiENSGT00390000002761
HOGENOMiHOG000224023
HOVERGENiHBG031727
InParanoidiQ5I0M2
KOiK00767
OMAiVIMLDNM
OrthoDBiEOG091G10SF
PhylomeDBiQ5I0M2
TreeFamiTF300845

Family and domain databases

CDDicd01572 QPRTase, 1 hit
Gene3Di3.20.20.70, 1 hit
3.90.1170.20, 2 hits
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR004393 NadC
IPR027277 NadC/ModD
IPR036068 Nicotinate_pribotase_like_C
IPR037128 Quinolinate_PRibosylTase_N_sf
IPR002638 Quinolinate_PRibosylTrfase_C
IPR022412 Quinolinate_PRibosylTrfase_N
PANTHERiPTHR32179 PTHR32179, 1 hit
PfamiView protein in Pfam
PF01729 QRPTase_C, 1 hit
PF02749 QRPTase_N, 1 hit
PIRSFiPIRSF006250 NadC_ModD, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR00078 nadC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5I0M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEGLQFLL PPASLAALAN SWLQEDCPGL NFASLVTGSA PAQAVLWAKS
60 70 80 90 100
PGVLAGRPFF DAIFTQLNCQ VSWLLPEGSK LVPVVKVAEV RGPAHHLLLG
110 120 130 140 150
ERVALNTLAR CSGIASAAAT AVEVATSTGW AGHVAGTRKT TPGFRLVEKY
160 170 180 190 200
GLLVGGAECH RYDLGGLVMV KDNHVVAAGS MEKAVLKARQ AAGFPLKVEV
210 220 230 240 250
ECSSLKEALQ AAEAGADLVM LDNFKPEELH PTAATLKAKF PNVSVEASGG
260 270 280 290
VTLDNLPQFC GTNIDVISLG MLTQAAPALD FSLKLYAEGD IPVPHARRS
Length:299
Mass (Da):31,297
Last modified:February 15, 2005 - v1
Checksum:i7ADC91705C422FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088177 mRNA Translation: AAH88177.1
RefSeqiNP_001009646.1, NM_001009646.1
UniGeneiRn.9220

Genome annotation databases

EnsembliENSRNOT00000023080; ENSRNOP00000023080; ENSRNOG00000016980
GeneIDi293504
KEGGirno:293504
UCSCiRGD:1310309 rat

Similar proteinsi

Entry informationi

Entry nameiNADC_RAT
AccessioniPrimary (citable) accession number: Q5I0M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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