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Protein

Histone-lysine N-methyltransferase SETMAR

Gene

Setmar

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Zinc 1By similarity1
Metal bindingi76Zinc 2By similarity1
Metal bindingi78Zinc 1By similarity1
Metal bindingi83Zinc 1By similarity1
Metal bindingi83Zinc 3By similarity1
Metal bindingi88Zinc 1By similarity1
Metal bindingi90Zinc 2By similarity1
Metal bindingi119Zinc 2By similarity1
Metal bindingi119Zinc 3By similarity1
Metal bindingi123Zinc 2By similarity1
Metal bindingi125Zinc 3By similarity1
Metal bindingi129Zinc 3By similarity1
Binding sitei193S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei221S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi227Zinc 4By similarity1
Metal bindingi288Zinc 4By similarity1
Metal bindingi290Zinc 4By similarity1
Metal bindingi295Zinc 4By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETMARCurated (EC:2.1.1.43By similarity)
Alternative name(s):
SET domain and mariner transposase fusion protein homolog
Gene namesi
Name:SetmarImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1565882 Setmar

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595281 – 315Histone-lysine N-methyltransferase SETMARAdd BLAST315

Proteomic databases

PaxDbiQ5I0M0

PTM databases

PhosphoSitePlusiQ5I0M0

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008892

Structurei

3D structure databases

ProteinModelPortaliQ5I0M0
SMRiQ5I0M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 137Pre-SETPROSITE-ProRule annotationAdd BLAST64
Domaini140 – 264SETPROSITE-ProRule annotationAdd BLAST125
Domaini284 – 300Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 152S-adenosyl-L-methionine bindingBy similarity3
Regioni224 – 225S-adenosyl-L-methionine bindingBy similarity2

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG2940 LUCA
HOGENOMiHOG000020052
HOVERGENiHBG093940
InParanoidiQ5I0M0
KOiK11433
PhylomeDBiQ5I0M0

Family and domain databases

InterProiView protein in InterPro
IPR003616 Post-SET_dom
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PfamiView protein in Pfam
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q5I0M0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEAVKKLS FEIAPSEEES EATIEQQDVA CGLENLPVSL WPLGAGPRPK
60 70 80 90 100
PFQYTPDHVA GPGVDMDPTQ ITFPGCACIK TPCVPGTCSC LRHESNYNDN
110 120 130 140 150
LCLRDVGSEA KYAKPVFECN VLCQCGEHCR NRVVQSGLQF LLQVFQTEKK
160 170 180 190 200
GWGLRTLEYI PKGRFVCEYA GEVLGFSEVQ RRIHLQTAHD PNYIIALREH
210 220 230 240 250
TYNGQVMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS MVPKLALFAA
260 270 280 290 300
KDILPGEELS YDYSGRFLNQ ISSKDKERID CGQPRKPCYC GAQSCATFLP
310
YDSSLYGPLE NPGTS
Length:315
Mass (Da):35,030
Last modified:February 15, 2005 - v1
Checksum:i116FA04700614FEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088181 mRNA Translation: AAH88181.1
RefSeqiNP_001020219.1, NM_001025048.1
UniGeneiRn.7640

Genome annotation databases

GeneIDi500281
KEGGirno:500281
UCSCiRGD:1565882 rat

Similar proteinsi

Entry informationi

Entry nameiSETMR_RAT
AccessioniPrimary (citable) accession number: Q5I0M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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