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Protein

Tyrosine--tRNA ligase, mitochondrial

Gene

Yars2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).By similarity

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71TyrosineBy similarity1
Binding sitei75ATPBy similarity1
Binding sitei115TyrosineBy similarity1
Binding sitei215TyrosineBy similarity1
Binding sitei219TyrosineBy similarity1
Binding sitei222TyrosineBy similarity1
Binding sitei241TyrosineBy similarity1
Binding sitei268ATP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei278ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligase, mitochondrial (EC:6.1.1.1By similarity)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Gene namesi
Name:Yars2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1311696 Yars2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000250721? – 471Tyrosine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349N6-acetyllysineBy similarity1
Modified residuei361N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5I0L3
PRIDEiQ5I0L3

PTM databases

iPTMnetiQ5I0L3
PhosphoSitePlusiQ5I0L3

Expressioni

Gene expression databases

BgeeiENSRNOG00000025252
GenevisibleiQ5I0L3 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037398

Structurei

3D structure databases

ProteinModelPortaliQ5I0L3
SMRiQ5I0L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 85"HIGH" region10
Motifi275 – 279"KMSKS" region5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2623 Eukaryota
COG0162 LUCA
GeneTreeiENSGT00390000013709
HOGENOMiHOG000242790
HOVERGENiHBG056052
InParanoidiQ5I0L3
KOiK01866
OMAiVNYMMAK
OrthoDBiEOG091G06NG
PhylomeDBiQ5I0L3
TreeFamiTF105974

Family and domain databases

CDDicd00805 TyrRS_core, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMLRHLC RVPQSGVWTR GPRAVRPGAR GMLVAPRARG LFKEFFPESG
60 70 80 90 100
TKTELPELFD RRRAGSPQTV YCGFDPTGDS LHVGHLLTLL GLFHFQRAGH
110 120 130 140 150
NVIALVGGST ALLGDPSGRT KEREALSAEC VRANARALQR GLETLAANHA
160 170 180 190 200
RLFADGRPWG TFTVLDNAAW FQKQHLMDFL ATVGGHFRMG TLLSRLSVQS
210 220 230 240 250
RLKSPEGMSL AEFFYQVLQA YDFYYLFRHY GCRVQLGGSD QLGNIMSGYE
260 270 280 290 300
FIHKLTGEDV FGITVPLITS TTGAKLGKSA GNAVWLNREK TSPFELYQFF
310 320 330 340 350
IRQQDDSVER YLKLFTFLPL PEIDHIMQLH VKEPEKRIAQ KRLAAEVTKL
360 370 380 390 400
VHGQEGLDSA KRCTQALYHS SIEALEVMSD QELKELFKEA SFSELVLDPG
410 420 430 440 450
TSVIDTCRKA NAIPDGPRGY RMITEGGVSI NHRQVTNPES VLVIGQHILK
460 470
NGLSLLKIGK RNFYIIKWLQ L
Length:471
Mass (Da):52,628
Last modified:February 15, 2005 - v1
Checksum:iA9431FD9EA3FBE92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088224 mRNA Translation: AAH88224.1
RefSeqiNP_001009627.1, NM_001009627.1
UniGeneiRn.163187

Genome annotation databases

EnsembliENSRNOT00000034902; ENSRNOP00000037398; ENSRNOG00000025252
GeneIDi287924
KEGGirno:287924

Similar proteinsi

Entry informationi

Entry nameiSYYM_RAT
AccessioniPrimary (citable) accession number: Q5I0L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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