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Protein

Tyrosine--tRNA ligase, mitochondrial

Gene

Yars2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).By similarity

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei278ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligase, mitochondrial (EC:6.1.1.1)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Gene namesi
Name:Yars2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1311696. Yars2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000250721? – 471Tyrosine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349N6-acetyllysineBy similarity1
Modified residuei361N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5I0L3.
PRIDEiQ5I0L3.

PTM databases

iPTMnetiQ5I0L3.
PhosphoSitePlusiQ5I0L3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000025252.
GenevisibleiQ5I0L3. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037398.

Structurei

3D structure databases

ProteinModelPortaliQ5I0L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 85"HIGH" region10
Motifi275 – 279"KMSKS" region5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2623. Eukaryota.
COG0162. LUCA.
GeneTreeiENSGT00390000013709.
HOGENOMiHOG000242790.
HOVERGENiHBG056052.
InParanoidiQ5I0L3.
KOiK01866.
OMAiEFFLDPG.
OrthoDBiEOG091G06NG.
PhylomeDBiQ5I0L3.
TreeFamiTF105974.

Family and domain databases

CDDicd00805. TyrRS_core. 1 hit.
Gene3Di3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR11766. PTHR11766. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01040. TRNASYNTHTYR.
TIGRFAMsiTIGR00234. tyrS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPMLRHLC RVPQSGVWTR GPRAVRPGAR GMLVAPRARG LFKEFFPESG
60 70 80 90 100
TKTELPELFD RRRAGSPQTV YCGFDPTGDS LHVGHLLTLL GLFHFQRAGH
110 120 130 140 150
NVIALVGGST ALLGDPSGRT KEREALSAEC VRANARALQR GLETLAANHA
160 170 180 190 200
RLFADGRPWG TFTVLDNAAW FQKQHLMDFL ATVGGHFRMG TLLSRLSVQS
210 220 230 240 250
RLKSPEGMSL AEFFYQVLQA YDFYYLFRHY GCRVQLGGSD QLGNIMSGYE
260 270 280 290 300
FIHKLTGEDV FGITVPLITS TTGAKLGKSA GNAVWLNREK TSPFELYQFF
310 320 330 340 350
IRQQDDSVER YLKLFTFLPL PEIDHIMQLH VKEPEKRIAQ KRLAAEVTKL
360 370 380 390 400
VHGQEGLDSA KRCTQALYHS SIEALEVMSD QELKELFKEA SFSELVLDPG
410 420 430 440 450
TSVIDTCRKA NAIPDGPRGY RMITEGGVSI NHRQVTNPES VLVIGQHILK
460 470
NGLSLLKIGK RNFYIIKWLQ L
Length:471
Mass (Da):52,628
Last modified:February 15, 2005 - v1
Checksum:iA9431FD9EA3FBE92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088224 mRNA. Translation: AAH88224.1.
RefSeqiNP_001009627.1. NM_001009627.1.
UniGeneiRn.163187.

Genome annotation databases

EnsembliENSRNOT00000034902; ENSRNOP00000037398; ENSRNOG00000025252.
GeneIDi287924.
KEGGirno:287924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088224 mRNA. Translation: AAH88224.1.
RefSeqiNP_001009627.1. NM_001009627.1.
UniGeneiRn.163187.

3D structure databases

ProteinModelPortaliQ5I0L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037398.

PTM databases

iPTMnetiQ5I0L3.
PhosphoSitePlusiQ5I0L3.

Proteomic databases

PaxDbiQ5I0L3.
PRIDEiQ5I0L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034902; ENSRNOP00000037398; ENSRNOG00000025252.
GeneIDi287924.
KEGGirno:287924.

Organism-specific databases

CTDi51067.
RGDi1311696. Yars2.

Phylogenomic databases

eggNOGiKOG2623. Eukaryota.
COG0162. LUCA.
GeneTreeiENSGT00390000013709.
HOGENOMiHOG000242790.
HOVERGENiHBG056052.
InParanoidiQ5I0L3.
KOiK01866.
OMAiEFFLDPG.
OrthoDBiEOG091G06NG.
PhylomeDBiQ5I0L3.
TreeFamiTF105974.

Miscellaneous databases

PROiQ5I0L3.

Gene expression databases

BgeeiENSRNOG00000025252.
GenevisibleiQ5I0L3. RN.

Family and domain databases

CDDicd00805. TyrRS_core. 1 hit.
Gene3Di3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR11766. PTHR11766. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01040. TRNASYNTHTYR.
TIGRFAMsiTIGR00234. tyrS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYYM_RAT
AccessioniPrimary (citable) accession number: Q5I0L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.