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Protein

Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene

Abhd10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431Charge relay systemBy similarity
Active sitei240 – 2401Charge relay systemBy similarity
Active sitei270 – 2701Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-156588. Glucuronidation.

Protein family/group databases

ESTHERirat-abhda. AlphaBeta_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 10
Short name:
Abhydrolase domain-containing protein 10
Gene namesi
Name:Abhd10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1308084. Abhd10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343MitochondrionSequence analysisAdd
BLAST
Chaini44 – 297254Mycophenolic acid acyl-glucuronide esterase, mitochondrialPRO_0000280736Add
BLAST

Proteomic databases

PaxDbiQ5I0K5.
PRIDEiQ5I0K5.

PTM databases

iPTMnetiQ5I0K5.
PhosphoSiteiQ5I0K5.

Expressioni

Tissue specificityi

Expressed in epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000043107.
ExpressionAtlasiQ5I0K5. baseline.
GenevisibleiQ5I0K5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043990.

Structurei

3D structure databases

ProteinModelPortaliQ5I0K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHI0. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000017765.
HOGENOMiHOG000139902.
HOVERGENiHBG080562.
InParanoidiQ5I0K5.
KOiK13702.
OMAiYIRFDYS.
PhylomeDBiQ5I0K5.
TreeFamiTF329757.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAWVPCRKW GWAAVSFGRH RGLIASLARK PPWAWWLSAC RQKTTLSFLK
60 70 80 90 100
RPELPSLAYK RLKGKNPGII FIPGYLSNMN GKKAVAIEEF CKSIGHAFIR
110 120 130 140 150
FDYSGVGSSD GNLAECSVGK WRKDVLSILD DIAEGPQILV GSSLGGWLML
160 170 180 190 200
HAAIARPEKV IALIGIASAT DGVVTQFHSL PVEMQKEIEM KGEWSLPSKY
210 220 230 240 250
NKEGYYSIPY SFIKEAAHHC LLHSPIPVTC PVRLLHGMKD EIVPWHRSLQ
260 270 280 290
VADRVVSPDV DVILRKHSDH RMKETADIHL LICTIDDLID KLSTVTH
Length:297
Mass (Da):33,153
Last modified:March 20, 2007 - v2
Checksum:iDEF615DED420BBF8
GO

Mass spectrometryi

Molecular mass is 33131.31 Da from positions 1 - 297. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088235 mRNA. Translation: AAH88235.1.
RefSeqiNP_001116824.1. NM_001123352.1.
UniGeneiRn.138774.

Genome annotation databases

EnsembliENSRNOT00000048533; ENSRNOP00000043990; ENSRNOG00000043107.
ENSRNOT00000086393; ENSRNOP00000075644; ENSRNOG00000043107.
ENSRNOT00000091756; ENSRNOP00000071368; ENSRNOG00000054334.
GeneIDi303953.
KEGGirno:303953.
UCSCiRGD:1308084. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088235 mRNA. Translation: AAH88235.1.
RefSeqiNP_001116824.1. NM_001123352.1.
UniGeneiRn.138774.

3D structure databases

ProteinModelPortaliQ5I0K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043990.

Protein family/group databases

ESTHERirat-abhda. AlphaBeta_hydrolase.

PTM databases

iPTMnetiQ5I0K5.
PhosphoSiteiQ5I0K5.

Proteomic databases

PaxDbiQ5I0K5.
PRIDEiQ5I0K5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048533; ENSRNOP00000043990; ENSRNOG00000043107.
ENSRNOT00000086393; ENSRNOP00000075644; ENSRNOG00000043107.
ENSRNOT00000091756; ENSRNOP00000071368; ENSRNOG00000054334.
GeneIDi303953.
KEGGirno:303953.
UCSCiRGD:1308084. rat.

Organism-specific databases

CTDi55347.
RGDi1308084. Abhd10.

Phylogenomic databases

eggNOGiENOG410IHI0. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000017765.
HOGENOMiHOG000139902.
HOVERGENiHBG080562.
InParanoidiQ5I0K5.
KOiK13702.
OMAiYIRFDYS.
PhylomeDBiQ5I0K5.
TreeFamiTF329757.

Enzyme and pathway databases

ReactomeiR-RNO-156588. Glucuronidation.

Miscellaneous databases

PROiQ5I0K5.

Gene expression databases

BgeeiENSRNOG00000043107.
ExpressionAtlasiQ5I0K5. baseline.
GenevisibleiQ5I0K5. RN.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHDA_RAT
AccessioniPrimary (citable) accession number: Q5I0K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.