ID   ASPDH_RAT               Reviewed;         297 AA.
AC   Q5I0J9;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   RecName: Full=Aspartate dehydrogenase domain-containing protein {ECO:0000305};
GN   Name=Aspdh {ECO:0000312|RGD:1310111};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the L-aspartate dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; BC088252; AAH88252.1; -; mRNA.
DR   RefSeq; NP_001009643.2; NM_001009643.2.
DR   AlphaFoldDB; Q5I0J9; -.
DR   SMR; Q5I0J9; -.
DR   STRING; 10116.ENSRNOP00000073291; -.
DR   PhosphoSitePlus; Q5I0J9; -.
DR   PaxDb; 10116-ENSRNOP00000063826; -.
DR   GeneID; 292875; -.
DR   KEGG; rno:292875; -.
DR   UCSC; RGD:1310111; rat.
DR   AGR; RGD:1310111; -.
DR   CTD; 554235; -.
DR   RGD; 1310111; Aspdh.
DR   VEuPathDB; HostDB:ENSRNOG00000019424; -.
DR   eggNOG; ENOG502QVGC; Eukaryota.
DR   InParanoid; Q5I0J9; -.
DR   OrthoDB; 2879851at2759; -.
DR   PhylomeDB; Q5I0J9; -.
DR   TreeFam; TF315092; -.
DR   PRO; PR:Q5I0J9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019424; Expressed in liver and 10 other cell types or tissues.
DR   ExpressionAtlas; Q5I0J9; baseline and differential.
DR   GO; GO:0033735; F:aspartate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR002811; Asp_DH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR31873:SF6; ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31873; L-ASPARTATE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01958; Asp_DH_C; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   Genevisible; Q5I0J9; RN.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Aspartate dehydrogenase domain-containing protein"
FT                   /id="PRO_0000144902"
FT   MOD_RES         24
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A6ND91"
FT   MOD_RES         172
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A6ND91"
SQ   SEQUENCE   297 AA;  31260 MW;  572A02B436161734 CRC64;
     MDASMVPRVP HKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR MAGSVPPALQ
     LEDLTTLEER HPDLVVEVAH PKIIHESGVQ ILRHANLLVG SPSALADQTT ERQLLEASNH
     WGHTVFVARG ALWGCEDISR LDAAGGLQSL RVTMATHPDG FRLEGPLAAA HSSGPRTVLY
     EGPVRGLCPL APRNSNTMAA AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELTGPQGPQ
     AAALPCTPTE RTQPSLALSL APLLLQPSGT AYWAAVSFPP DLGSASAEFP PLPLLSP
//