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Q5I0J9

- ASPD_RAT

UniProt

Q5I0J9 - ASPD_RAT

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Protein
Putative L-aspartate dehydrogenase
Gene
Aspdh
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NAD; via amide nitrogen By similarity
Binding sitei196 – 1961NAD By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. aspartate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-aspartate dehydrogenase (EC:1.4.1.21)
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene namesi
Name:Aspdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1310111. Aspdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Putative L-aspartate dehydrogenase
PRO_0000144902Add
BLAST

Proteomic databases

PaxDbiQ5I0J9.
PRIDEiQ5I0J9.

Expressioni

Gene expression databases

GenevestigatoriQ5I0J9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026291.

Structurei

3D structure databases

ProteinModelPortaliQ5I0J9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ5I0J9.
PhylomeDBiQ5I0J9.
TreeFamiTF315092.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I0J9-1 [UniParc]FASTAAdd to Basket

« Hide

MDASMVPRVP HKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR    50
MAGSVPPALQ LEDLTTLEER HPDLVVEVAH PKIIHESGVQ ILRHANLLVG 100
SPSALADQTT ERQLLEASNH WGHTVFVARG ALWGCEDISR LDAAGGLQSL 150
RVTMATHPDG FRLEGPLAAA HSSGPRTVLY EGPVRGLCPL APRNSNTMAA 200
AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELTGPQGPQ AAALPCTPTE 250
RTQPSLALSL APLLLQPSGT AYWAAVSFPP DLGSASAEFP PLPLLSP 297
Length:297
Mass (Da):31,260
Last modified:February 15, 2005 - v1
Checksum:i572A02B436161734
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088252 mRNA. Translation: AAH88252.1.
RefSeqiNP_001009643.2. NM_001009643.2.
UniGeneiRn.54118.

Genome annotation databases

GeneIDi292875.
KEGGirno:292875.
UCSCiRGD:1310111. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088252 mRNA. Translation: AAH88252.1 .
RefSeqi NP_001009643.2. NM_001009643.2.
UniGenei Rn.54118.

3D structure databases

ProteinModelPortali Q5I0J9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026291.

Proteomic databases

PaxDbi Q5I0J9.
PRIDEi Q5I0J9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 292875.
KEGGi rno:292875.
UCSCi RGD:1310111. rat.

Organism-specific databases

CTDi 554235.
RGDi 1310111. Aspdh.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000007399.
HOVERGENi HBG062283.
InParanoidi Q5I0J9.
PhylomeDBi Q5I0J9.
TreeFami TF315092.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .

Miscellaneous databases

NextBioi 634962.

Gene expression databases

Genevestigatori Q5I0J9.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiASPD_RAT
AccessioniPrimary (citable) accession number: Q5I0J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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