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Q5I0J9

- ASPD_RAT

UniProt

Q5I0J9 - ASPD_RAT

Protein

Putative L-aspartate dehydrogenase

Gene

Aspdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei131 – 1311NAD; via amide nitrogenBy similarity
    Binding sitei196 – 1961NADBy similarity

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative L-aspartate dehydrogenase (EC:1.4.1.21)
    Alternative name(s):
    Aspartate dehydrogenase domain-containing protein
    Gene namesi
    Name:Aspdh
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1310111. Aspdh.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Putative L-aspartate dehydrogenasePRO_0000144902Add
    BLAST

    Proteomic databases

    PaxDbiQ5I0J9.
    PRIDEiQ5I0J9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5I0J9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026291.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5I0J9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000007399.
    HOVERGENiHBG062283.
    InParanoidiQ5I0J9.
    PhylomeDBiQ5I0J9.
    TreeFamiTF315092.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5I0J9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDASMVPRVP HKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR    50
    MAGSVPPALQ LEDLTTLEER HPDLVVEVAH PKIIHESGVQ ILRHANLLVG 100
    SPSALADQTT ERQLLEASNH WGHTVFVARG ALWGCEDISR LDAAGGLQSL 150
    RVTMATHPDG FRLEGPLAAA HSSGPRTVLY EGPVRGLCPL APRNSNTMAA 200
    AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELTGPQGPQ AAALPCTPTE 250
    RTQPSLALSL APLLLQPSGT AYWAAVSFPP DLGSASAEFP PLPLLSP 297
    Length:297
    Mass (Da):31,260
    Last modified:February 15, 2005 - v1
    Checksum:i572A02B436161734
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088252 mRNA. Translation: AAH88252.1.
    RefSeqiNP_001009643.2. NM_001009643.2.
    UniGeneiRn.54118.

    Genome annotation databases

    GeneIDi292875.
    KEGGirno:292875.
    UCSCiRGD:1310111. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088252 mRNA. Translation: AAH88252.1 .
    RefSeqi NP_001009643.2. NM_001009643.2.
    UniGenei Rn.54118.

    3D structure databases

    ProteinModelPortali Q5I0J9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026291.

    Proteomic databases

    PaxDbi Q5I0J9.
    PRIDEi Q5I0J9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 292875.
    KEGGi rno:292875.
    UCSCi RGD:1310111. rat.

    Organism-specific databases

    CTDi 554235.
    RGDi 1310111. Aspdh.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000007399.
    HOVERGENi HBG062283.
    InParanoidi Q5I0J9.
    PhylomeDBi Q5I0J9.
    TreeFami TF315092.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .

    Miscellaneous databases

    NextBioi 634962.

    Gene expression databases

    Genevestigatori Q5I0J9.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiASPD_RAT
    AccessioniPrimary (citable) accession number: Q5I0J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3