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Protein

Putative L-aspartate dehydrogenase

Gene

Aspdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NAD; via amide nitrogenBy similarity
Binding sitei196 – 1961NADBy similarity

GO - Molecular functioni

  1. aspartate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-aspartate dehydrogenase (EC:1.4.1.21)
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene namesi
Name:Aspdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1310111. Aspdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Putative L-aspartate dehydrogenasePRO_0000144902Add
BLAST

Proteomic databases

PaxDbiQ5I0J9.
PRIDEiQ5I0J9.

Expressioni

Gene expression databases

GenevestigatoriQ5I0J9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026291.

Structurei

3D structure databases

ProteinModelPortaliQ5I0J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ5I0J9.
PhylomeDBiQ5I0J9.
TreeFamiTF315092.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I0J9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDASMVPRVP HKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR
60 70 80 90 100
MAGSVPPALQ LEDLTTLEER HPDLVVEVAH PKIIHESGVQ ILRHANLLVG
110 120 130 140 150
SPSALADQTT ERQLLEASNH WGHTVFVARG ALWGCEDISR LDAAGGLQSL
160 170 180 190 200
RVTMATHPDG FRLEGPLAAA HSSGPRTVLY EGPVRGLCPL APRNSNTMAA
210 220 230 240 250
AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELTGPQGPQ AAALPCTPTE
260 270 280 290
RTQPSLALSL APLLLQPSGT AYWAAVSFPP DLGSASAEFP PLPLLSP
Length:297
Mass (Da):31,260
Last modified:February 15, 2005 - v1
Checksum:i572A02B436161734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088252 mRNA. Translation: AAH88252.1.
RefSeqiNP_001009643.2. NM_001009643.2.
UniGeneiRn.54118.

Genome annotation databases

GeneIDi292875.
KEGGirno:292875.
UCSCiRGD:1310111. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088252 mRNA. Translation: AAH88252.1.
RefSeqiNP_001009643.2. NM_001009643.2.
UniGeneiRn.54118.

3D structure databases

ProteinModelPortaliQ5I0J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026291.

Proteomic databases

PaxDbiQ5I0J9.
PRIDEiQ5I0J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi292875.
KEGGirno:292875.
UCSCiRGD:1310111. rat.

Organism-specific databases

CTDi554235.
RGDi1310111. Aspdh.

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ5I0J9.
PhylomeDBiQ5I0J9.
TreeFamiTF315092.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Miscellaneous databases

NextBioi634962.

Gene expression databases

GenevestigatoriQ5I0J9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiASPD_RAT
AccessioniPrimary (citable) accession number: Q5I0J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 15, 2005
Last modified: January 7, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.