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Protein

Putative L-aspartate dehydrogenase

Gene

Aspdh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Putative L-aspartate dehydrogenase (Aspdh)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131NAD; via amide nitrogenBy similarity1
Binding sitei196NADBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-aspartate dehydrogenase (EC:1.4.1.21)
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene namesi
Name:Aspdh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310111. Aspdh.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001449021 – 297Putative L-aspartate dehydrogenaseAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei172PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5I0J9.

Expressioni

Gene expression databases

ExpressionAtlasiQ5I0J9. baseline and differential.
GenevisibleiQ5I0J9. RN.

Structurei

3D structure databases

ProteinModelPortaliQ5I0J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000004452.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ5I0J9.
PhylomeDBiQ5I0J9.
TreeFamiTF315092.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I0J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASMVPRVP HKVGVVGYGR LGQSLVSRLL AQGSELGLEL VFVWNRDPGR
60 70 80 90 100
MAGSVPPALQ LEDLTTLEER HPDLVVEVAH PKIIHESGVQ ILRHANLLVG
110 120 130 140 150
SPSALADQTT ERQLLEASNH WGHTVFVARG ALWGCEDISR LDAAGGLQSL
160 170 180 190 200
RVTMATHPDG FRLEGPLAAA HSSGPRTVLY EGPVRGLCPL APRNSNTMAA
210 220 230 240 250
AALAAPSLGF DRVIGVLVAD LSLTDMHVVD VELTGPQGPQ AAALPCTPTE
260 270 280 290
RTQPSLALSL APLLLQPSGT AYWAAVSFPP DLGSASAEFP PLPLLSP
Length:297
Mass (Da):31,260
Last modified:February 15, 2005 - v1
Checksum:i572A02B436161734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088252 mRNA. Translation: AAH88252.1.
RefSeqiNP_001009643.2. NM_001009643.2.
UniGeneiRn.54118.

Genome annotation databases

EnsembliENSRNOT00000067562; ENSRNOP00000063826; ENSRNOG00000019424.
GeneIDi292875.
KEGGirno:292875.
UCSCiRGD:1310111. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088252 mRNA. Translation: AAH88252.1.
RefSeqiNP_001009643.2. NM_001009643.2.
UniGeneiRn.54118.

3D structure databases

ProteinModelPortaliQ5I0J9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5I0J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067562; ENSRNOP00000063826; ENSRNOG00000019424.
GeneIDi292875.
KEGGirno:292875.
UCSCiRGD:1310111. rat.

Organism-specific databases

CTDi554235.
RGDi1310111. Aspdh.

Phylogenomic databases

GeneTreeiENSGT00390000004452.
HOGENOMiHOG000007399.
HOVERGENiHBG062283.
InParanoidiQ5I0J9.
PhylomeDBiQ5I0J9.
TreeFamiTF315092.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00456.

Miscellaneous databases

PROiQ5I0J9.

Gene expression databases

ExpressionAtlasiQ5I0J9. baseline and differential.
GenevisibleiQ5I0J9. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASPD_RAT
AccessioniPrimary (citable) accession number: Q5I0J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.