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Protein

U6 snRNA phosphodiesterase

Gene

Usb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122Proton donor/acceptorUniRule annotation1
Active sitei210Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Usb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1305215 Usb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743931 – 267U6 snRNA phosphodiesteraseAdd BLAST267

Proteomic databases

PaxDbiQ5I0I5
PRIDEiQ5I0I5

Expressioni

Gene expression databases

BgeeiENSRNOG00000013216
GenevisibleiQ5I0I5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017960

Structurei

3D structure databases

SMRiQ5I0I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2H phosphoesterase superfamily. USB1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3102 Eukaryota
ENOG4111KT5 LUCA
GeneTreeiENSGT00390000004596
HOGENOMiHOG000047515
HOVERGENiHBG081315
InParanoidiQ5I0I5
OMAiTFYKDPS
OrthoDBiEOG091G0HOU
PhylomeDBiQ5I0I5
TreeFamiTF324364

Family and domain databases

HAMAPiMF_03040 USB1, 1 hit
InterProiView protein in InterPro
IPR009097 cNuc_Pdiesterase
IPR027521 Usb1
PANTHERiPTHR13522 PTHR13522, 1 hit
PfamiView protein in Pfam
PF09749 HVSL, 1 hit
SUPFAMiSSF55144 SSF55144, 1 hit

Sequencei

Sequence statusi: Complete.

Q5I0I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAPLVGYS SSGSEDEAEA VAAGRSKPGS GLHRCGQNPL PSQRFPVPDS
60 70 80 90 100
VLNMFPSTEE GPEDDSARHG GRIRTFPHER GNWATHIYIP YEANEEFQDL
110 120 130 140 150
LDVLLPRAQM FAPRLVQMEE FHLSLSQSVV LRHHWILPFV QVLKDRMASF
160 170 180 190 200
QRFFFTANRV KIYTNQEKTR TFIGLEVSSG HAQFLDMVSE VDRVMKEFDL
210 220 230 240 250
TTFYQDPSFH VSLAWCVGDA RLQLEGQCQQ ELQEIVDEFE DSEMLLRVLA
260
EQVRCKSGNK FFSMPLK
Length:267
Mass (Da):30,475
Last modified:February 15, 2005 - v1
Checksum:iB678B7E0F6AD3B50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088280 mRNA Translation: AAH88280.1
RefSeqiNP_001014035.1, NM_001014013.1
UniGeneiRn.95149

Genome annotation databases

EnsembliENSRNOT00000017960; ENSRNOP00000017960; ENSRNOG00000013216
GeneIDi307643
KEGGirno:307643
UCSCiRGD:1305215 rat

Similar proteinsi

Entry informationi

Entry nameiUSB1_RAT
AccessioniPrimary (citable) accession number: Q5I0I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 15, 2005
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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