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Q5I0H9 (PDIA5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein disulfide-isomerase A5

EC=5.3.4.1
Gene names
Name:Pdia5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 3 thioredoxin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 517496Protein disulfide-isomerase A5
PRO_0000034235

Regions

Domain132 – 259128Thioredoxin 1
Domain268 – 382115Thioredoxin 2
Domain376 – 504129Thioredoxin 3
Motif514 – 5174Prevents secretion from ER Potential

Amino acid modifications

Disulfide bond180 ↔ 183Redox-active By similarity
Disulfide bond303 ↔ 306Redox-active By similarity
Disulfide bond424 ↔ 427Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5I0H9 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 038F0B07E1C15A0A

FASTA51759,399
        10         20         30         40         50         60 
MARAWGLLLA IGVILPTWLS STKVSSLIER ISDPKDLKKL LRTRNNVLVL YSESEVAAES 

        70         80         90        100        110        120 
HLKLLSTVAQ AVKGQGTICW VDCGDAESRK LCKKMKVDLS PKDKKIELFH YQDGAFHMQY 

       130        140        150        160        170        180 
DRAVTLKSIV AFLKDPKGPP LWEEDPGAKD VVHIDSEKDF RRLLKKEEKP LLMMFYAPWC 

       190        200        210        220        230        240 
SMCKRIMPHF QKAATQVRGH TVLAGMNVYP PEFENIKEEY NVRGYPTICY FEKGRFLFQY 

       250        260        270        280        290        300 
ENYGSTAEDI VEWLKNPQPP QPQVPETPWA DEGGSVYHLT DEDFDQFVKE HSSVLVMFHA 

       310        320        330        340        350        360 
PWCGHCKKMK PEFESAAEVL HGDAESSGVL AAVDATINEA LAERFHISAF PTLKYFKNGE 

       370        380        390        400        410        420 
QQAVPALRTK KKFIEWMQNP EAPPPPEPTW EEQQTSVLHL VGDNFRETLK KKKHTLVMFY 

       430        440        450        460        470        480 
APWCPHCKKV IPHFTATADA FKDDRKIACA AVDCVKDKNQ DLCQQESVKA YPTFHYYHYG 

       490        500        510 
KLVEKYESDR TELGFTSFIR TLREGDLKRL EKRREDL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC088305 mRNA. Translation: AAH88305.1.
RefSeqNP_001014147.1. NM_001014125.1.
UniGeneRn.162053.

3D structure databases

ProteinModelPortalQ5I0H9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4573704.
STRING10116.ENSRNOP00000059945.

Proteomic databases

PaxDbQ5I0H9.
PRIDEQ5I0H9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID360722.
KEGGrno:360722.
UCSCRGD:1359236. rat.

Organism-specific databases

CTD10954.
RGD1359236. Pdia5.

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000039967.
HOVERGENHBG053547.
InParanoidQ5I0H9.
KOK09583.
OrthoDBEOG74TWZ6.
PhylomeDBQ5I0H9.
TreeFamTF106379.

Gene expression databases

GenevestigatorQ5I0H9.

Family and domain databases

Gene3D3.40.30.10. 4 hits.
InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 3 hits.
[Graphical view]
PRINTSPR00421. THIOREDOXIN.
SUPFAMSSF52833. SSF52833. 4 hits.
PROSITEPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio673887.

Entry information

Entry namePDIA5_RAT
AccessionPrimary (citable) accession number: Q5I0H9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families