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Q5I0H9

- PDIA5_RAT

UniProt

Q5I0H9 - PDIA5_RAT

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Protein
Protein disulfide-isomerase A5
Gene
Pdia5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: RefGenome

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. protein folding Source: RefGenome
  3. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_93415. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A5 (EC:5.3.4.1)
Gene namesi
Name:Pdia5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1359236. Pdia5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 517496Protein disulfide-isomerase A5
PRO_0000034235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi180 ↔ 183Redox-active By similarity
Disulfide bondi303 ↔ 306Redox-active By similarity
Disulfide bondi424 ↔ 427Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5I0H9.
PRIDEiQ5I0H9.

Expressioni

Gene expression databases

GenevestigatoriQ5I0H9.

Interactioni

Protein-protein interaction databases

MINTiMINT-4573704.
STRINGi10116.ENSRNOP00000059945.

Structurei

3D structure databases

ProteinModelPortaliQ5I0H9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 259128Thioredoxin 1
Add
BLAST
Domaini268 – 382115Thioredoxin 2
Add
BLAST
Domaini376 – 504129Thioredoxin 3
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi514 – 5174Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 3 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000039967.
HOVERGENiHBG053547.
InParanoidiQ5I0H9.
KOiK09583.
OrthoDBiEOG74TWZ6.
PhylomeDBiQ5I0H9.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0H9-1 [UniParc]FASTAAdd to Basket

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MARAWGLLLA IGVILPTWLS STKVSSLIER ISDPKDLKKL LRTRNNVLVL    50
YSESEVAAES HLKLLSTVAQ AVKGQGTICW VDCGDAESRK LCKKMKVDLS 100
PKDKKIELFH YQDGAFHMQY DRAVTLKSIV AFLKDPKGPP LWEEDPGAKD 150
VVHIDSEKDF RRLLKKEEKP LLMMFYAPWC SMCKRIMPHF QKAATQVRGH 200
TVLAGMNVYP PEFENIKEEY NVRGYPTICY FEKGRFLFQY ENYGSTAEDI 250
VEWLKNPQPP QPQVPETPWA DEGGSVYHLT DEDFDQFVKE HSSVLVMFHA 300
PWCGHCKKMK PEFESAAEVL HGDAESSGVL AAVDATINEA LAERFHISAF 350
PTLKYFKNGE QQAVPALRTK KKFIEWMQNP EAPPPPEPTW EEQQTSVLHL 400
VGDNFRETLK KKKHTLVMFY APWCPHCKKV IPHFTATADA FKDDRKIACA 450
AVDCVKDKNQ DLCQQESVKA YPTFHYYHYG KLVEKYESDR TELGFTSFIR 500
TLREGDLKRL EKRREDL 517
Length:517
Mass (Da):59,399
Last modified:February 15, 2005 - v1
Checksum:i038F0B07E1C15A0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088305 mRNA. Translation: AAH88305.1.
RefSeqiNP_001014147.1. NM_001014125.1.
UniGeneiRn.162053.

Genome annotation databases

GeneIDi360722.
KEGGirno:360722.
UCSCiRGD:1359236. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088305 mRNA. Translation: AAH88305.1 .
RefSeqi NP_001014147.1. NM_001014125.1.
UniGenei Rn.162053.

3D structure databases

ProteinModelPortali Q5I0H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4573704.
STRINGi 10116.ENSRNOP00000059945.

Proteomic databases

PaxDbi Q5I0H9.
PRIDEi Q5I0H9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 360722.
KEGGi rno:360722.
UCSCi RGD:1359236. rat.

Organism-specific databases

CTDi 10954.
RGDi 1359236. Pdia5.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000039967.
HOVERGENi HBG053547.
InParanoidi Q5I0H9.
KOi K09583.
OrthoDBi EOG74TWZ6.
PhylomeDBi Q5I0H9.
TreeFami TF106379.

Enzyme and pathway databases

Reactomei REACT_93415. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 673887.

Gene expression databases

Genevestigatori Q5I0H9.

Family and domain databases

Gene3Di 3.40.30.10. 4 hits.
InterProi IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 3 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 4 hits.
PROSITEi PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiPDIA5_RAT
AccessioniPrimary (citable) accession number: Q5I0H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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