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Protein

Cyclin-L2

Gene

Ccnl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L2
Gene namesi
Name:Ccnl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1309149 Ccnl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804891 – 520Cyclin-L2Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei330PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei368PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5I0H5
PRIDEiQ5I0H5

PTM databases

iPTMnetiQ5I0H5
PhosphoSitePlusiQ5I0H5

Expressioni

Gene expression databases

BgeeiENSRNOG00000018691
ExpressionAtlasiQ5I0H5 baseline and differential

Interactioni

Subunit structurei

Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025531

Structurei

3D structure databases

ProteinModelPortaliQ5I0H5
SMRiQ5I0H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 183Cyclin-like 1Add BLAST103
Regioni196 – 280Cyclin-like 2Add BLAST85
Regioni384 – 422RSAdd BLAST39

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000231292
HOVERGENiHBG056044
InParanoidiQ5I0H5
OrthoDBiEOG091G0BW9
PhylomeDBiQ5I0H5
TreeFamiTF101011

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5I0H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAGASG LMAPALAACS SGSGGAAPGS QGVLIGDRLY SGVLITLENC
60 70 80 90 100
LLPDDKLRFT PSMSSGLDID TETGLRVVGC ELIQAAGILL RLPQVAMATG
110 120 130 140 150
QVLFQRFFYT KSFVKHSMEH VSMACVHLAS KIEEAPRRIR DVINVFHRLR
160 170 180 190 200
HLREKKKPVP LVLDQEYVNL KNQIIKAERR VLKELGFCVH VKHPHKIIVM
210 220 230 240 250
YLQVLECERN QHLVQTAWNY MNDSLRTDVF VRFQPESIAC ACIYLAARTL
260 270 280 290 300
EIPLPNRPHW FLLFGATEEE IQEICFKILQ LYTRKKVDLT HLESEVEKRK
310 320 330 340 350
HAIEEAKARA KGLLPPGSAP GLDSATAGFS PAPKPESPKE GKGSKSSPLS
360 370 380 390 400
VKNAKRKMEG PKKAKGDSPV NGLLKGQESR SQSRSREQSY SRSPSRSASP
410 420 430 440 450
KRRKSDSGST SGGSKSQSRS RSRSDSPPRQ VHRGAPYKGS EVRGSRKSKD
460 470 480 490 500
CKHLTQKPHK SRSRSSSRSR SRSRERTDSS GKYKKKSHYY RDQRRERSRS
510 520
YERTGHRYER DHPGHSRHRR
Length:520
Mass (Da):58,246
Last modified:November 8, 2005 - v2
Checksum:iCF78FB24BE3EFA7C
GO
Isoform 2 (identifier: Q5I0H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-224: NYMNDS → VASEGK
     225-520: Missing.

Show »
Length:224
Mass (Da):24,620
Checksum:iEEB2D3920BF2C54C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016136219 – 224NYMNDS → VASEGK in isoform 2. 1 Publication6
Alternative sequenceiVSP_016137225 – 520Missing in isoform 2. 1 PublicationAdd BLAST296

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040241 Genomic DNA No translation available.
BC088316 mRNA Translation: AAH88316.1
RefSeqiNP_001013112.1, NM_001013094.1 [Q5I0H5-2]
XP_006239607.1, XM_006239545.3 [Q5I0H5-1]
UniGeneiRn.232195
Rn.43669

Genome annotation databases

EnsembliENSRNOT00000089936; ENSRNOP00000068952; ENSRNOG00000018691 [Q5I0H5-2]
GeneIDi298686
KEGGirno:298686

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNL2_RAT
AccessioniPrimary (citable) accession number: Q5I0H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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