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Protein

Kinesin-like protein KIF22

Gene

Kif22

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi119 – 126ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-RNO-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF22
Gene namesi
Name:Kif22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311886. Kif22.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeleton Curated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002629231 – 657Kinesin-like protein KIF22Add BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei404PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei573PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5I0E8.
PRIDEiQ5I0E8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047950.
ExpressionAtlasiQ5I0E8. baseline and differential.

Interactioni

Subunit structurei

Interacts with FAM83D and SIAH1.By similarity

Protein-protein interaction databases

BioGridi254299. 1 interactor.
STRINGi10116.ENSRNOP00000064910.

Structurei

3D structure databases

ProteinModelPortaliQ5I0E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 360Kinesin motorPROSITE-ProRule annotationAdd BLAST323

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili457 – 502Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000007569.
HOVERGENiHBG052252.
InParanoidiQ5I0E8.
KOiK10403.
OMAiAGQRCGP.
OrthoDBiEOG091G0FFB.
PhylomeDBiQ5I0E8.
TreeFamiTF105233.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR010994. RuvA_2-like.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00278. HhH1. 2 hits.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I0E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVRAKKKPQ QREMASASSG PSRSLSKGGV SRRPPLARVR VAVRLRPFMD
60 70 80 90 100
EAKEPPCVRG IDSCSLEVAN WRKYQETLKY QFDAFYGEKS TQQDVYVGSV
110 120 130 140 150
QPILRHLLEG QNASVLAYGP TGAGKTHTML GSPEQPGVIP RALMDLLQLT
160 170 180 190 200
REESAEGRPW DISVAMSYLE IYQEKVLDLL DPASGDLVIR EDCRGNILIP
210 220 230 240 250
GLTQKPITSF SEFEQHFLPA SRNRVVGATR LNQRSSRSHA VLLVKVEQRE
260 270 280 290 300
RLTPFRQREG KLYLIDLAGS EDNRRTGNQG IRLKESGAIN TSLFVLGKVV
310 320 330 340 350
DALNQGLPRI PYRDSKLTRL LQDSLGGSAH SILIANIAPE RRFYQDTISA
360 370 380 390 400
LNFTARSKEV INRPFTNESL QPHALAPVKL PQKELLGPSE AKKAKGPEEE
410 420 430 440 450
STGSPESTAA PASASQKLSL LQKLSNMDPA MLENLLSMER LLGSQGSQGI
460 470 480 490 500
PLLNTPKRER MVLIKTVEEK NLEIERLKMK QKELEAKVLA QEALDPKEKE
510 520 530 540 550
NTPTILQPSS SCSGSVAKPL KKAVVMPLQR IQKQSESSNK IHLLKKGHKR
560 570 580 590 600
KLESSHESEA VEKDEDYWEI QISPELLARG RKKLLHLLNE GSARDLRSLQ
610 620 630 640 650
RIGQKKAQLI VGWRELHGPF NEVEDLEQVE GISGKQVESF LKANLLSLAA

SQHSGPS
Length:657
Mass (Da):73,056
Last modified:February 15, 2005 - v1
Checksum:iCB0446720DBBD945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088421 mRNA. Translation: AAH88421.1.
RefSeqiNP_001009645.1. NM_001009645.1.
UniGeneiRn.8601.

Genome annotation databases

EnsembliENSRNOT00000027525; ENSRNOP00000027525; ENSRNOG00000020281.
GeneIDi293502.
KEGGirno:293502.
UCSCiRGD:1311886. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088421 mRNA. Translation: AAH88421.1.
RefSeqiNP_001009645.1. NM_001009645.1.
UniGeneiRn.8601.

3D structure databases

ProteinModelPortaliQ5I0E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi254299. 1 interactor.
STRINGi10116.ENSRNOP00000064910.

Proteomic databases

PaxDbiQ5I0E8.
PRIDEiQ5I0E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027525; ENSRNOP00000027525; ENSRNOG00000020281.
GeneIDi293502.
KEGGirno:293502.
UCSCiRGD:1311886. rat.

Organism-specific databases

CTDi3835.
RGDi1311886. Kif22.

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000007569.
HOVERGENiHBG052252.
InParanoidiQ5I0E8.
KOiK10403.
OMAiAGQRCGP.
OrthoDBiEOG091G0FFB.
PhylomeDBiQ5I0E8.
TreeFamiTF105233.

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-RNO-983189. Kinesins.

Miscellaneous databases

PROiQ5I0E8.

Gene expression databases

BgeeiENSRNOG00000047950.
ExpressionAtlasiQ5I0E8. baseline and differential.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR010994. RuvA_2-like.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00278. HhH1. 2 hits.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF22_RAT
AccessioniPrimary (citable) accession number: Q5I0E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.