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Q5I0D6

- NOSTN_RAT

UniProt

Q5I0D6 - NOSTN_RAT

Protein

Nostrin

Gene

Nostrin

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.By similarity

    GO - Molecular functioni

    1. DNA binding Source: Ensembl

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. negative regulation of transcription, DNA-templated Source: Ensembl
    3. regulation of nitric-oxide synthase activity Source: InterPro

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nostrin
    Alternative name(s):
    BM247
    Nitric oxide synthase trafficker
    eNOS-trafficking inducer
    Gene namesi
    Name:Nostrin
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi727920. Nostrin.

    Subcellular locationi

    Cell membrane By similarity. Cytoplasmic vesicle By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502NostrinPRO_0000289091Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei479 – 4791PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5I0D6.
    PRIDEiQ5I0D6.

    Expressioni

    Tissue specificityi

    Over-expressed in brain microcapillaries from spontaneously hypertensive rats.1 Publication

    Gene expression databases

    GenevestigatoriQ5I0D6.

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000062066.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5I0D6.
    SMRiQ5I0D6. Positions 432-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6666FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini438 – 49760SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili160 – 23071Sequence AnalysisAdd
    BLAST
    Coiled coili305 – 33531Sequence AnalysisAdd
    BLAST

    Domaini

    The SH3 domain mediates interaction with NOS3, DNM2 and WASL.By similarity
    The FCH domain is necessary for membrane targeting.By similarity

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG266189.
    GeneTreeiENSGT00510000048120.
    HOGENOMiHOG000113830.
    HOVERGENiHBG101730.
    InParanoidiQ5I0D6.
    OMAiWAWVSEG.
    OrthoDBiEOG7BCNBJ.
    PhylomeDBiQ5I0D6.

    Family and domain databases

    InterProiIPR001060. FCH_dom.
    IPR028535. Nostrin.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    [Graphical view]
    PANTHERiPTHR14167:SF22. PTHR14167:SF22. 1 hit.
    PfamiPF00611. FCH. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5I0D6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDPLTDCSY NKVYKSLKEF AQNGDNFCKQ ITSVLQQRAN LEISYAKGLQ    50
    KLAVKLSKAL QSTKKNCLST AWAWASESMK SAADLHQKLG KAIELEAIKP 100
    THQVLSMQEK KRKSLDNEVE KSANLVINNW NQQIKAKKKL MMSTKKHEAL 150
    FHLIESSKQS MTQKEKQKLL NKLKKSTEKL EKEDESYYQK NMAGYSTRLK 200
    WESTLEKCYK SMLELEKERI QLLCNNLNQY SQHISLFGQT LTTCHTQIHC 250
    AISKVDVEKD IQALMEETAV LSLENKSELL LADYFEEDPK NPMDKERRKS 300
    LIKPKLWRLQ KDIEKASRDK EGLEQKLKAL ASSASFSDAK SQKDAETLMD 350
    ENSLKLDLLQ ANSYKLSTVL ADLEQRPKPC HPCSNCIFKW KEKEHSHSYV 400
    KISRPLLTKR LEKAESKAPA GEQNNPSSSR PGSSVSQGNN QLCKALYTFQ 450
    ARQDDELNLE KGDIVTIHEK KEEGWWFGSL NGKKGHFPAA YVEELPPKAG 500
    QA 502
    Length:502
    Mass (Da):57,352
    Last modified:February 15, 2005 - v1
    Checksum:iDE8944D1939CCC4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088446 mRNA. Translation: AAH88446.1.
    AY032855 mRNA. Translation: AAK64518.1.
    RefSeqiNP_001019431.1. NM_001024260.1.
    UniGeneiRn.39383.

    Genome annotation databases

    EnsembliENSRNOT00000067161; ENSRNOP00000062066; ENSRNOG00000006611.
    GeneIDi311111.
    KEGGirno:311111.
    UCSCiRGD:727920. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088446 mRNA. Translation: AAH88446.1 .
    AY032855 mRNA. Translation: AAK64518.1 .
    RefSeqi NP_001019431.1. NM_001024260.1.
    UniGenei Rn.39383.

    3D structure databases

    ProteinModelPortali Q5I0D6.
    SMRi Q5I0D6. Positions 432-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000062066.

    Proteomic databases

    PaxDbi Q5I0D6.
    PRIDEi Q5I0D6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000067161 ; ENSRNOP00000062066 ; ENSRNOG00000006611 .
    GeneIDi 311111.
    KEGGi rno:311111.
    UCSCi RGD:727920. rat.

    Organism-specific databases

    CTDi 115677.
    RGDi 727920. Nostrin.

    Phylogenomic databases

    eggNOGi NOG266189.
    GeneTreei ENSGT00510000048120.
    HOGENOMi HOG000113830.
    HOVERGENi HBG101730.
    InParanoidi Q5I0D6.
    OMAi WAWVSEG.
    OrthoDBi EOG7BCNBJ.
    PhylomeDBi Q5I0D6.

    Miscellaneous databases

    NextBioi 662980.
    PROi Q5I0D6.

    Gene expression databases

    Genevestigatori Q5I0D6.

    Family and domain databases

    InterProi IPR001060. FCH_dom.
    IPR028535. Nostrin.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    [Graphical view ]
    PANTHERi PTHR14167:SF22. PTHR14167:SF22. 1 hit.
    Pfami PF00611. FCH. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. "Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats."
      Kirsch T., Wellner M., Luft F.C., Haller H., Lippoldt A.
      Brain Res. 910:106-115(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-143, TISSUE SPECIFICITY.
      Strain: SHRSP.

    Entry informationi

    Entry nameiNOSTN_RAT
    AccessioniPrimary (citable) accession number: Q5I0D6
    Secondary accession number(s): Q923J7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3