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Q5I0D6 (NOSTN_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nostrin
Alternative name(s):
BM247
Nitric oxide synthase trafficker
eNOS-trafficking inducer
Gene names
Name:Nostrin
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane By similarity.

Subunit structure

Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 By similarity.

Subcellular location

Cell membrane By similarity. Cytoplasmic vesicle By similarity. Cytoplasm By similarity.

Tissue specificity

Over-expressed in brain microcapillaries from spontaneously hypertensive rats. Ref.2

Domain

The SH3 domain mediates interaction with NOS3, DNM2 and WASL By similarity.

The FCH domain is necessary for membrane targeting By similarity.

Sequence similarities

Contains 1 FCH domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Nostrin
PRO_0000289091

Regions

Domain1 – 6666FCH
Domain438 – 49760SH3
Coiled coil160 – 23071 Potential
Coiled coil305 – 33531 Potential

Amino acid modifications

Modified residue4791Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5I0D6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: DE8944D1939CCC4C

FASTA50257,352
        10         20         30         40         50         60 
MRDPLTDCSY NKVYKSLKEF AQNGDNFCKQ ITSVLQQRAN LEISYAKGLQ KLAVKLSKAL 

        70         80         90        100        110        120 
QSTKKNCLST AWAWASESMK SAADLHQKLG KAIELEAIKP THQVLSMQEK KRKSLDNEVE 

       130        140        150        160        170        180 
KSANLVINNW NQQIKAKKKL MMSTKKHEAL FHLIESSKQS MTQKEKQKLL NKLKKSTEKL 

       190        200        210        220        230        240 
EKEDESYYQK NMAGYSTRLK WESTLEKCYK SMLELEKERI QLLCNNLNQY SQHISLFGQT 

       250        260        270        280        290        300 
LTTCHTQIHC AISKVDVEKD IQALMEETAV LSLENKSELL LADYFEEDPK NPMDKERRKS 

       310        320        330        340        350        360 
LIKPKLWRLQ KDIEKASRDK EGLEQKLKAL ASSASFSDAK SQKDAETLMD ENSLKLDLLQ 

       370        380        390        400        410        420 
ANSYKLSTVL ADLEQRPKPC HPCSNCIFKW KEKEHSHSYV KISRPLLTKR LEKAESKAPA 

       430        440        450        460        470        480 
GEQNNPSSSR PGSSVSQGNN QLCKALYTFQ ARQDDELNLE KGDIVTIHEK KEEGWWFGSL 

       490        500 
NGKKGHFPAA YVEELPPKAG QA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]"Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats."
Kirsch T., Wellner M., Luft F.C., Haller H., Lippoldt A.
Brain Res. 910:106-115(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-143, TISSUE SPECIFICITY.
Strain: SHRSP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC088446 mRNA. Translation: AAH88446.1.
AY032855 mRNA. Translation: AAK64518.1.
RefSeqNP_001019431.1. NM_001024260.1.
UniGeneRn.39383.

3D structure databases

ProteinModelPortalQ5I0D6.
SMRQ5I0D6. Positions 432-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000062066.

Proteomic databases

PaxDbQ5I0D6.
PRIDEQ5I0D6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000067161; ENSRNOP00000062066; ENSRNOG00000006611.
GeneID311111.
KEGGrno:311111.
UCSCRGD:727920. rat.

Organism-specific databases

CTD115677.
RGD727920. Nostrin.

Phylogenomic databases

eggNOGNOG266189.
GeneTreeENSGT00510000048120.
HOGENOMHOG000113830.
HOVERGENHBG101730.
InParanoidQ5I0D6.
OMAWAWVSEG.
OrthoDBEOG7BCNBJ.
PhylomeDBQ5I0D6.

Gene expression databases

GenevestigatorQ5I0D6.

Family and domain databases

InterProIPR001060. FCH_dom.
IPR028535. Nostrin.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PANTHERPTHR14167:SF1. PTHR14167:SF1. 1 hit.
PfamPF00611. FCH. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio662980.
PROQ5I0D6.

Entry information

Entry nameNOSTN_RAT
AccessionPrimary (citable) accession number: Q5I0D6
Secondary accession number(s): Q923J7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families