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Q5I0D6

- NOSTN_RAT

UniProt

Q5I0D6 - NOSTN_RAT

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Protein

Nostrin

Gene

Nostrin

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.By similarity

GO - Molecular functioni

  1. DNA binding Source: Ensembl

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
  2. negative regulation of transcription, DNA-templated Source: Ensembl
  3. regulation of nitric-oxide synthase activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Nostrin
Alternative name(s):
BM247
Nitric oxide synthase trafficker
eNOS-trafficking inducer
Gene namesi
Name:Nostrin
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi727920. Nostrin.

Subcellular locationi

Cell membrane By similarity. Cytoplasmic vesicle By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. nucleus Source: Ensembl
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502NostrinPRO_0000289091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei479 – 4791PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5I0D6.
PRIDEiQ5I0D6.

Expressioni

Tissue specificityi

Over-expressed in brain microcapillaries from spontaneously hypertensive rats.1 Publication

Gene expression databases

GenevestigatoriQ5I0D6.

Interactioni

Subunit structurei

Homotrimer. Interacts with DAB2. Interacts with NOS3, DNM2, WASL and CAV1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062066.

Structurei

3D structure databases

ProteinModelPortaliQ5I0D6.
SMRiQ5I0D6. Positions 432-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6666FCHPROSITE-ProRule annotationAdd
BLAST
Domaini438 – 49760SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili160 – 23071Sequence AnalysisAdd
BLAST
Coiled coili305 – 33531Sequence AnalysisAdd
BLAST

Domaini

The SH3 domain mediates interaction with NOS3, DNM2 and WASL.By similarity
The FCH domain is necessary for membrane targeting.By similarity

Sequence similaritiesi

Contains 1 FCH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG266189.
GeneTreeiENSGT00510000048120.
HOGENOMiHOG000113830.
HOVERGENiHBG101730.
InParanoidiQ5I0D6.
OMAiWAWVSEG.
OrthoDBiEOG7BCNBJ.
PhylomeDBiQ5I0D6.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR028535. Nostrin.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view]
PANTHERiPTHR14167:SF22. PTHR14167:SF22. 1 hit.
PfamiPF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I0D6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDPLTDCSY NKVYKSLKEF AQNGDNFCKQ ITSVLQQRAN LEISYAKGLQ
60 70 80 90 100
KLAVKLSKAL QSTKKNCLST AWAWASESMK SAADLHQKLG KAIELEAIKP
110 120 130 140 150
THQVLSMQEK KRKSLDNEVE KSANLVINNW NQQIKAKKKL MMSTKKHEAL
160 170 180 190 200
FHLIESSKQS MTQKEKQKLL NKLKKSTEKL EKEDESYYQK NMAGYSTRLK
210 220 230 240 250
WESTLEKCYK SMLELEKERI QLLCNNLNQY SQHISLFGQT LTTCHTQIHC
260 270 280 290 300
AISKVDVEKD IQALMEETAV LSLENKSELL LADYFEEDPK NPMDKERRKS
310 320 330 340 350
LIKPKLWRLQ KDIEKASRDK EGLEQKLKAL ASSASFSDAK SQKDAETLMD
360 370 380 390 400
ENSLKLDLLQ ANSYKLSTVL ADLEQRPKPC HPCSNCIFKW KEKEHSHSYV
410 420 430 440 450
KISRPLLTKR LEKAESKAPA GEQNNPSSSR PGSSVSQGNN QLCKALYTFQ
460 470 480 490 500
ARQDDELNLE KGDIVTIHEK KEEGWWFGSL NGKKGHFPAA YVEELPPKAG

QA
Length:502
Mass (Da):57,352
Last modified:February 15, 2005 - v1
Checksum:iDE8944D1939CCC4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088446 mRNA. Translation: AAH88446.1.
AY032855 mRNA. Translation: AAK64518.1.
RefSeqiNP_001019431.1. NM_001024260.1.
UniGeneiRn.39383.

Genome annotation databases

EnsembliENSRNOT00000067161; ENSRNOP00000062066; ENSRNOG00000006611.
GeneIDi311111.
KEGGirno:311111.
UCSCiRGD:727920. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088446 mRNA. Translation: AAH88446.1 .
AY032855 mRNA. Translation: AAK64518.1 .
RefSeqi NP_001019431.1. NM_001024260.1.
UniGenei Rn.39383.

3D structure databases

ProteinModelPortali Q5I0D6.
SMRi Q5I0D6. Positions 432-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000062066.

Proteomic databases

PaxDbi Q5I0D6.
PRIDEi Q5I0D6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000067161 ; ENSRNOP00000062066 ; ENSRNOG00000006611 .
GeneIDi 311111.
KEGGi rno:311111.
UCSCi RGD:727920. rat.

Organism-specific databases

CTDi 115677.
RGDi 727920. Nostrin.

Phylogenomic databases

eggNOGi NOG266189.
GeneTreei ENSGT00510000048120.
HOGENOMi HOG000113830.
HOVERGENi HBG101730.
InParanoidi Q5I0D6.
OMAi WAWVSEG.
OrthoDBi EOG7BCNBJ.
PhylomeDBi Q5I0D6.

Miscellaneous databases

NextBioi 662980.
PROi Q5I0D6.

Gene expression databases

Genevestigatori Q5I0D6.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR028535. Nostrin.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
[Graphical view ]
PANTHERi PTHR14167:SF22. PTHR14167:SF22. 1 hit.
Pfami PF00611. FCH. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats."
    Kirsch T., Wellner M., Luft F.C., Haller H., Lippoldt A.
    Brain Res. 910:106-115(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-143, TISSUE SPECIFICITY.
    Strain: SHRSP.

Entry informationi

Entry nameiNOSTN_RAT
AccessioniPrimary (citable) accession number: Q5I0D6
Secondary accession number(s): Q923J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3