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Protein

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Gene

Lhpp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).By similarity

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17MagnesiumBy similarity1
Metal bindingi19Magnesium; via carbonyl oxygenBy similarity1
Binding sitei189SubstrateBy similarity1
Metal bindingi214MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-73817 Purine ribonucleoside monophosphate biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC:3.1.3.-, EC:3.6.1.1)
Gene namesi
Name:Lhpp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359187 Lhpp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050761 – 270Phospholysine phosphohistidine inorganic pyrophosphate phosphataseAdd BLAST270

Proteomic databases

PaxDbiQ5I0D5
PRIDEiQ5I0D5

PTM databases

PhosphoSitePlusiQ5I0D5

Expressioni

Gene expression databases

BgeeiENSRNOG00000017097
GenevisibleiQ5I0D5 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022971

Structurei

3D structure databases

ProteinModelPortaliQ5I0D5
SMRiQ5I0D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 19Substrate bindingBy similarity3
Regioni54 – 55Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG3040 Eukaryota
COG0647 LUCA
GeneTreeiENSGT00510000046678
HOGENOMiHOG000068106
HOVERGENiHBG075146
InParanoidiQ5I0D5
KOiK11725
OMAiRPYLLIH
OrthoDBiEOG091G191B
PhylomeDBiQ5I0D5
TreeFamiTF314344

Family and domain databases

CDDicd07509 HAD_PPase, 1 hit
Gene3Di3.40.50.1000, 3 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006357 HAD-SF_hydro_IIA
IPR023214 HAD_sf
IPR006355 LHPP/HDHD2
PfamiView protein in Pfam
PF13344 Hydrolase_6, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01460 HAD-SF-IIA, 1 hit
TIGR01458 HAD-SF-IIA-hyp3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5I0D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAWAERLSG VRGVLLDISG VLYDSGTGGG AAIAGSVEAV ARLKRSPLKV
60 70 80 90 100
RFCTNESQKS RRELVGVLQR LGFDISEGEV TAPAPATCQI LKERGLRPHL
110 120 130 140 150
LIHEGVRSEF DDIDMSNPNC VVIADAGEGF SYQNMNRAFQ VLMELENPVL
160 170 180 190 200
ISLGKGRYYK ETSGLMLDVG GYMKALEYAC GIEAEVVGKP SPEFFRSALQ
210 220 230 240 250
AIGVEAHQAI MIGDDIVGDV GGAQQCGMRA LQVRTGKFRP GDEHHPEVRA
260 270
DGYVDNLAEA VDLLLQHMDK
Length:270
Mass (Da):29,190
Last modified:February 15, 2005 - v1
Checksum:iFDBBCD6C5E3DCDBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088448 mRNA Translation: AAH88448.1
RefSeqiNP_001009706.1, NM_001009706.1
UniGeneiRn.15275

Genome annotation databases

EnsembliENSRNOT00000022971; ENSRNOP00000022971; ENSRNOG00000017097
GeneIDi361663
KEGGirno:361663
UCSCiRGD:1359187 rat

Similar proteinsi

Entry informationi

Entry nameiLHPP_RAT
AccessioniPrimary (citable) accession number: Q5I0D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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