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Protein

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Gene

Lhpp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).By similarity

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171MagnesiumBy similarity
Metal bindingi19 – 191Magnesium; via carbonyl oxygenBy similarity
Binding sitei189 – 1891SubstrateBy similarity
Metal bindingi214 – 2141MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-73817. Purine ribonucleoside monophosphate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC:3.1.3.-, EC:3.6.1.1)
Gene namesi
Name:Lhpp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359187. Lhpp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Phospholysine phosphohistidine inorganic pyrophosphate phosphatasePRO_0000305076Add
BLAST

Proteomic databases

PaxDbiQ5I0D5.
PRIDEiQ5I0D5.

PTM databases

PhosphoSiteiQ5I0D5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017097.
GenevisibleiQ5I0D5. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022971.

Structurei

3D structure databases

ProteinModelPortaliQ5I0D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 193Substrate bindingBy similarity
Regioni54 – 552Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG3040. Eukaryota.
COG0647. LUCA.
GeneTreeiENSGT00510000046678.
HOGENOMiHOG000068106.
HOVERGENiHBG075146.
InParanoidiQ5I0D5.
KOiK11725.
OMAiRPYLLIH.
OrthoDBiEOG091G191B.
PhylomeDBiQ5I0D5.
TreeFamiTF314344.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR006355. HAD-SF_hydro_IIA_hyp2.
IPR023215. NPhePase-like_dom.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01458. HAD-SF-IIA-hyp3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I0D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAWAERLSG VRGVLLDISG VLYDSGTGGG AAIAGSVEAV ARLKRSPLKV
60 70 80 90 100
RFCTNESQKS RRELVGVLQR LGFDISEGEV TAPAPATCQI LKERGLRPHL
110 120 130 140 150
LIHEGVRSEF DDIDMSNPNC VVIADAGEGF SYQNMNRAFQ VLMELENPVL
160 170 180 190 200
ISLGKGRYYK ETSGLMLDVG GYMKALEYAC GIEAEVVGKP SPEFFRSALQ
210 220 230 240 250
AIGVEAHQAI MIGDDIVGDV GGAQQCGMRA LQVRTGKFRP GDEHHPEVRA
260 270
DGYVDNLAEA VDLLLQHMDK
Length:270
Mass (Da):29,190
Last modified:February 15, 2005 - v1
Checksum:iFDBBCD6C5E3DCDBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088448 mRNA. Translation: AAH88448.1.
RefSeqiNP_001009706.1. NM_001009706.1.
UniGeneiRn.15275.

Genome annotation databases

EnsembliENSRNOT00000022971; ENSRNOP00000022971; ENSRNOG00000017097.
GeneIDi361663.
KEGGirno:361663.
UCSCiRGD:1359187. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088448 mRNA. Translation: AAH88448.1.
RefSeqiNP_001009706.1. NM_001009706.1.
UniGeneiRn.15275.

3D structure databases

ProteinModelPortaliQ5I0D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022971.

PTM databases

PhosphoSiteiQ5I0D5.

Proteomic databases

PaxDbiQ5I0D5.
PRIDEiQ5I0D5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022971; ENSRNOP00000022971; ENSRNOG00000017097.
GeneIDi361663.
KEGGirno:361663.
UCSCiRGD:1359187. rat.

Organism-specific databases

CTDi64077.
RGDi1359187. Lhpp.

Phylogenomic databases

eggNOGiKOG3040. Eukaryota.
COG0647. LUCA.
GeneTreeiENSGT00510000046678.
HOGENOMiHOG000068106.
HOVERGENiHBG075146.
InParanoidiQ5I0D5.
KOiK11725.
OMAiRPYLLIH.
OrthoDBiEOG091G191B.
PhylomeDBiQ5I0D5.
TreeFamiTF314344.

Enzyme and pathway databases

ReactomeiR-RNO-73817. Purine ribonucleoside monophosphate biosynthesis.

Miscellaneous databases

PROiQ5I0D5.

Gene expression databases

BgeeiENSRNOG00000017097.
GenevisibleiQ5I0D5. RN.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR006355. HAD-SF_hydro_IIA_hyp2.
IPR023215. NPhePase-like_dom.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01458. HAD-SF-IIA-hyp3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLHPP_RAT
AccessioniPrimary (citable) accession number: Q5I0D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.