Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methionyl-tRNA formyltransferase, mitochondrial

Gene

Mtfmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).By similarity

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase, mitochondrial (EC:2.1.2.9)
Short name:
MtFMT
Gene namesi
Name:Mtfmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309462 Mtfmt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010095? – 385Methionyl-tRNA formyltransferase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ5I0C5
PRIDEiQ5I0C5

Expressioni

Gene expression databases

BgeeiENSRNOG00000014602
GenevisibleiQ5I0C5 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019671

Structurei

3D structure databases

ProteinModelPortaliQ5I0C5
SMRiQ5I0C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.

Sequence similaritiesi

Belongs to the Fmt family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3082 Eukaryota
COG0223 LUCA
GeneTreeiENSGT00390000017828
HOGENOMiHOG000261177
HOVERGENiHBG031552
InParanoidiQ5I0C5
KOiK00604
OMAiNFYKYKR
OrthoDBiEOG091G0QUP
PhylomeDBiQ5I0C5
TreeFamiTF323405

Family and domain databases

InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPRRCWGP WLAGRRPRCS CQSPAGFSGK DRRSSRVREK PPWRVLFFGT
60 70 80 90 100
DHFAREALRA LHAARDNKEE KLIEKLEVVT VPSISPKGLP VKQYAIQSQL
110 120 130 140 150
PVYEWPDMGS GEYDVGVVAS FGRLLSEALI LKFPYGILNV HPSCLPRWRG
160 170 180 190 200
PAPIIHTVLH GDTVTGVTIM QVRPKRFDVG PILKQETVAV PPKSTSKELE
210 220 230 240 250
AVLSKLGANM LISVLKNLPE SLNNGRPQPA EGVTYAPKVS AGTSCVKWEE
260 270 280 290 300
QTSEQVLRLH LAIGDIVPLQ TLWMENTVKL LDLVEVNNSI LADPKVMGQT
310 320 330 340 350
VTPGSVVYHR PSQMLLVHCK DGWIGVRSIM HKKTLTATDF YNGYLHAWYQ
360 370 380
KNSHAYPSQC KFQTLRLPTK TQQKTKLLLC SALSS
Length:385
Mass (Da):42,997
Last modified:February 15, 2005 - v1
Checksum:i2CFD3CF0AAABC7F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088470 mRNA Translation: AAH88470.1
RefSeqiNP_001009697.1, NM_001009697.1
UniGeneiRn.34645

Genome annotation databases

EnsembliENSRNOT00000019671; ENSRNOP00000019671; ENSRNOG00000014602
GeneIDi315763
KEGGirno:315763
UCSCiRGD:1309462 rat

Similar proteinsi

Entry informationi

Entry nameiFMT_RAT
AccessioniPrimary (citable) accession number: Q5I0C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health