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Protein

Methionyl-tRNA formyltransferase, mitochondrial

Gene

Mtfmt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity).By similarity

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase, mitochondrial (EC:2.1.2.9)
Short name:
MtFMT
Gene namesi
Name:Mtfmt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309462. Mtfmt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010095? – 385Methionyl-tRNA formyltransferase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ5I0C5.
PRIDEiQ5I0C5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014602.
GenevisibleiQ5I0C5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019671.

Structurei

3D structure databases

ProteinModelPortaliQ5I0C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction.

Sequence similaritiesi

Belongs to the Fmt family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3082. Eukaryota.
COG0223. LUCA.
GeneTreeiENSGT00390000017828.
HOGENOMiHOG000261177.
HOVERGENiHBG031552.
InParanoidiQ5I0C5.
KOiK00604.
OMAiVEGRKPM.
OrthoDBiEOG091G0QUP.
PhylomeDBiQ5I0C5.
TreeFamiTF323405.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5I0C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPRRCWGP WLAGRRPRCS CQSPAGFSGK DRRSSRVREK PPWRVLFFGT
60 70 80 90 100
DHFAREALRA LHAARDNKEE KLIEKLEVVT VPSISPKGLP VKQYAIQSQL
110 120 130 140 150
PVYEWPDMGS GEYDVGVVAS FGRLLSEALI LKFPYGILNV HPSCLPRWRG
160 170 180 190 200
PAPIIHTVLH GDTVTGVTIM QVRPKRFDVG PILKQETVAV PPKSTSKELE
210 220 230 240 250
AVLSKLGANM LISVLKNLPE SLNNGRPQPA EGVTYAPKVS AGTSCVKWEE
260 270 280 290 300
QTSEQVLRLH LAIGDIVPLQ TLWMENTVKL LDLVEVNNSI LADPKVMGQT
310 320 330 340 350
VTPGSVVYHR PSQMLLVHCK DGWIGVRSIM HKKTLTATDF YNGYLHAWYQ
360 370 380
KNSHAYPSQC KFQTLRLPTK TQQKTKLLLC SALSS
Length:385
Mass (Da):42,997
Last modified:February 15, 2005 - v1
Checksum:i2CFD3CF0AAABC7F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088470 mRNA. Translation: AAH88470.1.
RefSeqiNP_001009697.1. NM_001009697.1.
UniGeneiRn.34645.

Genome annotation databases

EnsembliENSRNOT00000019671; ENSRNOP00000019671; ENSRNOG00000014602.
GeneIDi315763.
KEGGirno:315763.
UCSCiRGD:1309462. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088470 mRNA. Translation: AAH88470.1.
RefSeqiNP_001009697.1. NM_001009697.1.
UniGeneiRn.34645.

3D structure databases

ProteinModelPortaliQ5I0C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019671.

Proteomic databases

PaxDbiQ5I0C5.
PRIDEiQ5I0C5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019671; ENSRNOP00000019671; ENSRNOG00000014602.
GeneIDi315763.
KEGGirno:315763.
UCSCiRGD:1309462. rat.

Organism-specific databases

CTDi123263.
RGDi1309462. Mtfmt.

Phylogenomic databases

eggNOGiKOG3082. Eukaryota.
COG0223. LUCA.
GeneTreeiENSGT00390000017828.
HOGENOMiHOG000261177.
HOVERGENiHBG031552.
InParanoidiQ5I0C5.
KOiK00604.
OMAiVEGRKPM.
OrthoDBiEOG091G0QUP.
PhylomeDBiQ5I0C5.
TreeFamiTF323405.

Miscellaneous databases

PROiQ5I0C5.

Gene expression databases

BgeeiENSRNOG00000014602.
GenevisibleiQ5I0C5. RN.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFMT_RAT
AccessioniPrimary (citable) accession number: Q5I0C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.