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Protein

Protein ABHD14A

Gene

Abhd14a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in granule neuron development.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421Charge relay systemBy similarity
Active sitei193 – 1931Charge relay systemBy similarity
Active sitei220 – 2201Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERirat-abhea. CIB-CCG1-interacting-factor-B.
MEROPSiS33.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD14ACurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 14ACurated
Short name:
Abhydrolase domain-containing protein 14AImported
Gene namesi
Name:Abhd14aImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309721. Abhd14a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Protein ABHD14APRO_0000282287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5I0C4.
PRIDEiQ5I0C4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5I0C4. baseline and differential.
GenevisibleiQ5I0C4. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4577697.
STRINGi10116.ENSRNOP00000016056.

Structurei

3D structure databases

ProteinModelPortaliQ5I0C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWCE. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00510000046860.
HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ5I0C4.
KOiK13706.
OMAiDLEVHNA.
OrthoDBiEOG7WDN4H.
PhylomeDBiQ5I0C4.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I0C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYQAALLG LGLLLMFLLY MGLPGPPKQT SQLGRGPNVT VLTGLTRGSS
60 70 80 90 100
QIFYREVLPL QQTHRAEVVF LHGKAFNSHT WEQLGTLQLL SKRGYRAVAV
110 120 130 140 150
DLPGFGNSAP SKEVSTESGR VELLEGVLRD LQLQNTVLVS PSLSGSYALP
160 170 180 190 200
FLMQSHHQLC GFVPIAPTST RNYAQEQFQA VKTPTLILYG ELDHTLARES
210 220 230 240
LQQLRHLPNH SVVKLHNAGH ACYLHKPEAF HLALLAFLDH LP
Length:242
Mass (Da):26,761
Last modified:February 15, 2005 - v1
Checksum:iF1AF6D8519EA7041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088472 mRNA. Translation: AAH88472.1.
RefSeqiNP_001009670.1. NM_001009670.1.
XP_006243779.1. XM_006243717.2.
XP_006243782.1. XM_006243720.2.
XP_008764716.1. XM_008766494.1.
XP_008764717.1. XM_008766495.1.
XP_008764718.1. XM_008766496.1.
XP_008764719.1. XM_008766497.1.
XP_008764720.1. XM_008766498.1.
UniGeneiRn.41351.

Genome annotation databases

EnsembliENSRNOT00000016056; ENSRNOP00000016056; ENSRNOG00000011936.
ENSRNOT00000077514; ENSRNOP00000073526; ENSRNOG00000011936.
GeneIDi300982.
KEGGirno:300982.
UCSCiRGD:1309721. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088472 mRNA. Translation: AAH88472.1.
RefSeqiNP_001009670.1. NM_001009670.1.
XP_006243779.1. XM_006243717.2.
XP_006243782.1. XM_006243720.2.
XP_008764716.1. XM_008766494.1.
XP_008764717.1. XM_008766495.1.
XP_008764718.1. XM_008766496.1.
XP_008764719.1. XM_008766497.1.
XP_008764720.1. XM_008766498.1.
UniGeneiRn.41351.

3D structure databases

ProteinModelPortaliQ5I0C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4577697.
STRINGi10116.ENSRNOP00000016056.

Protein family/group databases

ESTHERirat-abhea. CIB-CCG1-interacting-factor-B.
MEROPSiS33.981.

Proteomic databases

PaxDbiQ5I0C4.
PRIDEiQ5I0C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016056; ENSRNOP00000016056; ENSRNOG00000011936.
ENSRNOT00000077514; ENSRNOP00000073526; ENSRNOG00000011936.
GeneIDi300982.
KEGGirno:300982.
UCSCiRGD:1309721. rat.

Organism-specific databases

CTDi25864.
RGDi1309721. Abhd14a.

Phylogenomic databases

eggNOGiENOG410IWCE. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00510000046860.
HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ5I0C4.
KOiK13706.
OMAiDLEVHNA.
OrthoDBiEOG7WDN4H.
PhylomeDBiQ5I0C4.

Miscellaneous databases

NextBioi647834.
PROiQ5I0C4.

Gene expression databases

ExpressionAtlasiQ5I0C4. baseline and differential.
GenevisibleiQ5I0C4. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiABHEA_RAT
AccessioniPrimary (citable) accession number: Q5I0C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 15, 2005
Last modified: May 11, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.