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Q5I0A0

- MAP1_XENTR

UniProt

Q5I0A0 - MAP1_XENTR

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Protein

Methionine aminopeptidase 1

Gene
metap1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei203 – 2031Substrate By similarity
Metal bindingi220 – 2201Divalent metal cation 1 By similarity
Metal bindingi231 – 2311Divalent metal cation 1 By similarity
Metal bindingi231 – 2311Divalent metal cation 2; catalytic By similarity
Metal bindingi294 – 2941Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei301 – 3011Substrate By similarity
Metal bindingi327 – 3271Divalent metal cation 2; catalytic By similarity
Metal bindingi358 – 3581Divalent metal cation 1 By similarity
Metal bindingi358 – 3581Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Protein family/group databases

MEROPSiM24.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 1 (EC:3.4.11.18)
Short name:
MAP 1
Short name:
MetAP 1
Alternative name(s):
Peptidase M 1
Gene namesi
Name:metap1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-985733. metap1.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytosolic ribosome Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Methionine aminopeptidase 1UniRule annotationPRO_0000323739Add
BLAST

Proteomic databases

PaxDbiQ5I0A0.
PRIDEiQ5I0A0.

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit of the 80S translational complex By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020516.

Structurei

3D structure databases

ProteinModelPortaliQ5I0A0.
SMRiQ5I0A0. Positions 81-385.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 5244Zinc finger-like; important for proper ribosome association By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0024.
HOVERGENiHBG067178.
KOiK01265.

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
HAMAPiMF_01974. MetAP_1.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
TIGRFAMsiTIGR00500. met_pdase_I. 1 hit.
PROSITEiPS00680. MAP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5I0A0-1 [UniParc]FASTAAdd to Basket

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MAAVESRVCE TEGCSSEAKL QCPTCIKLGI QGSYFCSQEC FKGSWASHKL    50
LHKKAKDDKI KPETSPWTMD GDINTDPWPG YRYTGKLRPH YPLTPMRPVP 100
SYIQRPDYAD HPLGMSESEQ ALKGTSQIKI LSTEDIEGMR VVCRLAREVL 150
GVAAMMVKSG ITTEEIDHAV HLACISRNCY PSPLNYYNFP KSCCTSVNEV 200
ICHGIPDRRP LQDGDIVNVD ITVYRDGYHG DLNETFYVGD VDEGAKRLVE 250
TTYECLMQAI DEVKPGVRYR ELGNIIQKHA QANGFSVVRS YCGHGIHKLF 300
HTAPNVPHYA KNKAVGVMKP GHVFTIEPMI CEGGWQDETW PDGWTAITRD 350
GKRSAQFEHT LLVTETGCEI LTRRLEENGR PHFIS 385
Length:385
Mass (Da):43,197
Last modified:February 15, 2005 - v1
Checksum:i4FDED5D82AA81873
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088554 mRNA. Translation: AAH88554.1.
RefSeqiNP_001011454.1. NM_001011454.1.
UniGeneiStr.48028.

Genome annotation databases

GeneIDi496944.
KEGGixtr:496944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088554 mRNA. Translation: AAH88554.1 .
RefSeqi NP_001011454.1. NM_001011454.1.
UniGenei Str.48028.

3D structure databases

ProteinModelPortali Q5I0A0.
SMRi Q5I0A0. Positions 81-385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000020516.

Protein family/group databases

MEROPSi M24.017.

Proteomic databases

PaxDbi Q5I0A0.
PRIDEi Q5I0A0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 496944.
KEGGi xtr:496944.

Organism-specific databases

CTDi 23173.
Xenbasei XB-GENE-985733. metap1.

Phylogenomic databases

eggNOGi COG0024.
HOVERGENi HBG067178.
KOi K01265.

Family and domain databases

Gene3Di 3.90.230.10. 1 hit.
HAMAPi MF_01974. MetAP_1.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 1 hit.
TIGRFAMsi TIGR00500. met_pdase_I. 1 hit.
PROSITEi PS00680. MAP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiMAP1_XENTR
AccessioniPrimary (citable) accession number: Q5I0A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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