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Protein

CDGSH iron-sulfur domain-containing protein 2

Gene

cisd2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy (By similarity).By similarity

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi101Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi110Iron-sulfur (2Fe-2S)By similarity1
Metal bindingi114Iron-sulfur (2Fe-2S); via pros nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CDGSH iron-sulfur domain-containing protein 2
Gene namesi
Name:cisd2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5969737. cisd2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37LumenalSequence analysisAdd BLAST37
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 135CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003160091 – 135CDGSH iron-sulfur domain-containing protein 2Add BLAST135

Proteomic databases

PaxDbiQ5I027.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000046116.

Structurei

3D structure databases

ProteinModelPortaliQ5I027.
SMRiQ5I027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CISD protein family. CISD2 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3461. Eukaryota.
ENOG41122II. LUCA.
HOGENOMiHOG000242301.
HOVERGENiHBG052444.
InParanoidiQ5I027.

Family and domain databases

InterProiView protein in InterPro
IPR018967. FeS-contain_CDGSH-typ.
IPR019610. FeS-contain_mitoNEET_N.
PfamiView protein in Pfam
PF10660. MitoNEET_N. 1 hit.
PF09360. zf-CDGSH. 1 hit.
SMARTiView protein in SMART
SM00704. ZnF_CDGSH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5I027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLESIARVI KVQLPAYLKR LPIPDSIAGF IRLTVSEWLR LLPFLGVLAL
60 70 80 90 100
LGYLAIRPFL PKKKQQKDSL INLKIQKENP KVVNEINIED LHLAKAAYCR
110 120 130
CWRSKTFPVC DGSHNKHNEL TGDNVGPLIL KKKEV
Length:135
Mass (Da):15,350
Last modified:February 15, 2005 - v1
Checksum:iC0AA4E88946701DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088777 mRNA. Translation: AAH88777.1.
RefSeqiNP_001011479.1. NM_001011479.1.
UniGeneiStr.15414.

Genome annotation databases

GeneIDi496970.
KEGGixtr:496970.

Similar proteinsi

Entry informationi

Entry nameiCISD2_XENTR
AccessioniPrimary (citable) accession number: Q5I027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 15, 2005
Last modified: September 27, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families