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Q5I012

- S38AA_MOUSE

UniProt

Q5I012 - S38AA_MOUSE

Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene

Slc38a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Putative sodium-dependent amino acid/proton antiporter.By similarity

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW
    2. bone development Source: MGI
    3. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 10
    Alternative name(s):
    Solute carrier family 38 member 10
    Gene namesi
    Name:Slc38a10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1919305. Slc38a10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10901090Putative sodium-coupled neutral amino acid transporter 10PRO_0000318976Add
    BLAST

    Proteomic databases

    PaxDbiQ5I012.
    PRIDEiQ5I012.

    PTM databases

    PhosphoSiteiQ5I012.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5I012.
    BgeeiQ5I012.
    CleanExiMM_SLC38A10.
    GenevestigatoriQ5I012.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5I012.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 3123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00710000106531.
    HOVERGENiHBG097690.
    InParanoidiQ5I012.
    KOiK14996.
    OMAiARMACEF.
    OrthoDBiEOG7KM5SR.
    PhylomeDBiQ5I012.
    TreeFamiTF320116.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5I012-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTAASTSKWG LITNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT     50
    HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF 100
    YVVIGDLGSN FFAPLLGLQV TRTVRVFLLF AVSLFIVLPL SLQRNMMASI 150
    QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRQVSYIR WEGVFRCVPI 200
    FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF YVMVGFFGYV 250
    SFTDATTGNV LIHFPSNPVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL 300
    FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG 350
    ATMGSLICFI CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVTEE 400
    APLDLTQEAR SGHRGDAEGA MKVEAARLSV QDPVVVVAED SQEKLKPAED 450
    KEVLEQAQIK GPVDVPGGEA PKEKQEAAQL DRPGQGIAVP MGEAHRHEPP 500
    IPHDKVVVDE GQDQEGPEEK KPPPRLPDEG DPAGRGQGAP PLPESEKEKQ 550
    EPERGGEGKR PGQVLAVGET EHPQKVPEAN GQPPVQPRKE DSRPGNRDPQ 600
    PAAQARDSVE LKALAADDGR EPAQKAGGAL WKPVESAAES DAGGKAGLPV 650
    QRPEAAEQRE KKEAEQQGGD QAGSKLEAEI KKLVAEAGRA EMLDHAVLLQ 700
    VIQEQQVQQK RLLDQQEKLL AVIEEQHKEI RQQRQEGEED KPKPADVQPE 750
    PGVAVLRGQE EEAEHAGETL GDDPSQPLQP VLGAPRGRPA PSQDMGQHLP 800
    GEVKVLPGRD LADLPAGGSE TEPQGAPIDL REDPKAAIKA AGAGKELVPG 850
    DLEAVHKAAP PEVPKSPEKQ VAKAVAGQRQ DVFGEGSEER KETGKEAMAP 900
    GADTQKEAVQ PLVGAEAKDT KSRQSGPTKA PVQTQAKFHP EPQAIFDTGQ 950
    GSHPEVRSEA PRAVHIPPEE QHKGKGGAAI QEAKQRPDPN SGPKLAVPAG 1000
    QKPENAKPNR DLKVQAGSDL RRRRRDLASH PEQELAPKDG VIISFNSLPN 1050
    VQVNDLRSAL DTQLRQAAGA ALQVVHSRQI KQLSGDLEEA 1090
    Length:1,090
    Mass (Da):117,194
    Last modified:February 26, 2008 - v2
    Checksum:i15321AFC6FCDBDA9
    GO
    Isoform 2 (identifier: Q5I012-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         745-745: Missing.

    Show »
    Length:1,089
    Mass (Da):117,123
    Checksum:iF8094792E2952E13
    GO
    Isoform 3 (identifier: Q5I012-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         678-685: Missing.

    Show »
    Length:1,082
    Mass (Da):116,341
    Checksum:i9410B2CD25B4ACD5
    GO
    Isoform 4 (identifier: Q5I012-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         678-685: Missing.
         745-745: Missing.

    Show »
    Length:1,081
    Mass (Da):116,270
    Checksum:iBAA176D89B8452F1
    GO
    Isoform 5 (identifier: Q5I012-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         378-408: VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE → GLPTEPWLSWYSLYRPGWPRTQGSPDSHPEC
         409-1090: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:408
    Mass (Da):44,779
    Checksum:i539548A91CDA6A99
    GO
    Isoform 6 (identifier: Q5I012-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         378-428: VVLWVGLGIL...GAMKVEAARL → DLESCRRQPS...GRAPGFISTC
         429-1090: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:428
    Mass (Da):46,430
    Checksum:iF6211EECE1EC0CC6
    GO

    Sequence cautioni

    The sequence AAH43299.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951A → T in BAC27777. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei378 – 42851VVLWV…EAARL → DLESCRRQPSGRGCLGLSDM GGATLTTVPGPEVRANQRGM SGRAPGFISTC in isoform 6. 1 PublicationVSP_031328Add
    BLAST
    Alternative sequencei378 – 40831VVLWV…DLTQE → GLPTEPWLSWYSLYRPGWPR TQGSPDSHPEC in isoform 5. 1 PublicationVSP_031329Add
    BLAST
    Alternative sequencei409 – 1090682Missing in isoform 5. 1 PublicationVSP_031330Add
    BLAST
    Alternative sequencei429 – 1090662Missing in isoform 6. 1 PublicationVSP_031331Add
    BLAST
    Alternative sequencei678 – 6858Missing in isoform 3 and isoform 4. 2 PublicationsVSP_031332
    Alternative sequencei745 – 7451Missing in isoform 2 and isoform 4. 1 PublicationVSP_031333

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007977 mRNA. Translation: BAB25384.1.
    AK032245 mRNA. Translation: BAC27777.1.
    AK090050 mRNA. Translation: BAC41066.1.
    AK159948 mRNA. Translation: BAE35504.1.
    AL807824 Genomic DNA. Translation: CAM22601.1.
    AL807824 Genomic DNA. Translation: CAM22602.1.
    AL807824 Genomic DNA. Translation: CAM22603.1.
    AL807824 Genomic DNA. Translation: CAM22604.1.
    BC043299 mRNA. Translation: AAH43299.1. Different initiation.
    BC082300 mRNA. Translation: AAH82300.1.
    BC088811 mRNA. Translation: AAH88811.1.
    CCDSiCCDS25728.1. [Q5I012-1]
    CCDS49000.1. [Q5I012-3]
    CCDS49001.1. [Q5I012-5]
    CCDS49002.1. [Q5I012-6]
    RefSeqiNP_001158270.1. NM_001164798.1. [Q5I012-2]
    NP_001158271.1. NM_001164799.1. [Q5I012-3]
    NP_001158272.1. NM_001164800.1. [Q5I012-4]
    NP_001158273.1. NM_001164801.1. [Q5I012-6]
    NP_001158274.1. NM_001164802.1. [Q5I012-5]
    NP_077211.4. NM_024249.5. [Q5I012-1]
    UniGeneiMm.253403.

    Genome annotation databases

    EnsembliENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. [Q5I012-3]
    ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. [Q5I012-6]
    ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. [Q5I012-5]
    ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. [Q5I012-1]
    GeneIDi72055.
    KEGGimmu:72055.
    UCSCiuc007mrv.2. mouse. [Q5I012-1]
    uc007mrw.2. mouse. [Q5I012-3]
    uc007mrx.2. mouse. [Q5I012-2]
    uc007mry.2. mouse. [Q5I012-4]
    uc007mrz.2. mouse. [Q5I012-5]
    uc007msa.2. mouse. [Q5I012-6]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007977 mRNA. Translation: BAB25384.1 .
    AK032245 mRNA. Translation: BAC27777.1 .
    AK090050 mRNA. Translation: BAC41066.1 .
    AK159948 mRNA. Translation: BAE35504.1 .
    AL807824 Genomic DNA. Translation: CAM22601.1 .
    AL807824 Genomic DNA. Translation: CAM22602.1 .
    AL807824 Genomic DNA. Translation: CAM22603.1 .
    AL807824 Genomic DNA. Translation: CAM22604.1 .
    BC043299 mRNA. Translation: AAH43299.1 . Different initiation.
    BC082300 mRNA. Translation: AAH82300.1 .
    BC088811 mRNA. Translation: AAH88811.1 .
    CCDSi CCDS25728.1. [Q5I012-1 ]
    CCDS49000.1. [Q5I012-3 ]
    CCDS49001.1. [Q5I012-5 ]
    CCDS49002.1. [Q5I012-6 ]
    RefSeqi NP_001158270.1. NM_001164798.1. [Q5I012-2 ]
    NP_001158271.1. NM_001164799.1. [Q5I012-3 ]
    NP_001158272.1. NM_001164800.1. [Q5I012-4 ]
    NP_001158273.1. NM_001164801.1. [Q5I012-6 ]
    NP_001158274.1. NM_001164802.1. [Q5I012-5 ]
    NP_077211.4. NM_024249.5. [Q5I012-1 ]
    UniGenei Mm.253403.

    3D structure databases

    ProteinModelPortali Q5I012.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5I012.

    Proteomic databases

    PaxDbi Q5I012.
    PRIDEi Q5I012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045402 ; ENSMUSP00000048675 ; ENSMUSG00000061306 . [Q5I012-3 ]
    ENSMUST00000053692 ; ENSMUSP00000057615 ; ENSMUSG00000061306 . [Q5I012-6 ]
    ENSMUST00000076697 ; ENSMUSP00000075989 ; ENSMUSG00000061306 . [Q5I012-5 ]
    ENSMUST00000103018 ; ENSMUSP00000099307 ; ENSMUSG00000061306 . [Q5I012-1 ]
    GeneIDi 72055.
    KEGGi mmu:72055.
    UCSCi uc007mrv.2. mouse. [Q5I012-1 ]
    uc007mrw.2. mouse. [Q5I012-3 ]
    uc007mrx.2. mouse. [Q5I012-2 ]
    uc007mry.2. mouse. [Q5I012-4 ]
    uc007mrz.2. mouse. [Q5I012-5 ]
    uc007msa.2. mouse. [Q5I012-6 ]

    Organism-specific databases

    CTDi 124565.
    MGIi MGI:1919305. Slc38a10.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00710000106531.
    HOVERGENi HBG097690.
    InParanoidi Q5I012.
    KOi K14996.
    OMAi ARMACEF.
    OrthoDBi EOG7KM5SR.
    PhylomeDBi Q5I012.
    TreeFami TF320116.

    Miscellaneous databases

    ChiTaRSi SLC38A10. mouse.
    NextBioi 335328.
    PROi Q5I012.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5I012.
    Bgeei Q5I012.
    CleanExi MM_SLC38A10.
    Genevestigatori Q5I012.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6).
      Strain: C57BL/6J.
      Tissue: Kidney, Olfactory bulb and Pancreas.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1090 (ISOFORM 3).
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain, Colon and Eye.

    Entry informationi

    Entry nameiS38AA_MOUSE
    AccessioniPrimary (citable) accession number: Q5I012
    Secondary accession number(s): A2AMZ5
    , Q3TVW4, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3