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Q5I012 (S38AA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene names
Name:Slc38a10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1090 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative sodium-dependent amino acid/proton antiporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Sequence caution

The sequence AAH43299.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5I012-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5I012-2)

The sequence of this isoform differs from the canonical sequence as follows:
     745-745: Missing.
Isoform 3 (identifier: Q5I012-3)

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.
Isoform 4 (identifier: Q5I012-4)

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.
     745-745: Missing.
Isoform 5 (identifier: Q5I012-5)

The sequence of this isoform differs from the canonical sequence as follows:
     378-408: VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE → GLPTEPWLSWYSLYRPGWPRTQGSPDSHPEC
     409-1090: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q5I012-6)

The sequence of this isoform differs from the canonical sequence as follows:
     378-428: VVLWVGLGIL...GAMKVEAARL → DLESCRRQPS...GRAPGFISTC
     429-1090: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10901090Putative sodium-coupled neutral amino acid transporter 10
PRO_0000318976

Regions

Transmembrane9 – 3123Helical; Potential
Transmembrane36 – 5823Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane378 – 39821Helical; Potential

Natural variations

Alternative sequence378 – 42851VVLWV…EAARL → DLESCRRQPSGRGCLGLSDM GGATLTTVPGPEVRANQRGM SGRAPGFISTC in isoform 6.
VSP_031328
Alternative sequence378 – 40831VVLWV…DLTQE → GLPTEPWLSWYSLYRPGWPR TQGSPDSHPEC in isoform 5.
VSP_031329
Alternative sequence409 – 1090682Missing in isoform 5.
VSP_031330
Alternative sequence429 – 1090662Missing in isoform 6.
VSP_031331
Alternative sequence678 – 6858Missing in isoform 3 and isoform 4.
VSP_031332
Alternative sequence7451Missing in isoform 2 and isoform 4.
VSP_031333

Experimental info

Sequence conflict2951A → T in BAC27777. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 15321AFC6FCDBDA9

FASTA1,090117,194
        10         20         30         40         50         60 
MTAASTSKWG LITNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS 

        70         80         90        100        110        120 
ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF YVVIGDLGSN FFAPLLGLQV 

       130        140        150        160        170        180 
TRTVRVFLLF AVSLFIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSLKHGLFSG 

       190        200        210        220        230        240 
QWLRQVSYIR WEGVFRCVPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF 

       250        260        270        280        290        300 
YVMVGFFGYV SFTDATTGNV LIHFPSNPVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL 

       310        320        330        340        350        360 
FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG ATMGSLICFI 

       370        380        390        400        410        420 
CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVTEE APLDLTQEAR SGHRGDAEGA 

       430        440        450        460        470        480 
MKVEAARLSV QDPVVVVAED SQEKLKPAED KEVLEQAQIK GPVDVPGGEA PKEKQEAAQL 

       490        500        510        520        530        540 
DRPGQGIAVP MGEAHRHEPP IPHDKVVVDE GQDQEGPEEK KPPPRLPDEG DPAGRGQGAP 

       550        560        570        580        590        600 
PLPESEKEKQ EPERGGEGKR PGQVLAVGET EHPQKVPEAN GQPPVQPRKE DSRPGNRDPQ 

       610        620        630        640        650        660 
PAAQARDSVE LKALAADDGR EPAQKAGGAL WKPVESAAES DAGGKAGLPV QRPEAAEQRE 

       670        680        690        700        710        720 
KKEAEQQGGD QAGSKLEAEI KKLVAEAGRA EMLDHAVLLQ VIQEQQVQQK RLLDQQEKLL 

       730        740        750        760        770        780 
AVIEEQHKEI RQQRQEGEED KPKPADVQPE PGVAVLRGQE EEAEHAGETL GDDPSQPLQP 

       790        800        810        820        830        840 
VLGAPRGRPA PSQDMGQHLP GEVKVLPGRD LADLPAGGSE TEPQGAPIDL REDPKAAIKA 

       850        860        870        880        890        900 
AGAGKELVPG DLEAVHKAAP PEVPKSPEKQ VAKAVAGQRQ DVFGEGSEER KETGKEAMAP 

       910        920        930        940        950        960 
GADTQKEAVQ PLVGAEAKDT KSRQSGPTKA PVQTQAKFHP EPQAIFDTGQ GSHPEVRSEA 

       970        980        990       1000       1010       1020 
PRAVHIPPEE QHKGKGGAAI QEAKQRPDPN SGPKLAVPAG QKPENAKPNR DLKVQAGSDL 

      1030       1040       1050       1060       1070       1080 
RRRRRDLASH PEQELAPKDG VIISFNSLPN VQVNDLRSAL DTQLRQAAGA ALQVVHSRQI 

      1090 
KQLSGDLEEA 

« Hide

Isoform 2 [UniParc].

Checksum: F8094792E2952E13
Show »

FASTA1,089117,123
Isoform 3 [UniParc].

Checksum: 9410B2CD25B4ACD5
Show »

FASTA1,082116,341
Isoform 4 [UniParc].

Checksum: BAA176D89B8452F1
Show »

FASTA1,081116,270
Isoform 5 [UniParc].

Checksum: 539548A91CDA6A99
Show »

FASTA40844,779
Isoform 6 [UniParc].

Checksum: F6211EECE1EC0CC6
Show »

FASTA42846,430

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6).
Strain: C57BL/6J.
Tissue: Kidney, Olfactory bulb and Pancreas.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1090 (ISOFORM 3).
Strain: C57BL/6 and FVB/N.
Tissue: Brain, Colon and Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK007977 mRNA. Translation: BAB25384.1.
AK032245 mRNA. Translation: BAC27777.1.
AK090050 mRNA. Translation: BAC41066.1.
AK159948 mRNA. Translation: BAE35504.1.
AL807824 Genomic DNA. Translation: CAM22601.1.
AL807824 Genomic DNA. Translation: CAM22602.1.
AL807824 Genomic DNA. Translation: CAM22603.1.
AL807824 Genomic DNA. Translation: CAM22604.1.
BC043299 mRNA. Translation: AAH43299.1. Different initiation.
BC082300 mRNA. Translation: AAH82300.1.
BC088811 mRNA. Translation: AAH88811.1.
RefSeqNP_001158270.1. NM_001164798.1.
NP_001158271.1. NM_001164799.1.
NP_001158272.1. NM_001164800.1.
NP_001158273.1. NM_001164801.1.
NP_001158274.1. NM_001164802.1.
NP_077211.4. NM_024249.5.
UniGeneMm.253403.

3D structure databases

ProteinModelPortalQ5I012.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5I012.

Proteomic databases

PaxDbQ5I012.
PRIDEQ5I012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. [Q5I012-3]
ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. [Q5I012-6]
ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. [Q5I012-5]
ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. [Q5I012-1]
GeneID72055.
KEGGmmu:72055.
UCSCuc007mrv.2. mouse. [Q5I012-1]
uc007mrw.2. mouse. [Q5I012-3]
uc007mrx.2. mouse. [Q5I012-2]
uc007mry.2. mouse. [Q5I012-4]
uc007mrz.2. mouse. [Q5I012-5]
uc007msa.2. mouse. [Q5I012-6]

Organism-specific databases

CTD124565.
MGIMGI:1919305. Slc38a10.

Phylogenomic databases

eggNOGCOG0814.
GeneTreeENSGT00710000106531.
HOVERGENHBG097690.
InParanoidQ5I012.
KOK14996.
OMARVSYARW.
OrthoDBEOG7KM5SR.
PhylomeDBQ5I012.
TreeFamTF320116.

Gene expression databases

ArrayExpressQ5I012.
BgeeQ5I012.
CleanExMM_SLC38A10.
GenevestigatorQ5I012.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC38A10. mouse.
NextBio335328.
PROQ5I012.
SOURCESearch...

Entry information

Entry nameS38AA_MOUSE
AccessionPrimary (citable) accession number: Q5I012
Secondary accession number(s): A2AMZ5 expand/collapse secondary AC list , Q3TVW4, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot