Q5I012 (S38AA_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative sodium-coupled neutral amino acid transporter 10 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 1090 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Putative sodium-dependent amino acid/proton antiporter By similarity. |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the amino acid/polyamine transporter 2 family. |
| Sequence caution | The sequence AAH43299.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid transport Ion transport Sodium transport Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Sodium |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW bone developmentInferred from mutant phenotype PubMed 22876197. Source: MGI sodium ion transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 6 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q5I012-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q5I012-2) The sequence of this isoform differs from the canonical sequence as follows: 745-745: Missing. | ||||||
| Isoform 3 (identifier: Q5I012-3) The sequence of this isoform differs from the canonical sequence as follows: 678-685: Missing. | ||||||
| Isoform 4 (identifier: Q5I012-4) The sequence of this isoform differs from the canonical sequence as follows: 678-685: Missing. 745-745: Missing. | ||||||
| Isoform 5 (identifier: Q5I012-5) The sequence of this isoform differs from the canonical sequence as follows: 378-408: VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE → GLPTEPWLSWYSLYRPGWPRTQGSPDSHPEC 409-1090: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 6 (identifier: Q5I012-6) The sequence of this isoform differs from the canonical sequence as follows: 378-428: VVLWVGLGIL...GAMKVEAARL → DLESCRRQPS...GRAPGFISTC 429-1090: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1090 | 1090 | Putative sodium-coupled neutral amino acid transporter 10 | PRO_0000318976 | |||||
Regions | |||||||||
| Transmembrane | 9 – 31 | 23 | Helical; Potential | ||||||
| Transmembrane | 36 – 58 | 23 | Helical; Potential | ||||||
| Transmembrane | 84 – 104 | 21 | Helical; Potential | ||||||
| Transmembrane | 123 – 143 | 21 | Helical; Potential | ||||||
| Transmembrane | 153 – 173 | 21 | Helical; Potential | ||||||
| Transmembrane | 229 – 249 | 21 | Helical; Potential | ||||||
| Transmembrane | 272 – 292 | 21 | Helical; Potential | ||||||
| Transmembrane | 323 – 343 | 21 | Helical; Potential | ||||||
| Transmembrane | 345 – 365 | 21 | Helical; Potential | ||||||
| Transmembrane | 378 – 398 | 21 | Helical; Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 441 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 887 | 1 | Phosphoserine Ref.4 | ||||||
Natural variations | |||||||||
| Alternative sequence | 378 – 428 | 51 | VVLWV…EAARL → DLESCRRQPSGRGCLGLSDM GGATLTTVPGPEVRANQRGM SGRAPGFISTC in isoform 6. | VSP_031328 | |||||
| Alternative sequence | 378 – 408 | 31 | VVLWV…DLTQE → GLPTEPWLSWYSLYRPGWPR TQGSPDSHPEC in isoform 5. | VSP_031329 | |||||
| Alternative sequence | 409 – 1090 | 682 | Missing in isoform 5. | VSP_031330 | |||||
| Alternative sequence | 429 – 1090 | 662 | Missing in isoform 6. | VSP_031331 | |||||
| Alternative sequence | 678 – 685 | 8 | Missing in isoform 3 and isoform 4. | VSP_031332 | |||||
| Alternative sequence | 745 | 1 | Missing in isoform 2 and isoform 4. | VSP_031333 | |||||
Experimental info | |||||||||
| Sequence conflict | 295 | 1 | A → T in BAC27777. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6). Strain: C57BL/6J. Tissue: Kidney, Olfactory bulb and Pancreas. |
| [2] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1090 (ISOFORM 3). Strain: C57BL/6 and FVB/N. Tissue: Brain, Colon and Eye. |
| [4] | "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441 AND SER-887, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK007977 mRNA. Translation: BAB25384.1. AK032245 mRNA. Translation: BAC27777.1. AK090050 mRNA. Translation: BAC41066.1. AK159948 mRNA. Translation: BAE35504.1. AL807824 Genomic DNA. Translation: CAM22601.1. AL807824 Genomic DNA. Translation: CAM22602.1. AL807824 Genomic DNA. Translation: CAM22603.1. AL807824 Genomic DNA. Translation: CAM22604.1. BC043299 mRNA. Translation: AAH43299.1. Different initiation. BC082300 mRNA. Translation: AAH82300.1. BC088811 mRNA. Translation: AAH88811.1. |
| IPI | IPI00111582. IPI00228647. IPI00404588. IPI00649374. IPI00885760. IPI00886114. |
| RefSeq | NP_001158270.1. NM_001164798.1. NP_001158271.1. NM_001164799.1. NP_001158272.1. NM_001164800.1. NP_001158273.1. NM_001164801.1. NP_001158274.1. NM_001164802.1. NP_077211.4. NM_024249.5. |
| UniGene | Mm.253403. |
3D structure databases | |
| ProteinModelPortal | Q5I012. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q5I012. |
Proteomic databases | |
| PaxDb | Q5I012. |
| PRIDE | Q5I012. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. |
| GeneID | 72055. |
| KEGG | mmu:72055. |
| UCSC | uc007mrv.2. mouse. uc007mrw.2. mouse. uc007mrx.2. mouse. uc007mry.2. mouse. uc007mrz.2. mouse. uc007msa.2. mouse. |
Organism-specific databases | |
| CTD | 124565. |
| MGI | MGI:1919305. Slc38a10. |
Phylogenomic databases | |
| eggNOG | COG0814. |
| GeneTree | ENSGT00700000104173. |
| HOVERGEN | HBG097690. |
| InParanoid | Q5I012. |
| KO | K14996. |
| OMA | VVTEMIR. |
| OrthoDB | EOG4QRH38. |
Gene expression databases | |
| ArrayExpress | Q5I012. |
| Bgee | Q5I012. |
| CleanEx | MM_SLC38A10. |
| Genevestigator | Q5I012. |
Family and domain databases | |
| InterPro | IPR013057. AA_transpt_TM. [Graphical view] |
| Pfam | PF01490. Aa_trans. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | SLC38A10. mouse. |
| NextBio | 335328. |
| SOURCE | Search... |
Entry information
| Entry name | S38AA_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q5I012 Secondary accession number(s): A2AMZ5 Q9D8J3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
