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Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene

Slc38a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane transport Source: GO_Central
  • bone development Source: MGI
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene namesi
Name:Slc38a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919305. Slc38a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 3123HelicalSequence AnalysisAdd
BLAST
Transmembranei36 – 5823HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10901090Putative sodium-coupled neutral amino acid transporter 10PRO_0000318976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei769 – 7691PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5I012.
PaxDbiQ5I012.
PRIDEiQ5I012.

PTM databases

PhosphoSiteiQ5I012.

Expressioni

Gene expression databases

BgeeiQ5I012.
CleanExiMM_SLC38A10.
ExpressionAtlasiQ5I012. baseline and differential.
GenevisibleiQ5I012. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099307.

Structurei

3D structure databases

ProteinModelPortaliQ5I012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOVERGENiHBG097690.
InParanoidiQ5I012.
KOiK14996.
OMAiCESNASQ.
OrthoDBiEOG7KM5SR.
PhylomeDBiQ5I012.
TreeFamiTF320116.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5I012-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAASTSKWG LITNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT
60 70 80 90 100
HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF
110 120 130 140 150
YVVIGDLGSN FFAPLLGLQV TRTVRVFLLF AVSLFIVLPL SLQRNMMASI
160 170 180 190 200
QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRQVSYIR WEGVFRCVPI
210 220 230 240 250
FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF YVMVGFFGYV
260 270 280 290 300
SFTDATTGNV LIHFPSNPVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL
310 320 330 340 350
FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG
360 370 380 390 400
ATMGSLICFI CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVTEE
410 420 430 440 450
APLDLTQEAR SGHRGDAEGA MKVEAARLSV QDPVVVVAED SQEKLKPAED
460 470 480 490 500
KEVLEQAQIK GPVDVPGGEA PKEKQEAAQL DRPGQGIAVP MGEAHRHEPP
510 520 530 540 550
IPHDKVVVDE GQDQEGPEEK KPPPRLPDEG DPAGRGQGAP PLPESEKEKQ
560 570 580 590 600
EPERGGEGKR PGQVLAVGET EHPQKVPEAN GQPPVQPRKE DSRPGNRDPQ
610 620 630 640 650
PAAQARDSVE LKALAADDGR EPAQKAGGAL WKPVESAAES DAGGKAGLPV
660 670 680 690 700
QRPEAAEQRE KKEAEQQGGD QAGSKLEAEI KKLVAEAGRA EMLDHAVLLQ
710 720 730 740 750
VIQEQQVQQK RLLDQQEKLL AVIEEQHKEI RQQRQEGEED KPKPADVQPE
760 770 780 790 800
PGVAVLRGQE EEAEHAGETL GDDPSQPLQP VLGAPRGRPA PSQDMGQHLP
810 820 830 840 850
GEVKVLPGRD LADLPAGGSE TEPQGAPIDL REDPKAAIKA AGAGKELVPG
860 870 880 890 900
DLEAVHKAAP PEVPKSPEKQ VAKAVAGQRQ DVFGEGSEER KETGKEAMAP
910 920 930 940 950
GADTQKEAVQ PLVGAEAKDT KSRQSGPTKA PVQTQAKFHP EPQAIFDTGQ
960 970 980 990 1000
GSHPEVRSEA PRAVHIPPEE QHKGKGGAAI QEAKQRPDPN SGPKLAVPAG
1010 1020 1030 1040 1050
QKPENAKPNR DLKVQAGSDL RRRRRDLASH PEQELAPKDG VIISFNSLPN
1060 1070 1080 1090
VQVNDLRSAL DTQLRQAAGA ALQVVHSRQI KQLSGDLEEA
Length:1,090
Mass (Da):117,194
Last modified:February 26, 2008 - v2
Checksum:i15321AFC6FCDBDA9
GO
Isoform 2 (identifier: Q5I012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-745: Missing.

Show »
Length:1,089
Mass (Da):117,123
Checksum:iF8094792E2952E13
GO
Isoform 3 (identifier: Q5I012-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.

Show »
Length:1,082
Mass (Da):116,341
Checksum:i9410B2CD25B4ACD5
GO
Isoform 4 (identifier: Q5I012-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.
     745-745: Missing.

Show »
Length:1,081
Mass (Da):116,270
Checksum:iBAA176D89B8452F1
GO
Isoform 5 (identifier: Q5I012-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-408: VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE → GLPTEPWLSWYSLYRPGWPRTQGSPDSHPEC
     409-1090: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):44,779
Checksum:i539548A91CDA6A99
GO
Isoform 6 (identifier: Q5I012-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-428: VVLWVGLGIL...GAMKVEAARL → DLESCRRQPS...GRAPGFISTC
     429-1090: Missing.

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):46,430
Checksum:iF6211EECE1EC0CC6
GO

Sequence cautioni

The sequence AAH43299.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951A → T in BAC27777 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei378 – 42851VVLWV…EAARL → DLESCRRQPSGRGCLGLSDM GGATLTTVPGPEVRANQRGM SGRAPGFISTC in isoform 6. 1 PublicationVSP_031328Add
BLAST
Alternative sequencei378 – 40831VVLWV…DLTQE → GLPTEPWLSWYSLYRPGWPR TQGSPDSHPEC in isoform 5. 1 PublicationVSP_031329Add
BLAST
Alternative sequencei409 – 1090682Missing in isoform 5. 1 PublicationVSP_031330Add
BLAST
Alternative sequencei429 – 1090662Missing in isoform 6. 1 PublicationVSP_031331Add
BLAST
Alternative sequencei678 – 6858Missing in isoform 3 and isoform 4. 2 PublicationsVSP_031332
Alternative sequencei745 – 7451Missing in isoform 2 and isoform 4. 1 PublicationVSP_031333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007977 mRNA. Translation: BAB25384.1.
AK032245 mRNA. Translation: BAC27777.1.
AK090050 mRNA. Translation: BAC41066.1.
AK159948 mRNA. Translation: BAE35504.1.
AL807824 Genomic DNA. Translation: CAM22601.1.
AL807824 Genomic DNA. Translation: CAM22602.1.
AL807824 Genomic DNA. Translation: CAM22603.1.
AL807824 Genomic DNA. Translation: CAM22604.1.
BC043299 mRNA. Translation: AAH43299.1. Different initiation.
BC082300 mRNA. Translation: AAH82300.1.
BC088811 mRNA. Translation: AAH88811.1.
CCDSiCCDS25728.1. [Q5I012-1]
CCDS49000.1. [Q5I012-3]
CCDS49001.1. [Q5I012-5]
CCDS49002.1. [Q5I012-6]
RefSeqiNP_001158270.1. NM_001164798.1. [Q5I012-2]
NP_001158271.1. NM_001164799.1. [Q5I012-3]
NP_001158272.1. NM_001164800.1. [Q5I012-4]
NP_001158273.1. NM_001164801.1. [Q5I012-6]
NP_001158274.1. NM_001164802.1. [Q5I012-5]
NP_077211.4. NM_024249.5. [Q5I012-1]
UniGeneiMm.253403.

Genome annotation databases

EnsembliENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. [Q5I012-3]
ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. [Q5I012-6]
ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. [Q5I012-5]
ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. [Q5I012-1]
GeneIDi72055.
KEGGimmu:72055.
UCSCiuc007mrv.2. mouse. [Q5I012-1]
uc007mrw.2. mouse. [Q5I012-3]
uc007mrx.2. mouse. [Q5I012-2]
uc007mry.2. mouse. [Q5I012-4]
uc007mrz.2. mouse. [Q5I012-5]
uc007msa.2. mouse. [Q5I012-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007977 mRNA. Translation: BAB25384.1.
AK032245 mRNA. Translation: BAC27777.1.
AK090050 mRNA. Translation: BAC41066.1.
AK159948 mRNA. Translation: BAE35504.1.
AL807824 Genomic DNA. Translation: CAM22601.1.
AL807824 Genomic DNA. Translation: CAM22602.1.
AL807824 Genomic DNA. Translation: CAM22603.1.
AL807824 Genomic DNA. Translation: CAM22604.1.
BC043299 mRNA. Translation: AAH43299.1. Different initiation.
BC082300 mRNA. Translation: AAH82300.1.
BC088811 mRNA. Translation: AAH88811.1.
CCDSiCCDS25728.1. [Q5I012-1]
CCDS49000.1. [Q5I012-3]
CCDS49001.1. [Q5I012-5]
CCDS49002.1. [Q5I012-6]
RefSeqiNP_001158270.1. NM_001164798.1. [Q5I012-2]
NP_001158271.1. NM_001164799.1. [Q5I012-3]
NP_001158272.1. NM_001164800.1. [Q5I012-4]
NP_001158273.1. NM_001164801.1. [Q5I012-6]
NP_001158274.1. NM_001164802.1. [Q5I012-5]
NP_077211.4. NM_024249.5. [Q5I012-1]
UniGeneiMm.253403.

3D structure databases

ProteinModelPortaliQ5I012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099307.

PTM databases

PhosphoSiteiQ5I012.

Proteomic databases

MaxQBiQ5I012.
PaxDbiQ5I012.
PRIDEiQ5I012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. [Q5I012-3]
ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. [Q5I012-6]
ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. [Q5I012-5]
ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. [Q5I012-1]
GeneIDi72055.
KEGGimmu:72055.
UCSCiuc007mrv.2. mouse. [Q5I012-1]
uc007mrw.2. mouse. [Q5I012-3]
uc007mrx.2. mouse. [Q5I012-2]
uc007mry.2. mouse. [Q5I012-4]
uc007mrz.2. mouse. [Q5I012-5]
uc007msa.2. mouse. [Q5I012-6]

Organism-specific databases

CTDi124565.
MGIiMGI:1919305. Slc38a10.

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOVERGENiHBG097690.
InParanoidiQ5I012.
KOiK14996.
OMAiCESNASQ.
OrthoDBiEOG7KM5SR.
PhylomeDBiQ5I012.
TreeFamiTF320116.

Miscellaneous databases

ChiTaRSiSlc38a10. mouse.
NextBioi335328.
PROiQ5I012.
SOURCEiSearch...

Gene expression databases

BgeeiQ5I012.
CleanExiMM_SLC38A10.
ExpressionAtlasiQ5I012. baseline and differential.
GenevisibleiQ5I012. MM.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6).
    Strain: C57BL/6J.
    Tissue: Kidney, Olfactory bulb and Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1090 (ISOFORM 3).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain, Colon and Eye.

Entry informationi

Entry nameiS38AA_MOUSE
AccessioniPrimary (citable) accession number: Q5I012
Secondary accession number(s): A2AMZ5
, Q3TVW4, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 24, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.