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Q5I012

- S38AA_MOUSE

UniProt

Q5I012 - S38AA_MOUSE

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Protein

Putative sodium-coupled neutral amino acid transporter 10

Gene
Slc38a10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter By similarity.

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. bone development Source: MGI
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 10
Alternative name(s):
Solute carrier family 38 member 10
Gene namesi
Name:Slc38a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919305. Slc38a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 3123Helical; Reviewed predictionAdd
BLAST
Transmembranei36 – 5823Helical; Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei123 – 14321Helical; Reviewed predictionAdd
BLAST
Transmembranei153 – 17321Helical; Reviewed predictionAdd
BLAST
Transmembranei229 – 24921Helical; Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Reviewed predictionAdd
BLAST
Transmembranei345 – 36521Helical; Reviewed predictionAdd
BLAST
Transmembranei378 – 39821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10901090Putative sodium-coupled neutral amino acid transporter 10PRO_0000318976Add
BLAST

Proteomic databases

PaxDbiQ5I012.
PRIDEiQ5I012.

PTM databases

PhosphoSiteiQ5I012.

Expressioni

Gene expression databases

ArrayExpressiQ5I012.
BgeeiQ5I012.
CleanExiMM_SLC38A10.
GenevestigatoriQ5I012.

Structurei

3D structure databases

ProteinModelPortaliQ5I012.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00710000106531.
HOVERGENiHBG097690.
InParanoidiQ5I012.
KOiK14996.
OMAiARMACEF.
OrthoDBiEOG7KM5SR.
PhylomeDBiQ5I012.
TreeFamiTF320116.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5I012-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTAASTSKWG LITNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT     50
HQSCMFLVKS ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF 100
YVVIGDLGSN FFAPLLGLQV TRTVRVFLLF AVSLFIVLPL SLQRNMMASI 150
QSFSAMALLF YTVFMFVIVL SSLKHGLFSG QWLRQVSYIR WEGVFRCVPI 200
FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF YVMVGFFGYV 250
SFTDATTGNV LIHFPSNPVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL 300
FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG 350
ATMGSLICFI CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVTEE 400
APLDLTQEAR SGHRGDAEGA MKVEAARLSV QDPVVVVAED SQEKLKPAED 450
KEVLEQAQIK GPVDVPGGEA PKEKQEAAQL DRPGQGIAVP MGEAHRHEPP 500
IPHDKVVVDE GQDQEGPEEK KPPPRLPDEG DPAGRGQGAP PLPESEKEKQ 550
EPERGGEGKR PGQVLAVGET EHPQKVPEAN GQPPVQPRKE DSRPGNRDPQ 600
PAAQARDSVE LKALAADDGR EPAQKAGGAL WKPVESAAES DAGGKAGLPV 650
QRPEAAEQRE KKEAEQQGGD QAGSKLEAEI KKLVAEAGRA EMLDHAVLLQ 700
VIQEQQVQQK RLLDQQEKLL AVIEEQHKEI RQQRQEGEED KPKPADVQPE 750
PGVAVLRGQE EEAEHAGETL GDDPSQPLQP VLGAPRGRPA PSQDMGQHLP 800
GEVKVLPGRD LADLPAGGSE TEPQGAPIDL REDPKAAIKA AGAGKELVPG 850
DLEAVHKAAP PEVPKSPEKQ VAKAVAGQRQ DVFGEGSEER KETGKEAMAP 900
GADTQKEAVQ PLVGAEAKDT KSRQSGPTKA PVQTQAKFHP EPQAIFDTGQ 950
GSHPEVRSEA PRAVHIPPEE QHKGKGGAAI QEAKQRPDPN SGPKLAVPAG 1000
QKPENAKPNR DLKVQAGSDL RRRRRDLASH PEQELAPKDG VIISFNSLPN 1050
VQVNDLRSAL DTQLRQAAGA ALQVVHSRQI KQLSGDLEEA 1090
Length:1,090
Mass (Da):117,194
Last modified:February 26, 2008 - v2
Checksum:i15321AFC6FCDBDA9
GO
Isoform 2 (identifier: Q5I012-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-745: Missing.

Show »
Length:1,089
Mass (Da):117,123
Checksum:iF8094792E2952E13
GO
Isoform 3 (identifier: Q5I012-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.

Show »
Length:1,082
Mass (Da):116,341
Checksum:i9410B2CD25B4ACD5
GO
Isoform 4 (identifier: Q5I012-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-685: Missing.
     745-745: Missing.

Show »
Length:1,081
Mass (Da):116,270
Checksum:iBAA176D89B8452F1
GO
Isoform 5 (identifier: Q5I012-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-408: VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE → GLPTEPWLSWYSLYRPGWPRTQGSPDSHPEC
     409-1090: Missing.

Note: No experimental confirmation available.

Show »
Length:408
Mass (Da):44,779
Checksum:i539548A91CDA6A99
GO
Isoform 6 (identifier: Q5I012-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-428: VVLWVGLGIL...GAMKVEAARL → DLESCRRQPS...GRAPGFISTC
     429-1090: Missing.

Note: No experimental confirmation available.

Show »
Length:428
Mass (Da):46,430
Checksum:iF6211EECE1EC0CC6
GO

Sequence cautioni

The sequence AAH43299.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei378 – 42851VVLWV…EAARL → DLESCRRQPSGRGCLGLSDM GGATLTTVPGPEVRANQRGM SGRAPGFISTC in isoform 6. VSP_031328Add
BLAST
Alternative sequencei378 – 40831VVLWV…DLTQE → GLPTEPWLSWYSLYRPGWPR TQGSPDSHPEC in isoform 5. VSP_031329Add
BLAST
Alternative sequencei409 – 1090682Missing in isoform 5. VSP_031330Add
BLAST
Alternative sequencei429 – 1090662Missing in isoform 6. VSP_031331Add
BLAST
Alternative sequencei678 – 6858Missing in isoform 3 and isoform 4. VSP_031332
Alternative sequencei745 – 7451Missing in isoform 2 and isoform 4. VSP_031333

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951A → T in BAC27777. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007977 mRNA. Translation: BAB25384.1.
AK032245 mRNA. Translation: BAC27777.1.
AK090050 mRNA. Translation: BAC41066.1.
AK159948 mRNA. Translation: BAE35504.1.
AL807824 Genomic DNA. Translation: CAM22601.1.
AL807824 Genomic DNA. Translation: CAM22602.1.
AL807824 Genomic DNA. Translation: CAM22603.1.
AL807824 Genomic DNA. Translation: CAM22604.1.
BC043299 mRNA. Translation: AAH43299.1. Different initiation.
BC082300 mRNA. Translation: AAH82300.1.
BC088811 mRNA. Translation: AAH88811.1.
CCDSiCCDS25728.1. [Q5I012-1]
CCDS49000.1. [Q5I012-3]
CCDS49001.1. [Q5I012-5]
CCDS49002.1. [Q5I012-6]
RefSeqiNP_001158270.1. NM_001164798.1. [Q5I012-2]
NP_001158271.1. NM_001164799.1. [Q5I012-3]
NP_001158272.1. NM_001164800.1. [Q5I012-4]
NP_001158273.1. NM_001164801.1. [Q5I012-6]
NP_001158274.1. NM_001164802.1. [Q5I012-5]
NP_077211.4. NM_024249.5. [Q5I012-1]
UniGeneiMm.253403.

Genome annotation databases

EnsembliENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. [Q5I012-3]
ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. [Q5I012-6]
ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. [Q5I012-5]
ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. [Q5I012-1]
GeneIDi72055.
KEGGimmu:72055.
UCSCiuc007mrv.2. mouse. [Q5I012-1]
uc007mrw.2. mouse. [Q5I012-3]
uc007mrx.2. mouse. [Q5I012-2]
uc007mry.2. mouse. [Q5I012-4]
uc007mrz.2. mouse. [Q5I012-5]
uc007msa.2. mouse. [Q5I012-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK007977 mRNA. Translation: BAB25384.1 .
AK032245 mRNA. Translation: BAC27777.1 .
AK090050 mRNA. Translation: BAC41066.1 .
AK159948 mRNA. Translation: BAE35504.1 .
AL807824 Genomic DNA. Translation: CAM22601.1 .
AL807824 Genomic DNA. Translation: CAM22602.1 .
AL807824 Genomic DNA. Translation: CAM22603.1 .
AL807824 Genomic DNA. Translation: CAM22604.1 .
BC043299 mRNA. Translation: AAH43299.1 . Different initiation.
BC082300 mRNA. Translation: AAH82300.1 .
BC088811 mRNA. Translation: AAH88811.1 .
CCDSi CCDS25728.1. [Q5I012-1 ]
CCDS49000.1. [Q5I012-3 ]
CCDS49001.1. [Q5I012-5 ]
CCDS49002.1. [Q5I012-6 ]
RefSeqi NP_001158270.1. NM_001164798.1. [Q5I012-2 ]
NP_001158271.1. NM_001164799.1. [Q5I012-3 ]
NP_001158272.1. NM_001164800.1. [Q5I012-4 ]
NP_001158273.1. NM_001164801.1. [Q5I012-6 ]
NP_001158274.1. NM_001164802.1. [Q5I012-5 ]
NP_077211.4. NM_024249.5. [Q5I012-1 ]
UniGenei Mm.253403.

3D structure databases

ProteinModelPortali Q5I012.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5I012.

Proteomic databases

PaxDbi Q5I012.
PRIDEi Q5I012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045402 ; ENSMUSP00000048675 ; ENSMUSG00000061306 . [Q5I012-3 ]
ENSMUST00000053692 ; ENSMUSP00000057615 ; ENSMUSG00000061306 . [Q5I012-6 ]
ENSMUST00000076697 ; ENSMUSP00000075989 ; ENSMUSG00000061306 . [Q5I012-5 ]
ENSMUST00000103018 ; ENSMUSP00000099307 ; ENSMUSG00000061306 . [Q5I012-1 ]
GeneIDi 72055.
KEGGi mmu:72055.
UCSCi uc007mrv.2. mouse. [Q5I012-1 ]
uc007mrw.2. mouse. [Q5I012-3 ]
uc007mrx.2. mouse. [Q5I012-2 ]
uc007mry.2. mouse. [Q5I012-4 ]
uc007mrz.2. mouse. [Q5I012-5 ]
uc007msa.2. mouse. [Q5I012-6 ]

Organism-specific databases

CTDi 124565.
MGIi MGI:1919305. Slc38a10.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00710000106531.
HOVERGENi HBG097690.
InParanoidi Q5I012.
KOi K14996.
OMAi ARMACEF.
OrthoDBi EOG7KM5SR.
PhylomeDBi Q5I012.
TreeFami TF320116.

Miscellaneous databases

ChiTaRSi SLC38A10. mouse.
NextBioi 335328.
PROi Q5I012.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5I012.
Bgeei Q5I012.
CleanExi MM_SLC38A10.
Genevestigatori Q5I012.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6).
    Strain: C57BL/6J.
    Tissue: Kidney, Olfactory bulb and Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 353-1090 (ISOFORM 3).
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain, Colon and Eye.

Entry informationi

Entry nameiS38AA_MOUSE
AccessioniPrimary (citable) accession number: Q5I012
Secondary accession number(s): A2AMZ5
, Q3TVW4, Q641M1, Q80ZZ4, Q8C1Y0, Q8CCR5, Q9D8J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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