ID Q5HZY7_MOUSE Unreviewed; 118 AA. AC Q5HZY7; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 24-JAN-2024, entry version 131. DE RecName: Full=V-type proton ATPase subunit G {ECO:0000256|RuleBase:RU364019}; GN Name=Atp6v1g1 {ECO:0000313|EMBL:AAH88836.1, GN ECO:0000313|MGI:MGI:1913540}; GN Synonyms=Atp6g1 {ECO:0000313|EMBL:BAC10289.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH88836.1}; RN [1] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC10289.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12133826; DOI=10.1074/jbc.M200586200; RA Murata Y., Sun-Wada G.H., Yoshimizu T., Yamamoto A., Wada Y., Futai M.; RT "Differential localization of the vacuolar H+ pump with G subunit isoforms RT (G1 and G2) in mouse neurons."; RL J. Biol. Chem. 277:36296-36303(2002). RN [6] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAH88836.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N-3 {ECO:0000313|EMBL:AAH88836.1}; RC TISSUE=Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by RC biopsy. {ECO:0000313|EMBL:AAH88836.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] {ECO:0000313|EMBL:BAE40775.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE35183.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [11] {ECO:0000313|EMBL:BAC38271.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38271.1}, and NOD RC {ECO:0000313|EMBL:BAC40520.1}; RC TISSUE=Amnion {ECO:0000313|EMBL:BAE40775.1}, Head RC {ECO:0000313|EMBL:BAC38271.1}, and Thymus RC {ECO:0000313|EMBL:BAC40520.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [12] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), CC a multisubunit enzyme composed of a peripheral complex (V1) that CC hydrolyzes ATP and a membrane integral complex (V0) that translocates CC protons. V-ATPase is responsible for acidifying and maintaining the pH CC of intracellular compartments and in some cell types, is targeted to CC the plasma membrane, where it is responsible for acidifying the CC extracellular environment. {ECO:0000256|RuleBase:RU364019}. CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme made up of two CC complexes: the ATP-hydrolytic V1 complex and the proton translocation CC V0 complex. {ECO:0000256|RuleBase:RU364019}. CC -!- SIMILARITY: Belongs to the V-ATPase G subunit family. CC {ECO:0000256|ARBA:ARBA00010066, ECO:0000256|RuleBase:RU364019}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC088836; AAH88836.1; -; mRNA. DR EMBL; AB076406; BAC10289.1; -; mRNA. DR EMBL; AK081611; BAC38271.1; -; mRNA. DR EMBL; AK088712; BAC40520.1; -; mRNA. DR EMBL; AK159558; BAE35183.1; -; mRNA. DR EMBL; AK168972; BAE40775.1; -; mRNA. DR RefSeq; NP_077135.1; NM_024173.2. DR AlphaFoldDB; Q5HZY7; -. DR SMR; Q5HZY7; -. DR SwissPalm; Q5HZY7; -. DR PeptideAtlas; Q5HZY7; -. DR Antibodypedia; 3900; 165 antibodies from 24 providers. DR DNASU; 66290; -. DR GeneID; 66290; -. DR KEGG; mmu:66290; -. DR AGR; MGI:1913540; -. DR CTD; 9550; -. DR MGI; MGI:1913540; Atp6v1g1. DR VEuPathDB; HostDB:ENSMUSG00000039105; -. DR HOGENOM; CLU_125101_1_1_1; -. DR OMA; ARKYRQD; -. DR OrthoDB; 33708at2759; -. DR BioGRID-ORCS; 66290; 25 hits in 77 CRISPR screens. DR ChiTaRS; Atp6v1g1; mouse. DR ExpressionAtlas; Q5HZY7; baseline and differential. DR GO; GO:0098850; C:extrinsic component of synaptic vesicle membrane; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IEA:Ensembl. DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl. DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro. DR GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl. DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl. DR Gene3D; 1.20.5.2950; -; 1. DR InterPro; IPR005124; V-ATPase_G. DR NCBIfam; TIGR01147; V_ATP_synt_G; 1. DR PANTHER; PTHR12713:SF12; V-TYPE PROTON ATPASE SUBUNIT G 1; 1. DR PANTHER; PTHR12713; VACUOLAR ATP SYNTHASE SUBUNIT G; 1. DR Pfam; PF03179; V-ATPase_G; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Hydrogen ion transport {ECO:0000256|RuleBase:RU364019}; KW Ion transport {ECO:0000256|RuleBase:RU364019}; KW Transport {ECO:0000256|RuleBase:RU364019}. FT COILED 8..57 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 118 AA; 13724 MW; 1FC54025CFCFD951 CRC64; MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ REKEFKAKEA AALGSHGSCS SEVEKETREK MTVLQNYFEQ NRDEVLDNLL AFVCDIRPEI HENYRING //