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Protein

GTP-binding protein SAR1b

Gene

Sar1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341MagnesiumBy similarity
Metal bindingi75 – 751MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398GTPBy similarity
Nucleotide bindingi75 – 784GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein SAR1b
Gene namesi
Name:Sar1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1305590. Sar1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198GTP-binding protein SAR1bPRO_0000312558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei164 – 1641PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5HZY2.
PRIDEiQ5HZY2.

PTM databases

iPTMnetiQ5HZY2.
PhosphoSiteiQ5HZY2.

Expressioni

Gene expression databases

GenevisibleiQ5HZY2. RN.

Interactioni

Subunit structurei

Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006567.

Structurei

3D structure databases

ProteinModelPortaliQ5HZY2.
SMRiQ5HZY2. Positions 13-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. SAR1 family.Curated

Phylogenomic databases

eggNOGiKOG0077. Eukaryota.
ENOG410YIKI. LUCA.
GeneTreeiENSGT00550000074696.
HOGENOMiHOG000163690.
HOVERGENiHBG104997.
InParanoidiQ5HZY2.
KOiK07953.
OMAiMKELNTR.
OrthoDBiEOG7W1550.
PhylomeDBiQ5HZY2.
TreeFamiTF312890.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51422. SAR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIFDWIYS GFSSVLQFLG LYKKTGKLVF LGLDNAGKTT LLHMLKDDRL
60 70 80 90 100
GQHVPTLHPT SEELTIAGMT FTTFDLGGHL QARRVWKNYL PAINGIVFLV
110 120 130 140 150
DCADHERLLE SKEELDSLMT DETIANVPIL ILGNKIDRPE AISEERLREM
160 170 180 190
FGLYGQTTGK GSVSLKELNA RPLEVFMCSV LKRQGYGEGF RWMAQYID
Length:198
Mass (Da):22,410
Last modified:February 15, 2005 - v1
Checksum:i3556769075CE9221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088842 mRNA. Translation: AAH88842.1.
RefSeqiNP_001009622.1. NM_001009622.1.
UniGeneiRn.36748.

Genome annotation databases

EnsembliENSRNOT00000006567; ENSRNOP00000006567; ENSRNOG00000004820.
GeneIDi287276.
KEGGirno:287276.
UCSCiRGD:1305590. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088842 mRNA. Translation: AAH88842.1.
RefSeqiNP_001009622.1. NM_001009622.1.
UniGeneiRn.36748.

3D structure databases

ProteinModelPortaliQ5HZY2.
SMRiQ5HZY2. Positions 13-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006567.

PTM databases

iPTMnetiQ5HZY2.
PhosphoSiteiQ5HZY2.

Proteomic databases

PaxDbiQ5HZY2.
PRIDEiQ5HZY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006567; ENSRNOP00000006567; ENSRNOG00000004820.
GeneIDi287276.
KEGGirno:287276.
UCSCiRGD:1305590. rat.

Organism-specific databases

CTDi51128.
RGDi1305590. Sar1b.

Phylogenomic databases

eggNOGiKOG0077. Eukaryota.
ENOG410YIKI. LUCA.
GeneTreeiENSGT00550000074696.
HOGENOMiHOG000163690.
HOVERGENiHBG104997.
InParanoidiQ5HZY2.
KOiK07953.
OMAiMKELNTR.
OrthoDBiEOG7W1550.
PhylomeDBiQ5HZY2.
TreeFamiTF312890.

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

NextBioi625787.
PROiQ5HZY2.

Gene expression databases

GenevisibleiQ5HZY2. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR006689. Small_GTPase_ARF/SAR.
IPR006687. Small_GTPase_SAR1.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51422. SAR1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiSAR1B_RAT
AccessioniPrimary (citable) accession number: Q5HZY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 15, 2005
Last modified: January 20, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.