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Protein

CD320 antigen

Gene

Cd320

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
CD320 antigen
Alternative name(s):
Transcobalamin receptor
Short name:
TCblR
CD_antigen: CD320
Gene namesi
Name:Cd320
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305860. Cd320.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 264236CD320 antigenPRO_0000354053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 64PROSITE-ProRule annotation
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi71 ↔ 86PROSITE-ProRule annotation
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi135 ↔ 154PROSITE-ProRule annotation
Disulfide bondi148 ↔ 163PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5HZW5.
PRIDEiQ5HZW5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006901.
GenevisibleiQ5HZW5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009067.

Structurei

3D structure databases

ProteinModelPortaliQ5HZW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 8738LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16438LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00730000111436.
HOGENOMiHOG000111486.
HOVERGENiHBG056019.
InParanoidiQ5HZW5.
KOiK06734.
OMAiEECRIEP.
OrthoDBiEOG091G0M4G.
PhylomeDBiQ5HZW5.
TreeFamiTF337215.

Family and domain databases

Gene3Di4.10.400.10. 2 hits.
InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCGAGRAA ALGLVLRLLL GLRTGPEAAP APTSAPAHTL VQVSGPRAGS
60 70 80 90 100
CPTDTFKCLT SGYCVPLSWR CDGDRDCSDG SDEEECRIEP CAQNRQCQPQ
110 120 130 140 150
PALPCSCDNI SGCSAGSDKN LNCSRSPCQE GELRCILDDV CIPHTWRCDG
160 170 180 190 200
HPDCPDSSDE LSCDTDTETD KIFQEENATT SMSSMIVEKE TSFRNVTVAS
210 220 230 240 250
AGHPSRNPNA YGVIAAAGVL SAILVSATIL ILLRLRGQGY LPPTGLLVAV
260
KESLLLSERK TSLI
Length:264
Mass (Da):27,943
Last modified:February 15, 2005 - v1
Checksum:iFD32FAAB1D1EA4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088861 mRNA. Translation: AAH88861.1.
RefSeqiNP_001014223.1. NM_001014201.1.
UniGeneiRn.224481.

Genome annotation databases

EnsembliENSRNOT00000009067; ENSRNOP00000009067; ENSRNOG00000006901.
GeneIDi362851.
KEGGirno:362851.
UCSCiRGD:1305860. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088861 mRNA. Translation: AAH88861.1.
RefSeqiNP_001014223.1. NM_001014201.1.
UniGeneiRn.224481.

3D structure databases

ProteinModelPortaliQ5HZW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009067.

Proteomic databases

PaxDbiQ5HZW5.
PRIDEiQ5HZW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009067; ENSRNOP00000009067; ENSRNOG00000006901.
GeneIDi362851.
KEGGirno:362851.
UCSCiRGD:1305860. rat.

Organism-specific databases

CTDi51293.
RGDi1305860. Cd320.

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00730000111436.
HOGENOMiHOG000111486.
HOVERGENiHBG056019.
InParanoidiQ5HZW5.
KOiK06734.
OMAiEECRIEP.
OrthoDBiEOG091G0M4G.
PhylomeDBiQ5HZW5.
TreeFamiTF337215.

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

PROiQ5HZW5.

Gene expression databases

BgeeiENSRNOG00000006901.
GenevisibleiQ5HZW5. RN.

Family and domain databases

Gene3Di4.10.400.10. 2 hits.
InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 2 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiPS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD320_RAT
AccessioniPrimary (citable) accession number: Q5HZW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.