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Protein

CD320 antigen

Gene

Cd320

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi72Calcium 1By similarity1
Metal bindingi74Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi76Calcium 1By similarity1
Metal bindingi82Calcium 1By similarity1
Metal bindingi83Calcium 1By similarity1
Metal bindingi146Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi149Calcium 2By similarity1
Metal bindingi151Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi153Calcium 2By similarity1
Metal bindingi159Calcium 2By similarity1
Metal bindingi160Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-RNO-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
CD320 antigen
Alternative name(s):
Transcobalamin receptor
Short name:
TCblR
CD_antigen: CD320
Gene namesi
Name:Cd320
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305860 Cd320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000035405329 – 264CD320 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 64PROSITE-ProRule annotation
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi71 ↔ 86PROSITE-ProRule annotation
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi135 ↔ 154PROSITE-ProRule annotation
Disulfide bondi148 ↔ 163PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5HZW5
PRIDEiQ5HZW5

Expressioni

Gene expression databases

BgeeiENSRNOG00000006901
GenevisibleiQ5HZW5 RN

Interactioni

Subunit structurei

Interacts (via LDL-receptor class A domains) with TCN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009067

Structurei

3D structure databases

ProteinModelPortaliQ5HZW5
SMRiQ5HZW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 87LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini127 – 164LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215 Eukaryota
ENOG410XP34 LUCA
GeneTreeiENSGT00730000111436
HOGENOMiHOG000111486
HOVERGENiHBG056019
InParanoidiQ5HZW5
KOiK06734
OMAiEECRIEP
OrthoDBiEOG091G0M4G
PhylomeDBiQ5HZW5
TreeFamiTF337215

Family and domain databases

CDDicd00112 LDLa, 2 hits
InterProiView protein in InterPro
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 2 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00192 LDLa, 2 hits
SUPFAMiSSF57424 SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCGAGRAA ALGLVLRLLL GLRTGPEAAP APTSAPAHTL VQVSGPRAGS
60 70 80 90 100
CPTDTFKCLT SGYCVPLSWR CDGDRDCSDG SDEEECRIEP CAQNRQCQPQ
110 120 130 140 150
PALPCSCDNI SGCSAGSDKN LNCSRSPCQE GELRCILDDV CIPHTWRCDG
160 170 180 190 200
HPDCPDSSDE LSCDTDTETD KIFQEENATT SMSSMIVEKE TSFRNVTVAS
210 220 230 240 250
AGHPSRNPNA YGVIAAAGVL SAILVSATIL ILLRLRGQGY LPPTGLLVAV
260
KESLLLSERK TSLI
Length:264
Mass (Da):27,943
Last modified:February 15, 2005 - v1
Checksum:iFD32FAAB1D1EA4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088861 mRNA Translation: AAH88861.1
RefSeqiNP_001014223.1, NM_001014201.1
UniGeneiRn.224481

Genome annotation databases

EnsembliENSRNOT00000009067; ENSRNOP00000009067; ENSRNOG00000006901
GeneIDi362851
KEGGirno:362851
UCSCiRGD:1305860 rat

Similar proteinsi

Entry informationi

Entry nameiCD320_RAT
AccessioniPrimary (citable) accession number: Q5HZW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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