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Protein

CD320 antigen

Gene

Cd320

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells. Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation. Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi72Calcium 1By similarity1
Metal bindingi74Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi76Calcium 1By similarity1
Metal bindingi82Calcium 1By similarity1
Metal bindingi83Calcium 1By similarity1
Metal bindingi146Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi149Calcium 2By similarity1
Metal bindingi151Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi153Calcium 2By similarity1
Metal bindingi159Calcium 2By similarity1
Metal bindingi160Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
CD320 antigen
Alternative name(s):
Transcobalamin receptor
Short name:
TCblR
CD_antigen: CD320
Gene namesi
Name:Cd320
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305860. Cd320.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000035405329 – 264CD320 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 64PROSITE-ProRule annotation
Disulfide bondi58 ↔ 77PROSITE-ProRule annotation
Disulfide bondi71 ↔ 86PROSITE-ProRule annotation
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi135 ↔ 154PROSITE-ProRule annotation
Disulfide bondi148 ↔ 163PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5HZW5.
PRIDEiQ5HZW5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006901.
GenevisibleiQ5HZW5. RN.

Interactioni

Subunit structurei

Interacts (via LDL-receptor class A domains) with TCN2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009067.

Structurei

3D structure databases

ProteinModelPortaliQ5HZW5.
SMRiQ5HZW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 87LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST38
Domaini127 – 164LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00730000111436.
HOGENOMiHOG000111486.
HOVERGENiHBG056019.
InParanoidiQ5HZW5.
KOiK06734.
OMAiEECRIEP.
OrthoDBiEOG091G0M4G.
PhylomeDBiQ5HZW5.
TreeFamiTF337215.

Family and domain databases

InterProiView protein in InterPro
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
PfamiView protein in Pfam
PF00057. Ldl_recept_a. 2 hits.
PRINTSiPR00261. LDLRECEPTOR.
SMARTiView protein in SMART
SM00192. LDLa. 2 hits.
SUPFAMiSSF57424. SSF57424. 2 hits.
PROSITEiView protein in PROSITE
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCGAGRAA ALGLVLRLLL GLRTGPEAAP APTSAPAHTL VQVSGPRAGS
60 70 80 90 100
CPTDTFKCLT SGYCVPLSWR CDGDRDCSDG SDEEECRIEP CAQNRQCQPQ
110 120 130 140 150
PALPCSCDNI SGCSAGSDKN LNCSRSPCQE GELRCILDDV CIPHTWRCDG
160 170 180 190 200
HPDCPDSSDE LSCDTDTETD KIFQEENATT SMSSMIVEKE TSFRNVTVAS
210 220 230 240 250
AGHPSRNPNA YGVIAAAGVL SAILVSATIL ILLRLRGQGY LPPTGLLVAV
260
KESLLLSERK TSLI
Length:264
Mass (Da):27,943
Last modified:February 15, 2005 - v1
Checksum:iFD32FAAB1D1EA4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088861 mRNA. Translation: AAH88861.1.
RefSeqiNP_001014223.1. NM_001014201.1.
UniGeneiRn.224481.

Genome annotation databases

EnsembliENSRNOT00000009067; ENSRNOP00000009067; ENSRNOG00000006901.
GeneIDi362851.
KEGGirno:362851.
UCSCiRGD:1305860. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD320_RAT
AccessioniPrimary (citable) accession number: Q5HZW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 15, 2005
Last modified: May 10, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome