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Protein

Protein phosphatase 1 regulatory subunit 7

Gene

Ppp1r7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 7
Alternative name(s):
Protein phosphatase 1 regulatory subunit 22
Gene namesi
Name:Ppp1r7
Synonyms:Sds22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308169. Ppp1r7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002396162 – 360Protein phosphatase 1 regulatory subunit 7Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5HZV9.
PRIDEiQ5HZV9.

PTM databases

iPTMnetiQ5HZV9.
PhosphoSitePlusiQ5HZV9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016974.

Interactioni

Subunit structurei

Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G.By similarity

Protein-protein interaction databases

IntActiQ5HZV9. 1 interactor.
STRINGi10116.ENSRNOP00000022854.

Structurei

3D structure databases

ProteinModelPortaliQ5HZV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati77 – 98LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati121 – 142LRR 3Add BLAST22
Repeati143 – 164LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati187 – 208LRR 6Add BLAST22
Repeati209 – 230LRR 7Add BLAST22
Repeati231 – 252LRR 8Add BLAST22
Repeati253 – 274LRR 9Add BLAST22
Repeati275 – 296LRR 10Add BLAST22
Repeati297 – 318LRR 11Add BLAST22
Domaini331 – 360LRRCTAdd BLAST30

Sequence similaritiesi

Belongs to the SDS22 family.Curated
Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000211189.
HOVERGENiHBG082161.
InParanoidiQ5HZV9.
KOiK17550.
PhylomeDBiQ5HZV9.
TreeFamiTF105538.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: Q5HZV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHGGGIV ADLSQQSLKD
60 70 80 90 100
GVERGAEDPE EEHELAVDME TISLDRDAED VDLNHYRIGK IEGFEVLKKV
110 120 130 140 150
KSLCLRQNLI KCIENLDELQ SLRELDLYDN QIKKIENLEA LTELEVLDIS
160 170 180 190 200
FNLLRNIEGI DKLTQLKKLF LVNNKINKIE NISTLQQLQM LELGSNRIRA
210 220 230 240 250
IENIDTLTNL ESLFLGKNKI TKLQNLDALS NLTVLSMQSN RLTKIEGLQN
260 270 280 290 300
LVNLRELYLS HNGIEVIEGL ENNNKLTMLD IASNRIKKIE NISHLTELQE
310 320 330 340 350
FWMNDNLLES WSDLDELKGA RSLETVYLER NPLQKDPQYR RKVMLALPSV
360
RQIDATFVRF
Length:360
Mass (Da):41,297
Last modified:February 15, 2005 - v1
Checksum:i1CDA9FB2ACC02400
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088868 mRNA. Translation: AAH88868.1.
RefSeqiNP_001009825.1. NM_001009825.1. [Q5HZV9-1]
UniGeneiRn.19437.

Genome annotation databases

GeneIDi301618.
KEGGirno:301618.
UCSCiRGD:1308169. rat. [Q5HZV9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088868 mRNA. Translation: AAH88868.1.
RefSeqiNP_001009825.1. NM_001009825.1. [Q5HZV9-1]
UniGeneiRn.19437.

3D structure databases

ProteinModelPortaliQ5HZV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5HZV9. 1 interactor.
STRINGi10116.ENSRNOP00000022854.

PTM databases

iPTMnetiQ5HZV9.
PhosphoSitePlusiQ5HZV9.

Proteomic databases

PaxDbiQ5HZV9.
PRIDEiQ5HZV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301618.
KEGGirno:301618.
UCSCiRGD:1308169. rat. [Q5HZV9-1]

Organism-specific databases

CTDi5510.
RGDi1308169. Ppp1r7.

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000211189.
HOVERGENiHBG082161.
InParanoidiQ5HZV9.
KOiK17550.
PhylomeDBiQ5HZV9.
TreeFamiTF105538.

Miscellaneous databases

PROiQ5HZV9.

Gene expression databases

BgeeiENSRNOG00000016974.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00446. LRRcap. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP1R7_RAT
AccessioniPrimary (citable) accession number: Q5HZV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.