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Protein

Protein canopy homolog 3

Gene

cnpy3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 3
Gene namesi
Name:cnpy3
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000031378520 – 242Protein canopy homolog 3Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 187By similarity
Disulfide bondi31 ↔ 175By similarity
Disulfide bondi85 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ5HZV5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 235Saposin B-typeAdd BLAST210

Sequence similaritiesi

Belongs to the canopy family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107736
InParanoidiQ5HZV5

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HZV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLLLLLPLW GGCAEPGDSE WVNLPSKCEV CKYVALELKS SFDETSRTRE
60 70 80 90 100
LIDTRYGFLE DDKKAKKIKY TNSDIRLIEV TEGLCSRLLE YNLHKERSGS
110 120 130 140 150
NRFAKGMSET FQTLHHLVHK GVKVVMDIPY ELWNETSAEV ADMKKQCDVM
160 170 180 190 200
METYEDVIED WYRHHQEADL TEFLCARHVL RGQDQSCLEE HWDSRKGDTG
210 220 230 240
PSTGTKKQKK QGEKKNKSKK ENSGPEEERR QMEQPTAAKE EL
Length:242
Mass (Da):28,120
Last modified:January 15, 2008 - v2
Checksum:i985D24FBD48EC41E
GO

Sequence cautioni

The sequence AAH88872 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088872 mRNA Translation: AAH88872.1 Different initiation.
UniGeneiStr.22034

Similar proteinsi

Entry informationi

Entry nameiCNPY3_XENTR
AccessioniPrimary (citable) accession number: Q5HZV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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