Q5HZV5 (CNPY3_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein canopy homolog 3

Gene names

Name:

cnpy3

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses By similarity.
Subcellular location	Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the canopy family. Contains 1 saposin B-type domain.
Sequence caution	The sequence AAH88872.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Chaperone
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 242	223	Protein canopy homolog 3		PRO_0000313785
Regions
	Domain	26 – 235	210	Saposin B-type
Amino acid modifications
	Disulfide bond	28 ↔ 187		By similarity
	Disulfide bond	31 ↔ 175		By similarity
	Disulfide bond	85 ↔ 147		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HZV5 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 985D24FBD48EC41E	FASTA	242	28,120
	10 20 30 40 50 60 MWLLLLLPLW GGCAEPGDSE WVNLPSKCEV CKYVALELKS SFDETSRTRE LIDTRYGFLE 70 80 90 100 110 120 DDKKAKKIKY TNSDIRLIEV TEGLCSRLLE YNLHKERSGS NRFAKGMSET FQTLHHLVHK 130 140 150 160 170 180 GVKVVMDIPY ELWNETSAEV ADMKKQCDVM METYEDVIED WYRHHQEADL TEFLCARHVL 190 200 210 220 230 240 RGQDQSCLEE HWDSRKGDTG PSTGTKKQKK QGEKKNKSKK ENSGPEEERR QMEQPTAAKE EL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC088872 mRNA. Translation: AAH88872.1. Different initiation.
UniGene	Str.22034.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-6455266. cnpy3.
Phylogenomic databases
HOVERGEN	HBG107736.
Family and domain databases
InterPro	IPR021852. DUF3456. [Graphical view]
Pfam	PF11938. DUF3456. 1 hit. [Graphical view]
PROSITE	PS50015. SAP_B. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CNPY3_XENTR

Accession

Primary (citable) accession number: Q5HZV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	July 11, 2012
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program