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Q5HZV5 (CNPY3_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein canopy homolog 3
Gene names
Name:cnpy3
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the canopy family.

Contains 1 saposin B-type domain.

Sequence caution

The sequence AAH88872.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processImmunity
Innate immunity
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionChaperone
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinnate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 242223Protein canopy homolog 3
PRO_0000313785

Regions

Domain26 – 235210Saposin B-type

Amino acid modifications

Disulfide bond28 ↔ 187 By similarity
Disulfide bond31 ↔ 175 By similarity
Disulfide bond85 ↔ 147 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HZV5 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 985D24FBD48EC41E

FASTA24228,120
        10         20         30         40         50         60 
MWLLLLLPLW GGCAEPGDSE WVNLPSKCEV CKYVALELKS SFDETSRTRE LIDTRYGFLE 

        70         80         90        100        110        120 
DDKKAKKIKY TNSDIRLIEV TEGLCSRLLE YNLHKERSGS NRFAKGMSET FQTLHHLVHK 

       130        140        150        160        170        180 
GVKVVMDIPY ELWNETSAEV ADMKKQCDVM METYEDVIED WYRHHQEADL TEFLCARHVL 

       190        200        210        220        230        240 
RGQDQSCLEE HWDSRKGDTG PSTGTKKQKK QGEKKNKSKK ENSGPEEERR QMEQPTAAKE 


EL 

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC088872 mRNA. Translation: AAH88872.1. Different initiation.
UniGeneStr.22034.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6455266. cnpy3.

Phylogenomic databases

HOVERGENHBG107736.

Family and domain databases

InterProIPR021852. DUF3456.
[Graphical view]
PfamPF11938. DUF3456. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCNPY3_XENTR
AccessionPrimary (citable) accession number: Q5HZV5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families