Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5HZQ8 (ECHD1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ethylmalonyl-CoA decarboxylase

EC=4.1.1.94
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase
Short name=MMCD
EC=4.1.1.41
Gene names
Name:echdc1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activity

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.

(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionLyase
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncarboxy-lyase activity

Inferred from sequence or structural similarity. Source: UniProtKB

methylmalonyl-CoA decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Ethylmalonyl-CoA decarboxylase
PRO_0000416273

Sequences

Sequence LengthMass (Da)Tools
Q5HZQ8 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 189E9519536368FA

FASTA29932,656
        10         20         30         40         50         60 
MGIFVWRSSL SMTNIRWLHH RCLSLYNSSH GFNEAKIKKK LAQFTGGSVD LSKSDDGIAE 

        70         80         90        100        110        120 
ICINNPTRMN AFTGTMMIEL EERISDLENW QDGKGLIVYG AENTFCSGSD LNAVKAISNP 

       130        140        150        160        170        180 
QEGMMMCMLM QNTLTRLQRL PLVSVALIQG KALGGGAELC TACDFRLMTE GSEIRFVHKQ 

       190        200        210        220        230        240 
MGLVPGWGGA ARLIHIVGSR HALKLLSGAP RVQPENALEL GLADNILTGT EAGVLSEAKN 

       250        260        270        280        290 
WIMPYIKGPS DVTRAVKKVI ISGREQNLED ALRTEKEIFG TVWGGLANLQ ALAKGTKHK 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC088922 mRNA. Translation: AAH88922.1.
RefSeqNP_001088953.1. NM_001095484.1.
UniGeneXl.50100.

3D structure databases

ProteinModelPortalQ5HZQ8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496330.
KEGGxla:496330.

Organism-specific databases

CTD55862.
XenbaseXB-GENE-958561. echdc1.

Phylogenomic databases

HOVERGENHBG054783.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
InterProIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF52096. SSF52096. 1 hit.
PROSITEPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameECHD1_XENLA
AccessionPrimary (citable) accession number: Q5HZQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families