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Q5HZQ8

- ECHD1_XENLA

UniProt

Q5HZQ8 - ECHD1_XENLA

Protein

Ethylmalonyl-CoA decarboxylase

Gene

echdc1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.By similarity

    Catalytic activityi

    (S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
    (S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

    GO - Molecular functioni

    1. carboxy-lyase activity Source: UniProtKB
    2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
    Alternative name(s):
    Enoyl-CoA hydratase domain-containing protein 1
    Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
    Short name:
    MMCD
    Gene namesi
    Name:echdc1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-958561. echdc1.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Ethylmalonyl-CoA decarboxylasePRO_0000416273Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HZQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG054783.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view]
    PfamiPF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HZQ8-1 [UniParc]FASTAAdd to Basket

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    MGIFVWRSSL SMTNIRWLHH RCLSLYNSSH GFNEAKIKKK LAQFTGGSVD    50
    LSKSDDGIAE ICINNPTRMN AFTGTMMIEL EERISDLENW QDGKGLIVYG 100
    AENTFCSGSD LNAVKAISNP QEGMMMCMLM QNTLTRLQRL PLVSVALIQG 150
    KALGGGAELC TACDFRLMTE GSEIRFVHKQ MGLVPGWGGA ARLIHIVGSR 200
    HALKLLSGAP RVQPENALEL GLADNILTGT EAGVLSEAKN WIMPYIKGPS 250
    DVTRAVKKVI ISGREQNLED ALRTEKEIFG TVWGGLANLQ ALAKGTKHK 299
    Length:299
    Mass (Da):32,656
    Last modified:February 15, 2005 - v1
    Checksum:i189E9519536368FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088922 mRNA. Translation: AAH88922.1.
    RefSeqiNP_001088953.1. NM_001095484.1.
    UniGeneiXl.50100.

    Genome annotation databases

    GeneIDi496330.
    KEGGixla:496330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088922 mRNA. Translation: AAH88922.1 .
    RefSeqi NP_001088953.1. NM_001095484.1.
    UniGenei Xl.50100.

    3D structure databases

    ProteinModelPortali Q5HZQ8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 496330.
    KEGGi xla:496330.

    Organism-specific databases

    CTDi 55862.
    Xenbasei XB-GENE-958561. echdc1.

    Phylogenomic databases

    HOVERGENi HBG054783.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR018376. Enoyl-CoA_hyd/isom_CS.
    [Graphical view ]
    Pfami PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.

    Entry informationi

    Entry nameiECHD1_XENLA
    AccessioniPrimary (citable) accession number: Q5HZQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3