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Q5HZQ8

- ECHD1_XENLA

UniProt

Q5HZQ8 - ECHD1_XENLA

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Protein
Ethylmalonyl-CoA decarboxylase
Gene
echdc1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level By similarity.

Catalytic activityi

(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2.
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2.

GO - Molecular functioni

  1. carboxy-lyase activity Source: UniProtKB
  2. methylmalonyl-CoA decarboxylase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylmalonyl-CoA decarboxylase (EC:4.1.1.94)
Alternative name(s):
Enoyl-CoA hydratase domain-containing protein 1
Methylmalonyl-CoA decarboxylase (EC:4.1.1.41)
Short name:
MMCD
Gene namesi
Name:echdc1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-958561. echdc1.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Ethylmalonyl-CoA decarboxylase
PRO_0000416273Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5HZQ8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG054783.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZQ8-1 [UniParc]FASTAAdd to Basket

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MGIFVWRSSL SMTNIRWLHH RCLSLYNSSH GFNEAKIKKK LAQFTGGSVD    50
LSKSDDGIAE ICINNPTRMN AFTGTMMIEL EERISDLENW QDGKGLIVYG 100
AENTFCSGSD LNAVKAISNP QEGMMMCMLM QNTLTRLQRL PLVSVALIQG 150
KALGGGAELC TACDFRLMTE GSEIRFVHKQ MGLVPGWGGA ARLIHIVGSR 200
HALKLLSGAP RVQPENALEL GLADNILTGT EAGVLSEAKN WIMPYIKGPS 250
DVTRAVKKVI ISGREQNLED ALRTEKEIFG TVWGGLANLQ ALAKGTKHK 299
Length:299
Mass (Da):32,656
Last modified:February 15, 2005 - v1
Checksum:i189E9519536368FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088922 mRNA. Translation: AAH88922.1.
RefSeqiNP_001088953.1. NM_001095484.1.
UniGeneiXl.50100.

Genome annotation databases

GeneIDi496330.
KEGGixla:496330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC088922 mRNA. Translation: AAH88922.1 .
RefSeqi NP_001088953.1. NM_001095484.1.
UniGenei Xl.50100.

3D structure databases

ProteinModelPortali Q5HZQ8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 496330.
KEGGi xla:496330.

Organism-specific databases

CTDi 55862.
Xenbasei XB-GENE-958561. echdc1.

Phylogenomic databases

HOVERGENi HBG054783.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view ]
Pfami PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
PROSITEi PS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.

Entry informationi

Entry nameiECHD1_XENLA
AccessioniPrimary (citable) accession number: Q5HZQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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