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Q5HZM6 (ELP3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongator complex protein 3

EC=2.3.1.48
Gene names
Name:elp3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ELP3 family.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Elongator complex protein 3
PRO_0000283990

Regions

Domain398 – 549152N-acetyltransferase

Sites

Metal binding1011Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1111Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1141Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HZM6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 3DBC66E707E42063

FASTA54962,577
        10         20         30         40         50         60 
MKPDRGMRGN MSQAELMMMT VADVIKQLVE AHEQGKDVNL NKLKTKTSAK YGLSAQPRLV 

        70         80         90        100        110        120 
DIIAAVPPQY RKILVPKLKA KPIRTASGIA VVAVMCKPHR CPHINFTGNI CVYCPGGPDS 

       130        140        150        160        170        180 
DFEYSTQSYT GYEPTSMRAI RARYDPYLQT RHRVEQLKQL GHNVDKVEFI VMGGTFMALP 

       190        200        210        220        230        240 
EDYRDFFIRN LHDALSGHTS NSVSEAVRYS ERSNTKCVGI TIETRPDYCL KRHLSDMLCY 

       250        260        270        280        290        300 
GCTRLEIGVQ SVYEDVARDT NRGHTVKAVC ESFHLSKDAG FKVVSHMMPD LPNMGLERDI 

       310        320        330        340        350        360 
EQFIEFFENP AFRPDGMKLY PTLVIRGTGL YELWKTGRYR SYSPSTLVDL VARILALVPP 

       370        380        390        400        410        420 
WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTEC RDVRTREVGI QEIHHKVRPY 

       430        440        450        460        470        480 
QVELIRRDYV ANGGWETFLS YEDPEQDILI GLLRLRKCSE ESFRPELKGG VSIVRELHVY 

       490        500        510        520        530        540 
GSVVPISSRD PSKFQHQGFG MLLMEEAERI ARDEHGSWKI AVISGVGTRN YYRKIGYELE 


GPYMVKRLD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC088956 mRNA. Translation: AAH88956.1.
RefSeqNP_001088974.1. NM_001095505.1.
UniGeneXl.16750.

3D structure databases

ProteinModelPortalQ5HZM6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID496354.
KEGGxla:496354.

Organism-specific databases

CTD55140.
XenbaseXB-GENE-957353. elp3.

Phylogenomic databases

HOVERGENHBG107845.
KOK07739.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
TIGRFAMsTIGR01211. ELP3. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameELP3_XENLA
AccessionPrimary (citable) accession number: Q5HZM6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families