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Q5HZM6

- ELP3_XENLA

UniProt

Q5HZM6 - ELP3_XENLA

Protein

Elongator complex protein 3

Gene

elp3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi114 – 1141Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. phosphorylase kinase regulator activity Source: UniProtKB

    GO - Biological processi

    1. regulation of protein kinase activity Source: GOC
    2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:elp3
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-957353. elp3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. transcription elongation factor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Elongator complex protein 3PRO_0000283990Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HZM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini398 – 549152N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG107845.
    KOiK07739.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HZM6-1 [UniParc]FASTAAdd to Basket

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    MKPDRGMRGN MSQAELMMMT VADVIKQLVE AHEQGKDVNL NKLKTKTSAK    50
    YGLSAQPRLV DIIAAVPPQY RKILVPKLKA KPIRTASGIA VVAVMCKPHR 100
    CPHINFTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYDPYLQT 150
    RHRVEQLKQL GHNVDKVEFI VMGGTFMALP EDYRDFFIRN LHDALSGHTS 200
    NSVSEAVRYS ERSNTKCVGI TIETRPDYCL KRHLSDMLCY GCTRLEIGVQ 250
    SVYEDVARDT NRGHTVKAVC ESFHLSKDAG FKVVSHMMPD LPNMGLERDI 300
    EQFIEFFENP AFRPDGMKLY PTLVIRGTGL YELWKTGRYR SYSPSTLVDL 350
    VARILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTEC 400
    RDVRTREVGI QEIHHKVRPY QVELIRRDYV ANGGWETFLS YEDPEQDILI 450
    GLLRLRKCSE ESFRPELKGG VSIVRELHVY GSVVPISSRD PSKFQHQGFG 500
    MLLMEEAERI ARDEHGSWKI AVISGVGTRN YYRKIGYELE GPYMVKRLD 549
    Length:549
    Mass (Da):62,577
    Last modified:February 15, 2005 - v1
    Checksum:i3DBC66E707E42063
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088956 mRNA. Translation: AAH88956.1.
    RefSeqiNP_001088974.1. NM_001095505.1.
    UniGeneiXl.16750.

    Genome annotation databases

    GeneIDi496354.
    KEGGixla:496354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC088956 mRNA. Translation: AAH88956.1 .
    RefSeqi NP_001088974.1. NM_001095505.1.
    UniGenei Xl.16750.

    3D structure databases

    ProteinModelPortali Q5HZM6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 496354.
    KEGGi xla:496354.

    Organism-specific databases

    CTDi 55140.
    Xenbasei XB-GENE-957353. elp3.

    Phylogenomic databases

    HOVERGENi HBG107845.
    KOi K07739.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.

    Entry informationi

    Entry nameiELP3_XENLA
    AccessioniPrimary (citable) accession number: Q5HZM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3