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Protein

Elongator complex protein 3

Gene

elp3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. Involved in acetylation of alpha-tubulin (By similarity). May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi114Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandIron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elp3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-957353 elp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002839901 – 549Elongator complex protein 3Add BLAST549

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

BioGridi106434, 1 interactor
IntActiQ5HZM6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ5HZM6
SMRiQ5HZM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini398 – 549N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.Curated

Phylogenomic databases

HOVERGENiHBG107845
KOiK07739

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HZM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPDRGMRGN MSQAELMMMT VADVIKQLVE AHEQGKDVNL NKLKTKTSAK
60 70 80 90 100
YGLSAQPRLV DIIAAVPPQY RKILVPKLKA KPIRTASGIA VVAVMCKPHR
110 120 130 140 150
CPHINFTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYDPYLQT
160 170 180 190 200
RHRVEQLKQL GHNVDKVEFI VMGGTFMALP EDYRDFFIRN LHDALSGHTS
210 220 230 240 250
NSVSEAVRYS ERSNTKCVGI TIETRPDYCL KRHLSDMLCY GCTRLEIGVQ
260 270 280 290 300
SVYEDVARDT NRGHTVKAVC ESFHLSKDAG FKVVSHMMPD LPNMGLERDI
310 320 330 340 350
EQFIEFFENP AFRPDGMKLY PTLVIRGTGL YELWKTGRYR SYSPSTLVDL
360 370 380 390 400
VARILALVPP WTRVYRVQRD IPMPLVSSGV EHGNLRELAL ARMKDLGTEC
410 420 430 440 450
RDVRTREVGI QEIHHKVRPY QVELIRRDYV ANGGWETFLS YEDPEQDILI
460 470 480 490 500
GLLRLRKCSE ESFRPELKGG VSIVRELHVY GSVVPISSRD PSKFQHQGFG
510 520 530 540
MLLMEEAERI ARDEHGSWKI AVISGVGTRN YYRKIGYELE GPYMVKRLD
Length:549
Mass (Da):62,577
Last modified:February 15, 2005 - v1
Checksum:i3DBC66E707E42063
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088956 mRNA Translation: AAH88956.1
RefSeqiNP_001088974.1, NM_001095505.1
UniGeneiXl.16750

Genome annotation databases

GeneIDi496354
KEGGixla:496354

Similar proteinsi

Entry informationi

Entry nameiELP3_XENLA
AccessioniPrimary (citable) accession number: Q5HZM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health