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Protein

Microtubule-associated tumor suppressor 1 homolog

Gene

Mtus1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation.3 Publications

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • regulation of macrophage chemotaxis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated tumor suppressor 1 homolog
Alternative name(s):
AT2 receptor-binding protein
Angiotensin-II type 2 receptor-interacting protein
Coiled-coiled tumor suppressor gene 1 protein
Mitochondrial tumor suppressor 1 homolog
Gene namesi
Name:Mtus1
Synonyms:Atbp, Atip, Cctsg1, Kiaa1288, Mtsg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2142572. Mtus1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051981 – 1210Microtubule-associated tumor suppressor 1 homologAdd BLAST1210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei375PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei1143PhosphoserineBy similarity1
Modified residuei1164PhosphoserineCombined sources1
Modified residuei1185PhosphoserineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1199PhosphoserineBy similarity1
Modified residuei1201PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1204PhosphoserineBy similarity1
Modified residuei1208PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5HZI1.
PeptideAtlasiQ5HZI1.
PRIDEiQ5HZI1.

PTM databases

iPTMnetiQ5HZI1.
PhosphoSitePlusiQ5HZI1.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in uterus and adrenal gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000045636.
CleanExiMM_MTUS1.

Interactioni

Subunit structurei

Homodimer. Interacts with AGTR2. Interacts with PTPN6.3 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059503.

Structurei

3D structure databases

ProteinModelPortaliQ5HZI1.
SMRiQ5HZI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili876 – 1171Sequence analysisAdd BLAST296

Sequence similaritiesi

Belongs to the MTUS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEXM. Eukaryota.
ENOG41118DX. LUCA.
HOVERGENiHBG108158.
InParanoidiQ5HZI1.
PhylomeDBiQ5HZI1.
TreeFamiTF333416.

Family and domain databases

InterProiIPR029786. MTUS1.
[Graphical view]
PANTHERiPTHR24200:SF7. PTHR24200:SF7. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5HZI1-1) [UniParc]FASTAAdd to basket
Also known as: ATBP135

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNDDNSDRTE DGSRYVFIRD KNSNPSEYYQ TSLSAQCPSV SHGDWNSDNP
60 70 80 90 100
DAMVVDYEMD PAVDSSESVS LSHQCVEELA YPEPSSDFMG KHEFTMYSEL
110 120 130 140 150
TCQSPALVNT GKPQDLHSNC DSLEAIQDEK FDPLKPCECR SDDDYACGDS
160 170 180 190 200
PEVLELKQTY GMKVDTANYT FIARHDIEQG QPLHAPGGLQ TTVRDRNALS
210 220 230 240 250
SCGRTPPHSS KMYVRGVNYN RENFENLQAT PSKTLNTTFT VISDVLMQTD
260 270 280 290 300
SPDVGVQGQN SLGNVTKEYT DGTRRGLIGE KEIQAVTLVS DGMEVPNGSA
310 320 330 340 350
SQEFYCVSED DPNSETHSHG PYAQQEMGQN LRGTLPNCHV DGECPVLVPA
360 370 380 390 400
FEKSKTRVLG SECKVTVTED PHIDSHDNDS DIQSSTEELT LRSVSGQRGS
410 420 430 440 450
PYEMGWGENG GAICTDKAGC MSTPVEQPPN LSFRLEPAEV KKYNNVENGP
460 470 480 490 500
RDAKRAPNLK GEPTNMPKPN LGKSATKTNT TVGSKVRKTE IISYPTPNFK
510 520 530 540 550
NIKAKVISRS VLQPKDTSIM KDTPSPQVTG GSSPSPGPSK HLTMMNKAPR
560 570 580 590 600
SDFKASKKAE IPINKTHKQQ FNKLITSQAA QVTTHSKNAS LGVPRTTSAT
610 620 630 640 650
KSNQENVDKT GSPHAGSETG SVAAFFQKIK GILPVKMKSS ECLEVTYVSH
660 670 680 690 700
IDQISPEKGE QDGEAPMEKQ ELGKQATNEI FESKSLLVGS APKTSTTPGR
710 720 730 740 750
SSSKPDSRSL RKTPGLKAKV GPTAACLRRK SESRTLGSDR ALSPQRIRRV
760 770 780 790 800
SGSGGHAAIN KYEEKPPKQA FQNGSGPLYL KPLVPRAHSH LLKTSPKGPS
810 820 830 840 850
RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE LAQYKTKCES
860 870 880 890 900
QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH KTLSQELVSL
910 920 930 940 950
RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR TELENRLKDL
960 970 980 990 1000
YTAECEKLQS IYIEEAEKYK TQLQEQFDNL NAAHETTKLE IEASHSEKVE
1010 1020 1030 1040 1050
LLKKTYETSL SEIKKSHEME KKSLEDLLNE KQESLEKQIN DLKSENDALN
1060 1070 1080 1090 1100
ERLKSEEQKQ LSREKANSKN PQVMYLEQEL ESLKAVLEIK NEKLHQQDMK
1110 1120 1130 1140 1150
LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR QLSTEQAALQ
1160 1170 1180 1190 1200
ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG
1210
SFSSPSISPR
Length:1,210
Mass (Da):134,379
Last modified:October 2, 2007 - v2
Checksum:i42642BCAE0759B25
GO
Isoform 2 (identifier: Q5HZI1-2) [UniParc]FASTAAdd to basket
Also known as: ATBP50

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT

Show »
Length:440
Mass (Da):50,738
Checksum:i7FE4CC7C854EE926
GO
Isoform 3 (identifier: Q5HZI1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT
     977-1011: FDNLNAAHETTKLEIEASHSEKVELLKKTYETSLS → LP

Show »
Length:407
Mass (Da):46,989
Checksum:i5FEA9F591DBF72CE
GO
Isoform 4 (identifier: Q5HZI1-4) [UniParc]FASTAAdd to basket
Also known as: ATBP60

The sequence of this isoform differs from the canonical sequence as follows:
     1-690: Missing.
     691-754: APKTSTTPGR...QRIRRVSGSG → MTIPGGFRSC...LLATLTRKKS

Show »
Length:520
Mass (Da):59,167
Checksum:iE3D57A7993B2F0AA
GO

Sequence cautioni

The sequence AAH41777 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH42206 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401P → S in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti401P → S in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti426E → K in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti426E → K in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti455R → S in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti455R → S in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti519I → V in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti519I → V in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti525S → N in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti525S → N in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti541H → Q in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti541H → Q in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti553F → L in AAH89009 (PubMed:15489334).Curated1
Sequence conflicti556S → G in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti556S → G in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti600T → A in AAH41777 (PubMed:15489334).Curated1
Sequence conflicti600T → A in AAH42206 (PubMed:15489334).Curated1
Sequence conflicti646T → A in BAE25537 (PubMed:16141072).Curated1
Sequence conflicti867T → N in AAD49746 (PubMed:15123706).Curated1
Sequence conflicti867T → N in AAT45892 (PubMed:15539617).Curated1
Sequence conflicti919A → T in AAT45893 (PubMed:15539617).Curated1
Sequence conflicti919A → T in AAT45894 (PubMed:15539617).Curated1
Sequence conflicti919A → T in BAC26996 (PubMed:16141072).Curated1
Sequence conflicti919A → T in BAC27517 (PubMed:16141072).Curated1
Sequence conflicti919A → T in AAH43321 (PubMed:15489334).Curated1
Sequence conflicti919A → T in AAH89009 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q5HZI1-2)
Sequence conflicti22Missing in BAC27517 (PubMed:16141072).Curated1
Sequence conflicti29S → P in BAC27517 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282791 – 767Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST767
Alternative sequenceiVSP_0282801 – 690Missing in isoform 4. 2 PublicationsAdd BLAST690
Alternative sequenceiVSP_028281691 – 754APKTS…VSGSG → MTIPGGFRSCTETDISSTIF INSTLTPPAGSERQYDATLL ALLVVGSYSLCIIPLLATLT RKKS in isoform 4. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_028282768 – 810KQAFQ…TAFNS → MLLSPKFSLSTIHVRLTAKG LLRNLRLPSGLRKNTVIFHT in isoform 2 and isoform 3. 5 PublicationsAdd BLAST43
Alternative sequenceiVSP_028283977 – 1011FDNLN…ETSLS → LP in isoform 3. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173380 mRNA. Translation: AAD49746.1.
AY626781 mRNA. Translation: AAT45892.1.
AY626782 mRNA. Translation: AAT45893.1.
AY626783 mRNA. Translation: AAT45894.1.
AY246699 mRNA. Translation: AAO88908.1.
AF493235 mRNA. Translation: AAQ06609.1.
AK129324 mRNA. Translation: BAC98134.1. Different initiation.
AK030510 mRNA. Translation: BAC26996.1.
AK031693 mRNA. Translation: BAC27517.1.
AK143781 mRNA. Translation: BAE25537.1.
BC041777 mRNA. Translation: AAH41777.1. Different initiation.
BC042206 mRNA. Translation: AAH42206.1. Different initiation.
BC043321 mRNA. Translation: AAH43321.1.
BC089009 mRNA. Translation: AAH89009.1.
CCDSiCCDS40328.1. [Q5HZI1-1]
CCDS40329.1. [Q5HZI1-4]
CCDS40330.1. [Q5HZI1-2]
RefSeqiNP_001005863.1. NM_001005863.2.
NP_001005864.1. NM_001005864.3.
NP_001005865.2. NM_001005865.3.
NP_001273342.1. NM_001286413.1.
UniGeneiMm.149438.

Genome annotation databases

GeneIDi102103.
KEGGimmu:102103.
UCSCiuc009lnk.2. mouse. [Q5HZI1-2]
uc009lnl.2. mouse. [Q5HZI1-4]
uc009lnm.1. mouse. [Q5HZI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173380 mRNA. Translation: AAD49746.1.
AY626781 mRNA. Translation: AAT45892.1.
AY626782 mRNA. Translation: AAT45893.1.
AY626783 mRNA. Translation: AAT45894.1.
AY246699 mRNA. Translation: AAO88908.1.
AF493235 mRNA. Translation: AAQ06609.1.
AK129324 mRNA. Translation: BAC98134.1. Different initiation.
AK030510 mRNA. Translation: BAC26996.1.
AK031693 mRNA. Translation: BAC27517.1.
AK143781 mRNA. Translation: BAE25537.1.
BC041777 mRNA. Translation: AAH41777.1. Different initiation.
BC042206 mRNA. Translation: AAH42206.1. Different initiation.
BC043321 mRNA. Translation: AAH43321.1.
BC089009 mRNA. Translation: AAH89009.1.
CCDSiCCDS40328.1. [Q5HZI1-1]
CCDS40329.1. [Q5HZI1-4]
CCDS40330.1. [Q5HZI1-2]
RefSeqiNP_001005863.1. NM_001005863.2.
NP_001005864.1. NM_001005864.3.
NP_001005865.2. NM_001005865.3.
NP_001273342.1. NM_001286413.1.
UniGeneiMm.149438.

3D structure databases

ProteinModelPortaliQ5HZI1.
SMRiQ5HZI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059503.

PTM databases

iPTMnetiQ5HZI1.
PhosphoSitePlusiQ5HZI1.

Proteomic databases

PaxDbiQ5HZI1.
PeptideAtlasiQ5HZI1.
PRIDEiQ5HZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102103.
KEGGimmu:102103.
UCSCiuc009lnk.2. mouse. [Q5HZI1-2]
uc009lnl.2. mouse. [Q5HZI1-4]
uc009lnm.1. mouse. [Q5HZI1-1]

Organism-specific databases

CTDi57509.
MGIiMGI:2142572. Mtus1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IEXM. Eukaryota.
ENOG41118DX. LUCA.
HOVERGENiHBG108158.
InParanoidiQ5HZI1.
PhylomeDBiQ5HZI1.
TreeFamiTF333416.

Miscellaneous databases

PROiQ5HZI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045636.
CleanExiMM_MTUS1.

Family and domain databases

InterProiIPR029786. MTUS1.
[Graphical view]
PANTHERiPTHR24200:SF7. PTHR24200:SF7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTUS1_MOUSE
AccessioniPrimary (citable) accession number: Q5HZI1
Secondary accession number(s): Q3UP60
, Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.