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Q5HZI1 (MTUS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microtubule-associated tumor suppressor 1 homolog
Alternative name(s):
AT2 receptor-binding protein
Angiotensin-II type 2 receptor-interacting protein
Coiled-coiled tumor suppressor gene 1 protein
Mitochondrial tumor suppressor 1 homolog
Gene names
Name:Mtus1
Synonyms:Atbp, Atip, Cctsg1, Kiaa1288, Mtsg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Ref.1 Ref.2 Ref.7

Subunit structure

Homodimer. Interacts with AGTR2. Interacts with PTPN6. Ref.1 Ref.2 Ref.7

Subcellular location

Mitochondrion By similarity. Golgi apparatus. Cell membrane. Nucleus. Note: In neurons, translocates into the nucleus after treatment with angiotensin-II. Ref.2 Ref.7

Tissue specificity

Ubiquitously expressed, with highest levels in uterus and adrenal gland. Ref.2

Sequence similarities

Belongs to the MTUS1 family.

Sequence caution

The sequence AAH41777.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH42206.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC98134.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentCell membrane
Golgi apparatus
Membrane
Mitochondrion
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to peptide hormone stimulus

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5HZI1-1)

Also known as: ATBP135;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5HZI1-2)

Also known as: ATBP50;

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT
Isoform 3 (identifier: Q5HZI1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.
     768-810: KQAFQNGSGP...RKSLFTAFNS → MLLSPKFSLS...LRKNTVIFHT
     977-1011: FDNLNAAHETTKLEIEASHSEKVELLKKTYETSLS → LP
Isoform 4 (identifier: Q5HZI1-4)

Also known as: ATBP60;

The sequence of this isoform differs from the canonical sequence as follows:
     1-690: Missing.
     691-754: APKTSTTPGR...QRIRRVSGSG → MTIPGGFRSC...LLATLTRKKS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12101210Microtubule-associated tumor suppressor 1 homolog
PRO_0000305198

Regions

Coiled coil876 – 1171296 Potential

Amino acid modifications

Modified residue3751Phosphoserine Ref.8
Modified residue3801Phosphoserine Ref.8
Modified residue11641Phosphoserine By similarity
Modified residue11951Phosphoserine Ref.8
Modified residue12031Phosphoserine Ref.8
Modified residue12041Phosphoserine By similarity
Modified residue12081Phosphoserine Ref.8

Natural variations

Alternative sequence1 – 767767Missing in isoform 2 and isoform 3.
VSP_028279
Alternative sequence1 – 690690Missing in isoform 4.
VSP_028280
Alternative sequence691 – 75464APKTS…VSGSG → MTIPGGFRSCTETDISSTIF INSTLTPPAGSERQYDATLL ALLVVGSYSLCIIPLLATLT RKKS in isoform 4.
VSP_028281
Alternative sequence768 – 81043KQAFQ…TAFNS → MLLSPKFSLSTIHVRLTAKG LLRNLRLPSGLRKNTVIFHT in isoform 2 and isoform 3.
VSP_028282
Alternative sequence977 – 101135FDNLN…ETSLS → LP in isoform 3.
VSP_028283

Experimental info

Sequence conflict4011P → S in AAH41777. Ref.6
Sequence conflict4011P → S in AAH42206. Ref.6
Sequence conflict4261E → K in AAH41777. Ref.6
Sequence conflict4261E → K in AAH42206. Ref.6
Sequence conflict4551R → S in AAH41777. Ref.6
Sequence conflict4551R → S in AAH42206. Ref.6
Sequence conflict5191I → V in AAH41777. Ref.6
Sequence conflict5191I → V in AAH42206. Ref.6
Sequence conflict5251S → N in AAH41777. Ref.6
Sequence conflict5251S → N in AAH42206. Ref.6
Sequence conflict5411H → Q in AAH41777. Ref.6
Sequence conflict5411H → Q in AAH42206. Ref.6
Sequence conflict5531F → L in AAH89009. Ref.6
Sequence conflict5561S → G in AAH41777. Ref.6
Sequence conflict5561S → G in AAH42206. Ref.6
Sequence conflict6001T → A in AAH41777. Ref.6
Sequence conflict6001T → A in AAH42206. Ref.6
Sequence conflict6461T → A in BAE25537. Ref.5
Sequence conflict8671T → N in AAD49746. Ref.1
Sequence conflict8671T → N in AAT45892. Ref.2
Sequence conflict9191A → T in AAT45893. Ref.2
Sequence conflict9191A → T in AAT45894. Ref.2
Sequence conflict9191A → T in BAC26996. Ref.5
Sequence conflict9191A → T in BAC27517. Ref.5
Sequence conflict9191A → T in AAH43321. Ref.6
Sequence conflict9191A → T in AAH89009. Ref.6
Isoform 2:
Sequence conflict221Missing in BAC27517. Ref.5
Sequence conflict291S → P in BAC27517. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ATBP135) [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: 42642BCAE0759B25

FASTA1,210134,379
        10         20         30         40         50         60 
MNDDNSDRTE DGSRYVFIRD KNSNPSEYYQ TSLSAQCPSV SHGDWNSDNP DAMVVDYEMD 

        70         80         90        100        110        120 
PAVDSSESVS LSHQCVEELA YPEPSSDFMG KHEFTMYSEL TCQSPALVNT GKPQDLHSNC 

       130        140        150        160        170        180 
DSLEAIQDEK FDPLKPCECR SDDDYACGDS PEVLELKQTY GMKVDTANYT FIARHDIEQG 

       190        200        210        220        230        240 
QPLHAPGGLQ TTVRDRNALS SCGRTPPHSS KMYVRGVNYN RENFENLQAT PSKTLNTTFT 

       250        260        270        280        290        300 
VISDVLMQTD SPDVGVQGQN SLGNVTKEYT DGTRRGLIGE KEIQAVTLVS DGMEVPNGSA 

       310        320        330        340        350        360 
SQEFYCVSED DPNSETHSHG PYAQQEMGQN LRGTLPNCHV DGECPVLVPA FEKSKTRVLG 

       370        380        390        400        410        420 
SECKVTVTED PHIDSHDNDS DIQSSTEELT LRSVSGQRGS PYEMGWGENG GAICTDKAGC 

       430        440        450        460        470        480 
MSTPVEQPPN LSFRLEPAEV KKYNNVENGP RDAKRAPNLK GEPTNMPKPN LGKSATKTNT 

       490        500        510        520        530        540 
TVGSKVRKTE IISYPTPNFK NIKAKVISRS VLQPKDTSIM KDTPSPQVTG GSSPSPGPSK 

       550        560        570        580        590        600 
HLTMMNKAPR SDFKASKKAE IPINKTHKQQ FNKLITSQAA QVTTHSKNAS LGVPRTTSAT 

       610        620        630        640        650        660 
KSNQENVDKT GSPHAGSETG SVAAFFQKIK GILPVKMKSS ECLEVTYVSH IDQISPEKGE 

       670        680        690        700        710        720 
QDGEAPMEKQ ELGKQATNEI FESKSLLVGS APKTSTTPGR SSSKPDSRSL RKTPGLKAKV 

       730        740        750        760        770        780 
GPTAACLRRK SESRTLGSDR ALSPQRIRRV SGSGGHAAIN KYEEKPPKQA FQNGSGPLYL 

       790        800        810        820        830        840 
KPLVPRAHSH LLKTSPKGPS RKSLFTAFNS VEKGRQKNPR SLCIQTQTAP DVLSSERTLE 

       850        860        870        880        890        900 
LAQYKTKCES QSGFILHLRQ LLSRGNTKFE ALTVVIQHLL SEREEALKQH KTLSQELVSL 

       910        920        930        940        950        960 
RGELVAASSA CEKLEKARAD LQTAYQEFVQ KLNQQHQTDR TELENRLKDL YTAECEKLQS 

       970        980        990       1000       1010       1020 
IYIEEAEKYK TQLQEQFDNL NAAHETTKLE IEASHSEKVE LLKKTYETSL SEIKKSHEME 

      1030       1040       1050       1060       1070       1080 
KKSLEDLLNE KQESLEKQIN DLKSENDALN ERLKSEEQKQ LSREKANSKN PQVMYLEQEL 

      1090       1100       1110       1120       1130       1140 
ESLKAVLEIK NEKLHQQDMK LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR 

      1150       1160       1170       1180       1190       1200 
QLSTEQAALQ ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPFQSPRNSG 

      1210 
SFSSPSISPR 

« Hide

Isoform 2 (ATBP50) [UniParc].

Checksum: 7FE4CC7C854EE926
Show »

FASTA44050,738
Isoform 3 [UniParc].

Checksum: 5FEA9F591DBF72CE
Show »

FASTA40746,989
Isoform 4 (ATBP60) [UniParc].

Checksum: E3D57A7993B2F0AA
Show »

FASTA52059,167

References

« Hide 'large scale' references
[1]"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP."
Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C.
J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH AGTR2, FUNCTION.
[2]"Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein."
Wruck C.J., Funke-Kaiser H., Pufe T., Kusserow H., Menk M., Schefe J.H., Kruse M.L., Stoll M., Unger T.
Arterioscler. Thromb. Vasc. Biol. 25:57-64(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4), SUBUNIT, INTERACTION WITH AGTR2, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
Strain: Swiss Webster / NIH.
Tissue: Embryo.
[3]"Cloning and characterization of MTSG1."
Seibold S., Wanner C., Galle J.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: C57BL/6N.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-759 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Pituitary, Spleen and Testis.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
Strain: C57BL/6 and FVB/N.
Tissue: Brain, Eye and Kidney.
[7]"Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1."
Li J.-M., Mogi M., Tsukuda K., Tomochika H., Iwanami J., Min L.-J., Nahmias C., Iwai M., Horiuchi M.
Mol. Endocrinol. 21:499-511(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PTPN6, FUNCTION.
[8]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375; SER-380; SER-1195; SER-1203 AND SER-1208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF173380 mRNA. Translation: AAD49746.1.
AY626781 mRNA. Translation: AAT45892.1.
AY626782 mRNA. Translation: AAT45893.1.
AY626783 mRNA. Translation: AAT45894.1.
AY246699 mRNA. Translation: AAO88908.1.
AF493235 mRNA. Translation: AAQ06609.1.
AK129324 mRNA. Translation: BAC98134.1. Different initiation.
AK030510 mRNA. Translation: BAC26996.1.
AK031693 mRNA. Translation: BAC27517.1.
AK143781 mRNA. Translation: BAE25537.1.
BC041777 mRNA. Translation: AAH41777.1. Different initiation.
BC042206 mRNA. Translation: AAH42206.1. Different initiation.
BC043321 mRNA. Translation: AAH43321.1.
BC089009 mRNA. Translation: AAH89009.1.
RefSeqNP_001005863.1. NM_001005863.2.
NP_001005864.1. NM_001005864.3.
NP_001005865.2. NM_001005865.3.
NP_001273342.1. NM_001286413.1.
UniGeneMm.149438.

3D structure databases

ProteinModelPortalQ5HZI1.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5HZI1.

Proteomic databases

PaxDbQ5HZI1.
PRIDEQ5HZI1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000051379; ENSMUSP00000053554; ENSMUSG00000045636.
ENSMUST00000059115; ENSMUSP00000059503; ENSMUSG00000045636.
ENSMUST00000093534; ENSMUSP00000091252; ENSMUSG00000045636.
ENSMUST00000118835; ENSMUSP00000112626; ENSMUSG00000045636.
GeneID102103.
KEGGmmu:102103.
UCSCuc009lnk.1. mouse. [Q5HZI1-2]
uc009lnl.1. mouse. [Q5HZI1-4]
uc009lnm.1. mouse. [Q5HZI1-1]

Organism-specific databases

CTD57509.
MGIMGI:2142572. Mtus1.
RougeSearch...

Phylogenomic databases

eggNOGNOG117251.
GeneTreeENSGT00390000006245.
HOVERGENHBG108158.
InParanoidQ5HZI1.
OrthoDBEOG76X5Z9.
PhylomeDBQ5HZI1.
TreeFamTF333416.

Gene expression databases

ArrayExpressQ5HZI1.
BgeeQ5HZI1.
CleanExMM_MTUS1.
GenevestigatorQ5HZI1.

Family and domain databases

ProtoNetSearch...

Other

NextBio355284.
PROQ5HZI1.
SOURCESearch...

Entry information

Entry nameMTUS1_MOUSE
AccessionPrimary (citable) accession number: Q5HZI1
Secondary accession number(s): Q3UP60 expand/collapse secondary AC list , Q6ITD2, Q6ZPU5, Q80YG5, Q80YV9, Q80ZZ2, Q8BH23, Q8BMM8, Q8C0C8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot