Reviewed, UniProtKB/Swiss-Prot Q5HZH2 (CP042_MOUSE)

Names and origin

Protein names	Recommended name:     UPF0293 protein C16orf42 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0293 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	UPF0293 protein C16orf42 homolog		PRO_0000278670
Regions
	Transmembrane	165 – 185	21	Potential
Amino acid modifications
	Modified residue	266	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	245	1	V → E in BAB22003. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5HZH2-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: CCBE907B0F811EBB	FASTA	323	35,334
	10 20 30 40 50 60 MGRKKVARGS RKESGRVRRP SGRSLDAFAE EVGAALRASV QPEEAEDQGG PGPAALPCAL 70 80 90 100 110 120 AMWELGHCDP KRCTGRKLAR LGLVRCLRLS QRFGGLVLSP VGTEYVSPAD RQLVAQSGVA 130 140 150 160 170 180 VIDCSWAKLD DTPFQKMRGS HLRLLPYLVA ANPVNYGRPC KLSCVEAFAA AFCIVGFSDL 190 200 210 220 230 240 AVILLRKFKW GKGFLDLNRE LLDKYAACRG PEEVLQAEQG YLASTRDTPE EDIDPFDVDS 250 260 270 280 290 300 GREFVNLNRP VASTRLPEDM DDTDGSEEHS EDSEEDSDEC EEPGPGANGG DSNYSGAEET 310 320 PEQEAQARDS TEIWKGIKKR QRD

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Kidney and Visual cortex.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002309 mRNA. Translation: BAB22003.1. AK158743 mRNA. Translation: BAE34637.1. AK170074 mRNA. Translation: BAE41547.1. BC089019 mRNA. Translation: AAH89019.1.
IPI	IPI00121172.
RefSeq	NP_001157190.1. NP_080952.2.
UniGene	Mm.180687
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HZH2.
PTM databases
PhosphoSite	Q5HZH2.
Proteomic databases
PRIDE	Q5HZH2.
Genome annotation databases
Ensembl	ENSMUST00000063574; ENSMUSP00000068511; ENSMUSG00000015126; Mus musculus. [Genome view]
GeneID	68327.
KEGG	mmu:68327.
NMPDR	fig|10090.3.peg.2378.
UCSC	uc008baf.1. mouse.
Organism-specific databases
MGI	MGI:1915577. 0610007P22Rik.
Phylogenomic databases
HOVERGEN	Q5HZH2.
OMA	TLAMWEL
OrthoDB	EOG9K9DXN
Gene expression databases
ArrayExpress	Q5HZH2.
Bgee	Q5HZH2.
CleanEx	MM_0610007P22RIK.
Genevestigator	Q5HZH2.
Family and domain databases
InterPro	IPR007177. DUF367. IPR007209. RNaseL-inhib_metal-bd. [Graphical view]
Pfam	PF04034. DUF367. 1 hit. PF04068. RLI. 1 hit. [Graphical view]
ProDom	PD016638. DUF367. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	327001.

Entry information

Entry name

CP042_MOUSE

Accession

Primary (citable) accession number: Q5HZH2
Secondary accession number(s): Q9DD00

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 15, 2005
Last modified:	November 24, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)