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Protein

WW domain-binding protein 4

Gene

Wbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 4232Matrin-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 4
Short name:
WBP-4
Alternative name(s):
Formin-binding protein 21
WW domain-containing-binding protein 4
Gene namesi
Name:Wbp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620033. Wbp4.

Subcellular locationi

  • Nucleus speckle PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374WW domain-binding protein 4PRO_0000076067Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5HZF2.

Expressioni

Gene expression databases

GenevisibleiQ5HZF2. RN.

Interactioni

Subunit structurei

Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 and WBP11.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015605.

Structurei

3D structure databases

ProteinModelPortaliQ5HZF2.
SMRiQ5HZF2. Positions 122-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 15434WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini162 – 19534WW 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi113 – 12412Lys-richAdd
BLAST

Domaini

The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.By similarity

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 4232Matrin-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0150. Eukaryota.
ENOG4111SKN. LUCA.
GeneTreeiENSGT00390000013956.
HOGENOMiHOG000067962.
HOVERGENiHBG053152.
InParanoidiQ5HZF2.
KOiK13220.
OMAiESHEEVD.
OrthoDBiEOG7H7930.
PhylomeDBiQ5HZF2.
TreeFamiTF316671.

Family and domain databases

InterProiIPR001202. WW_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PfamiPF00397. WW. 2 hits.
PF06220. zf-U1. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
SM00451. ZnF_U1. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYWKSQPK KFCDYCKCWI ADNRPSVEFH ERGKNHKENV ARKISEIKQK
60 70 80 90 100
SLDKAKEEEK ASKEFAAMEA AALKAYQEDL KRLGLQSDIS EPTISPVTNT
110 120 130 140 150
VQPTPTANQQ KEKKKKKKKK EASKGRWVEG VTADGHCYYY DLVTGASQWE
160 170 180 190 200
KPEGFQGNLK KTAAKAIWVE GLSEDGYTYY YNTETGESKW EKPDDFIPHG
210 220 230 240 250
GDVLSSKDSE KLPDTLEDSK SSDSHSDSDD EQKKAGEASA ETKKLIIKFK
260 270 280 290 300
EKNKSTEKRI GPEIQKEKTT PKQNPSNTNE EKPKTPKKST NPYGEWQEIK
310 320 330 340 350
QEAESQEEVD LELPSTENEC LSSSEAGAGE IKVVFKEKTV SSLGVAADGV
360 370
APVFKKRRIE NGKSRNLRQR GEDE
Length:374
Mass (Da):42,157
Last modified:February 15, 2005 - v1
Checksum:i96F2CFCE686F7A57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089052 mRNA. Translation: AAH89052.1.
RefSeqiNP_446218.1. NM_053766.1.
UniGeneiRn.144631.

Genome annotation databases

EnsembliENSRNOT00000015605; ENSRNOP00000015605; ENSRNOG00000011678.
GeneIDi114765.
KEGGirno:114765.
UCSCiRGD:620033. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089052 mRNA. Translation: AAH89052.1.
RefSeqiNP_446218.1. NM_053766.1.
UniGeneiRn.144631.

3D structure databases

ProteinModelPortaliQ5HZF2.
SMRiQ5HZF2. Positions 122-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015605.

Proteomic databases

PaxDbiQ5HZF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015605; ENSRNOP00000015605; ENSRNOG00000011678.
GeneIDi114765.
KEGGirno:114765.
UCSCiRGD:620033. rat.

Organism-specific databases

CTDi11193.
RGDi620033. Wbp4.

Phylogenomic databases

eggNOGiKOG0150. Eukaryota.
ENOG4111SKN. LUCA.
GeneTreeiENSGT00390000013956.
HOGENOMiHOG000067962.
HOVERGENiHBG053152.
InParanoidiQ5HZF2.
KOiK13220.
OMAiESHEEVD.
OrthoDBiEOG7H7930.
PhylomeDBiQ5HZF2.
TreeFamiTF316671.

Miscellaneous databases

NextBioi618853.
PROiQ5HZF2.

Gene expression databases

GenevisibleiQ5HZF2. RN.

Family and domain databases

InterProiIPR001202. WW_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PfamiPF00397. WW. 2 hits.
PF06220. zf-U1. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
SM00451. ZnF_U1. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiWBP4_RAT
AccessioniPrimary (citable) accession number: Q5HZF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: November 11, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.