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Protein

WW domain-binding protein 4

Gene

Wbp4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42Matrin-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 4
Short name:
WBP-4
Alternative name(s):
Formin-binding protein 21
WW domain-containing-binding protein 4
Gene namesi
Name:Wbp4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620033. Wbp4.

Subcellular locationi

  • Nucleus speckle PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760671 – 374WW domain-binding protein 4Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5HZF2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011678.
GenevisibleiQ5HZF2. RN.

Interactioni

Subunit structurei

Associated with U2 snRNPs. Binds splicing factors SNRPB, SNRPC and SF1. Interacts via the WW domains with the Pro-rich domains of KHDRBS1/SAM68 and WBP11.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015605.

Structurei

3D structure databases

ProteinModelPortaliQ5HZF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 154WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini162 – 195WW 2PROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 124Lys-richAdd BLAST12

Domaini

The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins.By similarity

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 42Matrin-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0150. Eukaryota.
ENOG4111SKN. LUCA.
GeneTreeiENSGT00390000013956.
HOGENOMiHOG000067962.
HOVERGENiHBG053152.
InParanoidiQ5HZF2.
KOiK13220.
OMAiESHEEVD.
OrthoDBiEOG091G0GZ4.
PhylomeDBiQ5HZF2.
TreeFamiTF316671.

Family and domain databases

InterProiIPR001202. WW_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PfamiPF00397. WW. 2 hits.
PF06220. zf-U1. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
SM00451. ZnF_U1. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYWKSQPK KFCDYCKCWI ADNRPSVEFH ERGKNHKENV ARKISEIKQK
60 70 80 90 100
SLDKAKEEEK ASKEFAAMEA AALKAYQEDL KRLGLQSDIS EPTISPVTNT
110 120 130 140 150
VQPTPTANQQ KEKKKKKKKK EASKGRWVEG VTADGHCYYY DLVTGASQWE
160 170 180 190 200
KPEGFQGNLK KTAAKAIWVE GLSEDGYTYY YNTETGESKW EKPDDFIPHG
210 220 230 240 250
GDVLSSKDSE KLPDTLEDSK SSDSHSDSDD EQKKAGEASA ETKKLIIKFK
260 270 280 290 300
EKNKSTEKRI GPEIQKEKTT PKQNPSNTNE EKPKTPKKST NPYGEWQEIK
310 320 330 340 350
QEAESQEEVD LELPSTENEC LSSSEAGAGE IKVVFKEKTV SSLGVAADGV
360 370
APVFKKRRIE NGKSRNLRQR GEDE
Length:374
Mass (Da):42,157
Last modified:February 15, 2005 - v1
Checksum:i96F2CFCE686F7A57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089052 mRNA. Translation: AAH89052.1.
RefSeqiNP_446218.1. NM_053766.1.
UniGeneiRn.144631.

Genome annotation databases

EnsembliENSRNOT00000015605; ENSRNOP00000015605; ENSRNOG00000011678.
GeneIDi114765.
KEGGirno:114765.
UCSCiRGD:620033. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089052 mRNA. Translation: AAH89052.1.
RefSeqiNP_446218.1. NM_053766.1.
UniGeneiRn.144631.

3D structure databases

ProteinModelPortaliQ5HZF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015605.

Proteomic databases

PaxDbiQ5HZF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015605; ENSRNOP00000015605; ENSRNOG00000011678.
GeneIDi114765.
KEGGirno:114765.
UCSCiRGD:620033. rat.

Organism-specific databases

CTDi11193.
RGDi620033. Wbp4.

Phylogenomic databases

eggNOGiKOG0150. Eukaryota.
ENOG4111SKN. LUCA.
GeneTreeiENSGT00390000013956.
HOGENOMiHOG000067962.
HOVERGENiHBG053152.
InParanoidiQ5HZF2.
KOiK13220.
OMAiESHEEVD.
OrthoDBiEOG091G0GZ4.
PhylomeDBiQ5HZF2.
TreeFamiTF316671.

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ5HZF2.

Gene expression databases

BgeeiENSRNOG00000011678.
GenevisibleiQ5HZF2. RN.

Family and domain databases

InterProiIPR001202. WW_dom.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PfamiPF00397. WW. 2 hits.
PF06220. zf-U1. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
SM00451. ZnF_U1. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWBP4_RAT
AccessioniPrimary (citable) accession number: Q5HZF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: October 5, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.