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Q5HZE5

- TMM17_RAT

UniProt

Q5HZE5 - TMM17_RAT

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Protein

Transmembrane protein 17

Gene

Tmem17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).By similarity

GO - Biological processi

  1. cilium assembly Source: UniProtKB
  2. smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 17
Gene namesi
Name:Tmem17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 14

Organism-specific databases

RGDi1310566. Tmem17.

Subcellular locationi

Cell projectioncilium membrane By similarity; Multi-pass membrane protein By similarity
Note: Localizes to the transition zone of primary cilia.By similarity

GO - Cellular componenti

  1. ciliary membrane Source: UniProtKB
  2. ciliary transition zone Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. TCTN-B9D complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Transmembrane protein 17PRO_0000255262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5HZE5.

Expressioni

Gene expression databases

GenevestigatoriQ5HZE5.

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012224.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM17 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280423.
GeneTreeiENSGT00390000006643.
HOGENOMiHOG000253940.
HOVERGENiHBG088848.
InParanoidiQ5HZE5.
OMAiAIHIIFT.
OrthoDBiEOG70CR89.
PhylomeDBiQ5HZE5.
TreeFamiTF323824.

Family and domain databases

InterProiIPR019184. Uncharacterised_TM-17.
[Graphical view]
PfamiPF09799. Transmemb_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN
60 70 80 90 100
SYFFPLWWVS CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM
110 120 130 140 150
GNLQEKVPEL AGFWLLSLLL QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF
160 170 180 190
LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ LSASSATGRR ARQSSEEL
Length:198
Mass (Da):22,555
Last modified:February 15, 2005 - v1
Checksum:i5640DFA8C44FA164
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089059 mRNA. Translation: AAH89059.1.
RefSeqiNP_001010961.1. NM_001010961.1.
UniGeneiRn.8102.

Genome annotation databases

EnsembliENSRNOT00000012224; ENSRNOP00000012224; ENSRNOG00000009220.
GeneIDi360985.
KEGGirno:360985.
UCSCiRGD:1310566. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089059 mRNA. Translation: AAH89059.1 .
RefSeqi NP_001010961.1. NM_001010961.1.
UniGenei Rn.8102.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000012224.

Proteomic databases

PRIDEi Q5HZE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012224 ; ENSRNOP00000012224 ; ENSRNOG00000009220 .
GeneIDi 360985.
KEGGi rno:360985.
UCSCi RGD:1310566. rat.

Organism-specific databases

CTDi 200728.
RGDi 1310566. Tmem17.

Phylogenomic databases

eggNOGi NOG280423.
GeneTreei ENSGT00390000006643.
HOGENOMi HOG000253940.
HOVERGENi HBG088848.
InParanoidi Q5HZE5.
OMAi AIHIIFT.
OrthoDBi EOG70CR89.
PhylomeDBi Q5HZE5.
TreeFami TF323824.

Miscellaneous databases

NextBioi 674796.
PROi Q5HZE5.

Gene expression databases

Genevestigatori Q5HZE5.

Family and domain databases

InterProi IPR019184. Uncharacterised_TM-17.
[Graphical view ]
Pfami PF09799. Transmemb_17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTMM17_RAT
AccessioniPrimary (citable) accession number: Q5HZE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3