Q5HZE5 (TMM17_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 17

Gene names

Name:

Tmem17

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling By similarity.
Subunit structure	Part of the tectonic-like complex (also named B9 complex) By similarity.
Subcellular location	Cell projection › cilium membrane; Multi-pass membrane protein By similarity. Note: Localizes to the transition zone of primary cilia By similarity.
Sequence similarities	Belongs to the TMEM17 family.

Ontologies

Keywords
Biological process	Cilium biogenesis/degradation
Cellular component	Cell membrane Cell projection Cilium Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium assembly Inferred from sequence or structural similarity. Source: UniProtKB smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	TCTN-B9D complex Inferred from sequence or structural similarity. Source: UniProtKB cilium membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Transmembrane protein 17		PRO_0000255262
Regions
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	142 – 162	21	Helical; Potential
Amino acid modifications
	Glycosylation	13	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5HZE5 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 5640DFA8C44FA164	FASTA	198	22,555
	10 20 30 40 50 60 MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN SYFFPLWWVS 70 80 90 100 110 120 CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM GNLQEKVPEL AGFWLLSLLL 130 140 150 160 170 180 QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ 190 LSASSATGRR ARQSSEEL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089059 mRNA. Translation: AAH89059.1.
IPI	IPI00200545.
RefSeq	NP_001010961.1. NM_001010961.1.
UniGene	Rn.8102.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000012224.
Proteomic databases
PRIDE	Q5HZE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000012224; ENSRNOP00000012224; ENSRNOG00000009220.
GeneID	360985.
KEGG	rno:360985.
UCSC	RGD:1310566. rat.
Organism-specific databases
CTD	200728.
RGD	1310566. Tmem17.
Phylogenomic databases
eggNOG	NOG280423.
GeneTree	ENSGT00390000006643.
HOGENOM	HOG000253940.
HOVERGEN	HBG088848.
InParanoid	Q5HZE5.
OMA	KAIHIIF.
OrthoDB	EOG4T4CWP.
Gene expression databases
Genevestigator	Q5HZE5.
GermOnline	ENSRNOG00000009220. Rattus norvegicus.
Family and domain databases
InterPro	IPR019184. Uncharacterised_TM-17. [Graphical view]
Pfam	PF09799. Transmemb_17. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	674796.

Entry information

Entry name

TMM17_RAT

Accession

Primary (citable) accession number: Q5HZE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	February 15, 2005
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program