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Q5HZE5

- TMM17_RAT

UniProt

Q5HZE5 - TMM17_RAT

Protein

Transmembrane protein 17

Gene

Tmem17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling By similarity.By similarity

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. smoothened signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 17
    Gene namesi
    Name:Tmem17
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 14

    Organism-specific databases

    RGDi1310566. Tmem17.

    Subcellular locationi

    Cell projectioncilium membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localizes to the transition zone of primary cilia.By similarity

    GO - Cellular componenti

    1. ciliary membrane Source: UniProtKB
    2. ciliary transition zone Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. TCTN-B9D complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Transmembrane protein 17PRO_0000255262Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5HZE5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5HZE5.

    Interactioni

    Subunit structurei

    Part of the tectonic-like complex (also named B9 complex).By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012224.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM17 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280423.
    GeneTreeiENSGT00390000006643.
    HOGENOMiHOG000253940.
    HOVERGENiHBG088848.
    InParanoidiQ5HZE5.
    OMAiAIHIIFT.
    OrthoDBiEOG70CR89.
    PhylomeDBiQ5HZE5.
    TreeFamiTF323824.

    Family and domain databases

    InterProiIPR019184. Uncharacterised_TM-17.
    [Graphical view]
    PfamiPF09799. Transmemb_17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HZE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN    50
    SYFFPLWWVS CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM 100
    GNLQEKVPEL AGFWLLSLLL QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF 150
    LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ LSASSATGRR ARQSSEEL 198
    Length:198
    Mass (Da):22,555
    Last modified:February 15, 2005 - v1
    Checksum:i5640DFA8C44FA164
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089059 mRNA. Translation: AAH89059.1.
    RefSeqiNP_001010961.1. NM_001010961.1.
    XP_006251619.1. XM_006251557.1.
    XP_006251620.1. XM_006251558.1.
    UniGeneiRn.8102.

    Genome annotation databases

    EnsembliENSRNOT00000012224; ENSRNOP00000012224; ENSRNOG00000009220.
    GeneIDi360985.
    KEGGirno:360985.
    UCSCiRGD:1310566. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089059 mRNA. Translation: AAH89059.1 .
    RefSeqi NP_001010961.1. NM_001010961.1.
    XP_006251619.1. XM_006251557.1.
    XP_006251620.1. XM_006251558.1.
    UniGenei Rn.8102.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012224.

    Proteomic databases

    PRIDEi Q5HZE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012224 ; ENSRNOP00000012224 ; ENSRNOG00000009220 .
    GeneIDi 360985.
    KEGGi rno:360985.
    UCSCi RGD:1310566. rat.

    Organism-specific databases

    CTDi 200728.
    RGDi 1310566. Tmem17.

    Phylogenomic databases

    eggNOGi NOG280423.
    GeneTreei ENSGT00390000006643.
    HOGENOMi HOG000253940.
    HOVERGENi HBG088848.
    InParanoidi Q5HZE5.
    OMAi AIHIIFT.
    OrthoDBi EOG70CR89.
    PhylomeDBi Q5HZE5.
    TreeFami TF323824.

    Miscellaneous databases

    NextBioi 674796.
    PROi Q5HZE5.

    Gene expression databases

    Genevestigatori Q5HZE5.

    Family and domain databases

    InterProi IPR019184. Uncharacterised_TM-17.
    [Graphical view ]
    Pfami PF09799. Transmemb_17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTMM17_RAT
    AccessioniPrimary (citable) accession number: Q5HZE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3