Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5HZE5 (TMM17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 17
Gene names
Name:Tmem17
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling By similarity.

Subunit structure

Part of the tectonic-like complex (also named B9 complex) By similarity.

Subcellular location

Cell projectioncilium membrane; Multi-pass membrane protein By similarity. Note: Localizes to the transition zone of primary cilia By similarity.

Sequence similarities

Belongs to the TMEM17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Transmembrane protein 17
PRO_0000255262

Regions

Transmembrane47 – 6721Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane142 – 16221Helical; Potential

Amino acid modifications

Glycosylation131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5HZE5 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 5640DFA8C44FA164

FASTA19822,555
        10         20         30         40         50         60 
MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN SYFFPLWWVS 

        70         80         90        100        110        120 
CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM GNLQEKVPEL AGFWLLSLLL 

       130        140        150        160        170        180 
QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ 

       190 
LSASSATGRR ARQSSEEL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089059 mRNA. Translation: AAH89059.1.
RefSeqNP_001010961.1. NM_001010961.1.
XP_006251619.1. XM_006251557.1.
XP_006251620.1. XM_006251558.1.
UniGeneRn.8102.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012224.

Proteomic databases

PRIDEQ5HZE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012224; ENSRNOP00000012224; ENSRNOG00000009220.
GeneID360985.
KEGGrno:360985.
UCSCRGD:1310566. rat.

Organism-specific databases

CTD200728.
RGD1310566. Tmem17.

Phylogenomic databases

eggNOGNOG280423.
GeneTreeENSGT00390000006643.
HOGENOMHOG000253940.
HOVERGENHBG088848.
InParanoidQ5HZE5.
OMAAIHIIFT.
OrthoDBEOG70CR89.
PhylomeDBQ5HZE5.
TreeFamTF323824.

Gene expression databases

GenevestigatorQ5HZE5.

Family and domain databases

InterProIPR019184. Uncharacterised_TM-17.
[Graphical view]
PfamPF09799. Transmemb_17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio674796.
PROQ5HZE5.

Entry information

Entry nameTMM17_RAT
AccessionPrimary (citable) accession number: Q5HZE5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families