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Protein

Transmembrane protein 17

Gene

Tmem17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 17
Gene namesi
Name:Tmem17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310566 Tmem17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552621 – 198Transmembrane protein 17Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5HZE5
PRIDEiQ5HZE5

Expressioni

Gene expression databases

BgeeiENSRNOG00000009220
GenevisibleiQ5HZE5 RN

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012224

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM17 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4694 Eukaryota
ENOG4111T47 LUCA
GeneTreeiENSGT00390000006643
HOGENOMiHOG000253940
HOVERGENiHBG088848
InParanoidiQ5HZE5
KOiK19384
OMAiRTGPEYN
OrthoDBiEOG091G0PKA
PhylomeDBiQ5HZE5
TreeFamiTF323824

Family and domain databases

InterProiView protein in InterPro
IPR019184 Uncharacterised_TM-17
PANTHERiPTHR13531 PTHR13531, 1 hit
PfamiView protein in Pfam
PF09799 Transmemb_17, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HZE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN
60 70 80 90 100
SYFFPLWWVS CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM
110 120 130 140 150
GNLQEKVPEL AGFWLLSLLL QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF
160 170 180 190
LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ LSASSATGRR ARQSSEEL
Length:198
Mass (Da):22,555
Last modified:February 15, 2005 - v1
Checksum:i5640DFA8C44FA164
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089059 mRNA Translation: AAH89059.1
RefSeqiNP_001010961.1, NM_001010961.1
XP_017454809.1, XM_017599320.1
XP_017454810.1, XM_017599321.1
UniGeneiRn.8102

Genome annotation databases

EnsembliENSRNOT00000012224; ENSRNOP00000012224; ENSRNOG00000009220
GeneIDi360985
KEGGirno:360985
UCSCiRGD:1310566 rat

Similar proteinsi

Entry informationi

Entry nameiTMM17_RAT
AccessioniPrimary (citable) accession number: Q5HZE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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