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Protein

Methylthioribose-1-phosphate isomerase

Gene

Mri1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Methylthioribose-1-phosphate isomerase (Mri1)
  2. Methylthioribulose-1-phosphate dehydratase (Apip)
  3. Enolase-phosphatase E1 (Enoph1)
  4. Enolase-phosphatase E1 (Enoph1)
  5. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (Adi1)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Transition state stabilizerUniRule annotation1
Active sitei248Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-1237112 Methionine salvage pathway
UniPathwayiUPA00904; UER00874

Names & Taxonomyi

Protein namesi
Recommended name:
Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation
Gene namesi
Name:Mri1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1307789 Mri1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173271 – 369Methylthioribose-1-phosphate isomeraseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei158Omega-N-methylarginineBy similarity1
Modified residuei366PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5HZE4
PRIDEiQ5HZE4

PTM databases

iPTMnetiQ5HZE4
PhosphoSitePlusiQ5HZE4

Expressioni

Gene expression databases

BgeeiENSRNOG00000026211
GenevisibleiQ5HZE4 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003762

Structurei

3D structure databases

ProteinModelPortaliQ5HZE4
SMRiQ5HZE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1468 Eukaryota
COG0182 LUCA
GeneTreeiENSGT00390000013732
HOGENOMiHOG000224730
InParanoidiQ5HZE4
KOiK08963
OMAiVNVLTHC
OrthoDBiEOG091G0BA6
PhylomeDBiQ5HZE4
TreeFamiTF300852

Family and domain databases

Gene3Di1.20.120.420, 1 hit
HAMAPiMF_01678 Salvage_MtnA, 1 hit
InterProiView protein in InterPro
IPR000649 IF-2B-related
IPR005251 IF-M1Pi
IPR011559 Initiation_fac_2B_a/b/d
IPR027363 M1Pi_N
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF01008 IF-2B, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00524 eIF-2B_rel, 1 hit
TIGR00512 salvage_mtnA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HZE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLEAIRYSP GSLQILDQLQ LPEHCHYETL SSVQQAREAI RAMKVRGAPA
60 70 80 90 100
IALVGCLSLA VELQAGAGGP GLAALVAFVR DQLSLLVAAR PTAVNMARAA
110 120 130 140 150
RDLTHMAARE AELEGATEET VRERVIRFAE DMLEKDLKDN RSIGDLGARH
160 170 180 190 200
LLEQTNPRGG KVTVLTHCNT GALATAGYGT ALGVIRSLHE MGRLEHTFCT
210 220 230 240 250
ETRPYNQGAR LTAFELVYEK IPATLITDSM AAAAMVHQGV SAVVVGADRV
260 270 280 290 300
VANGDTANKI GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIVIEER
310 320 330 340 350
PSQELTDLNG VRIAAQGIRV WNPAFDVTPH ELITGGIITE LGVFAPEELR
360
AALSATIFSE GQTLDSPQM
Length:369
Mass (Da):39,587
Last modified:February 15, 2005 - v1
Checksum:i1163019AB4B5EC64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089060 mRNA Translation: AAH89060.1
RefSeqiNP_001010947.1, NM_001010947.1
UniGeneiRn.16390

Genome annotation databases

EnsembliENSRNOT00000003762; ENSRNOP00000003762; ENSRNOG00000026211
GeneIDi288912
KEGGirno:288912

Similar proteinsi

Entry informationi

Entry nameiMTNA_RAT
AccessioniPrimary (citable) accession number: Q5HZE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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