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Protein

Mitochondrial basic amino acids transporter

Gene

Slc25a29

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial basic amino acids transporter
Alternative name(s):
Carnitine/acylcarnitine translocase-like
Short name:
CACT-like
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Mitochondrial ornithine transporter 3
Solute carrier family 25 member 29
Gene namesi
Name:Slc25a29
Synonyms:Ornt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1308104. Slc25a29.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei153 – 17220Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei255 – 27521Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Mitochondrial basic amino acids transporterPRO_0000329031Add
BLAST

Proteomic databases

PaxDbiQ5HZE0.
PRIDEiQ5HZE0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004351.
GenevisibleiQ5HZE0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005753.

Structurei

3D structure databases

ProteinModelPortaliQ5HZE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 8685Solcar 1Add
BLAST
Repeati90 – 17889Solcar 2Add
BLAST
Repeati190 – 27586Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ5HZE0.
KOiK15109.
OMAiETPSFGF.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ5HZE0.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDFLAGCA GGVAGVIVGH PFDTVKVRLQ VQNTEKPQYR GTLHCFQSII
60 70 80 90 100
KQESVLGLYK GLGSPLMGLT FINALVFGVQ GNTLRALGQD SPLNQFLAGA
110 120 130 140 150
AAGAIQCVIC CPMELAKTRL QLQAAGPARA YKGSLDCLVQ IYRHEGLRGI
160 170 180 190 200
NRGMVSTLLR ETPSFGVYFL TYDVLTRAMG CEPGDRLLVP KLLLAGGTSG
210 220 230 240 250
ITSWLSTYPM DVVKSRLQAD GLQGTPRYRG IVDCMRQSYQ AEGWQVFTRG
260 270 280 290 300
LASTLLRAFP VNAATFATVT VVLTYIRGEE DQVDSEAAPG ASTTPAGPAL

AQPSSL
Length:306
Mass (Da):32,635
Last modified:February 15, 2005 - v1
Checksum:i7C55B36754CB63CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089065 mRNA. Translation: AAH89065.1.
RefSeqiNP_001010958.1. NM_001010958.1.
UniGeneiRn.15047.

Genome annotation databases

EnsembliENSRNOT00000005753; ENSRNOP00000005753; ENSRNOG00000004351.
GeneIDi314441.
KEGGirno:314441.
UCSCiRGD:1308104. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089065 mRNA. Translation: AAH89065.1.
RefSeqiNP_001010958.1. NM_001010958.1.
UniGeneiRn.15047.

3D structure databases

ProteinModelPortaliQ5HZE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005753.

Proteomic databases

PaxDbiQ5HZE0.
PRIDEiQ5HZE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005753; ENSRNOP00000005753; ENSRNOG00000004351.
GeneIDi314441.
KEGGirno:314441.
UCSCiRGD:1308104. rat.

Organism-specific databases

CTDi123096.
RGDi1308104. Slc25a29.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ5HZE0.
KOiK15109.
OMAiETPSFGF.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ5HZE0.
TreeFamiTF351739.

Miscellaneous databases

PROiQ5HZE0.

Gene expression databases

BgeeiENSRNOG00000004351.
GenevisibleiQ5HZE0. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCATL_RAT
AccessioniPrimary (citable) accession number: Q5HZE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.