Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CLK4-associating serine/arginine rich protein

Gene

Clasrp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
CLK4-associating serine/arginine rich protein
Alternative name(s):
Splicing factor, arginine/serine-rich 16
Gene namesi
Name:Clasrp
Synonyms:Sfrs16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1563538. Clasrp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668CLK4-associating serine/arginine rich proteinPRO_0000370323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851PhosphoserineBy similarity
Modified residuei294 – 2941PhosphoserineCombined sources
Modified residuei327 – 3271PhosphothreonineBy similarity
Modified residuei331 – 3311PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei541 – 5411PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated in vitro by CLK4.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5HZB6.
PRIDEiQ5HZB6.

PTM databases

iPTMnetiQ5HZB6.
PhosphoSiteiQ5HZB6.

Expressioni

Gene expression databases

GenevisibleiQ5HZB6. RN.

Interactioni

Subunit structurei

Probably interacts with CLK4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066334.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili579 – 64163Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi369 – 667299Arg-richAdd
BLAST
Compositional biasi377 – 529153Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2548. Eukaryota.
COG0303. LUCA.
GeneTreeiENSGT00730000111260.
InParanoidiQ5HZB6.
KOiK13168.
OMAiHSGDRYR.
OrthoDBiEOG7G7KPW.
PhylomeDBiQ5HZB6.

Family and domain databases

InterProiIPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV
60 70 80 90 100
HLDSAVALAA ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI
110 120 130 140 150
SPEQESDERK CNYERYRGLV QNDFAGISEE QCLYQIYIDE LYGGLQRPSE
160 170 180 190 200
DEKKKLAEKK ASIGYTYEDS TVAEVEKVAE KPEEEESPAE EESNSDEDEV
210 220 230 240 250
IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR KDKEEAEAIK
260 270 280 290 300
HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
310 320 330 340 350
KRSPSESSSE SRSRSRSPSP GREEKITFIT SFGGSDEEAA AAAAAAAASG
360 370 380 390 400
AAPGKPPAPP QPGGPAPGRN ASARRRSSSS SASRTSSSRS SSRSSSRSRR
410 420 430 440 450
GYYRSGRHAR SRSRSWSRSR SRSRRYSRSR SRGRRHSDGG SRDGHRYSRS
460 470 480 490 500
PARRSGYAPR RRSRSRSRSG DRYKRGARGP RHHSSSHSRS SWSLSPSRSR
510 520 530 540 550
SLTRSGSRSQ SRSRSRSQSH SQSQSHSPSP PREKLTRPAA SPAVGEKLKK
560 570 580 590 600
TEPAAGKETG AAKPKLTPQE RLKLRMQKAL NRQFKADKKA AQEKMIQQEH
610 620 630 640 650
ERQEREDELR AMARKIRMKE RERREKEREE WERQYSRQSR SPSPRYSREY
660
SSSRRRSRSR SRSPHYRH
Length:668
Mass (Da):76,807
Last modified:May 15, 2007 - v2
Checksum:i1673410C203FF581
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM08179.1.
BC089090 mRNA. Translation: AAH89090.2.
RefSeqiNP_001019465.2. NM_001024294.1.
UniGeneiRn.17553.

Genome annotation databases

EnsembliENSRNOT00000075144; ENSRNOP00000066334; ENSRNOG00000046000.
ENSRNOT00000081565; ENSRNOP00000075310; ENSRNOG00000046000.
GeneIDi499390.
KEGGirno:499390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM08179.1.
BC089090 mRNA. Translation: AAH89090.2.
RefSeqiNP_001019465.2. NM_001024294.1.
UniGeneiRn.17553.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066334.

PTM databases

iPTMnetiQ5HZB6.
PhosphoSiteiQ5HZB6.

Proteomic databases

PaxDbiQ5HZB6.
PRIDEiQ5HZB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000075144; ENSRNOP00000066334; ENSRNOG00000046000.
ENSRNOT00000081565; ENSRNOP00000075310; ENSRNOG00000046000.
GeneIDi499390.
KEGGirno:499390.

Organism-specific databases

CTDi11129.
RGDi1563538. Clasrp.

Phylogenomic databases

eggNOGiKOG2548. Eukaryota.
COG0303. LUCA.
GeneTreeiENSGT00730000111260.
InParanoidiQ5HZB6.
KOiK13168.
OMAiHSGDRYR.
OrthoDBiEOG7G7KPW.
PhylomeDBiQ5HZB6.

Miscellaneous databases

PROiQ5HZB6.

Gene expression databases

GenevisibleiQ5HZB6. RN.

Family and domain databases

InterProiIPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294 AND SER-541, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLASR_RAT
AccessioniPrimary (citable) accession number: Q5HZB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 15, 2007
Last modified: June 8, 2016
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.