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Protein

Porimin

Gene

Tmem123

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Porimin
Alternative name(s):
Transmembrane protein 123
Gene namesi
Name:Tmem123
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305625. Tmem123.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 151ExtracellularSequence analysisAdd BLAST127
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 194CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004506025 – 194PoriminAdd BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Modified residuei186PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5HZB0.

PTM databases

iPTMnetiQ5HZB0.
PhosphoSitePlusiQ5HZB0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 143Thr-richAdd BLAST95

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1SC. Eukaryota.
ENOG410ZE8W. LUCA.
HOGENOMiHOG000115612.
HOVERGENiHBG059722.
InParanoidiQ5HZB0.
PhylomeDBiQ5HZB0.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HZB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALCARAALL LGALQVLALP GAVAQETYAQ GSPSGNHSVP LLTANVNVTE
60 70 80 90 100
NTTMQVVSNQ TSQISTVKPS SVLPKNVTAA TVRPATIKVS TPGVSPHVTP
110 120 130 140 150
SASKSTPKTS ASPNSTQTSA SMTTTAHSSL LTSVTVSATT HPTKGKGSKF
160 170 180 190
DAGSFVGGIV LTLGVLSILY IGCKMYYSRR GIRYRSIDEH DAII
Length:194
Mass (Da):19,984
Last modified:February 15, 2005 - v1
Checksum:iC603814422A186F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089103 mRNA. Translation: AAH89103.1.
RefSeqiNP_001014227.1. NM_001014205.1.
UniGeneiRn.12767.
Rn.179080.

Genome annotation databases

GeneIDi363013.
KEGGirno:363013.
UCSCiRGD:1305625. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089103 mRNA. Translation: AAH89103.1.
RefSeqiNP_001014227.1. NM_001014205.1.
UniGeneiRn.12767.
Rn.179080.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5HZB0.
PhosphoSitePlusiQ5HZB0.

Proteomic databases

PaxDbiQ5HZB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi363013.
KEGGirno:363013.
UCSCiRGD:1305625. rat.

Organism-specific databases

CTDi114908.
RGDi1305625. Tmem123.

Phylogenomic databases

eggNOGiENOG410J1SC. Eukaryota.
ENOG410ZE8W. LUCA.
HOGENOMiHOG000115612.
HOVERGENiHBG059722.
InParanoidiQ5HZB0.
PhylomeDBiQ5HZB0.

Miscellaneous databases

PROiQ5HZB0.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPORIM_RAT
AccessioniPrimary (citable) accession number: Q5HZB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.