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Protein

Porimin

Gene

Tmem123

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Porimin
Alternative name(s):
Transmembrane protein 123
Gene namesi
Name:Tmem123
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305625. Tmem123.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 151127ExtracellularSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 19422CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 194170PoriminPRO_0000045060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Modified residuei186 – 1861PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5HZB0.

PTM databases

iPTMnetiQ5HZB0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 14395Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1SC. Eukaryota.
ENOG410ZE8W. LUCA.
HOGENOMiHOG000115612.
HOVERGENiHBG059722.
InParanoidiQ5HZB0.
PhylomeDBiQ5HZB0.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HZB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALCARAALL LGALQVLALP GAVAQETYAQ GSPSGNHSVP LLTANVNVTE
60 70 80 90 100
NTTMQVVSNQ TSQISTVKPS SVLPKNVTAA TVRPATIKVS TPGVSPHVTP
110 120 130 140 150
SASKSTPKTS ASPNSTQTSA SMTTTAHSSL LTSVTVSATT HPTKGKGSKF
160 170 180 190
DAGSFVGGIV LTLGVLSILY IGCKMYYSRR GIRYRSIDEH DAII
Length:194
Mass (Da):19,984
Last modified:February 15, 2005 - v1
Checksum:iC603814422A186F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089103 mRNA. Translation: AAH89103.1.
RefSeqiNP_001014227.1. NM_001014205.1.
UniGeneiRn.12767.

Genome annotation databases

GeneIDi363013.
KEGGirno:363013.
UCSCiRGD:1305625. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089103 mRNA. Translation: AAH89103.1.
RefSeqiNP_001014227.1. NM_001014205.1.
UniGeneiRn.12767.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5HZB0.

Proteomic databases

PaxDbiQ5HZB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi363013.
KEGGirno:363013.
UCSCiRGD:1305625. rat.

Organism-specific databases

CTDi114908.
RGDi1305625. Tmem123.

Phylogenomic databases

eggNOGiENOG410J1SC. Eukaryota.
ENOG410ZE8W. LUCA.
HOGENOMiHOG000115612.
HOVERGENiHBG059722.
InParanoidiQ5HZB0.
PhylomeDBiQ5HZB0.

Miscellaneous databases

PROiQ5HZB0.

Family and domain databases

InterProiIPR007947. CD164_MGC24.
[Graphical view]
PANTHERiPTHR11337. PTHR11337. 1 hit.
PfamiPF05283. MGC-24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiPORIM_RAT
AccessioniPrimary (citable) accession number: Q5HZB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.