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Protein

Transmembrane protein 126A

Gene

Tmem126a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 126A
Gene namesi
Name:Tmem126a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305677. Tmem126a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 572Mitochondrial intermembraneSequence analysis
Transmembranei58 – 7821HelicalSequence analysisAdd
BLAST
Topological domaini79 – 10628Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 15932Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei160 – 17617HelicalSequence analysisAdd
BLAST
Topological domaini177 – 19620Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Transmembrane protein 126APRO_0000271002Add
BLAST

Proteomic databases

PaxDbiQ5HZA9.
PRIDEiQ5HZA9.

Expressioni

Gene expression databases

GenevisibleiQ5HZA9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032681.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM126 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFU0. Eukaryota.
ENOG4111M3W. LUCA.
GeneTreeiENSGT00520000055616.
HOGENOMiHOG000059536.
HOVERGENiHBG055992.
InParanoidiQ5HZA9.
KOiK18157.
OMAiGNILNYW.
OrthoDBiEOG7F513J.
PhylomeDBiQ5HZA9.
TreeFamiTF327069.

Family and domain databases

InterProiIPR009801. TMEM126.
[Graphical view]
PANTHERiPTHR16296. PTHR16296. 1 hit.
PfamiPF07114. DUF1370. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HZA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESHKPSTNK DDLIFNIIPR KIKQLPESDR NLLEYGSAYI GLNAAFGGLI
60 70 80 90 100
ANSLFRRILN VTQARVASSL PMAVIPFLTA NLSYHSFVSL PLSTGNLNCE
110 120 130 140 150
ICTTTRGTLV GFVLGGLYPI LLAIPVNGGL AARYESSPLP QRGNIFNYWI
160 170 180 190
TISKPVFRKM LFPTLLQTAF AAYLGSRQYK LLIKALQLPE PDLEIQ
Length:196
Mass (Da):21,657
Last modified:February 15, 2005 - v1
Checksum:iC2D8D4114EAB87CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089104 mRNA. Translation: AAH89104.1.
RefSeqiNP_001011557.1. NM_001011557.1.
XP_006229751.1. XM_006229689.2.
UniGeneiRn.143768.

Genome annotation databases

EnsembliENSRNOT00000038333; ENSRNOP00000032681; ENSRNOG00000022748.
GeneIDi293113.
KEGGirno:293113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089104 mRNA. Translation: AAH89104.1.
RefSeqiNP_001011557.1. NM_001011557.1.
XP_006229751.1. XM_006229689.2.
UniGeneiRn.143768.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032681.

Proteomic databases

PaxDbiQ5HZA9.
PRIDEiQ5HZA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038333; ENSRNOP00000032681; ENSRNOG00000022748.
GeneIDi293113.
KEGGirno:293113.

Organism-specific databases

CTDi84233.
RGDi1305677. Tmem126a.

Phylogenomic databases

eggNOGiENOG410IFU0. Eukaryota.
ENOG4111M3W. LUCA.
GeneTreeiENSGT00520000055616.
HOGENOMiHOG000059536.
HOVERGENiHBG055992.
InParanoidiQ5HZA9.
KOiK18157.
OMAiGNILNYW.
OrthoDBiEOG7F513J.
PhylomeDBiQ5HZA9.
TreeFamiTF327069.

Miscellaneous databases

PROiQ5HZA9.

Gene expression databases

GenevisibleiQ5HZA9. RN.

Family and domain databases

InterProiIPR009801. TMEM126.
[Graphical view]
PANTHERiPTHR16296. PTHR16296. 1 hit.
PfamiPF07114. DUF1370. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiT126A_RAT
AccessioniPrimary (citable) accession number: Q5HZA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.