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Protein

Zinc finger CCHC domain-containing protein 12

Gene

Zcchc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 362CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 12
Gene namesi
Name:Zcchc12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1359439. Zcchc12.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509731 – 401Zinc finger CCHC domain-containing protein 12Add BLAST401

Proteomic databases

PaxDbiQ5HZA3.
PRIDEiQ5HZA3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013162.
GenevisibleiQ5HZA3. RN.

Interactioni

Subunit structurei

Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017567.

Family & Domainsi

Sequence similaritiesi

Belongs to the ZCCHC12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri345 – 362CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J95G. Eukaryota.
ENOG4111945. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000230940.
HOVERGENiHBG073535.
InParanoidiQ5HZA3.
OMAiAFQGSPP.
OrthoDBiEOG091G0AM8.
PhylomeDBiQ5HZA3.
TreeFamiTF335054.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiView protein in InterPro
IPR026523. PNMA.
IPR001878. Znf_CCHC.
PANTHERiPTHR23095. PTHR23095. 1 hit.
PfamiView protein in Pfam
PF14893. PNMA. 1 hit.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HZA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASILSRMGN SRGQNSPLPP WAHSMLRSLG RSLGPLMASM AERNMKLFSG
60 70 80 90 100
RAEPAQGEET FENWLSQVTA VLPDWHMPEE EKVRRLMRTL RGPAREVMRL
110 120 130 140 150
LQAANPCLDV EDFLRAMKLV FGESESSVTA HSKFVNTVQE PGEKPSLYVI
160 170 180 190 200
RLEVQLQNAI QAGVFAEREA NQARLHQLLV GAEMSTDLRF RLKSLLRVYA
210 220 230 240 250
NEPERLPNFL ELIRMIREEE EWEEAFIHPK RPRRSQSVER ALSPTFQSSP
260 270 280 290 300
PVMISSIDCN VIEIDDSPDD SDEDVILVEP DDPPLPSSSA GPSFLGRAVS
310 320 330 340 350
EDQVLVIESP NIFEIQAPST SSGAGRKNNN NFGELRRARK RKHTVHCSHC
360 370 380 390 400
GEEGHSKETC DNESDRGQVF ENLIITLQEL THTEERAREI FGEAIGLSEL

H
Length:401
Mass (Da):45,154
Last modified:February 15, 2005 - v1
Checksum:i98845C1336208507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089115 mRNA. Translation: AAH89115.1.
RefSeqiNP_001014087.1. NM_001014065.2.
XP_006257510.1. XM_006257448.3.
XP_006257511.1. XM_006257449.3.
XP_006257513.1. XM_006257451.3.
XP_006257514.1. XM_006257452.3.
XP_017457523.1. XM_017602034.1.
XP_017457524.1. XM_017602035.1.
XP_017457525.1. XM_017602036.1.
UniGeneiRn.23849.

Genome annotation databases

EnsembliENSRNOT00000017567; ENSRNOP00000017567; ENSRNOG00000013162.
GeneIDi313436.
KEGGirno:313436.
UCSCiRGD:1359439. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZCH12_RAT
AccessioniPrimary (citable) accession number: Q5HZA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 15, 2005
Last modified: May 10, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families