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Protein

Retrotransposon Gag-like protein 5

Gene

RTL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

RTL5 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 5Imported
Alternative name(s):
Retrotransposon gag domain-containing protein 4Curated
Gene namesi
Name:RTL5Imported
Synonyms:KIAA2001, RGAG4Curated
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29430. RTL5.

Pathology & Biotechi

Organism-specific databases

DisGeNETi340526.
OpenTargetsiENSG00000242732.
PharmGKBiPA134992098.

Polymorphism and mutation databases

BioMutaiRGAG4.
DMDMi74741563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596291 – 569Retrotransposon Gag-like protein 5Add BLAST569

Proteomic databases

EPDiQ5HYW3.
PaxDbiQ5HYW3.
PeptideAtlasiQ5HYW3.
PRIDEiQ5HYW3.

PTM databases

iPTMnetiQ5HYW3.
PhosphoSitePlusiQ5HYW3.

Expressioni

Gene expression databases

BgeeiENSG00000242732.
CleanExiHS_RGAG4.
GenevisibleiQ5HYW3. HS.

Organism-specific databases

HPAiHPA003652.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000418667.

Structurei

3D structure databases

ProteinModelPortaliQ5HYW3.
SMRiQ5HYW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 129Poly-Pro6
Compositional biasi375 – 409Glu-richAdd BLAST35

Phylogenomic databases

eggNOGiENOG410J99I. Eukaryota.
ENOG41117C1. LUCA.
GeneTreeiENSGT00510000047956.
HOGENOMiHOG000147823.
HOVERGENiHBG055980.
InParanoidiQ5HYW3.
OMAiSSYIRWP.
OrthoDBiEOG091G02TH.
PhylomeDBiQ5HYW3.
TreeFamiTF337113.

Family and domain databases

InterProiView protein in InterPro
IPR032549. DUF4939.
IPR032567. LDOC1-rel.
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiView protein in Pfam
PF16297. DUF4939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HYW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEASGNLNS LRMANVALRE ELNALRGENA NLGLQLGRAL AEVNSLRGNV
60 70 80 90 100
SSYIRWPVPI VPVLAEENLE FALSEIEVIP GGELPFLCRP PPRAEPDCIS
110 120 130 140 150
DDLLINVIQD RSTPDGPADP PLLPIPPPPA LPPPASKEPP PQPPLAPLER
160 170 180 190 200
PEIEPFSGDP VYLAEFLMQL ETFIADHEVH FPGGAERVAF LISFFTGEAK
210 220 230 240 250
DWAISVTQEG SPLHANFPRF LDEIRKEFCG PIPPRVAKKA IRKLKQGHCT
260 270 280 290 300
LGSYADAFQF LAQFLSWDDC RLQNQFLKGL SEFFRKELLW STEMADLDEL
310 320 330 340 350
ILECVEIERK VRVPKPIPLP GVRNIIFPFA PSPNEEESED EEYYSEDEDQ
360 370 380 390 400
EARRHRLHSK DQRKRMRAFQ QEMKEKEEEE MKKEEEMKKK EEKEEEEEEE
410 420 430 440 450
MKQKEEEEEI RNKNEEEGES KDEEDEDEDG GQKPEGEPQQ DPGTEETYGE
460 470 480 490 500
VEEEPLDEAQ DDDLDELMEM EPTFVHASSQ TSGPTSGYHA ENFLGASPPI
510 520 530 540 550
IQPSRRRNQN RVPLLEGLPG TNSPFYSSPQ LIRRTGRLGQ RQVRRRPPVL
560
FRLTPRQGGH RAARGRIRV
Length:569
Mass (Da):64,711
Last modified:February 15, 2005 - v1
Checksum:iEF48B4A215DC99DE
GO

Sequence cautioni

The sequence BAC02710 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051319420S → R. Corresponds to variant dbSNP:rs6624595Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082532 mRNA. Translation: BAC02710.1. Different initiation.
BX119917 Genomic DNA. No translation available.
BC151224 mRNA. Translation: AAI51225.1.
AL359579 mRNA. Translation: CAB94872.2.
CCDSiCCDS55446.1.
PIRiT50613.
RefSeqiNP_001019626.1. NM_001024455.3.
UniGeneiHs.512180.

Genome annotation databases

EnsembliENST00000479991; ENSP00000418667; ENSG00000242732.
ENST00000609883; ENSP00000476792; ENSG00000242732.
GeneIDi340526.
KEGGihsa:340526.
UCSCiuc004eaj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRTL5_HUMAN
AccessioniPrimary (citable) accession number: Q5HYW3
Secondary accession number(s): A7E2W7, Q8NCM4, Q9NPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: June 7, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations