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Protein

NHS-like protein 2

Gene

NHSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-30929-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NHS-like protein 2
Gene namesi
Name:NHSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33737. NHSL2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204131.

Polymorphism and mutation databases

DMDMi74741562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003413551 – 709NHS-like protein 2Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei134PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5HYW2.
PaxDbiQ5HYW2.
PeptideAtlasiQ5HYW2.
PRIDEiQ5HYW2.

PTM databases

iPTMnetiQ5HYW2.
PhosphoSitePlusiQ5HYW2.

Expressioni

Gene expression databases

BgeeiENSG00000204131.
CleanExiHS_NHSL2.
ExpressionAtlasiQ5HYW2. baseline and differential.
GenevisibleiQ5HYW2. HS.

Organism-specific databases

HPAiHPA049771.
HPA054858.

Interactioni

Protein-protein interaction databases

IntActiQ5HYW2. 1 interactor.
STRINGi9606.ENSP00000444617.

Structurei

3D structure databases

ProteinModelPortaliQ5HYW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 435Ser-richAdd BLAST151

Sequence similaritiesi

Belongs to the NHS family.Curated

Phylogenomic databases

eggNOGiENOG410IJGU. Eukaryota.
ENOG410ZHHT. LUCA.
GeneTreeiENSGT00530000063248.
HOGENOMiHOG000113784.
HOVERGENiHBG095614.
InParanoidiQ5HYW2.
OrthoDBiEOG091G0BFN.
PhylomeDBiQ5HYW2.

Family and domain databases

InterProiIPR024845. NHS_fam.
[Graphical view]
PfamiPF15273. NHS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HYW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESMGMVYSV PSSCNGPTES TFSTSWKGDA FTYMTPSATS QSNQVNENGK
60 70 80 90 100
NPSCGNSWVS LNKVPPLVPK EAATLLVARD NPAGCSGSAG YPERLIQQRH
110 120 130 140 150
MPERPSKIGL LTSGTSRLET GPGGASRFRE RSLSVPTDSG TTDVDYDEEQ
160 170 180 190 200
KANEACALPF ASTSSEGSNS ADNIASLSAQ QEAQHRRQRS KSISLRKAKK
210 220 230 240 250
KPSPPTRSVS LVKDEPGLLP EGGSALPKDQ RPKSLCLSLE HQGHHSSHPD
260 270 280 290 300
AQGHPAIPNH KDPESTQFSH HWYLTDWKSG DTYQSLSSSS TATGTTVIEC
310 320 330 340 350
TQVQGSSESL ASPSTSRATT PSQLSIEVEA REISSPGRPP GLMSPSSGYS
360 370 380 390 400
SQSETPTPTV SMSLTLGHLP PPSSSVRVRP VVPERKSSLP PTSPMEKFPK
410 420 430 440 450
SRLSFDLPLT SSPNLDLSGM SISIRSKTKV SRHHSETNFG VKLAQKTNPN
460 470 480 490 500
QPIMPMVTQS DLRSVRLRSV SKSEPEDDIE SPEYAEEPRA EEVFTLPERK
510 520 530 540 550
TKPPVAEKPP VARRPPSLVH KPPSVPEEYA LTSPTLAMPP RSSIQHARPL
560 570 580 590 600
PQDSYTVVRK PKPSSFPDGR SPGESTAPSS LVFTPFASSS DAFFSGTQQP
610 620 630 640 650
PQGSVEDEGP KVRVLPERIS LQSQEEAEKK KGKIPPPVPK KPSVLYLPLT
660 670 680 690 700
SPTAQMEAYV AEPRLPLSPI ITLEEDTKCP ATGDDLQSLG QRVTSTPQAD

SEREASPLG
Length:709
Mass (Da):76,301
Last modified:February 15, 2005 - v1
Checksum:iFE6F060EB13DF34B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044057535T → I.Corresponds to variant rs7061150dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX119917 Genomic DNA. Translation: CAI39853.1.
BC033261 mRNA. No translation available.
BC136756 mRNA. Translation: AAI36757.1.
UniGeneiHs.397836.
Hs.496303.

Genome annotation databases

EnsembliENST00000510661; ENSP00000424079; ENSG00000204131.
UCSCiuc004eak.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX119917 Genomic DNA. Translation: CAI39853.1.
BC033261 mRNA. No translation available.
BC136756 mRNA. Translation: AAI36757.1.
UniGeneiHs.397836.
Hs.496303.

3D structure databases

ProteinModelPortaliQ5HYW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5HYW2. 1 interactor.
STRINGi9606.ENSP00000444617.

PTM databases

iPTMnetiQ5HYW2.
PhosphoSitePlusiQ5HYW2.

Polymorphism and mutation databases

DMDMi74741562.

Proteomic databases

EPDiQ5HYW2.
PaxDbiQ5HYW2.
PeptideAtlasiQ5HYW2.
PRIDEiQ5HYW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000510661; ENSP00000424079; ENSG00000204131.
UCSCiuc004eak.1. human.

Organism-specific databases

GeneCardsiNHSL2.
HGNCiHGNC:33737. NHSL2.
HPAiHPA049771.
HPA054858.
neXtProtiNX_Q5HYW2.
OpenTargetsiENSG00000204131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJGU. Eukaryota.
ENOG410ZHHT. LUCA.
GeneTreeiENSGT00530000063248.
HOGENOMiHOG000113784.
HOVERGENiHBG095614.
InParanoidiQ5HYW2.
OrthoDBiEOG091G0BFN.
PhylomeDBiQ5HYW2.

Enzyme and pathway databases

BioCyciZFISH:G66-30929-MONOMER.

Miscellaneous databases

PROiQ5HYW2.

Gene expression databases

BgeeiENSG00000204131.
CleanExiHS_NHSL2.
ExpressionAtlasiQ5HYW2. baseline and differential.
GenevisibleiQ5HYW2. HS.

Family and domain databases

InterProiIPR024845. NHS_fam.
[Graphical view]
PfamiPF15273. NHS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNHSL2_HUMAN
AccessioniPrimary (citable) accession number: Q5HYW2
Secondary accession number(s): B2RN94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.