Q5HYM0 (ZC12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ribonuclease ZC3H12B
EC=3.1.-.-

Alternative name(s):
MCP-induced protein 2
Zinc finger CCCH domain-containing protein 12B

Gene names

Name:	ZC3H12B
Synonyms:	CXorf32, MCPIP2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	825 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function as RNase and regulate the levels of target RNA species Potential.
Cofactor	Magnesium Potential.
Sequence similarities	Belongs to the ZC3H12 family. Contains 1 C3H1-type zinc finger.
Sequence caution	The sequence CAI42594.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI42834.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Magnesium Metal-binding Zinc
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5HYM0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5HYM0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     83-157: SSILQDGKLD...NLSLLVPRGP → NHLLMMYWQSLSDLGTKVIQKG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 825	825	Probable ribonuclease ZC3H12B		PRO_0000254045
Regions
	Zinc finger	344 – 369	26	C3H1-type
Natural variations
	Alternative sequence	83 – 157	75	SSILQ…VPRGP → NHLLMMYWQSLSDLGTKVIQ KG in isoform 2.		VSP_039896

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 2. Checksum: C89D20A47B42D812	FASTA	825	93,046
	10 20 30 40 50 60 MEKSASKEEK QQPKQDSTEQ GNADSEEWMS SESDPEQISL KSSDNSKSCQ PRDGQLKKKE 70 80 90 100 110 120 MHSKPHRQLC RSPCLDRPSF SQSSILQDGK LDLEKEYQAK MEFALKLGYA EEQIQSVLNK 130 140 150 160 170 180 LGPESLINDV LAELVRLGNK GDSEGQINLS LLVPRGPSSR EIASPELSLE DEIDNSDNLR 190 200 210 220 230 240 PVVIDGSNVA MSHGNKEEFS CRGIQLAVDW FLDKGHKDIT VFVPAWRKEQ SRPDAPITDQ 250 260 270 280 290 300 DILRKLEKEK ILVFTPSRRV QGRRVVCYDD RFIVKLAFDS DGIIVSNDNY RDLQVEKPEW 310 320 330 340 350 360 KKFIEERLLM YSFVNDKFMP PDDPLGRHGP SLENFLRKRP IVPEHKKQPC PYGKKCTYGH 370 380 390 400 410 420 KCKYYHPERA NQPQRSVADE LRISAKLSTV KTMSEGTLAK CGTGMSSAKG EITSEVKRVA 430 440 450 460 470 480 PKRQSDPSIR SVAMEPEEWL SIARKPEASS VPSLVTALSV PTIPPPKSHA VGALNTRSAS 490 500 510 520 530 540 SPVPGSSHFP HQKASLEHMA SMQYPPILVT NSHGTPISYA EQYPKFESMG DHGYYSMLGD 550 560 570 580 590 600 FSKLNINSMH NREYYMAEVD RGVYARNPNL CSDSRVSHTR NDNYSSYNNV YLAVADTHPE 610 620 630 640 650 660 GNLKLHRSAS QNRLQPFPHG YHEALTRVQS YGPEDSKQGP HKQSVPHLAL HAQHPSTGTR 670 680 690 700 710 720 SSCPADYPMP PNIHPGATPQ PGRALVMTRM DSISDSRLYE SNPVRQRRPP LCREQHASWD 730 740 750 760 770 780 PLPCTTDSYG YHSYPLSNSL MQPCYEPVMV RSVPEKMEQL WRNPWVGMCN DSREHMIPEH 790 800 810 820 QYQTYKNLCN IFPSNIVLAV MEKNPHTADA QQLAALIVAK LRAAR
	Isoform 2 [UniParc]. Checksum: 525EB6928A32CD9B	FASTA	772	87,384
	10 20 30 40 50 60 MEKSASKEEK QQPKQDSTEQ GNADSEEWMS SESDPEQISL KSSDNSKSCQ PRDGQLKKKE 70 80 90 100 110 120 MHSKPHRQLC RSPCLDRPSF SQNHLLMMYW QSLSDLGTKV IQKGSSREIA SPELSLEDEI 130 140 150 160 170 180 DNSDNLRPVV IDGSNVAMSH GNKEEFSCRG IQLAVDWFLD KGHKDITVFV PAWRKEQSRP 190 200 210 220 230 240 DAPITDQDIL RKLEKEKILV FTPSRRVQGR RVVCYDDRFI VKLAFDSDGI IVSNDNYRDL 250 260 270 280 290 300 QVEKPEWKKF IEERLLMYSF VNDKFMPPDD PLGRHGPSLE NFLRKRPIVP EHKKQPCPYG 310 320 330 340 350 360 KKCTYGHKCK YYHPERANQP QRSVADELRI SAKLSTVKTM SEGTLAKCGT GMSSAKGEIT 370 380 390 400 410 420 SEVKRVAPKR QSDPSIRSVA MEPEEWLSIA RKPEASSVPS LVTALSVPTI PPPKSHAVGA 430 440 450 460 470 480 LNTRSASSPV PGSSHFPHQK ASLEHMASMQ YPPILVTNSH GTPISYAEQY PKFESMGDHG 490 500 510 520 530 540 YYSMLGDFSK LNINSMHNRE YYMAEVDRGV YARNPNLCSD SRVSHTRNDN YSSYNNVYLA 550 560 570 580 590 600 VADTHPEGNL KLHRSASQNR LQPFPHGYHE ALTRVQSYGP EDSKQGPHKQ SVPHLALHAQ 610 620 630 640 650 660 HPSTGTRSSC PADYPMPPNI HPGATPQPGR ALVMTRMDSI SDSRLYESNP VRQRRPPLCR 670 680 690 700 710 720 EQHASWDPLP CTTDSYGYHS YPLSNSLMQP CYEPVMVRSV PEKMEQLWRN PWVGMCNDSR 730 740 750 760 770 EHMIPEHQYQ TYKNLCNIFP SNIVLAVMEK NPHTADAQQL AALIVAKLRA AR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages." Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M. J. Biol. Chem. 283:6337-6346(2008) [PubMed: 18178554] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX647241 mRNA. Translation: CAI46044.1. Z83841, AL050306 Genomic DNA. Translation: CAI42594.1. Sequence problems. AL050306, Z83841 Genomic DNA. Translation: CAI42834.1. Sequence problems. BC140767 mRNA. Translation: AAI40768.1. BC171781 mRNA. Translation: AAI71781.1.
IPI	IPI00232764. IPI00939228.
RefSeq	NP_001010888.3. NM_001010888.3.
UniGene	Hs.21249.
3D structure databases
ProteinModelPortal	Q5HYM0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HYM0.
Polymorphism databases
DMDM	308153529.
Proteomic databases
PRIDE	Q5HYM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000218172; ENSP00000218172; ENSG00000102053.
GeneID	340554.
KEGG	hsa:340554.
Organism-specific databases
CTD	340554.
GeneCards	GC0XP064708.
H-InvDB	HIX0016840.
HGNC	HGNC:17407. ZC3H12B.
HPA	HPA000836.
neXtProt	NX_Q5HYM0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17783.
GeneTree	ENSGT00550000074448.
HOVERGEN	HBG080308.
InParanoid	Q5HYM0.
OMA	YYHPERA.
PhylomeDB	Q5HYM0.
Gene expression databases
ArrayExpress	Q5HYM0.
Bgee	Q5HYM0.
CleanEx	HS_ZC3H12B.
Genevestigator	Q5HYM0.
GermOnline	ENSG00000102053. Homo sapiens.
Family and domain databases
InterPro	IPR021869. RNase_Zc3h12. IPR000571. Znf_CCCH. [Graphical view]
Pfam	PF11977. RNase_Zc3h12a. 1 hit. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	97925.

Entry information

Entry name

ZC12B_HUMAN

Accession

Primary (citable) accession number: Q5HYM0
Secondary accession number(s): B2RTQ3, Q5H9C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.