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Protein

Probable ribonuclease ZC3H12B

Gene

ZC3H12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as RNase and regulate the levels of target RNA species.Curated

Cofactori

Mg2+Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 38026C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribonuclease ZC3H12B (EC:3.1.-.-)
Alternative name(s):
MCP-induced protein 2
Zinc finger CCCH domain-containing protein 12B
Gene namesi
Name:ZC3H12B
Synonyms:CXorf32, MCPIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17407. ZC3H12B.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZC3H12B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Probable ribonuclease ZC3H12BPRO_0000254045Add
BLAST

Proteomic databases

PaxDbiQ5HYM0.
PRIDEiQ5HYM0.

PTM databases

iPTMnetiQ5HYM0.
PhosphoSiteiQ5HYM0.

Expressioni

Gene expression databases

BgeeiQ5HYM0.
CleanExiHS_ZC3H12B.
GenevisibleiQ5HYM0. HS.

Organism-specific databases

HPAiHPA000836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340839.

Structurei

3D structure databases

ProteinModelPortaliQ5HYM0.
SMRiQ5HYM0. Positions 189-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H12 family.Curated
Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 38026C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
ENOG410ZNK1. LUCA.
GeneTreeiENSGT00750000117218.
HOGENOMiHOG000060218.
HOVERGENiHBG080308.
InParanoidiQ5HYM0.
KOiK18668.
OMAiSIARKPE.
OrthoDBiEOG7NSB2F.
PhylomeDBiQ5HYM0.
TreeFamiTF315783.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12_NYN.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5HYM0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTATAEVETP KMEKSASKEE KQQPKQDSTE QGNADSEEWM SSESDPEQIS
60 70 80 90 100
LKSSDNSKSC QPRDGQLKKK EMHSKPHRQL CRSPCLDRPS FSQSSILQDG
110 120 130 140 150
KLDLEKEYQA KMEFALKLGY AEEQIQSVLN KLGPESLIND VLAELVRLGN
160 170 180 190 200
KGDSEGQINL SLLVPRGPSS REIASPELSL EDEIDNSDNL RPVVIDGSNV
210 220 230 240 250
AMSHGNKEEF SCRGIQLAVD WFLDKGHKDI TVFVPAWRKE QSRPDAPITD
260 270 280 290 300
QDILRKLEKE KILVFTPSRR VQGRRVVCYD DRFIVKLAFD SDGIIVSNDN
310 320 330 340 350
YRDLQVEKPE WKKFIEERLL MYSFVNDKFM PPDDPLGRHG PSLENFLRKR
360 370 380 390 400
PIVPEHKKQP CPYGKKCTYG HKCKYYHPER ANQPQRSVAD ELRISAKLST
410 420 430 440 450
VKTMSEGTLA KCGTGMSSAK GEITSEVKRV APKRQSDPSI RSVAMEPEEW
460 470 480 490 500
LSIARKPEAS SVPSLVTALS VPTIPPPKSH AVGALNTRSA SSPVPGSSHF
510 520 530 540 550
PHQKASLEHM ASMQYPPILV TNSHGTPISY AEQYPKFESM GDHGYYSMLG
560 570 580 590 600
DFSKLNINSM HNREYYMAEV DRGVYARNPN LCSDSRVSHT RNDNYSSYNN
610 620 630 640 650
VYLAVADTHP EGNLKLHRSA SQNRLQPFPH GYHEALTRVQ SYGPEDSKQG
660 670 680 690 700
PHKQSVPHLA LHAQHPSTGT RSSCPADYPM PPNIHPGATP QPGRALVMTR
710 720 730 740 750
MDSISDSRLY ESNPVRQRRP PLCREQHASW DPLPCTTDSY GYHSYPLSNS
760 770 780 790 800
LMQPCYEPVM VRSVPEKMEQ LWRNPWVGMC NDSREHMIPE HQYQTYKNLC
810 820 830
NIFPSNIVLA VMEKNPHTAD AQQLAALIVA KLRAAR
Length:836
Mass (Da):94,205
Last modified:April 16, 2014 - v3
Checksum:iC7B2D9A790579442
GO
Isoform 2 (identifier: Q5HYM0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-168: SSILQDGKLD...NLSLLVPRGP → NHLLMMYWQSLSDLGTKVIQKG

Show »
Length:783
Mass (Da):88,543
Checksum:iFE7B47E34D2469D4
GO

Sequence cautioni

The sequence AAI40768.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI71781.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI42594.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI42834.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI46044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 16875SSILQ…VPRGP → NHLLMMYWQSLSDLGTKVIQ KG in isoform 2. 1 PublicationVSP_039896Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83841, AL050306 Genomic DNA. Translation: CAI42594.1. Sequence problems.
AL050306, Z83841 Genomic DNA. Translation: CAI42834.1. Sequence problems.
BC140767 mRNA. Translation: AAI40768.1. Different initiation.
BC171781 mRNA. Translation: AAI71781.1. Different initiation.
BX647241 mRNA. Translation: CAI46044.1. Different initiation.
CCDSiCCDS48131.2. [Q5HYM0-1]
RefSeqiNP_001010888.3. NM_001010888.3. [Q5HYM0-1]
XP_011529240.1. XM_011530938.1. [Q5HYM0-1]
XP_011529241.1. XM_011530939.1. [Q5HYM0-1]
UniGeneiHs.21249.

Genome annotation databases

EnsembliENST00000338957; ENSP00000340839; ENSG00000102053. [Q5HYM0-1]
GeneIDi340554.
KEGGihsa:340554.
UCSCiuc010nko.3. human. [Q5HYM0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83841, AL050306 Genomic DNA. Translation: CAI42594.1. Sequence problems.
AL050306, Z83841 Genomic DNA. Translation: CAI42834.1. Sequence problems.
BC140767 mRNA. Translation: AAI40768.1. Different initiation.
BC171781 mRNA. Translation: AAI71781.1. Different initiation.
BX647241 mRNA. Translation: CAI46044.1. Different initiation.
CCDSiCCDS48131.2. [Q5HYM0-1]
RefSeqiNP_001010888.3. NM_001010888.3. [Q5HYM0-1]
XP_011529240.1. XM_011530938.1. [Q5HYM0-1]
XP_011529241.1. XM_011530939.1. [Q5HYM0-1]
UniGeneiHs.21249.

3D structure databases

ProteinModelPortaliQ5HYM0.
SMRiQ5HYM0. Positions 189-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340839.

PTM databases

iPTMnetiQ5HYM0.
PhosphoSiteiQ5HYM0.

Polymorphism and mutation databases

BioMutaiZC3H12B.

Proteomic databases

PaxDbiQ5HYM0.
PRIDEiQ5HYM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338957; ENSP00000340839; ENSG00000102053. [Q5HYM0-1]
GeneIDi340554.
KEGGihsa:340554.
UCSCiuc010nko.3. human. [Q5HYM0-1]

Organism-specific databases

CTDi340554.
GeneCardsiZC3H12B.
HGNCiHGNC:17407. ZC3H12B.
HPAiHPA000836.
MIMi300889. gene.
neXtProtiNX_Q5HYM0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
ENOG410ZNK1. LUCA.
GeneTreeiENSGT00750000117218.
HOGENOMiHOG000060218.
HOVERGENiHBG080308.
InParanoidiQ5HYM0.
KOiK18668.
OMAiSIARKPE.
OrthoDBiEOG7NSB2F.
PhylomeDBiQ5HYM0.
TreeFamiTF315783.

Miscellaneous databases

GenomeRNAii340554.
PROiQ5HYM0.
SOURCEiSearch...

Gene expression databases

BgeeiQ5HYM0.
CleanExiHS_ZC3H12B.
GenevisibleiQ5HYM0. HS.

Family and domain databases

InterProiIPR021869. RNase_Zc3h12_NYN.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF11977. RNase_Zc3h12a. 1 hit.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-836 (ISOFORM 2).
    Tissue: Amygdala.
  4. "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."
    Liang J., Wang J., Azfer A., Song W., Tromp G., Kolattukudy P.E., Fu M.
    J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiZC12B_HUMAN
AccessioniPrimary (citable) accession number: Q5HYM0
Secondary accession number(s): B2RTQ3, E9PAJ6, Q5H9C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 16, 2014
Last modified: June 8, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.