Q5HYK9 (ZN667_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 667

Gene names

Name:

ZNF667

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAH74898.2 differs from that shown. Reason: Erroneous initiation. The sequence AAH74899.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 610	610	Zinc finger protein 667		PRO_0000251897
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	144 – 166	23	C2H2-type 1
	Zinc finger	172 – 194	23	C2H2-type 2
	Zinc finger	200 – 222	23	C2H2-type 3
	Zinc finger	253 – 275	23	C2H2-type 4
	Zinc finger	281 – 303	23	C2H2-type 5; degenerate
	Zinc finger	330 – 352	23	C2H2-type 6
	Zinc finger	358 – 380	23	C2H2-type 7
	Zinc finger	386 – 408	23	C2H2-type 8
	Zinc finger	415 – 437	23	C2H2-type 9
	Zinc finger	443 – 465	23	C2H2-type 10
	Zinc finger	471 – 493	23	C2H2-type 11
	Zinc finger	499 – 521	23	C2H2-type 12
	Zinc finger	527 – 549	23	C2H2-type 13
	Zinc finger	555 – 577	23	C2H2-type 14
	Zinc finger	583 – 605	23	C2H2-type 15
Natural variations
	Natural variant	134	1	P → L. Ref.1 Ref.2 Ref.4 Corresponds to variant rs35914474 [ dbSNP | Ensembl ].		VAR_047330
	Natural variant	260	1	K → R. Corresponds to variant rs3760849 [ dbSNP | Ensembl ].		VAR_027716
	Natural variant	540	1	T → A. Corresponds to variant rs12610019 [ dbSNP | Ensembl ].		VAR_027717
Experimental info
	Sequence conflict	139	1	S → P in CAI46040. Ref.2
	Sequence conflict	512	1	A → T in AK024073. Ref.1
	Sequence conflict	593	1	S → G in AK024073. Ref.1
	Sequence conflict	593	1	S → G in CAI46040. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q5HYK9 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 658048EF4605B884	FASTA	610	70,161
	10 20 30 40 50 60 MPSARGKSKS KAPITFGDLA IYFSQEEWEW LSPIQKDLYE DVMLENYRNL VSLGLSFRRP 70 80 90 100 110 120 NVITLLEKGK APWMVEPVRR RRAPDSGSKC ETKKLPPNQC NKSGQSICQK LVSAQQKAPT 130 140 150 160 170 180 RKSGCNKNSV LVKPKKGHSG KKPLKCNDCG KTFSRSFSLK LHQNIHTGEK PFECSNCRKA 190 200 210 220 230 240 FRQISSILLH QRIHSGKKSH ECNKCGESFN QRTTLILHMR IHDGKEILDC GKALSQCQSF 250 260 270 280 290 300 NIHQKIHVVG NVCQCRKCGK AFNQMSSLLL HKKIHNGKKT HKYNKCGRGF KKKSVFVVHK 310 320 330 340 350 360 RIHAGEKIPE NAKALSQSLQ QRSHHLENPF KCRKCGKLFN RISPLMLHQR IHTSEKPYKC 370 380 390 400 410 420 DKCDKFFRRL STLILHLRIH NGEKLYRCNK CEKVCNRHSS LIQHQKVHTK KKKLFECKEC 430 440 450 460 470 480 GKMFSGTANL KIHQNIHSEE KPFKCNKCSK VFGRQSFLIE HQRIHTGEKP YQCEECGKAF 490 500 510 520 530 540 SHRISLTRHK RIHTEDRPYE CDQCGKAFSQ SAHLAQHERI HTGEKPYTCK TCGKAFSQRT 550 560 570 580 590 600 SLILHERSHT GEKPYECNEC GKAFSSGSDL IRHQRSHSSE KPYECSKCGK AYSRSSSLIR 610 HQNTHSEEKA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-134.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-134. Tissue: Endometrium.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-134. Tissue: Lung and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024073 mRNA. No translation available. AK056508 mRNA. Translation: BAG51734.1. BX647401 mRNA. Translation: CAI46040.1. AC006116 Genomic DNA. No translation available. AC013256 Genomic DNA. No translation available. BC074898 mRNA. Translation: AAH74898.2. Different initiation. BC074899 mRNA. Translation: AAH74899.2. Different initiation. BC136388 mRNA. Translation: AAI36389.1. BC150593 mRNA. Translation: AAI50594.1.
IPI	IPI00413718.
RefSeq	NP_071386.3. NM_022103.3.
UniGene	Hs.676605.
3D structure databases
HSSP	HSSP built from PDB template 1X6E based on UniProtKB P17028.
ProteinModelPortal	Q5HYK9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000292069.
PTM databases
PhosphoSite	Q5HYK9.
Polymorphism databases
DMDM	215273933.
Proteomic databases
PaxDb	Q5HYK9.
PRIDE	Q5HYK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292069; ENSP00000292069; ENSG00000198046. ENST00000504904; ENSP00000439402; ENSG00000198046.
GeneID	63934.
KEGG	hsa:63934.
UCSC	uc002qnd.3. human.
Organism-specific databases
CTD	63934.
GeneCards	GC19M056951.
HGNC	HGNC:28854. ZNF667.
HPA	HPA046673.
MIM	611024. gene.
neXtProt	NX_Q5HYK9.
PharmGKB	PA142670514.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
KO	K09228.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q5HYK9.
Bgee	Q5HYK9.
CleanEx	HS_ZNF667.
Genevestigator	Q5HYK9.
GermOnline	ENSG00000198046. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 16 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 14 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF667. human.
GenomeRNAi	63934.
NextBio	65694.
SOURCE	Search...

Entry information

Entry name

ZN667_HUMAN

Accession

Primary (citable) accession number: Q5HYK9
Secondary accession number(s): B2RMS6 , B9EK36, Q6B093, Q9H807

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.