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Protein

Zinc finger protein 667

Gene

ZNF667

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri583 – 60523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 667
Gene namesi
Name:ZNF667
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28854. ZNF667.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670514.

Polymorphism and mutation databases

BioMutaiZNF667.
DMDMi215273933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Zinc finger protein 667PRO_0000251897Add
BLAST

Proteomic databases

MaxQBiQ5HYK9.
PaxDbiQ5HYK9.
PRIDEiQ5HYK9.

PTM databases

iPTMnetiQ5HYK9.
PhosphoSiteiQ5HYK9.

Expressioni

Gene expression databases

BgeeiQ5HYK9.
CleanExiHS_ZNF667.
ExpressionAtlasiQ5HYK9. baseline and differential.
GenevisibleiQ5HYK9. HS.

Organism-specific databases

HPAiHPA046673.

Interactioni

Protein-protein interaction databases

BioGridi122002. 2 interactions.
IntActiQ5HYK9. 1 interaction.
MINTiMINT-7007374.
STRINGi9606.ENSP00000292069.

Structurei

3D structure databases

ProteinModelPortaliQ5HYK9.
SMRiQ5HYK9. Positions 8-58, 131-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri144 – 16623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri172 – 19423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 52123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri527 – 54923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri555 – 57723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri583 – 60523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
ENOG41112RA. LUCA.
GeneTreeiENSGT00390000021477.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5HYK9.
KOiK09228.
OMAiVCNRHSS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5HYK9.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HYK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSARGKSKS KAPITFGDLA IYFSQEEWEW LSPIQKDLYE DVMLENYRNL
60 70 80 90 100
VSLGLSFRRP NVITLLEKGK APWMVEPVRR RRAPDSGSKC ETKKLPPNQC
110 120 130 140 150
NKSGQSICQK LVSAQQKAPT RKSGCNKNSV LVKPKKGHSG KKPLKCNDCG
160 170 180 190 200
KTFSRSFSLK LHQNIHTGEK PFECSNCRKA FRQISSILLH QRIHSGKKSH
210 220 230 240 250
ECNKCGESFN QRTTLILHMR IHDGKEILDC GKALSQCQSF NIHQKIHVVG
260 270 280 290 300
NVCQCRKCGK AFNQMSSLLL HKKIHNGKKT HKYNKCGRGF KKKSVFVVHK
310 320 330 340 350
RIHAGEKIPE NAKALSQSLQ QRSHHLENPF KCRKCGKLFN RISPLMLHQR
360 370 380 390 400
IHTSEKPYKC DKCDKFFRRL STLILHLRIH NGEKLYRCNK CEKVCNRHSS
410 420 430 440 450
LIQHQKVHTK KKKLFECKEC GKMFSGTANL KIHQNIHSEE KPFKCNKCSK
460 470 480 490 500
VFGRQSFLIE HQRIHTGEKP YQCEECGKAF SHRISLTRHK RIHTEDRPYE
510 520 530 540 550
CDQCGKAFSQ SAHLAQHERI HTGEKPYTCK TCGKAFSQRT SLILHERSHT
560 570 580 590 600
GEKPYECNEC GKAFSSGSDL IRHQRSHSSE KPYECSKCGK AYSRSSSLIR
610
HQNTHSEEKA
Length:610
Mass (Da):70,161
Last modified:November 25, 2008 - v2
Checksum:i658048EF4605B884
GO

Sequence cautioni

The sequence AAH74898.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH74899.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391S → P in CAI46040 (PubMed:17974005).Curated
Sequence conflicti512 – 5121A → T in AK024073 (PubMed:14702039).Curated
Sequence conflicti593 – 5931S → G in AK024073 (PubMed:14702039).Curated
Sequence conflicti593 – 5931S → G in CAI46040 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341P → L.3 Publications
Corresponds to variant rs35914474 [ dbSNP | Ensembl ].
VAR_047330
Natural varianti260 – 2601K → R.
Corresponds to variant rs3760849 [ dbSNP | Ensembl ].
VAR_027716
Natural varianti540 – 5401T → A.
Corresponds to variant rs12610019 [ dbSNP | Ensembl ].
VAR_027717

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024073 mRNA. No translation available.
AK056508 mRNA. Translation: BAG51734.1.
BX647401 mRNA. Translation: CAI46040.1.
AC006116 Genomic DNA. No translation available.
AC013256 Genomic DNA. No translation available.
BC074898 mRNA. Translation: AAH74898.2. Different initiation.
BC074899 mRNA. Translation: AAH74899.2. Different initiation.
BC136388 mRNA. Translation: AAI36389.1.
BC150593 mRNA. Translation: AAI50594.1.
CCDSiCCDS12944.1.
RefSeqiNP_071386.3. NM_022103.3.
XP_011525509.1. XM_011527207.1.
XP_011525510.1. XM_011527208.1.
XP_011525511.1. XM_011527209.1.
UniGeneiHs.676605.

Genome annotation databases

EnsembliENST00000292069; ENSP00000292069; ENSG00000198046.
ENST00000504904; ENSP00000439402; ENSG00000198046.
GeneIDi63934.
KEGGihsa:63934.
UCSCiuc002qnd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024073 mRNA. No translation available.
AK056508 mRNA. Translation: BAG51734.1.
BX647401 mRNA. Translation: CAI46040.1.
AC006116 Genomic DNA. No translation available.
AC013256 Genomic DNA. No translation available.
BC074898 mRNA. Translation: AAH74898.2. Different initiation.
BC074899 mRNA. Translation: AAH74899.2. Different initiation.
BC136388 mRNA. Translation: AAI36389.1.
BC150593 mRNA. Translation: AAI50594.1.
CCDSiCCDS12944.1.
RefSeqiNP_071386.3. NM_022103.3.
XP_011525509.1. XM_011527207.1.
XP_011525510.1. XM_011527208.1.
XP_011525511.1. XM_011527209.1.
UniGeneiHs.676605.

3D structure databases

ProteinModelPortaliQ5HYK9.
SMRiQ5HYK9. Positions 8-58, 131-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122002. 2 interactions.
IntActiQ5HYK9. 1 interaction.
MINTiMINT-7007374.
STRINGi9606.ENSP00000292069.

PTM databases

iPTMnetiQ5HYK9.
PhosphoSiteiQ5HYK9.

Polymorphism and mutation databases

BioMutaiZNF667.
DMDMi215273933.

Proteomic databases

MaxQBiQ5HYK9.
PaxDbiQ5HYK9.
PRIDEiQ5HYK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292069; ENSP00000292069; ENSG00000198046.
ENST00000504904; ENSP00000439402; ENSG00000198046.
GeneIDi63934.
KEGGihsa:63934.
UCSCiuc002qnd.4. human.

Organism-specific databases

CTDi63934.
GeneCardsiZNF667.
HGNCiHGNC:28854. ZNF667.
HPAiHPA046673.
MIMi611024. gene.
neXtProtiNX_Q5HYK9.
PharmGKBiPA142670514.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
ENOG41112RA. LUCA.
GeneTreeiENSGT00390000021477.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5HYK9.
KOiK09228.
OMAiVCNRHSS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5HYK9.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF667. human.
GenomeRNAii63934.
PROiQ5HYK9.
SOURCEiSearch...

Gene expression databases

BgeeiQ5HYK9.
CleanExiHS_ZNF667.
ExpressionAtlasiQ5HYK9. baseline and differential.
GenevisibleiQ5HYK9. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-134.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-134.
    Tissue: Endometrium.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-134.
    Tissue: Lung and Testis.

Entry informationi

Entry nameiZN667_HUMAN
AccessioniPrimary (citable) accession number: Q5HYK9
Secondary accession number(s): B2RMS6
, B9EK36, Q6B093, Q9H807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 25, 2008
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.