Q5HYK7 (SH319_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 domain-containing protein 19

Alternative name(s):
ADAM-binding protein Eve-1
EEN-binding protein
Short name=EBP

Gene names

Name:

SH3D19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	790 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization. Ref.6 Ref.7 Ref.9
Subunit structure	Interacts with ADAM12. Isoform 4 and isoform 5 (but not isoform 1 and isoform 2) interact with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2. Interacts with SH3YL1 By similarity. Ref.6 Ref.7
Subcellular location	Cytoplasm. Nucleus. Note: Is recruited to the nucleus by the MLL-EEN fusion protein;. Ref.6
Tissue specificity	Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes. Ref.7
Sequence similarities	Contains 5 SH3 domains.
Caution	It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution	The sequence AAI08891.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI08892.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI08893.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI08894.1 differs from that shown. Reason: Erroneous initiation. The sequence BAF83714.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI46052.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Traceable author statement. Source: Reactome cytoskeleton organization Inferred from mutant phenotype Ref.9. Source: UniProtKB positive regulation of membrane protein ectodomain proteolysis Inferred from mutant phenotype Ref.7. Source: BHF-UCL post-Golgi vesicle-mediated transport Traceable author statement. Source: Reactome regulation of cell morphogenesis Inferred from mutant phenotype Ref.9. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA cytosol Traceable author statement. Source: Reactome nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay Ref.7. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5HYK7-1)

Also known as: Eve-1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5HYK7-2)

Also known as: Eve-1b;

The sequence of this isoform differs from the canonical sequence as follows:
     415-437: Missing.

Isoform 3 (identifier: Q5HYK7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     232-268: DPFQLPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKC → G
     415-437: Missing.

Isoform 4 (identifier: Q5HYK7-4)

Also known as: Eve-1c;

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.

Isoform 5 (identifier: Q5HYK7-5)

Also known as: Eve-1d;

The sequence of this isoform differs from the canonical sequence as follows:
     1-370: Missing.
     415-437: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 790	790	SH3 domain-containing protein 19		PRO_0000318197
Regions
	Domain	415 – 470	56	SH3 1
	Domain	495 – 554	60	SH3 2
	Domain	571 – 630	60	SH3 3
	Domain	661 – 720	60	SH3 4
	Domain	730 – 789	60	SH3 5
	Region	342 – 358	17	Interaction with SH3GL1
	Compositional bias	86 – 350	265	Pro-rich
Amino acid modifications
	Modified residue	677	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 370	370	Missing in isoform 4 and isoform 5.		VSP_031182
	Alternative sequence	232 – 268	37	DPFQL…KPGKC → G in isoform 3.		VSP_031183
	Alternative sequence	415 – 437	23	Missing in isoform 2, isoform 3 and isoform 5.		VSP_031184
Experimental info
	Sequence conflict	1	1	M → V in CAI46052. Ref.2
	Sequence conflict	264	1	K → R in CAI46052. Ref.2
	Sequence conflict	267	1	K → E in CAI46052. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Eve-1a) [UniParc]. Last modified February 5, 2008. Version 2. Checksum: FA860FB41FE8CDD5	FASTA	790	86,525
	10 20 30 40 50 60 MNIMNTEQSQ NSIVSRIKVF EGQTNIETSG LPKKPEITPR SLPPKPTVSS GKPSVAPKPA 70 80 90 100 110 120 ANRASGEWDS GTENRLKVTS KEGLTPYPPL QEAGSIPVTK PELPKKPNPG LIRSVNPEIP 130 140 150 160 170 180 GRGPLAESSD SGKKVPTPAP RPLLLKKSVS SENPTYPSAP LKPVTVPPRL AGASQAKAYK 190 200 210 220 230 240 SLGEGPPANP PVPVLQSKPL VDIDLISFDD DVLPTPSGNL AEESVGSEMV LDPFQLPAKT 250 260 270 280 290 300 EPIKERAVQP APTRKPTVIR IPAKPGKCLH EDPQSPPPLP AEKPIGNTFS TVSGKLSNVE 310 320 330 340 350 360 RTRNLESNHP GQTGGFVRVP PRLPPRPVNG KTIPTQQPPT KVPPERPPPP KLSATRRSNK 370 380 390 400 410 420 KLPFNRSSSD MDLQKKQSNL ATGLSKAKSQ VFKNQDPVLP PRPKPGHPLY SKYMLSVPHG 430 440 450 460 470 480 IANEDIVSQN PGELSCKRGD VLVMLKQTEN NYLECQKGED TGRVHLSQMK IITPLDEHLR 490 500 510 520 530 540 SRPNDPSHAQ KPVDSGAPHA VVLHDFPAEQ VDDLNLTSGE IVYLLEKIDT DWYRGNCRNQ 550 560 570 580 590 600 IGIFPANYVK VIIDIPEGGN GKRECVSSHC VKGSRCVARF EYIGEQKDEL SFSEGEIIIL 610 620 630 640 650 660 KEYVNEEWAR GEVRGRTGIF PLNFVEPVED YPTSGANVLS TKVPLKTKKE DSGSNSQVNS 670 680 690 700 710 720 LPAEWCEALH SFTAETSDDL SFKRGDRIQI LERLDSDWCR GRLQDREGIF PAVFVRPCPA 730 740 750 760 770 780 EAKSMLAIVP KGRKAKALYD FRGENEDELS FKAGDIITEL ESVDDDWMSG ELMGKSGIFP 790 KNYIQFLQIS
	Isoform 2 (Eve-1b) [UniParc]. Checksum: 9DC52412DD810D43	FASTA	767	84,136
	10 20 30 40 50 60 MNIMNTEQSQ NSIVSRIKVF EGQTNIETSG LPKKPEITPR SLPPKPTVSS GKPSVAPKPA 70 80 90 100 110 120 ANRASGEWDS GTENRLKVTS KEGLTPYPPL QEAGSIPVTK PELPKKPNPG LIRSVNPEIP 130 140 150 160 170 180 GRGPLAESSD SGKKVPTPAP RPLLLKKSVS SENPTYPSAP LKPVTVPPRL AGASQAKAYK 190 200 210 220 230 240 SLGEGPPANP PVPVLQSKPL VDIDLISFDD DVLPTPSGNL AEESVGSEMV LDPFQLPAKT 250 260 270 280 290 300 EPIKERAVQP APTRKPTVIR IPAKPGKCLH EDPQSPPPLP AEKPIGNTFS TVSGKLSNVE 310 320 330 340 350 360 RTRNLESNHP GQTGGFVRVP PRLPPRPVNG KTIPTQQPPT KVPPERPPPP KLSATRRSNK 370 380 390 400 410 420 KLPFNRSSSD MDLQKKQSNL ATGLSKAKSQ VFKNQDPVLP PRPKPGHPLY SKYMRGDVLV 430 440 450 460 470 480 MLKQTENNYL ECQKGEDTGR VHLSQMKIIT PLDEHLRSRP NDPSHAQKPV DSGAPHAVVL 490 500 510 520 530 540 HDFPAEQVDD LNLTSGEIVY LLEKIDTDWY RGNCRNQIGI FPANYVKVII DIPEGGNGKR 550 560 570 580 590 600 ECVSSHCVKG SRCVARFEYI GEQKDELSFS EGEIIILKEY VNEEWARGEV RGRTGIFPLN 610 620 630 640 650 660 FVEPVEDYPT SGANVLSTKV PLKTKKEDSG SNSQVNSLPA EWCEALHSFT AETSDDLSFK 670 680 690 700 710 720 RGDRIQILER LDSDWCRGRL QDREGIFPAV FVRPCPAEAK SMLAIVPKGR KAKALYDFRG 730 740 750 760 ENEDELSFKA GDIITELESV DDDWMSGELM GKSGIFPKNY IQFLQIS
	Isoform 3 [UniParc]. Checksum: 34B191C247F3D367	FASTA	731	80,131
	10 20 30 40 50 60 MNIMNTEQSQ NSIVSRIKVF EGQTNIETSG LPKKPEITPR SLPPKPTVSS GKPSVAPKPA 70 80 90 100 110 120 ANRASGEWDS GTENRLKVTS KEGLTPYPPL QEAGSIPVTK PELPKKPNPG LIRSVNPEIP 130 140 150 160 170 180 GRGPLAESSD SGKKVPTPAP RPLLLKKSVS SENPTYPSAP LKPVTVPPRL AGASQAKAYK 190 200 210 220 230 240 SLGEGPPANP PVPVLQSKPL VDIDLISFDD DVLPTPSGNL AEESVGSEMV LGLHEDPQSP 250 260 270 280 290 300 PPLPAEKPIG NTFSTVSGKL SNVERTRNLE SNHPGQTGGF VRVPPRLPPR PVNGKTIPTQ 310 320 330 340 350 360 QPPTKVPPER PPPPKLSATR RSNKKLPFNR SSSDMDLQKK QSNLATGLSK AKSQVFKNQD 370 380 390 400 410 420 PVLPPRPKPG HPLYSKYMRG DVLVMLKQTE NNYLECQKGE DTGRVHLSQM KIITPLDEHL 430 440 450 460 470 480 RSRPNDPSHA QKPVDSGAPH AVVLHDFPAE QVDDLNLTSG EIVYLLEKID TDWYRGNCRN 490 500 510 520 530 540 QIGIFPANYV KVIIDIPEGG NGKRECVSSH CVKGSRCVAR FEYIGEQKDE LSFSEGEIII 550 560 570 580 590 600 LKEYVNEEWA RGEVRGRTGI FPLNFVEPVE DYPTSGANVL STKVPLKTKK EDSGSNSQVN 610 620 630 640 650 660 SLPAEWCEAL HSFTAETSDD LSFKRGDRIQ ILERLDSDWC RGRLQDREGI FPAVFVRPCP 670 680 690 700 710 720 AEAKSMLAIV PKGRKAKALY DFRGENEDEL SFKAGDIITE LESVDDDWMS GELMGKSGIF 730 PKNYIQFLQI S
	Isoform 4 (Eve-1c) [UniParc]. Checksum: C49CE5F2A5DCAF1C	FASTA	420	47,056
	10 20 30 40 50 60 MDLQKKQSNL ATGLSKAKSQ VFKNQDPVLP PRPKPGHPLY SKYMLSVPHG IANEDIVSQN 70 80 90 100 110 120 PGELSCKRGD VLVMLKQTEN NYLECQKGED TGRVHLSQMK IITPLDEHLR SRPNDPSHAQ 130 140 150 160 170 180 KPVDSGAPHA VVLHDFPAEQ VDDLNLTSGE IVYLLEKIDT DWYRGNCRNQ IGIFPANYVK 190 200 210 220 230 240 VIIDIPEGGN GKRECVSSHC VKGSRCVARF EYIGEQKDEL SFSEGEIIIL KEYVNEEWAR 250 260 270 280 290 300 GEVRGRTGIF PLNFVEPVED YPTSGANVLS TKVPLKTKKE DSGSNSQVNS LPAEWCEALH 310 320 330 340 350 360 SFTAETSDDL SFKRGDRIQI LERLDSDWCR GRLQDREGIF PAVFVRPCPA EAKSMLAIVP 370 380 390 400 410 420 KGRKAKALYD FRGENEDELS FKAGDIITEL ESVDDDWMSG ELMGKSGIFP KNYIQFLQIS
	Isoform 5 (Eve-1d) [UniParc]. Checksum: 813BAA810E48B27B	FASTA	397	44,667
	10 20 30 40 50 60 MDLQKKQSNL ATGLSKAKSQ VFKNQDPVLP PRPKPGHPLY SKYMRGDVLV MLKQTENNYL 70 80 90 100 110 120 ECQKGEDTGR VHLSQMKIIT PLDEHLRSRP NDPSHAQKPV DSGAPHAVVL HDFPAEQVDD 130 140 150 160 170 180 LNLTSGEIVY LLEKIDTDWY RGNCRNQIGI FPANYVKVII DIPEGGNGKR ECVSSHCVKG 190 200 210 220 230 240 SRCVARFEYI GEQKDELSFS EGEIIILKEY VNEEWARGEV RGRTGIFPLN FVEPVEDYPT 250 260 270 280 290 300 SGANVLSTKV PLKTKKEDSG SNSQVNSLPA EWCEALHSFT AETSDDLSFK RGDRIQILER 310 320 330 340 350 360 LDSDWCRGRL QDREGIFPAV FVRPCPAEAK SMLAIVPKGR KAKALYDFRG ENEDELSFKA 370 380 390 GDIITELESV DDDWMSGELM GKSGIFPKNY IQFLQIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 275-790 (ISOFORM 1). Tissue: Amygdala.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon endothelium and Testis.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 312-790 (ISOFORM 1). Tissue: Brain, Chondrosarcoma and Lung.
[6]	"Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein." Yam J.W., Jin D.Y., So C.W., Chan L.C. Blood 103:1445-1453(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SH3GL1 AND SOS2.
[7]	"ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands." Tanaka M., Nanba D., Mori S., Shiba F., Ishiguro H., Yoshino K., Matsuura N., Higashiyama S. J. Biol. Chem. 279:41950-41959(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ALTERNATIVE SPLICING (ISOFORMS 1; 2; 4 AND 5), TISSUE SPECIFICITY, INTERACTION WITH ADAM9; ADAM10; ADAM12; ADAM15 AND ADAM17.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration." Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J. BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK291025 mRNA. Translation: BAF83714.1. Different initiation. AK294476 mRNA. Translation: BAH11782.1. AL133047 mRNA. Translation: CAB61374.1. BX647422 mRNA. Translation: CAI46052.1. Different initiation. AC095055 Genomic DNA. No translation available. CH471056 Genomic DNA. Translation: EAX04986.1. BC032468 mRNA. Translation: AAH32468.1. BC045742 mRNA. Translation: AAH45742.1. BC085613 mRNA. Translation: AAH85613.2. BC108890 mRNA. Translation: AAI08891.1. Different initiation. BC108891 mRNA. Translation: AAI08892.1. Different initiation. BC108892 mRNA. Translation: AAI08893.1. Different initiation. BC108893 mRNA. Translation: AAI08894.1. Different initiation.
IPI	IPI00472155. IPI00884903. IPI00884923. IPI00885020. IPI00885212.
RefSeq	NP_001009555.3. NM_001009555.3. NP_001122395.1. NM_001128923.1. NP_001122396.1. NM_001128924.1. NP_001230278.1. NM_001243349.1.
UniGene	Hs.567725.
3D structure databases
HSSP	HSSP built from PDB template 1GRI based on UniProtKB P62993.
ProteinModelPortal	Q5HYK7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5HYK7. 4 interactions.
MINT	MINT-1203586.
STRING	9606.ENSP00000302913.
PTM databases
PhosphoSite	Q5HYK7.
Polymorphism databases
DMDM	166977688.
Proteomic databases
PaxDb	Q5HYK7.
PRIDE	Q5HYK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304527; ENSP00000302913; ENSG00000109686. ENST00000409252; ENSP00000386848; ENSG00000109686. ENST00000409598; ENSP00000387030; ENSG00000109686. ENST00000424281; ENSP00000404542; ENSG00000109686. ENST00000427414; ENSP00000415694; ENSG00000109686. ENST00000455740; ENSP00000416708; ENSG00000109686. ENST00000514152; ENSP00000423449; ENSG00000109686.
GeneID	152503.
KEGG	hsa:152503.
UCSC	uc003imc.2. human. uc003ime.2. human. uc010ipl.1. human.
Organism-specific databases
CTD	152503.
GeneCards	GC04M152041.
HGNC	HGNC:30418. SH3D19.
HPA	HPA016424.
MIM	608674. gene.
neXtProt	NX_Q5HYK7.
PharmGKB	PA162403244.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG296456.
HOVERGEN	HBG108486.
InParanoid	Q5HYK7.
OMA	MNIMNTE.
OrthoDB	EOG4GB75H.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	Q5HYK7.
Bgee	Q5HYK7.
CleanEx	HS_SH3D19.
Genevestigator	Q5HYK7.
Family and domain databases
InterPro	IPR000108. p67phox. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00018. SH3_1. 4 hits. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 5 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 5 hits.
PROSITE	PS50002. SH3. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SH3D19. human.
GenomeRNAi	152503.
NextBio	86965.
SOURCE	Search...

Entry information

Entry name

SH319_HUMAN

Accession

Primary (citable) accession number: Q5HYK7
Secondary accession number(s): B7Z296 , Q08EK1, Q32N10, Q5U3B8, Q86XB3, Q8N5E7, Q9UFC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.