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Q5HYK3 (COQ5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

EC=2.1.1.201
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5
Gene names
Name:COQ5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP-Rule MF_01813

Catalytic activity

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP-Rule MF_01813

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01813

Subcellular location

Mitochondrion By similarity HAMAP-Rule MF_01813.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.

Ontologies

Keywords
   Biological processUbiquinone biosynthesis
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransit peptide
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsmall molecule metabolic process

Traceable author statement. Source: Reactome

ubiquinone biosynthetic process

Traceable author statement. Source: Reactome

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5HYK3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5HYK3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     119-170: Missing.
     189-327: YRAGLAWVLG...IVAIHSGFKL → HDRRCRLSQG...GIWSVSLLNC
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4949Mitochondrion Potential
Chain50 – 3272782-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial HAMAP-Rule MF_01813
PRO_0000228628

Natural variations

Alternative sequence119 – 17052Missing in isoform 2.
VSP_017681
Alternative sequence189 – 327139YRAGL…SGFKL → HDRRCRLSQGDLRKSNIRHC GHSFWLQTLIPFLSWSMNQS YPVESLELKDNLANETAAEH LLLRIRALDSCLNRTVSKWK NKFLSLFYSFLWSCFSPSPR GIWSVSLLNC in isoform 2.
VSP_017682
Natural variant1521A → T. Ref.2 Ref.5
Corresponds to variant rs3742049 [ dbSNP | Ensembl ].
VAR_025702

Experimental info

Sequence conflict781K → R in CAI46073. Ref.3
Sequence conflict2911F → S in AAH04916. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 21, 2006. Version 2.
Checksum: 7D601DF6E74FFCC4

FASTA32737,140
        10         20         30         40         50         60 
MAAPGSCALW SYCGRGWSRA MRGCQLLGLR SSWPGDLLSA RLLSQEKRAA ETHFGFETVS 

        70         80         90        100        110        120 
EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW KMHPLPGTQL LDVAGGTGDI 

       130        140        150        160        170        180 
AFRFLNYVQS QHQRKQKRQL RAQQNLSWEE IAKEYQNEED SLGGSRVVVC DINKEMLKVG 

       190        200        210        220        230        240 
KQKALAQGYR AGLAWVLGDA EELPFDDDKF DIYTIAFGIR NVTHIDQALQ EAHRVLKPGG 

       250        260        270        280        290        300 
RFLCLEFSQV NNPLISRLYD LYSFQVIPVL GEVIAGDWKS YQYLVESIRR FPSQEEFKDM 

       310        320 
IEDAGFHKVT YESLTSGIVA IHSGFKL 

« Hide

Isoform 2 [UniParc].

Checksum: FBE03D6ED4624CF9
Show »

FASTA24627,914

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cerebellum.
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-152.
Tissue: Coronary artery.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Adipose tissue.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-152.
Tissue: Lung.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057777 mRNA. Translation: BAB71567.1.
AK222610 mRNA. Translation: BAD96330.1.
AK293656 mRNA. Translation: BAG57105.1.
BX647562 mRNA. Translation: CAI46073.1.
CH471054 Genomic DNA. Translation: EAW98198.1.
BC004916 mRNA. Translation: AAH04916.2.
BC107874 mRNA. Translation: AAI07875.1.
RefSeqNP_115690.3. NM_032314.3.
UniGeneHs.17250.

3D structure databases

ProteinModelPortalQ5HYK3.
SMRQ5HYK3. Positions 96-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124001. 1 interaction.
STRING9606.ENSP00000288532.

PTM databases

PhosphoSiteQ5HYK3.

Polymorphism databases

DMDM90111987.

Proteomic databases

PaxDbQ5HYK3.
PRIDEQ5HYK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000288532; ENSP00000288532; ENSG00000110871. [Q5HYK3-1]
GeneID84274.
KEGGhsa:84274.
UCSCuc001tyn.3. human. [Q5HYK3-1]

Organism-specific databases

CTD84274.
GeneCardsGC12M120941.
HGNCHGNC:28722. COQ5.
HPAHPA049487.
neXtProtNX_Q5HYK3.
PharmGKBPA143485438.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2226.
HOGENOMHOG000249463.
HOVERGENHBG081303.
InParanoidQ5HYK3.
KOK06127.
OMAIWKRFTI.
OrthoDBEOG712TXJ.
PhylomeDBQ5HYK3.
TreeFamTF106217.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
UniPathwayUPA00232.

Gene expression databases

ArrayExpressQ5HYK3.
BgeeQ5HYK3.
CleanExHS_COQ5.
GenevestigatorQ5HYK3.

Family and domain databases

HAMAPMF_01813. UbiE_methyltran.
InterProIPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCOQ5. human.
GenomeRNAi84274.
NextBio73846.
PROQ5HYK3.

Entry information

Entry nameCOQ5_HUMAN
AccessionPrimary (citable) accession number: Q5HYK3
Secondary accession number(s): B4DEJ4 expand/collapse secondary AC list , Q32Q28, Q53HH0, Q96LV1, Q9BSP8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM