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Q5HYK3

- COQ5_HUMAN

UniProt

Q5HYK3 - COQ5_HUMAN

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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

COQ5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).By similarity

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.

Pathwayi

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. small molecule metabolic process Source: Reactome
  2. ubiquinone biosynthetic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiREACT_160111. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC:2.1.1.201)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5
Gene namesi
Name:COQ5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:28722. COQ5.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
BLAST
Chaini50 – 3272782-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialPRO_0000228628Add
BLAST

Proteomic databases

MaxQBiQ5HYK3.
PaxDbiQ5HYK3.
PRIDEiQ5HYK3.

PTM databases

PhosphoSiteiQ5HYK3.

Expressioni

Gene expression databases

BgeeiQ5HYK3.
CleanExiHS_COQ5.
ExpressionAtlasiQ5HYK3. baseline.
GenevestigatoriQ5HYK3.

Organism-specific databases

HPAiHPA049487.

Interactioni

Protein-protein interaction databases

BioGridi124001. 3 interactions.
STRINGi9606.ENSP00000288532.

Structurei

3D structure databases

ProteinModelPortaliQ5HYK3.
SMRiQ5HYK3. Positions 164-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG2226.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ5HYK3.
KOiK06127.
OMAiGSHVMIC.
OrthoDBiEOG712TXJ.
PhylomeDBiQ5HYK3.
TreeFamiTF106217.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. UbiE_methyltran.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5HYK3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGSCALW SYCGRGWSRA MRGCQLLGLR SSWPGDLLSA RLLSQEKRAA
60 70 80 90 100
ETHFGFETVS EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW
110 120 130 140 150
KMHPLPGTQL LDVAGGTGDI AFRFLNYVQS QHQRKQKRQL RAQQNLSWEE
160 170 180 190 200
IAKEYQNEED SLGGSRVVVC DINKEMLKVG KQKALAQGYR AGLAWVLGDA
210 220 230 240 250
EELPFDDDKF DIYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFSQV
260 270 280 290 300
NNPLISRLYD LYSFQVIPVL GEVIAGDWKS YQYLVESIRR FPSQEEFKDM
310 320
IEDAGFHKVT YESLTSGIVA IHSGFKL
Length:327
Mass (Da):37,140
Last modified:March 21, 2006 - v2
Checksum:i7D601DF6E74FFCC4
GO
Isoform 2 (identifier: Q5HYK3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-170: Missing.
     189-327: YRAGLAWVLG...IVAIHSGFKL → HDRRCRLSQG...GIWSVSLLNC

Note: No experimental confirmation available.

Show »
Length:246
Mass (Da):27,914
Checksum:iFBE03D6ED4624CF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781K → R in CAI46073. (PubMed:17974005)Curated
Sequence conflicti291 – 2911F → S in AAH04916. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521A → T.2 Publications
Corresponds to variant rs3742049 [ dbSNP | Ensembl ].
VAR_025702

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 17052Missing in isoform 2. 1 PublicationVSP_017681Add
BLAST
Alternative sequencei189 – 327139YRAGL…SGFKL → HDRRCRLSQGDLRKSNIRHC GHSFWLQTLIPFLSWSMNQS YPVESLELKDNLANETAAEH LLLRIRALDSCLNRTVSKWK NKFLSLFYSFLWSCFSPSPR GIWSVSLLNC in isoform 2. 1 PublicationVSP_017682Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057777 mRNA. Translation: BAB71567.1.
AK222610 mRNA. Translation: BAD96330.1.
AK293656 mRNA. Translation: BAG57105.1.
BX647562 mRNA. Translation: CAI46073.1.
CH471054 Genomic DNA. Translation: EAW98198.1.
BC004916 mRNA. Translation: AAH04916.2.
BC107874 mRNA. Translation: AAI07875.1.
CCDSiCCDS31912.1. [Q5HYK3-1]
RefSeqiNP_115690.3. NM_032314.3. [Q5HYK3-1]
UniGeneiHs.17250.

Genome annotation databases

EnsembliENST00000288532; ENSP00000288532; ENSG00000110871. [Q5HYK3-1]
GeneIDi84274.
KEGGihsa:84274.
UCSCiuc001tyn.3. human. [Q5HYK3-1]

Polymorphism databases

DMDMi90111987.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057777 mRNA. Translation: BAB71567.1 .
AK222610 mRNA. Translation: BAD96330.1 .
AK293656 mRNA. Translation: BAG57105.1 .
BX647562 mRNA. Translation: CAI46073.1 .
CH471054 Genomic DNA. Translation: EAW98198.1 .
BC004916 mRNA. Translation: AAH04916.2 .
BC107874 mRNA. Translation: AAI07875.1 .
CCDSi CCDS31912.1. [Q5HYK3-1 ]
RefSeqi NP_115690.3. NM_032314.3. [Q5HYK3-1 ]
UniGenei Hs.17250.

3D structure databases

ProteinModelPortali Q5HYK3.
SMRi Q5HYK3. Positions 164-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124001. 3 interactions.
STRINGi 9606.ENSP00000288532.

PTM databases

PhosphoSitei Q5HYK3.

Polymorphism databases

DMDMi 90111987.

Proteomic databases

MaxQBi Q5HYK3.
PaxDbi Q5HYK3.
PRIDEi Q5HYK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000288532 ; ENSP00000288532 ; ENSG00000110871 . [Q5HYK3-1 ]
GeneIDi 84274.
KEGGi hsa:84274.
UCSCi uc001tyn.3. human. [Q5HYK3-1 ]

Organism-specific databases

CTDi 84274.
GeneCardsi GC12M120941.
HGNCi HGNC:28722. COQ5.
HPAi HPA049487.
neXtProti NX_Q5HYK3.
PharmGKBi PA143485438.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2226.
GeneTreei ENSGT00390000001654.
HOGENOMi HOG000249463.
HOVERGENi HBG081303.
InParanoidi Q5HYK3.
KOi K06127.
OMAi GSHVMIC.
OrthoDBi EOG712TXJ.
PhylomeDBi Q5HYK3.
TreeFami TF106217.

Enzyme and pathway databases

UniPathwayi UPA00232 .
Reactomei REACT_160111. Ubiquinol biosynthesis.

Miscellaneous databases

ChiTaRSi COQ5. human.
GenomeRNAii 84274.
NextBioi 73846.
PROi Q5HYK3.

Gene expression databases

Bgeei Q5HYK3.
CleanExi HS_COQ5.
ExpressionAtlasi Q5HYK3. baseline.
Genevestigatori Q5HYK3.

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
HAMAPi MF_01813. UbiE_methyltran.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view ]
Pfami PF01209. Ubie_methyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-152.
    Tissue: Coronary artery.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-152.
    Tissue: Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOQ5_HUMAN
AccessioniPrimary (citable) accession number: Q5HYK3
Secondary accession number(s): B4DEJ4
, Q32Q28, Q53HH0, Q96LV1, Q9BSP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3