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Q5HYK3

- COQ5_HUMAN

UniProt

Q5HYK3 - COQ5_HUMAN

Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

COQ5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.

    Pathwayi

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. small molecule metabolic process Source: Reactome
    2. ubiquinone biosynthetic process Source: Reactome

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    ReactomeiREACT_160111. Ubiquinol biosynthesis.
    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC:2.1.1.201)
    Alternative name(s):
    Ubiquinone biosynthesis methyltransferase COQ5
    Gene namesi
    Name:COQ5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:28722. COQ5.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485438.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
    BLAST
    Chaini50 – 3272782-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialPRO_0000228628Add
    BLAST

    Proteomic databases

    MaxQBiQ5HYK3.
    PaxDbiQ5HYK3.
    PRIDEiQ5HYK3.

    PTM databases

    PhosphoSiteiQ5HYK3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5HYK3.
    BgeeiQ5HYK3.
    CleanExiHS_COQ5.
    GenevestigatoriQ5HYK3.

    Organism-specific databases

    HPAiHPA049487.

    Interactioni

    Protein-protein interaction databases

    BioGridi124001. 1 interaction.
    STRINGi9606.ENSP00000288532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HYK3.
    SMRiQ5HYK3. Positions 96-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2226.
    HOGENOMiHOG000249463.
    HOVERGENiHBG081303.
    InParanoidiQ5HYK3.
    KOiK06127.
    OMAiGSHVMIC.
    OrthoDBiEOG712TXJ.
    PhylomeDBiQ5HYK3.
    TreeFamiTF106217.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    HAMAPiMF_01813. UbiE_methyltran.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view]
    PfamiPF01209. Ubie_methyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5HYK3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPGSCALW SYCGRGWSRA MRGCQLLGLR SSWPGDLLSA RLLSQEKRAA    50
    ETHFGFETVS EEEKGGKVYQ VFESVAKKYD VMNDMMSLGI HRVWKDLLLW 100
    KMHPLPGTQL LDVAGGTGDI AFRFLNYVQS QHQRKQKRQL RAQQNLSWEE 150
    IAKEYQNEED SLGGSRVVVC DINKEMLKVG KQKALAQGYR AGLAWVLGDA 200
    EELPFDDDKF DIYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFSQV 250
    NNPLISRLYD LYSFQVIPVL GEVIAGDWKS YQYLVESIRR FPSQEEFKDM 300
    IEDAGFHKVT YESLTSGIVA IHSGFKL 327
    Length:327
    Mass (Da):37,140
    Last modified:March 21, 2006 - v2
    Checksum:i7D601DF6E74FFCC4
    GO
    Isoform 2 (identifier: Q5HYK3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-170: Missing.
         189-327: YRAGLAWVLG...IVAIHSGFKL → HDRRCRLSQG...GIWSVSLLNC

    Note: No experimental confirmation available.

    Show »
    Length:246
    Mass (Da):27,914
    Checksum:iFBE03D6ED4624CF9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781K → R in CAI46073. (PubMed:17974005)Curated
    Sequence conflicti291 – 2911F → S in AAH04916. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521A → T.2 Publications
    Corresponds to variant rs3742049 [ dbSNP | Ensembl ].
    VAR_025702

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei119 – 17052Missing in isoform 2. 1 PublicationVSP_017681Add
    BLAST
    Alternative sequencei189 – 327139YRAGL…SGFKL → HDRRCRLSQGDLRKSNIRHC GHSFWLQTLIPFLSWSMNQS YPVESLELKDNLANETAAEH LLLRIRALDSCLNRTVSKWK NKFLSLFYSFLWSCFSPSPR GIWSVSLLNC in isoform 2. 1 PublicationVSP_017682Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057777 mRNA. Translation: BAB71567.1.
    AK222610 mRNA. Translation: BAD96330.1.
    AK293656 mRNA. Translation: BAG57105.1.
    BX647562 mRNA. Translation: CAI46073.1.
    CH471054 Genomic DNA. Translation: EAW98198.1.
    BC004916 mRNA. Translation: AAH04916.2.
    BC107874 mRNA. Translation: AAI07875.1.
    CCDSiCCDS31912.1. [Q5HYK3-1]
    RefSeqiNP_115690.3. NM_032314.3. [Q5HYK3-1]
    UniGeneiHs.17250.

    Genome annotation databases

    EnsembliENST00000288532; ENSP00000288532; ENSG00000110871. [Q5HYK3-1]
    GeneIDi84274.
    KEGGihsa:84274.
    UCSCiuc001tyn.3. human. [Q5HYK3-1]

    Polymorphism databases

    DMDMi90111987.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057777 mRNA. Translation: BAB71567.1 .
    AK222610 mRNA. Translation: BAD96330.1 .
    AK293656 mRNA. Translation: BAG57105.1 .
    BX647562 mRNA. Translation: CAI46073.1 .
    CH471054 Genomic DNA. Translation: EAW98198.1 .
    BC004916 mRNA. Translation: AAH04916.2 .
    BC107874 mRNA. Translation: AAI07875.1 .
    CCDSi CCDS31912.1. [Q5HYK3-1 ]
    RefSeqi NP_115690.3. NM_032314.3. [Q5HYK3-1 ]
    UniGenei Hs.17250.

    3D structure databases

    ProteinModelPortali Q5HYK3.
    SMRi Q5HYK3. Positions 96-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124001. 1 interaction.
    STRINGi 9606.ENSP00000288532.

    PTM databases

    PhosphoSitei Q5HYK3.

    Polymorphism databases

    DMDMi 90111987.

    Proteomic databases

    MaxQBi Q5HYK3.
    PaxDbi Q5HYK3.
    PRIDEi Q5HYK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000288532 ; ENSP00000288532 ; ENSG00000110871 . [Q5HYK3-1 ]
    GeneIDi 84274.
    KEGGi hsa:84274.
    UCSCi uc001tyn.3. human. [Q5HYK3-1 ]

    Organism-specific databases

    CTDi 84274.
    GeneCardsi GC12M120941.
    HGNCi HGNC:28722. COQ5.
    HPAi HPA049487.
    neXtProti NX_Q5HYK3.
    PharmGKBi PA143485438.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2226.
    HOGENOMi HOG000249463.
    HOVERGENi HBG081303.
    InParanoidi Q5HYK3.
    KOi K06127.
    OMAi GSHVMIC.
    OrthoDBi EOG712TXJ.
    PhylomeDBi Q5HYK3.
    TreeFami TF106217.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .
    Reactomei REACT_160111. Ubiquinol biosynthesis.

    Miscellaneous databases

    ChiTaRSi COQ5. human.
    GenomeRNAii 84274.
    NextBioi 73846.
    PROi Q5HYK3.

    Gene expression databases

    ArrayExpressi Q5HYK3.
    Bgeei Q5HYK3.
    CleanExi HS_COQ5.
    Genevestigatori Q5HYK3.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    HAMAPi MF_01813. UbiE_methyltran.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view ]
    Pfami PF01209. Ubie_methyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-152.
      Tissue: Coronary artery.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adipose tissue.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-152.
      Tissue: Lung.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOQ5_HUMAN
    AccessioniPrimary (citable) accession number: Q5HYK3
    Secondary accession number(s): B4DEJ4
    , Q32Q28, Q53HH0, Q96LV1, Q9BSP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3