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Q5HYJ3

- FA76B_HUMAN

UniProt

Q5HYJ3 - FA76B_HUMAN

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Protein

Protein FAM76B

Gene
FAM76B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM76B
Gene namesi
Name:FAM76B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:28492. FAM76B.

Subcellular locationi

Nucleus speckle 1 Publication

GO - Cellular componenti

  1. nuclear membrane Source: HPA
  2. nuclear speck Source: UniProtKB-SubCell
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671838.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 339338Protein FAM76BPRO_0000245763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei148 – 1481Phosphoserine1 Publication
Modified residuei193 – 1931Phosphoserine5 Publications
Cross-linki225 – 225Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Isoform 2 is ubiquitinated at Lys-225.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ5HYJ3.
PaxDbiQ5HYJ3.
PRIDEiQ5HYJ3.

PTM databases

PhosphoSiteiQ5HYJ3.

Expressioni

Gene expression databases

ArrayExpressiQ5HYJ3.
BgeeiQ5HYJ3.
CleanExiHS_FAM76B.
GenevestigatoriQ5HYJ3.

Organism-specific databases

HPAiHPA036608.

Interactioni

Protein-protein interaction databases

BioGridi126816. 7 interactions.
IntActiQ5HYJ3. 4 interactions.
MINTiMINT-1472951.
STRINGi9606.ENSP00000351631.

Structurei

3D structure databases

ProteinModelPortaliQ5HYJ3.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili248 – 32881 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 16010Poly-Ser
Compositional biasi167 – 18721His-richAdd
BLAST
Compositional biasi171 – 18010Poly-His

Domaini

The polyhistidine repeat acts as a targeting signal to nuclear speckles (1 Publication).

Sequence similaritiesi

Belongs to the FAM76 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG330390.
HOGENOMiHOG000231316.
HOVERGENiHBG080224.
InParanoidiQ5HYJ3.
OMAiNQRYPFE.
OrthoDBiEOG7TXKGS.
PhylomeDBiQ5HYJ3.
TreeFamiTF313644.

Family and domain databases

InterProiIPR029661. FAM76B.
[Graphical view]
PANTHERiPTHR22875:SF9. PTHR22875:SF9. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5HYJ3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASALYACT KCTQRYPFEE LSQGQQLCKE CRIAHPIVKC TYCRSEFQQE    50
SKTNTICKKC AQNVKQFGTP KPCQYCNIIA AFIGTKCQRC TNSEKKYGPP 100
QTCEQCKQQC AFDRKEEGRR KVDGKLLCWL CTLSYKRVLQ KTKEQRKSLG 150
SSHSNSSSSS LTEKDQHHPK HHHHHHHHHH RHSSSHHKIS NLSPEEEQGL 200
WKQSHKSSAT IQNETPKKKP KLESKPSNGD SSSINQSADS GGTDNFVLIS 250
QLKEEVMSLK RLLQQRDQTI LEKDKKLTEL KADFQYQESN LRTKMNSMEK 300
AHKETVEQLQ AKNRELLKQV AALSKGKKFD KSGSILTSP 339
Length:339
Mass (Da):38,708
Last modified:May 18, 2010 - v3
Checksum:i4ED7FEE05F23790C
GO
Isoform 2 (identifier: Q5HYJ3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-233: SSS → RSM
     234-339: Missing.

Note: Ubiquitinated at position 225.

Show »
Length:233
Mass (Da):26,771
Checksum:i3080A28B11A7C341
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 2333SSS → RSM in isoform 2. VSP_022679
Alternative sequencei234 – 339106Missing in isoform 2. VSP_022680Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281N → K in CAI46088. 1 Publication
Sequence conflicti328 – 3281K → E in CAI46088. 1 Publication
Sequence conflicti333 – 3331G → R in CAI46088. 1 Publication
Isoform 2 (identifier: Q5HYJ3-2)
Sequence conflicti232 – 2321S → C in AAH26013. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX647586 mRNA. Translation: CAI46088.1.
AP001877 Genomic DNA. No translation available.
BC026013 mRNA. Translation: AAH26013.1.
BC028727 mRNA. Translation: AAH28727.1.
CCDSiCCDS41700.1. [Q5HYJ3-1]
RefSeqiNP_653265.3. NM_144664.4. [Q5HYJ3-1]
XP_005273834.1. XM_005273777.2.
UniGeneiHs.288304.

Genome annotation databases

EnsembliENST00000358780; ENSP00000351631; ENSG00000077458. [Q5HYJ3-1]
GeneIDi143684.
KEGGihsa:143684.
UCSCiuc001pfn.2. human. [Q5HYJ3-1]

Polymorphism databases

DMDMi296439347.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX647586 mRNA. Translation: CAI46088.1 .
AP001877 Genomic DNA. No translation available.
BC026013 mRNA. Translation: AAH26013.1 .
BC028727 mRNA. Translation: AAH28727.1 .
CCDSi CCDS41700.1. [Q5HYJ3-1 ]
RefSeqi NP_653265.3. NM_144664.4. [Q5HYJ3-1 ]
XP_005273834.1. XM_005273777.2.
UniGenei Hs.288304.

3D structure databases

ProteinModelPortali Q5HYJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126816. 7 interactions.
IntActi Q5HYJ3. 4 interactions.
MINTi MINT-1472951.
STRINGi 9606.ENSP00000351631.

PTM databases

PhosphoSitei Q5HYJ3.

Polymorphism databases

DMDMi 296439347.

Proteomic databases

MaxQBi Q5HYJ3.
PaxDbi Q5HYJ3.
PRIDEi Q5HYJ3.

Protocols and materials databases

DNASUi 143684.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358780 ; ENSP00000351631 ; ENSG00000077458 . [Q5HYJ3-1 ]
GeneIDi 143684.
KEGGi hsa:143684.
UCSCi uc001pfn.2. human. [Q5HYJ3-1 ]

Organism-specific databases

CTDi 143684.
GeneCardsi GC11M095502.
H-InvDB HIX0010043.
HGNCi HGNC:28492. FAM76B.
HPAi HPA036608.
neXtProti NX_Q5HYJ3.
PharmGKBi PA142671838.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330390.
HOGENOMi HOG000231316.
HOVERGENi HBG080224.
InParanoidi Q5HYJ3.
OMAi NQRYPFE.
OrthoDBi EOG7TXKGS.
PhylomeDBi Q5HYJ3.
TreeFami TF313644.

Miscellaneous databases

GeneWikii FAM76B.
GenomeRNAii 143684.
NextBioi 84772.
PROi Q5HYJ3.

Gene expression databases

ArrayExpressi Q5HYJ3.
Bgeei Q5HYJ3.
CleanExi HS_FAM76B.
Genevestigatori Q5HYJ3.

Family and domain databases

InterProi IPR029661. FAM76B.
[Graphical view ]
PANTHERi PTHR22875:SF9. PTHR22875:SF9. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal skin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-225 (ISOFORM 2).
    Tissue: Lung adenocarcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. "Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
    Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.
    PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFA76B_HUMAN
AccessioniPrimary (citable) accession number: Q5HYJ3
Secondary accession number(s): Q6PIU3, Q8TC53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi