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Protein

Trans-2,3-enoyl-CoA reductase-like

Gene

TECRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

ReactomeiR-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2,3-enoyl-CoA reductase-like (EC:1.3.1.-)
Alternative name(s):
Steroid 5-alpha-reductase 2-like 2 protein
Gene namesi
Name:TECRL
Synonyms:SRD5A2L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27365. TECRL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664664.

Polymorphism and mutation databases

BioMutaiTECRL.
DMDMi74707936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Trans-2,3-enoyl-CoA reductase-likePRO_0000317713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5HYJ1.
PeptideAtlasiQ5HYJ1.
PRIDEiQ5HYJ1.

PTM databases

iPTMnetiQ5HYJ1.
PhosphoSiteiQ5HYJ1.

Expressioni

Gene expression databases

BgeeiQ5HYJ1.
ExpressionAtlasiQ5HYJ1. baseline and differential.
GenevisibleiQ5HYJ1. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370607.

Structurei

3D structure databases

ProteinModelPortaliQ5HYJ1.
SMRiQ5HYJ1. Positions 55-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1639. Eukaryota.
ENOG410XR2S. LUCA.
GeneTreeiENSGT00510000046645.
HOGENOMiHOG000190918.
InParanoidiQ5HYJ1.
OMAiICIVDKV.
PhylomeDBiQ5HYJ1.
TreeFamiTF300908.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HYJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRHKSLAS ERKRALLSQR ATRFILKDDM RNFHFLSKLV LSAGPLRPTP
60 70 80 90 100
AVKHSKTTHF EIEIFDAQTR KQICILDKVT QSSTIHDVKQ KFHKACPKWY
110 120 130 140 150
PSRVGLQLEC GGPFLKDYIT IQSIAASSIV TLYATDLGQQ VSWTTVFLAE
160 170 180 190 200
YTGPLLIYLL FYLRIPCIYD GKESARRLRH PVVHLACFCH CIHYIRYLLE
210 220 230 240 250
TLFVHKVSAG HTPLKNLIMS CAFYWGFTSW IAYYINHPLY TPPSFGNRQI
260 270 280 290 300
TVSAINFLIC EAGNHFINVM LSHPNHTGNN ACFPSPNYNP FTWMFFLVSC
310 320 330 340 350
PNYTYEIGSW ISFTVMTQTL PVGIFTLLMS IQMSLWAQKK HKIYLRKFNS
360
YIHRKSAMIP FIL
Length:363
Mass (Da):42,009
Last modified:February 15, 2005 - v1
Checksum:iD68F53FC397397AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691Y → H.1 Publication
VAR_074183

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290606 mRNA. Translation: BAF83295.1.
BX647590 mRNA. Translation: CAI46063.1.
AL833108 mRNA. Translation: CAI46109.1.
CCDSiCCDS33990.1.
RefSeqiNP_001010874.2. NM_001010874.4.
UniGeneiHs.227752.

Genome annotation databases

EnsembliENST00000381210; ENSP00000370607; ENSG00000205678.
GeneIDi253017.
KEGGihsa:253017.
UCSCiuc003hcv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290606 mRNA. Translation: BAF83295.1.
BX647590 mRNA. Translation: CAI46063.1.
AL833108 mRNA. Translation: CAI46109.1.
CCDSiCCDS33990.1.
RefSeqiNP_001010874.2. NM_001010874.4.
UniGeneiHs.227752.

3D structure databases

ProteinModelPortaliQ5HYJ1.
SMRiQ5HYJ1. Positions 55-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370607.

PTM databases

iPTMnetiQ5HYJ1.
PhosphoSiteiQ5HYJ1.

Polymorphism and mutation databases

BioMutaiTECRL.
DMDMi74707936.

Proteomic databases

PaxDbiQ5HYJ1.
PeptideAtlasiQ5HYJ1.
PRIDEiQ5HYJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381210; ENSP00000370607; ENSG00000205678.
GeneIDi253017.
KEGGihsa:253017.
UCSCiuc003hcv.4. human.

Organism-specific databases

CTDi253017.
GeneCardsiTECRL.
HGNCiHGNC:27365. TECRL.
neXtProtiNX_Q5HYJ1.
PharmGKBiPA165664664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1639. Eukaryota.
ENOG410XR2S. LUCA.
GeneTreeiENSGT00510000046645.
HOGENOMiHOG000190918.
InParanoidiQ5HYJ1.
OMAiICIVDKV.
PhylomeDBiQ5HYJ1.
TreeFamiTF300908.

Enzyme and pathway databases

ReactomeiR-HSA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

GenomeRNAii253017.
PROiQ5HYJ1.

Gene expression databases

BgeeiQ5HYJ1.
ExpressionAtlasiQ5HYJ1. baseline and differential.
GenevisibleiQ5HYJ1. HS.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Cited for: VARIANT HIS-169.

Entry informationi

Entry nameiTECRL_HUMAN
AccessioniPrimary (citable) accession number: Q5HYJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.