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Protein

Rab-like protein 3

Gene

RABL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi147 – 1504GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 3
Gene namesi
Name:RABL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18072. RABL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34161.

Polymorphism and mutation databases

BioMutaiRABL3.
DMDMi74762186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Rab-like protein 3PRO_0000312166Add
BLAST

Proteomic databases

EPDiQ5HYI8.
MaxQBiQ5HYI8.
PaxDbiQ5HYI8.
PRIDEiQ5HYI8.
TopDownProteomicsiQ5HYI8.

PTM databases

iPTMnetiQ5HYI8.
PhosphoSiteiQ5HYI8.

Expressioni

Gene expression databases

BgeeiQ5HYI8.
CleanExiHS_RABL3.
ExpressionAtlasiQ5HYI8. baseline and differential.
GenevisibleiQ5HYI8. HS.

Organism-specific databases

HPAiHPA035150.
HPA035151.

Interactioni

Protein-protein interaction databases

BioGridi130066. 25 interactions.
IntActiQ5HYI8. 21 interactions.
STRINGi9606.ENSP00000273375.

Structurei

3D structure databases

ProteinModelPortaliQ5HYI8.
SMRiQ5HYI8. Positions 6-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 236236Small GTPase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiENOG410IJY5. Eukaryota.
ENOG410YR8H. LUCA.
GeneTreeiENSGT00390000007467.
HOGENOMiHOG000006785.
HOVERGENiHBG108392.
InParanoidiQ5HYI8.
KOiK07933.
OMAiHKNTRSV.
OrthoDBiEOG76473G.
PhylomeDBiQ5HYI8.
TreeFamiTF320841.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08477. Roc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HYI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRVHDY
60 70 80 90 100
KEGTPEEKTY YIELWDVGGS VGSASSVKST RAVFYNSVNG IIFVHDLTNK
110 120 130 140 150
KSSQNLRRWS LEALNRDLVP TGVLVTNGDY DQEQFADNQI PLLVIGTKLD
160 170 180 190 200
QIHETKRHEV LTRTAFLAED FNPEEINLDC TNPRYLAAGS SNAVKLSRFF
210 220 230
DKVIEKRYFL REGNQIPGFP DRKRFGAGTL KSLHYD
Length:236
Mass (Da):26,423
Last modified:February 15, 2005 - v1
Checksum:iB80898B1293C88C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601Y → C in AAH20832 (PubMed:15489334).Curated
Sequence conflicti163 – 1631R → T in AAH20832 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293085 mRNA. Translation: BAF85774.1.
BX647664 mRNA. Translation: CAI46059.1.
BX647593 mRNA. Translation: CAI46064.1.
BX647559 mRNA. Translation: CAI46095.1.
CH471052 Genomic DNA. Translation: EAW79521.1.
BC020832 mRNA. Translation: AAH20832.1.
CCDSiCCDS3001.1.
RefSeqiNP_776186.2. NM_173825.3.
UniGeneiHs.444360.

Genome annotation databases

EnsembliENST00000273375; ENSP00000273375; ENSG00000144840.
GeneIDi285282.
KEGGihsa:285282.
UCSCiuc003edx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293085 mRNA. Translation: BAF85774.1.
BX647664 mRNA. Translation: CAI46059.1.
BX647593 mRNA. Translation: CAI46064.1.
BX647559 mRNA. Translation: CAI46095.1.
CH471052 Genomic DNA. Translation: EAW79521.1.
BC020832 mRNA. Translation: AAH20832.1.
CCDSiCCDS3001.1.
RefSeqiNP_776186.2. NM_173825.3.
UniGeneiHs.444360.

3D structure databases

ProteinModelPortaliQ5HYI8.
SMRiQ5HYI8. Positions 6-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130066. 25 interactions.
IntActiQ5HYI8. 21 interactions.
STRINGi9606.ENSP00000273375.

PTM databases

iPTMnetiQ5HYI8.
PhosphoSiteiQ5HYI8.

Polymorphism and mutation databases

BioMutaiRABL3.
DMDMi74762186.

Proteomic databases

EPDiQ5HYI8.
MaxQBiQ5HYI8.
PaxDbiQ5HYI8.
PRIDEiQ5HYI8.
TopDownProteomicsiQ5HYI8.

Protocols and materials databases

DNASUi285282.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273375; ENSP00000273375; ENSG00000144840.
GeneIDi285282.
KEGGihsa:285282.
UCSCiuc003edx.3. human.

Organism-specific databases

CTDi285282.
GeneCardsiRABL3.
HGNCiHGNC:18072. RABL3.
HPAiHPA035150.
HPA035151.
neXtProtiNX_Q5HYI8.
PharmGKBiPA34161.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJY5. Eukaryota.
ENOG410YR8H. LUCA.
GeneTreeiENSGT00390000007467.
HOGENOMiHOG000006785.
HOVERGENiHBG108392.
InParanoidiQ5HYI8.
KOiK07933.
OMAiHKNTRSV.
OrthoDBiEOG76473G.
PhylomeDBiQ5HYI8.
TreeFamiTF320841.

Miscellaneous databases

GenomeRNAii285282.
PROiQ5HYI8.

Gene expression databases

BgeeiQ5HYI8.
CleanExiHS_RABL3.
ExpressionAtlasiQ5HYI8. baseline and differential.
GenevisibleiQ5HYI8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013684. MIRO-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08477. Roc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Fetal skin and Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRABL3_HUMAN
AccessioniPrimary (citable) accession number: Q5HYI8
Secondary accession number(s): Q8WUD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.