Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metaxin-3

Gene

MTX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could function in transport of proteins into the mitochondrion.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Metaxin-3
Gene namesi
Name:MTX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24812. MTX3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924631.

Polymorphism and mutation databases

BioMutaiMTX3.
DMDMi189029218.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Metaxin-3PRO_0000337100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei311 – 3111PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5HYI7.
MaxQBiQ5HYI7.
PaxDbiQ5HYI7.
PeptideAtlasiQ5HYI7.
PRIDEiQ5HYI7.

PTM databases

iPTMnetiQ5HYI7.
PhosphoSiteiQ5HYI7.

Expressioni

Gene expression databases

BgeeiENSG00000177034.
CleanExiHS_MTX3.
GenevisibleiQ5HYI7. HS.

Organism-specific databases

HPAiHPA047858.
HPA062061.

Interactioni

Protein-protein interaction databases

BioGridi131365. 22 interactions.
IntActiQ5HYI7. 1 interaction.
STRINGi9606.ENSP00000423600.

Structurei

3D structure databases

ProteinModelPortaliQ5HYI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metaxin family.Curated

Phylogenomic databases

eggNOGiKOG3028. Eukaryota.
ENOG41100SS. LUCA.
GeneTreeiENSGT00530000063166.
HOGENOMiHOG000172354.
HOVERGENiHBG001655.
InParanoidiQ5HYI7.
KOiK17776.
OMAiPMELSCW.
OrthoDBiEOG091G0CWZ.
PhylomeDBiQ5HYI7.
TreeFamiTF313422.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR017410. Metaxin.
IPR033468. Metaxin_GST.
IPR019564. Sam37/metaxin_N.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF10568. Tom37. 1 hit.
[Graphical view]
PIRSFiPIRSF038150. Metaxin. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5HYI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLELSCW GGGWGLPSVH SESLVVMAYA KFSGAPLKVN VIDNTWRGSR
60 70 80 90 100
GDVPILTTED DMVSQPAKIL NFLRKQKYNA DYELSAKQGA DTLAYIALLE
110 120 130 140 150
EKLLPAVLHT FWVESDNYFT VTKPWFASQI PFPLSLILPG RMSKGALNRI
160 170 180 190 200
LLTRGQPPLY HLREVEAQIY RDAKECLNLL SNRLGTSQFF FGDTPSTLDA
210 220 230 240 250
YVFGFLAPLY KVRFPKVQLQ EHLKQLSNLC RFCDDILSSY FRLSLGGISP
260 270 280 290 300
AGQETVDANL QKLTQLVNKE SNLIEKMDDN LRQSPQLPPR KLPTLKLTPA
310
EEENNSFQRL SP
Length:312
Mass (Da):35,093
Last modified:May 20, 2008 - v2
Checksum:i3B9BAB7CF64FF8EF
GO
Isoform 2 (identifier: Q5HYI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-158: KGALNRILLTRGQPP → QQILSSRAGTHMLRK
     159-312: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,569
Checksum:iD1F883A663D02D5A
GO
Isoform 3 (identifier: Q5HYI7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-248: GI → DG
     249-312: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):27,901
Checksum:iBF7859179F6F9AF5
GO
Isoform 4 (identifier: Q5HYI7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:251
Mass (Da):28,608
Checksum:iE3C9240EDD986AC0
GO

Sequence cautioni

The sequence CAD97995 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501R → K in CAI46098 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381S → R.
Corresponds to variant rs9293796 [ dbSNP | Ensembl ].
VAR_043600

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161Missing in isoform 4. 1 PublicationVSP_046824Add
BLAST
Alternative sequencei144 – 15815KGALN…RGQPP → QQILSSRAGTHMLRK in isoform 2. 1 PublicationVSP_033893Add
BLAST
Alternative sequencei159 – 312154Missing in isoform 2. 1 PublicationVSP_033894Add
BLAST
Alternative sequencei247 – 2482GI → DG in isoform 3. 1 PublicationVSP_036207
Alternative sequencei249 – 31264Missing in isoform 3. 1 PublicationVSP_036208Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296864 mRNA. Translation: BAG59427.1.
BX538064 mRNA. Translation: CAD97995.1. Different initiation.
BX647596 mRNA. Translation: CAI46098.1.
AC112184 Genomic DNA. No translation available.
CCDSiCCDS47239.2. [Q5HYI7-4]
CCDS54872.1. [Q5HYI7-5]
RefSeqiNP_001010891.4. NM_001010891.4. [Q5HYI7-4]
NP_001161213.1. NM_001167741.1. [Q5HYI7-5]
XP_005248552.1. XM_005248495.3. [Q5HYI7-1]
UniGeneiHs.531418.

Genome annotation databases

EnsembliENST00000509852; ENSP00000423302; ENSG00000177034. [Q5HYI7-4]
ENST00000512528; ENSP00000424798; ENSG00000177034. [Q5HYI7-1]
ENST00000512560; ENSP00000423600; ENSG00000177034. [Q5HYI7-5]
ENST00000617335; ENSP00000484157; ENSG00000177034. [Q5HYI7-2]
GeneIDi345778.
KEGGihsa:345778.
UCSCiuc003kge.5. human. [Q5HYI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296864 mRNA. Translation: BAG59427.1.
BX538064 mRNA. Translation: CAD97995.1. Different initiation.
BX647596 mRNA. Translation: CAI46098.1.
AC112184 Genomic DNA. No translation available.
CCDSiCCDS47239.2. [Q5HYI7-4]
CCDS54872.1. [Q5HYI7-5]
RefSeqiNP_001010891.4. NM_001010891.4. [Q5HYI7-4]
NP_001161213.1. NM_001167741.1. [Q5HYI7-5]
XP_005248552.1. XM_005248495.3. [Q5HYI7-1]
UniGeneiHs.531418.

3D structure databases

ProteinModelPortaliQ5HYI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131365. 22 interactions.
IntActiQ5HYI7. 1 interaction.
STRINGi9606.ENSP00000423600.

PTM databases

iPTMnetiQ5HYI7.
PhosphoSiteiQ5HYI7.

Polymorphism and mutation databases

BioMutaiMTX3.
DMDMi189029218.

Proteomic databases

EPDiQ5HYI7.
MaxQBiQ5HYI7.
PaxDbiQ5HYI7.
PeptideAtlasiQ5HYI7.
PRIDEiQ5HYI7.

Protocols and materials databases

DNASUi345778.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000509852; ENSP00000423302; ENSG00000177034. [Q5HYI7-4]
ENST00000512528; ENSP00000424798; ENSG00000177034. [Q5HYI7-1]
ENST00000512560; ENSP00000423600; ENSG00000177034. [Q5HYI7-5]
ENST00000617335; ENSP00000484157; ENSG00000177034. [Q5HYI7-2]
GeneIDi345778.
KEGGihsa:345778.
UCSCiuc003kge.5. human. [Q5HYI7-1]

Organism-specific databases

CTDi345778.
GeneCardsiMTX3.
HGNCiHGNC:24812. MTX3.
HPAiHPA047858.
HPA062061.
neXtProtiNX_Q5HYI7.
PharmGKBiPA134924631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3028. Eukaryota.
ENOG41100SS. LUCA.
GeneTreeiENSGT00530000063166.
HOGENOMiHOG000172354.
HOVERGENiHBG001655.
InParanoidiQ5HYI7.
KOiK17776.
OMAiPMELSCW.
OrthoDBiEOG091G0CWZ.
PhylomeDBiQ5HYI7.
TreeFamiTF313422.

Miscellaneous databases

ChiTaRSiMTX3. human.
GenomeRNAii345778.
PROiQ5HYI7.

Gene expression databases

BgeeiENSG00000177034.
CleanExiHS_MTX3.
GenevisibleiQ5HYI7. HS.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR017410. Metaxin.
IPR033468. Metaxin_GST.
IPR019564. Sam37/metaxin_N.
[Graphical view]
PfamiPF17171. GST_C_6. 1 hit.
PF10568. Tom37. 1 hit.
[Graphical view]
PIRSFiPIRSF038150. Metaxin. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTX3_HUMAN
AccessioniPrimary (citable) accession number: Q5HYI7
Secondary accession number(s): B4DL65
, E9PB57, Q7Z380, Q8NB92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.