DKFZp686B0215

Functionⁱ

GO - Molecular functionⁱ

flavin adenine dinucleotide binding Source: InterPro
squalene monooxygenase activity Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized protein DKFZp686B0215Imported
Gene namesⁱ	Name:DKFZp686B0215Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO (Gene Ontology) annotation

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	20 – 42	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	63 – 81	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	517 – 535	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	547 – 566	HelicalSequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA36108.

PharmGKBⁱ

PA36108.

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q5HYI4.
PeptideAtlas More...PeptideAtlasⁱ	Q5HYI4.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q5HYI4. HS.

Genevisibleⁱ

Q5HYI4. HS.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5HYI4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	277 – 548	SEInterPro annotationAdd BLAST		272

Keywords - Domainⁱ

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1298. Eukaryota. COG0654. LUCA.
HOVERGENⁱ	HBG005603.
KEGG Orthology (KO) More...KOⁱ	K00511.

Family and domain databases

Gene3Dⁱ	3.50.50.60. 1 hit.
InterProⁱ	View protein in InterPro IPR023753. FAD/NAD-binding_dom. IPR013698. Squalene_epoxidase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08491. SE. 1 hit.
SUPFAMⁱ	SSF51905. SSF51905. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5HYI4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN 
        60         70         80         90        100
GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK 
       110        120        130        140        150
GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT 
       160        170        180        190        200
VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ 
       210        220        230        240        250
ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV 
       260        270        280        290        300
LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV 
       310        320        330        340        350
SVSSHFVGFL MKNAPQFKAN HAELILANPG PVLIYQISSS ETRVLVDIRG 
       360        370        380        390        400
EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK 
       410        420        430        440        450
RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA 
       460        470        480        490        500
KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLGKA CFLYFKLGGE 
       510        520        530        540        550
CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS 
       560        570 
GAVLYKACSV IFPLIYSEMK YMVH

Length:574

Mass (Da):63,794

Last modified:February 15, 2005 - v1

Checksum:ⁱC4C6B0DB5CBB8909

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX647605 mRNA. Translation: CAI46076.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_003120.2. NM_003129.3.
UniGeneⁱ	Hs.71465.

Genome annotation databases

GeneIDⁱ	6713.
KEGGⁱ	hsa:6713.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5HYI4	Q14534 Q9UNR6 B4DHX0 H0YBN7 UPI0001CA25AB UPI00027F9DA9 UPI000809C24A H9EWU0 G7PCT2 H2QWP8 +22	Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Cebus capucinus imitator Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) And more	574	UniRef90_Q14534	Cluster: Squalene monooxygenase	33

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5HYI4	P52020 Q8CJ80 UPI000A315936 G1KJU1 Q4SMS5 H3CS01 UPI00038BF6FD UPI000454180E UPI0004543B45 A0A1U7QNJ6 +269	Rattus norvegicus (Rat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Anolis carolinensis (Green anole) (American chameleon) Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Microtus ochrogaster (Prairie vole) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mesocricetus auratus (Golden hamster) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Peromyscus maniculatus bairdii (prairie deer mouse) Mus musculus (Mouse) And more	573	UniRef50_P52020	Cluster: Squalene monooxygenase	280

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX647605 mRNA. Translation: CAI46076.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_003120.2. NM_003129.3.
UniGeneⁱ	Hs.71465.

3D structure databases

ProteinModelPortalⁱ	Q5HYI4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q5HYI4.
PeptideAtlas More...PeptideAtlasⁱ	Q5HYI4.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6713.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	6713.
KEGGⁱ	hsa:6713.

Organism-specific databases

CTDⁱ	6713.
PharmGKBⁱ	PA36108.

Phylogenomic databases

eggNOGⁱ	KOG1298. Eukaryota. COG0654. LUCA.
HOVERGENⁱ	HBG005603.
KEGG Orthology (KO) More...KOⁱ	K00511.

Miscellaneous databases

GenomeRNAiⁱ	6713.

GenomeRNAiⁱ

6713.

Gene expression databases

Genevisibleⁱ	Q5HYI4. HS.

Genevisibleⁱ

Q5HYI4. HS.

Family and domain databases

Gene3Dⁱ	3.50.50.60. 1 hit.
InterProⁱ	View protein in InterPro IPR023753. FAD/NAD-binding_dom. IPR013698. Squalene_epoxidase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08491. SE. 1 hit.
SUPFAMⁱ	SSF51905. SSF51905. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5HYI4_HUMAN
Accessionⁱ	Q5HYI4Primary (citable) accession number: Q5HYI4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 15, 2005
	Last sequence update:	February 15, 2005
	Last modified:	August 30, 2017
	This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q5HYI4 (Q5HYI4_HUMAN)

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Uncharacterized protein DKFZp686B0215

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ