Q5HYE4 (Q5HYE4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cysteinyl-tRNA synthetase, isoform CRA_e EMBL EAX02541.1

Submitted name:
Putative uncharacterized protein DKFZp686F1612 EMBL CAI46108.1
Submitted name:
Uncharacterized protein Ensembl ENSP00000369897
Submitted name:
cDNA FLJ54741, highly similar to Homo sapiens cysteinyl-tRNA synthetase (CARS), transcript variant 3, mRNA EMBL BAG63885.1

Gene names

Name:	DKFZp686F1612 EMBL CAI46108.1
Synonyms:	CARS EMBL EAX02541.1 Ensembl ENSP00000369897
ORF Names:	hCG_16441 EMBL EAX02541.1

Organism

Homo sapiens (Human) EMBL CAI46108.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	831 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Aminoacyl-tRNA synthetase EMBL BAG63885.1 Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cysteinyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: HPA
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro cysteine-tRNA ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5HYE4 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: C0080CD332F79B8F	FASTA	831	94,638
	10 20 30 40 50 60 MADSSGQQAP DYRSILSISD EAARAQALNE HLSTRSYVQG YSLSQADVDA FRQLSAPPAD 70 80 90 100 110 120 PQLFHVARWF RHIEALLGSP CGKGQPCRLQ ASKGRRVQPQ WSPPAGTQPC RLHLYNSLTR 130 140 150 160 170 180 NKEVFIPQDG KKVTWYCCGP TVYDASHMGH ARSYISFDIL RRVLKDYFKF DVFYCMNITD 190 200 210 220 230 240 IDDKIIKRAR QNHLFEQYRE KRPEAAQLLE DVQAALKPFS VKLNETTDPD KKQMLERIQH 250 260 270 280 290 300 AVQLATEPLE KAVQSRLTGE EVNSCVEVLL EEAKDLLSDW LDSTLGCDVT DNSIFSKLPK 310 320 330 340 350 360 FWEGDFHRDM EALNVLPPDV LTRVSEYVPE IVNFVQKIVD NGYGYVSNGS VYFDTAKFAS 370 380 390 400 410 420 SEKHSYGKLV PEAVGDQKAL QEGEGDLSIS ADRLSEKRSP NDFALWKASK PGEPSWPCPW 430 440 450 460 470 480 GKGRPGWHIE CSAMAGTLLG ASMDIHGGGF DLRFPHHDNE LAQSEAYFEN DCWVRYFLHT 490 500 510 520 530 540 GHLTIAGCKM SKSLKNFITI KDALKKHSAR QLRLAFLMHS WKDTLDYSSN TMESALQYEK 550 560 570 580 590 600 FLNEFFLNVK DILRAPVDIT GQFEKWGEEE AELNKNFYDK KTAIHKALCD NVDTRTVMEE 610 620 630 640 650 660 MRALVSQCNL YMAARKAVRK RPNQALLENI ALYLTHMLKI FGAVEEDSSL GFPVGGPGTS 670 680 690 700 710 720 LSLEATVMPY LQVLSEFREG VRKIAREQKV PEILQLSDAL RDNILPELGV RFEDHEGLPT 730 740 750 760 770 780 VVKLVDRNTL LKEREEKRRV EEEKRKKKEE AARRKQEQEA AKLAKMKIPP SEMFLSETDK 790 800 810 820 830 YSKFDENGLP THDMEGKELS KGQAKKLKKL FEAQEKLYKE YLQMAQNGSF Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL BAG63885.1.
[3]	The German cDNA Consortium Poustka A., Albert R., Moosmayer P., Schupp I., Wellenreuther R., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Cervix EMBL CAI46108.1.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC108448 Genomic DNA. No translation available. AC131971 Genomic DNA. No translation available. AK302644 mRNA. Translation: BAG63885.1. BX647906 mRNA. Translation: CAI46108.1. CH471158 Genomic DNA. Translation: EAX02541.1.
IPI	IPI00027443.
RefSeq	NP_001014437.1. NM_001014437.2.
UniGene	Hs.274873.
3D structure databases
ProteinModelPortal	Q5HYE4.
SMR	Q5HYE4. Positions 22-75, 109-724.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HYE4.
Proteomic databases
PRIDE	Q5HYE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380525; ENSP00000369897; ENSG00000110619.
GeneID	833.
KEGG	hsa:833.
UCSC	uc001lxf.1. human.
Organism-specific databases
CTD	833.
HGNC	HGNC:1493. CARS.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000006347.
HOGENOM	HBG327651.
HOVERGEN	HBG002089.
OMA	EALCDNV.
PhylomeDB	Q5HYE4.
Gene expression databases
ArrayExpress	Q5HYE4.
Bgee	Q5HYE4.
Family and domain databases
HAMAP	MF_00041. Cys_tRNA_synth. [Tree]
InterPro	IPR015803. Cys-tRNA-synt. IPR024909. Cys-tRNA/MSH_ligase. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K01883.
PANTHER	PTHR10890. Cys_tRNA-synt_1a. 1 hit.
Pfam	PF01406. tRNA-synt_1e. 1 hit. [Graphical view]
PRINTS	PR00983. TRNASYNTHCYS.
SUPFAM	SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00435. CysS. 1 hit.
ProtoNet	Search...
Other
NextBio	3450.

Entry information

Entry name

Q5HYE4_HUMAN

Accession

Primary (citable) accession number: Q5HYE4

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.