Q5HYC2 (K2026_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein KIAA2026

Gene names

Name:

KIAA2026

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2103 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAI36847.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI45993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI95313.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5HYC2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5HYC2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     765-794: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2103	2103	Uncharacterized protein KIAA2026		PRO_0000288922
Regions
	Compositional bias	673 – 756	84	Lys-rich
	Compositional bias	1307 – 1421	115	Ser-rich
Natural variations
	Alternative sequence	765 – 794	30	Missing in isoform 2.		VSP_039334

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 15, 2010. Version 2. Checksum: 211E99364884045A	FASTA	2,103	228,087
	10 20 30 40 50 60 MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL EDADDQEEEM 70 80 90 100 110 120 EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP FLQPLGGVAT AEEEVAEGPR 130 140 150 160 170 180 SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ YGGITEFVAD FRLMLETCYR LHGVDHWISK 190 200 210 220 230 240 QGQKLEMMLE QKLALLSRHL REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT 250 260 270 280 290 300 SGVFESIMVQ VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET 310 320 330 340 350 360 MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS PPHRRPTLHR 370 380 390 400 410 420 RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC PQFFKVLGEV NPLEEKPFHE 430 440 450 460 470 480 LPFYQKVWLL KGLCDFVYET QKEVQDAVLG QPIHECREVI LGYDYLENAY VHFPQFCGAD 490 500 510 520 530 540 VRIYKQRPFQ APEFPIPPIK IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE 550 560 570 580 590 600 NNFDPACCPA KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG 610 620 630 640 650 660 FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD HPEINCHKVV 670 680 690 700 710 720 RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL QRKREGLHSL AFKSYKPEIQ 730 740 750 760 770 780 NKLLIIKKKA KHKKHKSGKK SVSKKAITKK RKTVIKSPTV PEFQLICTNL DELRELITKI 790 800 810 820 830 840 ENELKDLENS RKKSGKWYHR RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY 850 860 870 880 890 900 DDFRRQPDHD TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL 910 920 930 940 950 960 SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR KKAKLSTNET 970 980 990 1000 1010 1020 TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ KGTKPIQALL AKNIGNKVTL 1030 1040 1050 1060 1070 1080 TNQLPPSTGR NALAVEKPVL SPPEASPIKP ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN 1090 1100 1110 1120 1130 1140 SSVKIQVQPM VDPKTGEKIM QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP 1150 1160 1170 1180 1190 1200 QTTNINSSLA SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS 1210 1220 1230 1240 1250 1260 VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS SFNCFAQQTA 1270 1280 1290 1300 1310 1320 DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ NSPNTVSSSS VFTFAPQLQA 1330 1340 1350 1360 1370 1380 FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG 1390 1400 1410 1420 1430 1440 DLGHVIDKTS HMPSSPLKSS ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ 1450 1460 1470 1480 1490 1500 QVDYITKSYP VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG 1510 1520 1530 1540 1550 1560 VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL IPSTVGTPIK 1570 1580 1590 1600 1610 1620 INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ NVTPKGEDKS SKGYILPLST 1630 1640 1650 1660 1670 1680 SGNSVPVSSN FVSQNITPVN ESVVSSARAV NVLSVTGANL SLGSFPVTSA SASAGAQPPV 1690 1700 1710 1720 1730 1740 LVSGNDTSSR IMPILSNRLC SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL 1750 1760 1770 1780 1790 1800 QIPVTVALPT PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN 1810 1820 1830 1840 1850 1860 VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI HTASAPSNVT 1870 1880 1890 1900 1910 1920 SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP PQGLGAGSHV LLISTNPKYG 1930 1940 1950 1960 1970 1980 APLVLNSGQG IQSTPIDNSA QKITLASNNS LSGQPLQHPL RSPTKFINSF GNASSIPTVH 1990 2000 2010 2020 2030 2040 TSPQLINTTA KVPVPPPVPT VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD 2050 2060 2070 2080 2090 2100 PPVKKLLVSP EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR AAS
	Isoform 2 [UniParc]. Checksum: C15E6DA756FA6F6E	FASTA	2,073	224,546
	10 20 30 40 50 60 MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL EDADDQEEEM 70 80 90 100 110 120 EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP FLQPLGGVAT AEEEVAEGPR 130 140 150 160 170 180 SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ YGGITEFVAD FRLMLETCYR LHGVDHWISK 190 200 210 220 230 240 QGQKLEMMLE QKLALLSRHL REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT 250 260 270 280 290 300 SGVFESIMVQ VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET 310 320 330 340 350 360 MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS PPHRRPTLHR 370 380 390 400 410 420 RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC PQFFKVLGEV NPLEEKPFHE 430 440 450 460 470 480 LPFYQKVWLL KGLCDFVYET QKEVQDAVLG QPIHECREVI LGYDYLENAY VHFPQFCGAD 490 500 510 520 530 540 VRIYKQRPFQ APEFPIPPIK IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE 550 560 570 580 590 600 NNFDPACCPA KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG 610 620 630 640 650 660 FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD HPEINCHKVV 670 680 690 700 710 720 RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL QRKREGLHSL AFKSYKPEIQ 730 740 750 760 770 780 NKLLIIKKKA KHKKHKSGKK SVSKKAITKK RKTVIKSPTV PEFQGKWYHR RQAVKELHST 790 800 810 820 830 840 LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY DDFRRQPDHD TFNRELWTTD EGEGDLGKDS 850 860 870 880 890 900 PKGEISKSID STEPLDILEK DHFDSDDMKL SEIDFPMARS KLLKKELPSK DLPKTLLKTL 910 920 930 940 950 960 KRQSKQTDYV DDSTKELSPR KKAKLSTNET TVENLESDVQ IDCFSESKHT EPSFPESFAS 970 980 990 1000 1010 1020 LDSVPVSTLQ KGTKPIQALL AKNIGNKVTL TNQLPPSTGR NALAVEKPVL SPPEASPIKP 1030 1040 1050 1060 1070 1080 ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN SSVKIQVQPM VDPKTGEKIM QQVLILPKNF 1090 1100 1110 1120 1130 1140 VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP QTTNINSSLA SVFVNSPGTV STQLPNTAFN 1150 1160 1170 1180 1190 1200 KTITPLSNIS SARPQPLSPV TSVSNLLTPS VKTSQSEAGK AKNAVSAATF SLPSASPTIS 1210 1220 1230 1240 1250 1260 STGQPLSSTT TLNGSTNPGS SFNCFAQQTA DSSEAKQELK TVCIRDSQSI LVRTRGGNTG 1270 1280 1290 1300 1310 1320 VVKVQTNPDQ NSPNTVSSSS VFTFAPQLQA FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ 1330 1340 1350 1360 1370 1380 TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG DLGHVIDKTS HMPSSPLKSS ICSSTLLPST 1390 1400 1410 1420 1430 1440 TSSSVSVISI SAANFGQNNA NIIHTPTKQQ QVDYITKSYP VTRSEATAAT NGDVISGTPV 1450 1460 1470 1480 1490 1500 QKLMLVSAPS ILSSGNGTAI NMTPALTSTG VSAQKLVFIN APVPSGTSTP TLVAESLKQT 1510 1520 1530 1540 1550 1560 LPPPLHKAYV KTPEQPQIVL IPSTVGTPIK INSSPAVSQI KDVKIGLNIG QAIVNTSGTV 1570 1580 1590 1600 1610 1620 PAIPSINILQ NVTPKGEDKS SKGYILPLST SGNSVPVSSN FVSQNITPVN ESVVSSARAV 1630 1640 1650 1660 1670 1680 NVLSVTGANL SLGSFPVTSA SASAGAQPPV LVSGNDTSSR IMPILSNRLC SSSLGNTVAI 1690 1700 1710 1720 1730 1740 STVKTGHLAS SVLISTTQPV VSPKCLTSAL QIPVTVALPT PATTSPKIIN TVPHSAAVPG 1750 1760 1770 1780 1790 1800 ATRSVSISKR QSRTSLQFHS PGISTTVPTN VNTNKPQTEL SSLSTSPGKI TNTSNFASLP 1810 1820 1830 1840 1850 1860 NQQALVKTPS YSSAPGGTTI HTASAPSNVT SLVGSQFSEP CIQQKIVINT STPLAPGTQI 1870 1880 1890 1900 1910 1920 MINGTRFIVP PQGLGAGSHV LLISTNPKYG APLVLNSGQG IQSTPIDNSA QKITLASNNS 1930 1940 1950 1960 1970 1980 LSGQPLQHPL RSPTKFINSF GNASSIPTVH TSPQLINTTA KVPVPPPVPT VSLTSVIKSP 1990 2000 2010 2020 2030 2040 ATLLAKTSLV SAICPSNPPL PSSTSVFHLD PPVKKLLVSP EGAILNTINT PASKVSSLSP 2050 2060 2070 SLSQIVVSAS RSPASVFPAF QSSGLEKPDR AAS

References

[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 738-2103 (ISOFORM 2). Tissue: Esophageal carcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 819-2103 (ISOFORM 1). Tissue: Testis.
[4]	"The nucleotide sequence of a long cDNA clone isolated from human." Nagase T., Kikuno R., Ohara O. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1246-2103 (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL162384 Genomic DNA. No translation available. AL353606 Genomic DNA. No translation available. AL365360 Genomic DNA. Translation: CAI95313.1. Sequence problems. BX648372 mRNA. Translation: CAI45993.1. Different initiation. BC136846 mRNA. Translation: AAI36847.1. Different initiation. AB095946 mRNA. Translation: BAC23122.1.
IPI	IPI00216990. IPI00966688.
RefSeq	NP_001017969.2. NM_001017969.2.
UniGene	Hs.535060.
3D structure databases
ProteinModelPortal	Q5HYC2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5HYC2. 5 interactions.
MINT	MINT-2878922.
STRING	9606.ENSP00000382815.
PTM databases
PhosphoSite	Q5HYC2.
Polymorphism databases
DMDM	298286816.
Proteomic databases
PaxDb	Q5HYC2.
PRIDE	Q5HYC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381461; ENSP00000370870; ENSG00000183354. ENST00000399933; ENSP00000382815; ENSG00000183354.
GeneID	158358.
KEGG	hsa:158358.
UCSC	uc003zjq.4. human.
Organism-specific databases
CTD	158358.
GeneCards	GC09M005919.
HGNC	HGNC:23378. KIAA2026.
HPA	HPA002109.
neXtProt	NX_Q5HYC2.
PharmGKB	PA134907262.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000169712.
HOVERGEN	HBG108717.
InParanoid	Q5HYC2.
OMA	NANIIHT.
OrthoDB	EOG4S1T6C.
Gene expression databases
ArrayExpress	Q5HYC2.
Bgee	Q5HYC2.
CleanEx	HS_KIAA2026.
Genevestigator	Q5HYC2.
Family and domain databases
Gene3D	1.20.920.10. 1 hit.
InterPro	IPR001487. Bromodomain. [Graphical view]
SMART	SM00297. BROMO. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	KIAA2026. human.
GenomeRNAi	158358.
NextBio	87703.

Entry information

Entry name

K2026_HUMAN

Accession

Primary (citable) accession number: Q5HYC2
Secondary accession number(s): A8MTP2 , B9EGW7, Q4VXA2, Q8IVE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.