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Q5HYC2

- K2026_HUMAN

UniProt

Q5HYC2 - K2026_HUMAN

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Protein
Uncharacterized protein KIAA2026
Gene
KIAA2026
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA2026
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23378. KIAA2026.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21032103Uncharacterized protein KIAA2026
PRO_0000288922Add
BLAST

Proteomic databases

MaxQBiQ5HYC2.
PaxDbiQ5HYC2.
PRIDEiQ5HYC2.

PTM databases

PhosphoSiteiQ5HYC2.

Expressioni

Gene expression databases

ArrayExpressiQ5HYC2.
BgeeiQ5HYC2.
CleanExiHS_KIAA2026.
GenevestigatoriQ5HYC2.

Organism-specific databases

HPAiHPA002109.

Interactioni

Protein-protein interaction databases

BioGridi127672. 6 interactions.
IntActiQ5HYC2. 5 interactions.
MINTiMINT-2878922.
STRINGi9606.ENSP00000382815.

Structurei

3D structure databases

ProteinModelPortaliQ5HYC2.
SMRiQ5HYC2. Positions 137-196.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi673 – 75684Lys-rich
Add
BLAST
Compositional biasi1307 – 1421115Ser-rich
Add
BLAST

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000169712.
HOVERGENiHBG108717.
InParanoidiQ5HYC2.
OMAiKELHGTL.
OrthoDBiEOG7BKCSQ.
PhylomeDBiQ5HYC2.
TreeFamiTF336184.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5HYC2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL     50
EDADDQEEEM EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP 100
FLQPLGGVAT AEEEVAEGPR SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ 150
YGGITEFVAD FRLMLETCYR LHGVDHWISK QGQKLEMMLE QKLALLSRHL 200
REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT SGVFESIMVQ 250
VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET 300
MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS 350
PPHRRPTLHR RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC 400
PQFFKVLGEV NPLEEKPFHE LPFYQKVWLL KGLCDFVYET QKEVQDAVLG 450
QPIHECREVI LGYDYLENAY VHFPQFCGAD VRIYKQRPFQ APEFPIPPIK 500
IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE NNFDPACCPA 550
KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG 600
FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD 650
HPEINCHKVV RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL 700
QRKREGLHSL AFKSYKPEIQ NKLLIIKKKA KHKKHKSGKK SVSKKAITKK 750
RKTVIKSPTV PEFQLICTNL DELRELITKI ENELKDLENS RKKSGKWYHR 800
RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY DDFRRQPDHD 850
TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL 900
SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR 950
KKAKLSTNET TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ 1000
KGTKPIQALL AKNIGNKVTL TNQLPPSTGR NALAVEKPVL SPPEASPIKP 1050
ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN SSVKIQVQPM VDPKTGEKIM 1100
QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP QTTNINSSLA 1150
SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS 1200
VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS 1250
SFNCFAQQTA DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ 1300
NSPNTVSSSS VFTFAPQLQA FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ 1350
TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG DLGHVIDKTS HMPSSPLKSS 1400
ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ QVDYITKSYP 1450
VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG 1500
VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL 1550
IPSTVGTPIK INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ 1600
NVTPKGEDKS SKGYILPLST SGNSVPVSSN FVSQNITPVN ESVVSSARAV 1650
NVLSVTGANL SLGSFPVTSA SASAGAQPPV LVSGNDTSSR IMPILSNRLC 1700
SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL QIPVTVALPT 1750
PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN 1800
VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI 1850
HTASAPSNVT SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP 1900
PQGLGAGSHV LLISTNPKYG APLVLNSGQG IQSTPIDNSA QKITLASNNS 1950
LSGQPLQHPL RSPTKFINSF GNASSIPTVH TSPQLINTTA KVPVPPPVPT 2000
VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD PPVKKLLVSP 2050
EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR 2100
AAS 2103
Length:2,103
Mass (Da):228,087
Last modified:June 15, 2010 - v2
Checksum:i211E99364884045A
GO
Isoform 2 (identifier: Q5HYC2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-794: Missing.

Show »
Length:2,073
Mass (Da):224,546
Checksum:iC15E6DA756FA6F6E
GO

Sequence cautioni

The sequence AAI36847.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI45993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI95313.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei765 – 79430Missing in isoform 2.
VSP_039334Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL162384 Genomic DNA. No translation available.
AL353606 Genomic DNA. No translation available.
AL365360 Genomic DNA. Translation: CAI95313.1. Sequence problems.
BX648372 mRNA. Translation: CAI45993.1. Different initiation.
BC136846 mRNA. Translation: AAI36847.1. Different initiation.
AB095946 mRNA. Translation: BAC23122.1.
RefSeqiNP_001017969.2. NM_001017969.2. [Q5HYC2-1]
XP_005251442.1. XM_005251385.1. [Q5HYC2-2]
UniGeneiHs.535060.

Genome annotation databases

EnsembliENST00000381461; ENSP00000370870; ENSG00000183354. [Q5HYC2-2]
ENST00000399933; ENSP00000382815; ENSG00000183354. [Q5HYC2-1]
GeneIDi158358.
KEGGihsa:158358.
UCSCiuc003zjq.4. human. [Q5HYC2-1]

Polymorphism databases

DMDMi298286816.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL162384 Genomic DNA. No translation available.
AL353606 Genomic DNA. No translation available.
AL365360 Genomic DNA. Translation: CAI95313.1 . Sequence problems.
BX648372 mRNA. Translation: CAI45993.1 . Different initiation.
BC136846 mRNA. Translation: AAI36847.1 . Different initiation.
AB095946 mRNA. Translation: BAC23122.1 .
RefSeqi NP_001017969.2. NM_001017969.2. [Q5HYC2-1 ]
XP_005251442.1. XM_005251385.1. [Q5HYC2-2 ]
UniGenei Hs.535060.

3D structure databases

ProteinModelPortali Q5HYC2.
SMRi Q5HYC2. Positions 137-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127672. 6 interactions.
IntActi Q5HYC2. 5 interactions.
MINTi MINT-2878922.
STRINGi 9606.ENSP00000382815.

PTM databases

PhosphoSitei Q5HYC2.

Polymorphism databases

DMDMi 298286816.

Proteomic databases

MaxQBi Q5HYC2.
PaxDbi Q5HYC2.
PRIDEi Q5HYC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381461 ; ENSP00000370870 ; ENSG00000183354 . [Q5HYC2-2 ]
ENST00000399933 ; ENSP00000382815 ; ENSG00000183354 . [Q5HYC2-1 ]
GeneIDi 158358.
KEGGi hsa:158358.
UCSCi uc003zjq.4. human. [Q5HYC2-1 ]

Organism-specific databases

CTDi 158358.
GeneCardsi GC09M005919.
HGNCi HGNC:23378. KIAA2026.
HPAi HPA002109.
neXtProti NX_Q5HYC2.
PharmGKBi PA134907262.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000169712.
HOVERGENi HBG108717.
InParanoidi Q5HYC2.
OMAi KELHGTL.
OrthoDBi EOG7BKCSQ.
PhylomeDBi Q5HYC2.
TreeFami TF336184.

Miscellaneous databases

ChiTaRSi KIAA2026. human.
GenomeRNAii 158358.
NextBioi 87703.

Gene expression databases

ArrayExpressi Q5HYC2.
Bgeei Q5HYC2.
CleanExi HS_KIAA2026.
Genevestigatori Q5HYC2.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
InterProi IPR001487. Bromodomain.
[Graphical view ]
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 738-2103 (ISOFORM 2).
    Tissue: Esophageal carcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 819-2103 (ISOFORM 1).
    Tissue: Testis.
  4. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1246-2103 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiK2026_HUMAN
AccessioniPrimary (citable) accession number: Q5HYC2
Secondary accession number(s): A8MTP2
, B9EGW7, Q4VXA2, Q8IVE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

External Data

Dasty 3

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