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Q5HYC2 (K2026_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein KIAA2026
Gene names
Name:KIAA2026
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2103 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAI36847.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAI45993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAI95313.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5HYC2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5HYC2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     765-794: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21032103Uncharacterized protein KIAA2026
PRO_0000288922

Regions

Compositional bias673 – 75684Lys-rich
Compositional bias1307 – 1421115Ser-rich

Natural variations

Alternative sequence765 – 79430Missing in isoform 2.
VSP_039334

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 15, 2010. Version 2.
Checksum: 211E99364884045A

FASTA2,103228,087
        10         20         30         40         50         60 
MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL EDADDQEEEM 

        70         80         90        100        110        120 
EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP FLQPLGGVAT AEEEVAEGPR 

       130        140        150        160        170        180 
SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ YGGITEFVAD FRLMLETCYR LHGVDHWISK 

       190        200        210        220        230        240 
QGQKLEMMLE QKLALLSRHL REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT 

       250        260        270        280        290        300 
SGVFESIMVQ VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET 

       310        320        330        340        350        360 
MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS PPHRRPTLHR 

       370        380        390        400        410        420 
RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC PQFFKVLGEV NPLEEKPFHE 

       430        440        450        460        470        480 
LPFYQKVWLL KGLCDFVYET QKEVQDAVLG QPIHECREVI LGYDYLENAY VHFPQFCGAD 

       490        500        510        520        530        540 
VRIYKQRPFQ APEFPIPPIK IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE 

       550        560        570        580        590        600 
NNFDPACCPA KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG 

       610        620        630        640        650        660 
FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD HPEINCHKVV 

       670        680        690        700        710        720 
RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL QRKREGLHSL AFKSYKPEIQ 

       730        740        750        760        770        780 
NKLLIIKKKA KHKKHKSGKK SVSKKAITKK RKTVIKSPTV PEFQLICTNL DELRELITKI 

       790        800        810        820        830        840 
ENELKDLENS RKKSGKWYHR RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY 

       850        860        870        880        890        900 
DDFRRQPDHD TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL 

       910        920        930        940        950        960 
SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR KKAKLSTNET 

       970        980        990       1000       1010       1020 
TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ KGTKPIQALL AKNIGNKVTL 

      1030       1040       1050       1060       1070       1080 
TNQLPPSTGR NALAVEKPVL SPPEASPIKP ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN 

      1090       1100       1110       1120       1130       1140 
SSVKIQVQPM VDPKTGEKIM QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP 

      1150       1160       1170       1180       1190       1200 
QTTNINSSLA SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS 

      1210       1220       1230       1240       1250       1260 
VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS SFNCFAQQTA 

      1270       1280       1290       1300       1310       1320 
DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ NSPNTVSSSS VFTFAPQLQA 

      1330       1340       1350       1360       1370       1380 
FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG 

      1390       1400       1410       1420       1430       1440 
DLGHVIDKTS HMPSSPLKSS ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ 

      1450       1460       1470       1480       1490       1500 
QVDYITKSYP VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG 

      1510       1520       1530       1540       1550       1560 
VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL IPSTVGTPIK 

      1570       1580       1590       1600       1610       1620 
INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ NVTPKGEDKS SKGYILPLST 

      1630       1640       1650       1660       1670       1680 
SGNSVPVSSN FVSQNITPVN ESVVSSARAV NVLSVTGANL SLGSFPVTSA SASAGAQPPV 

      1690       1700       1710       1720       1730       1740 
LVSGNDTSSR IMPILSNRLC SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL 

      1750       1760       1770       1780       1790       1800 
QIPVTVALPT PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN 

      1810       1820       1830       1840       1850       1860 
VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI HTASAPSNVT 

      1870       1880       1890       1900       1910       1920 
SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP PQGLGAGSHV LLISTNPKYG 

      1930       1940       1950       1960       1970       1980 
APLVLNSGQG IQSTPIDNSA QKITLASNNS LSGQPLQHPL RSPTKFINSF GNASSIPTVH 

      1990       2000       2010       2020       2030       2040 
TSPQLINTTA KVPVPPPVPT VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD 

      2050       2060       2070       2080       2090       2100 
PPVKKLLVSP EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR 


AAS 

« Hide

Isoform 2 [UniParc].

Checksum: C15E6DA756FA6F6E
Show »

FASTA2,073224,546

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 738-2103 (ISOFORM 2).
Tissue: Esophageal carcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 819-2103 (ISOFORM 1).
Tissue: Testis.
[4]"The nucleotide sequence of a long cDNA clone isolated from human."
Nagase T., Kikuno R., Ohara O.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1246-2103 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL162384 Genomic DNA. No translation available.
AL353606 Genomic DNA. No translation available.
AL365360 Genomic DNA. Translation: CAI95313.1. Sequence problems.
BX648372 mRNA. Translation: CAI45993.1. Different initiation.
BC136846 mRNA. Translation: AAI36847.1. Different initiation.
AB095946 mRNA. Translation: BAC23122.1.
RefSeqNP_001017969.2. NM_001017969.2.
XP_005251442.1. XM_005251385.1.
UniGeneHs.535060.

3D structure databases

ProteinModelPortalQ5HYC2.
SMRQ5HYC2. Positions 75-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127672. 6 interactions.
IntActQ5HYC2. 5 interactions.
MINTMINT-2878922.
STRING9606.ENSP00000382815.

PTM databases

PhosphoSiteQ5HYC2.

Polymorphism databases

DMDM298286816.

Proteomic databases

PaxDbQ5HYC2.
PRIDEQ5HYC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381461; ENSP00000370870; ENSG00000183354. [Q5HYC2-2]
ENST00000399933; ENSP00000382815; ENSG00000183354. [Q5HYC2-1]
GeneID158358.
KEGGhsa:158358.
UCSCuc003zjq.4. human. [Q5HYC2-1]

Organism-specific databases

CTD158358.
GeneCardsGC09M005919.
HGNCHGNC:23378. KIAA2026.
HPAHPA002109.
neXtProtNX_Q5HYC2.
PharmGKBPA134907262.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000169712.
HOVERGENHBG108717.
InParanoidQ5HYC2.
OMAKELHGTL.
OrthoDBEOG7BKCSQ.
PhylomeDBQ5HYC2.
TreeFamTF336184.

Gene expression databases

ArrayExpressQ5HYC2.
BgeeQ5HYC2.
CleanExHS_KIAA2026.
GenevestigatorQ5HYC2.

Family and domain databases

Gene3D1.20.920.10. 1 hit.
InterProIPR001487. Bromodomain.
[Graphical view]
SMARTSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMSSF47370. SSF47370. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKIAA2026. human.
GenomeRNAi158358.
NextBio87703.

Entry information

Entry nameK2026_HUMAN
AccessionPrimary (citable) accession number: Q5HYC2
Secondary accession number(s): A8MTP2 expand/collapse secondary AC list , B9EGW7, Q4VXA2, Q8IVE5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM