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Q5HYC2

- K2026_HUMAN

UniProt

Q5HYC2 - K2026_HUMAN

Protein

Uncharacterized protein KIAA2026

Gene

KIAA2026

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein KIAA2026
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:23378. KIAA2026.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134907262.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21032103Uncharacterized protein KIAA2026PRO_0000288922Add
    BLAST

    Proteomic databases

    MaxQBiQ5HYC2.
    PaxDbiQ5HYC2.
    PRIDEiQ5HYC2.

    PTM databases

    PhosphoSiteiQ5HYC2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5HYC2.
    BgeeiQ5HYC2.
    CleanExiHS_KIAA2026.
    GenevestigatoriQ5HYC2.

    Organism-specific databases

    HPAiHPA002109.

    Interactioni

    Protein-protein interaction databases

    BioGridi127672. 6 interactions.
    IntActiQ5HYC2. 5 interactions.
    MINTiMINT-2878922.
    STRINGi9606.ENSP00000382815.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HYC2.
    SMRiQ5HYC2. Positions 137-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi673 – 75684Lys-richAdd
    BLAST
    Compositional biasi1307 – 1421115Ser-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000169712.
    HOVERGENiHBG108717.
    InParanoidiQ5HYC2.
    OMAiKELHGTL.
    OrthoDBiEOG7BKCSQ.
    PhylomeDBiQ5HYC2.
    TreeFamiTF336184.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    InterProiIPR001487. Bromodomain.
    [Graphical view]
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5HYC2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL     50
    EDADDQEEEM EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP 100
    FLQPLGGVAT AEEEVAEGPR SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ 150
    YGGITEFVAD FRLMLETCYR LHGVDHWISK QGQKLEMMLE QKLALLSRHL 200
    REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT SGVFESIMVQ 250
    VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET 300
    MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS 350
    PPHRRPTLHR RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC 400
    PQFFKVLGEV NPLEEKPFHE LPFYQKVWLL KGLCDFVYET QKEVQDAVLG 450
    QPIHECREVI LGYDYLENAY VHFPQFCGAD VRIYKQRPFQ APEFPIPPIK 500
    IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE NNFDPACCPA 550
    KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG 600
    FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD 650
    HPEINCHKVV RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL 700
    QRKREGLHSL AFKSYKPEIQ NKLLIIKKKA KHKKHKSGKK SVSKKAITKK 750
    RKTVIKSPTV PEFQLICTNL DELRELITKI ENELKDLENS RKKSGKWYHR 800
    RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY DDFRRQPDHD 850
    TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL 900
    SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR 950
    KKAKLSTNET TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ 1000
    KGTKPIQALL AKNIGNKVTL TNQLPPSTGR NALAVEKPVL SPPEASPIKP 1050
    ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN SSVKIQVQPM VDPKTGEKIM 1100
    QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP QTTNINSSLA 1150
    SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS 1200
    VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS 1250
    SFNCFAQQTA DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ 1300
    NSPNTVSSSS VFTFAPQLQA FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ 1350
    TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG DLGHVIDKTS HMPSSPLKSS 1400
    ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ QVDYITKSYP 1450
    VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG 1500
    VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL 1550
    IPSTVGTPIK INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ 1600
    NVTPKGEDKS SKGYILPLST SGNSVPVSSN FVSQNITPVN ESVVSSARAV 1650
    NVLSVTGANL SLGSFPVTSA SASAGAQPPV LVSGNDTSSR IMPILSNRLC 1700
    SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL QIPVTVALPT 1750
    PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN 1800
    VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI 1850
    HTASAPSNVT SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP 1900
    PQGLGAGSHV LLISTNPKYG APLVLNSGQG IQSTPIDNSA QKITLASNNS 1950
    LSGQPLQHPL RSPTKFINSF GNASSIPTVH TSPQLINTTA KVPVPPPVPT 2000
    VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD PPVKKLLVSP 2050
    EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR 2100
    AAS 2103
    Length:2,103
    Mass (Da):228,087
    Last modified:June 15, 2010 - v2
    Checksum:i211E99364884045A
    GO
    Isoform 2 (identifier: Q5HYC2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         765-794: Missing.

    Show »
    Length:2,073
    Mass (Da):224,546
    Checksum:iC15E6DA756FA6F6E
    GO

    Sequence cautioni

    The sequence AAI36847.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI45993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI95313.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei765 – 79430Missing in isoform 2. 1 PublicationVSP_039334Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL162384 Genomic DNA. No translation available.
    AL353606 Genomic DNA. No translation available.
    AL365360 Genomic DNA. Translation: CAI95313.1. Sequence problems.
    BX648372 mRNA. Translation: CAI45993.1. Different initiation.
    BC136846 mRNA. Translation: AAI36847.1. Different initiation.
    AB095946 mRNA. Translation: BAC23122.1.
    RefSeqiNP_001017969.2. NM_001017969.2. [Q5HYC2-1]
    XP_005251442.1. XM_005251385.1. [Q5HYC2-2]
    UniGeneiHs.535060.

    Genome annotation databases

    EnsembliENST00000381461; ENSP00000370870; ENSG00000183354. [Q5HYC2-2]
    ENST00000399933; ENSP00000382815; ENSG00000183354. [Q5HYC2-1]
    GeneIDi158358.
    KEGGihsa:158358.
    UCSCiuc003zjq.4. human. [Q5HYC2-1]

    Polymorphism databases

    DMDMi298286816.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL162384 Genomic DNA. No translation available.
    AL353606 Genomic DNA. No translation available.
    AL365360 Genomic DNA. Translation: CAI95313.1 . Sequence problems.
    BX648372 mRNA. Translation: CAI45993.1 . Different initiation.
    BC136846 mRNA. Translation: AAI36847.1 . Different initiation.
    AB095946 mRNA. Translation: BAC23122.1 .
    RefSeqi NP_001017969.2. NM_001017969.2. [Q5HYC2-1 ]
    XP_005251442.1. XM_005251385.1. [Q5HYC2-2 ]
    UniGenei Hs.535060.

    3D structure databases

    ProteinModelPortali Q5HYC2.
    SMRi Q5HYC2. Positions 137-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127672. 6 interactions.
    IntActi Q5HYC2. 5 interactions.
    MINTi MINT-2878922.
    STRINGi 9606.ENSP00000382815.

    PTM databases

    PhosphoSitei Q5HYC2.

    Polymorphism databases

    DMDMi 298286816.

    Proteomic databases

    MaxQBi Q5HYC2.
    PaxDbi Q5HYC2.
    PRIDEi Q5HYC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381461 ; ENSP00000370870 ; ENSG00000183354 . [Q5HYC2-2 ]
    ENST00000399933 ; ENSP00000382815 ; ENSG00000183354 . [Q5HYC2-1 ]
    GeneIDi 158358.
    KEGGi hsa:158358.
    UCSCi uc003zjq.4. human. [Q5HYC2-1 ]

    Organism-specific databases

    CTDi 158358.
    GeneCardsi GC09M005919.
    HGNCi HGNC:23378. KIAA2026.
    HPAi HPA002109.
    neXtProti NX_Q5HYC2.
    PharmGKBi PA134907262.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000169712.
    HOVERGENi HBG108717.
    InParanoidi Q5HYC2.
    OMAi KELHGTL.
    OrthoDBi EOG7BKCSQ.
    PhylomeDBi Q5HYC2.
    TreeFami TF336184.

    Miscellaneous databases

    ChiTaRSi KIAA2026. human.
    GenomeRNAii 158358.
    NextBioi 87703.

    Gene expression databases

    ArrayExpressi Q5HYC2.
    Bgeei Q5HYC2.
    CleanExi HS_KIAA2026.
    Genevestigatori Q5HYC2.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    InterProi IPR001487. Bromodomain.
    [Graphical view ]
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 738-2103 (ISOFORM 2).
      Tissue: Esophageal carcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 819-2103 (ISOFORM 1).
      Tissue: Testis.
    4. "The nucleotide sequence of a long cDNA clone isolated from human."
      Nagase T., Kikuno R., Ohara O.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1246-2103 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiK2026_HUMAN
    AccessioniPrimary (citable) accession number: Q5HYC2
    Secondary accession number(s): A8MTP2
    , B9EGW7, Q4VXA2, Q8IVE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM

    External Data

    Dasty 3