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Q5HYC2

- K2026_HUMAN

UniProt

Q5HYC2 - K2026_HUMAN

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Protein

Uncharacterized protein KIAA2026

Gene

KIAA2026

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA2026
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23378. KIAA2026.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134907262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21032103Uncharacterized protein KIAA2026PRO_0000288922Add
BLAST

Proteomic databases

MaxQBiQ5HYC2.
PaxDbiQ5HYC2.
PRIDEiQ5HYC2.

PTM databases

PhosphoSiteiQ5HYC2.

Expressioni

Gene expression databases

BgeeiQ5HYC2.
CleanExiHS_KIAA2026.
ExpressionAtlasiQ5HYC2. baseline and differential.
GenevestigatoriQ5HYC2.

Organism-specific databases

HPAiHPA002109.

Interactioni

Protein-protein interaction databases

BioGridi127672. 6 interactions.
IntActiQ5HYC2. 5 interactions.
MINTiMINT-2878922.
STRINGi9606.ENSP00000382815.

Structurei

3D structure databases

ProteinModelPortaliQ5HYC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi673 – 75684Lys-richAdd
BLAST
Compositional biasi1307 – 1421115Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00390000011483.
HOGENOMiHOG000169712.
HOVERGENiHBG108717.
InParanoidiQ5HYC2.
OMAiKELHGTL.
OrthoDBiEOG7BKCSQ.
PhylomeDBiQ5HYC2.
TreeFamiTF336184.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5HYC2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPGTPGAM EPAGEEERPP PAAEGEDDEE EVAAAAQTSG PAHGRSASSL
60 70 80 90 100
EDADDQEEEM EAMVIGGGCC KEQELTYELQ QGYRILGEFL QEKHRGLTAP
110 120 130 140 150
FLQPLGGVAT AEEEVAEGPR SGGRGGRAFP QQPGQGMCLL QMEEKFASGQ
160 170 180 190 200
YGGITEFVAD FRLMLETCYR LHGVDHWISK QGQKLEMMLE QKLALLSRHL
210 220 230 240 250
REKTTIAVTS RGYYGLEDEK GTACTSTRRR STPRSLAGLT SGVFESIMVQ
260 270 280 290 300
VLRQEEQLRA KEEKRLREQE RKEAEEASQK EIEEWERKLL AQAAPTCMET
310 320 330 340 350
MWEIPAIGHF LCLAQQILNL PEIVFYELER CLLMPQCNAF LSKIMTSLLS
360 370 380 390 400
PPHRRPTLHR RPTLPYRTWE AALRQKVQQW YTAVGQTENP DNCAEKLGLC
410 420 430 440 450
PQFFKVLGEV NPLEEKPFHE LPFYQKVWLL KGLCDFVYET QKEVQDAVLG
460 470 480 490 500
QPIHECREVI LGYDYLENAY VHFPQFCGAD VRIYKQRPFQ APEFPIPPIK
510 520 530 540 550
IQRVPRIKLE KLKCDYVSTS NGEHRCSRDS LPSSFKKEQE NNFDPACCPA
560 570 580 590 600
KMILDNHDIS VEMGVKSNYE IRIRRPCEIK KTDCCKENLE KPRSPGEVTG
610 620 630 640 650
FGEPLSPGEI RFIENQEKYG EASRIKIEPS PLKENTLKSC QIHVNGSHSD
660 670 680 690 700
HPEINCHKVV RDILLEQSLQ SHKKLKLTKM RAKKKKKKKK KLKDVLNENL
710 720 730 740 750
QRKREGLHSL AFKSYKPEIQ NKLLIIKKKA KHKKHKSGKK SVSKKAITKK
760 770 780 790 800
RKTVIKSPTV PEFQLICTNL DELRELITKI ENELKDLENS RKKSGKWYHR
810 820 830 840 850
RQAVKELHST LIRLLNELLP WEPKLMKAFQ RNRSRLKKDY DDFRRQPDHD
860 870 880 890 900
TFNRELWTTD EGEGDLGKDS PKGEISKSID STEPLDILEK DHFDSDDMKL
910 920 930 940 950
SEIDFPMARS KLLKKELPSK DLPKTLLKTL KRQSKQTDYV DDSTKELSPR
960 970 980 990 1000
KKAKLSTNET TVENLESDVQ IDCFSESKHT EPSFPESFAS LDSVPVSTLQ
1010 1020 1030 1040 1050
KGTKPIQALL AKNIGNKVTL TNQLPPSTGR NALAVEKPVL SPPEASPIKP
1060 1070 1080 1090 1100
ALTCHTNTKG PLQMVYKMPC GQWLPIDLQN SSVKIQVQPM VDPKTGEKIM
1110 1120 1130 1140 1150
QQVLILPKNF VIQHKEGKAV AKEVPPLQQK GTEQHCSSFP QTTNINSSLA
1160 1170 1180 1190 1200
SVFVNSPGTV STQLPNTAFN KTITPLSNIS SARPQPLSPV TSVSNLLTPS
1210 1220 1230 1240 1250
VKTSQSEAGK AKNAVSAATF SLPSASPTIS STGQPLSSTT TLNGSTNPGS
1260 1270 1280 1290 1300
SFNCFAQQTA DSSEAKQELK TVCIRDSQSI LVRTRGGNTG VVKVQTNPDQ
1310 1320 1330 1340 1350
NSPNTVSSSS VFTFAPQLQA FLVPKSTTSS SAFSPVAGTT TTSSLSPFSQ
1360 1370 1380 1390 1400
TPTSVSIPAS FAPSMGKNLK LTLGHTTGSG DLGHVIDKTS HMPSSPLKSS
1410 1420 1430 1440 1450
ICSSTLLPST TSSSVSVISI SAANFGQNNA NIIHTPTKQQ QVDYITKSYP
1460 1470 1480 1490 1500
VTRSEATAAT NGDVISGTPV QKLMLVSAPS ILSSGNGTAI NMTPALTSTG
1510 1520 1530 1540 1550
VSAQKLVFIN APVPSGTSTP TLVAESLKQT LPPPLHKAYV KTPEQPQIVL
1560 1570 1580 1590 1600
IPSTVGTPIK INSSPAVSQI KDVKIGLNIG QAIVNTSGTV PAIPSINILQ
1610 1620 1630 1640 1650
NVTPKGEDKS SKGYILPLST SGNSVPVSSN FVSQNITPVN ESVVSSARAV
1660 1670 1680 1690 1700
NVLSVTGANL SLGSFPVTSA SASAGAQPPV LVSGNDTSSR IMPILSNRLC
1710 1720 1730 1740 1750
SSSLGNTVAI STVKTGHLAS SVLISTTQPV VSPKCLTSAL QIPVTVALPT
1760 1770 1780 1790 1800
PATTSPKIIN TVPHSAAVPG ATRSVSISKR QSRTSLQFHS PGISTTVPTN
1810 1820 1830 1840 1850
VNTNKPQTEL SSLSTSPGKI TNTSNFASLP NQQALVKTPS YSSAPGGTTI
1860 1870 1880 1890 1900
HTASAPSNVT SLVGSQFSEP CIQQKIVINT STPLAPGTQI MINGTRFIVP
1910 1920 1930 1940 1950
PQGLGAGSHV LLISTNPKYG APLVLNSGQG IQSTPIDNSA QKITLASNNS
1960 1970 1980 1990 2000
LSGQPLQHPL RSPTKFINSF GNASSIPTVH TSPQLINTTA KVPVPPPVPT
2010 2020 2030 2040 2050
VSLTSVIKSP ATLLAKTSLV SAICPSNPPL PSSTSVFHLD PPVKKLLVSP
2060 2070 2080 2090 2100
EGAILNTINT PASKVSSLSP SLSQIVVSAS RSPASVFPAF QSSGLEKPDR

AAS
Length:2,103
Mass (Da):228,087
Last modified:June 15, 2010 - v2
Checksum:i211E99364884045A
GO
Isoform 2 (identifier: Q5HYC2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-794: Missing.

Show »
Length:2,073
Mass (Da):224,546
Checksum:iC15E6DA756FA6F6E
GO

Sequence cautioni

The sequence AAI36847.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI45993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI95313.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei765 – 79430Missing in isoform 2. 1 PublicationVSP_039334Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162384 Genomic DNA. No translation available.
AL353606 Genomic DNA. No translation available.
AL365360 Genomic DNA. Translation: CAI95313.1. Sequence problems.
BX648372 mRNA. Translation: CAI45993.1. Different initiation.
BC136846 mRNA. Translation: AAI36847.1. Different initiation.
AB095946 mRNA. Translation: BAC23122.1.
RefSeqiNP_001017969.2. NM_001017969.2. [Q5HYC2-1]
XP_005251442.1. XM_005251385.1. [Q5HYC2-2]
UniGeneiHs.535060.

Genome annotation databases

EnsembliENST00000381461; ENSP00000370870; ENSG00000183354. [Q5HYC2-2]
ENST00000399933; ENSP00000382815; ENSG00000183354. [Q5HYC2-1]
GeneIDi158358.
KEGGihsa:158358.
UCSCiuc003zjq.4. human. [Q5HYC2-1]

Polymorphism databases

DMDMi298286816.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162384 Genomic DNA. No translation available.
AL353606 Genomic DNA. No translation available.
AL365360 Genomic DNA. Translation: CAI95313.1 . Sequence problems.
BX648372 mRNA. Translation: CAI45993.1 . Different initiation.
BC136846 mRNA. Translation: AAI36847.1 . Different initiation.
AB095946 mRNA. Translation: BAC23122.1 .
RefSeqi NP_001017969.2. NM_001017969.2. [Q5HYC2-1 ]
XP_005251442.1. XM_005251385.1. [Q5HYC2-2 ]
UniGenei Hs.535060.

3D structure databases

ProteinModelPortali Q5HYC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127672. 6 interactions.
IntActi Q5HYC2. 5 interactions.
MINTi MINT-2878922.
STRINGi 9606.ENSP00000382815.

PTM databases

PhosphoSitei Q5HYC2.

Polymorphism databases

DMDMi 298286816.

Proteomic databases

MaxQBi Q5HYC2.
PaxDbi Q5HYC2.
PRIDEi Q5HYC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381461 ; ENSP00000370870 ; ENSG00000183354 . [Q5HYC2-2 ]
ENST00000399933 ; ENSP00000382815 ; ENSG00000183354 . [Q5HYC2-1 ]
GeneIDi 158358.
KEGGi hsa:158358.
UCSCi uc003zjq.4. human. [Q5HYC2-1 ]

Organism-specific databases

CTDi 158358.
GeneCardsi GC09M005882.
HGNCi HGNC:23378. KIAA2026.
HPAi HPA002109.
neXtProti NX_Q5HYC2.
PharmGKBi PA134907262.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00390000011483.
HOGENOMi HOG000169712.
HOVERGENi HBG108717.
InParanoidi Q5HYC2.
OMAi KELHGTL.
OrthoDBi EOG7BKCSQ.
PhylomeDBi Q5HYC2.
TreeFami TF336184.

Miscellaneous databases

ChiTaRSi KIAA2026. human.
GenomeRNAii 158358.
NextBioi 87703.

Gene expression databases

Bgeei Q5HYC2.
CleanExi HS_KIAA2026.
ExpressionAtlasi Q5HYC2. baseline and differential.
Genevestigatori Q5HYC2.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
InterProi IPR001487. Bromodomain.
[Graphical view ]
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 738-2103 (ISOFORM 2).
    Tissue: Esophageal carcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 819-2103 (ISOFORM 1).
    Tissue: Testis.
  4. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1246-2103 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiK2026_HUMAN
AccessioniPrimary (citable) accession number: Q5HYC2
Secondary accession number(s): A8MTP2
, B9EGW7, Q4VXA2, Q8IVE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

External Data

Dasty 3