Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 766

Gene

ZNF766

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri187 – 209C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 766
Gene namesi
Name:ZNF766
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196214.10
HGNCiHGNC:28063 ZNF766
neXtProtiNX_Q5HY98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196214
PharmGKBiPA162410313

Polymorphism and mutation databases

BioMutaiZNF766
DMDMi74755487

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804351 – 468Zinc finger protein 766Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ5HY98
PaxDbiQ5HY98
PeptideAtlasiQ5HY98
PRIDEiQ5HY98

PTM databases

iPTMnetiQ5HY98
PhosphoSitePlusiQ5HY98

Expressioni

Gene expression databases

BgeeiENSG00000196214
CleanExiHS_ZNF766
ExpressionAtlasiQ5HY98 baseline and differential
GenevisibleiQ5HY98 HS

Organism-specific databases

HPAiHPA044882
HPA063496

Interactioni

Protein-protein interaction databases

BioGridi124692, 2 interactors
IntActiQ5HY98, 3 interactors
STRINGi9606.ENSP00000409652

Structurei

3D structure databases

ProteinModelPortaliQ5HY98
SMRiQ5HY98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 80KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri187 – 209C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 462C2H2-type 10PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00690000102079
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ5HY98
KOiK09228
PhylomeDBiQ5HY98
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q5HY98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLRRGHLT FRDVAIEFSQ EEWKCLDPVQ KALYRDVMLE NYRNLVSLGI
60 70 80 90 100
CLPDLSIISM MKQRTEPWTV ENEMKVAKNP DRWEGIKDIN TGRSCAVRSK
110 120 130 140 150
AGNKPITNQL GLTFQLPLPE LEIFQGEGKI YECNQVQKFI SHSSSVSPLQ
160 170 180 190 200
RIYSGVKTHI FNKHRNDFVD FPLLSQEQKA HIRRKPYECN EQGKVFRVSS
210 220 230 240 250
SLPNHQVIHT ADKPNRCHEC GKTVRDKSGL AEHWRIRTGE KPYKCKECGK
260 270 280 290 300
LFNRIAYLAR HEKVHTGESP YKCNECGKVF SRITYLVRHQ KIHTREKPHK
310 320 330 340 350
CNKCGKVYSS SSYLAQHWRI HTGEKLYKCN KCGKEFSGHS SLTTHLLIHT
360 370 380 390 400
GEKPYKCKEC DKAFRHKFSL TVHQRNHNGE KPYKCHECGK VFTQVSHLAR
410 420 430 440 450
HQKIHTGEKP YKCNECGKVF TQNSHLANHQ RIHTGEKPYK CHVCGKVFRH
460
SSWFVQHQRS VHERVLTN
Length:468
Mass (Da):54,507
Last modified:February 15, 2005 - v1
Checksum:i7B44DD720845E9BA
GO

Sequence cautioni

The sequence CAD98055 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → S in CAD98055 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05289995C → Y. Corresponds to variant dbSNP:rs12462608Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538183 mRNA Translation: CAD98055.1 Different initiation.
BX648899 mRNA Translation: CAI45991.1
CH471135 Genomic DNA Translation: EAW72068.1
BC136833 mRNA Translation: AAI36834.1
BC136834 mRNA Translation: AAI36835.1
CCDSiCCDS46163.1
RefSeqiNP_001010851.1, NM_001010851.2
UniGeneiHs.439662

Genome annotation databases

EnsembliENST00000439461; ENSP00000409652; ENSG00000196214
GeneIDi90321
KEGGihsa:90321
UCSCiuc002pyr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN766_HUMAN
AccessioniPrimary (citable) accession number: Q5HY98
Secondary accession number(s): B2RNE0, Q7Z326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health