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Protein

Zinc finger protein 766

Gene

ZNF766

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri187 – 20923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46224C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 766
Gene namesi
Name:ZNF766
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28063. ZNF766.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410313.

Polymorphism and mutation databases

BioMutaiZNF766.
DMDMi74755487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Zinc finger protein 766PRO_0000280435Add
BLAST

Proteomic databases

EPDiQ5HY98.
MaxQBiQ5HY98.
PaxDbiQ5HY98.
PRIDEiQ5HY98.

PTM databases

iPTMnetiQ5HY98.
PhosphoSiteiQ5HY98.

Expressioni

Gene expression databases

BgeeiQ5HY98.
CleanExiHS_ZNF766.
ExpressionAtlasiQ5HY98. baseline and differential.
GenevisibleiQ5HY98. HS.

Organism-specific databases

HPAiHPA044882.

Interactioni

Protein-protein interaction databases

BioGridi124692. 2 interactions.
IntActiQ5HY98. 2 interactions.
STRINGi9606.ENSP00000409652.

Structurei

3D structure databases

ProteinModelPortaliQ5HY98.
SMRiQ5HY98. Positions 9-49, 129-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri187 – 20923C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46224C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5HY98.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5HY98.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HY98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLRRGHLT FRDVAIEFSQ EEWKCLDPVQ KALYRDVMLE NYRNLVSLGI
60 70 80 90 100
CLPDLSIISM MKQRTEPWTV ENEMKVAKNP DRWEGIKDIN TGRSCAVRSK
110 120 130 140 150
AGNKPITNQL GLTFQLPLPE LEIFQGEGKI YECNQVQKFI SHSSSVSPLQ
160 170 180 190 200
RIYSGVKTHI FNKHRNDFVD FPLLSQEQKA HIRRKPYECN EQGKVFRVSS
210 220 230 240 250
SLPNHQVIHT ADKPNRCHEC GKTVRDKSGL AEHWRIRTGE KPYKCKECGK
260 270 280 290 300
LFNRIAYLAR HEKVHTGESP YKCNECGKVF SRITYLVRHQ KIHTREKPHK
310 320 330 340 350
CNKCGKVYSS SSYLAQHWRI HTGEKLYKCN KCGKEFSGHS SLTTHLLIHT
360 370 380 390 400
GEKPYKCKEC DKAFRHKFSL TVHQRNHNGE KPYKCHECGK VFTQVSHLAR
410 420 430 440 450
HQKIHTGEKP YKCNECGKVF TQNSHLANHQ RIHTGEKPYK CHVCGKVFRH
460
SSWFVQHQRS VHERVLTN
Length:468
Mass (Da):54,507
Last modified:February 15, 2005 - v1
Checksum:i7B44DD720845E9BA
GO

Sequence cautioni

The sequence CAD98055.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91L → S in CAD98055 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951C → Y.
Corresponds to variant rs12462608 [ dbSNP | Ensembl ].
VAR_052899

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538183 mRNA. Translation: CAD98055.1. Different initiation.
BX648899 mRNA. Translation: CAI45991.1.
CH471135 Genomic DNA. Translation: EAW72068.1.
BC136833 mRNA. Translation: AAI36834.1.
BC136834 mRNA. Translation: AAI36835.1.
CCDSiCCDS46163.1.
RefSeqiNP_001010851.1. NM_001010851.2.
UniGeneiHs.439662.

Genome annotation databases

EnsembliENST00000439461; ENSP00000409652; ENSG00000196214.
GeneIDi90321.
KEGGihsa:90321.
UCSCiuc002pyr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538183 mRNA. Translation: CAD98055.1. Different initiation.
BX648899 mRNA. Translation: CAI45991.1.
CH471135 Genomic DNA. Translation: EAW72068.1.
BC136833 mRNA. Translation: AAI36834.1.
BC136834 mRNA. Translation: AAI36835.1.
CCDSiCCDS46163.1.
RefSeqiNP_001010851.1. NM_001010851.2.
UniGeneiHs.439662.

3D structure databases

ProteinModelPortaliQ5HY98.
SMRiQ5HY98. Positions 9-49, 129-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124692. 2 interactions.
IntActiQ5HY98. 2 interactions.
STRINGi9606.ENSP00000409652.

PTM databases

iPTMnetiQ5HY98.
PhosphoSiteiQ5HY98.

Polymorphism and mutation databases

BioMutaiZNF766.
DMDMi74755487.

Proteomic databases

EPDiQ5HY98.
MaxQBiQ5HY98.
PaxDbiQ5HY98.
PRIDEiQ5HY98.

Protocols and materials databases

DNASUi90321.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439461; ENSP00000409652; ENSG00000196214.
GeneIDi90321.
KEGGihsa:90321.
UCSCiuc002pyr.2. human.

Organism-specific databases

CTDi90321.
GeneCardsiZNF766.
HGNCiHGNC:28063. ZNF766.
HPAiHPA044882.
neXtProtiNX_Q5HY98.
PharmGKBiPA162410313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5HY98.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ5HY98.
TreeFamiTF341892.

Miscellaneous databases

ChiTaRSiZNF766. human.
GenomeRNAii90321.
PROiQ5HY98.

Gene expression databases

BgeeiQ5HY98.
CleanExiHS_ZNF766.
ExpressionAtlasiQ5HY98. baseline and differential.
GenevisibleiQ5HY98. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Esophageal carcinoma and Salivary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN766_HUMAN
AccessioniPrimary (citable) accession number: Q5HY98
Secondary accession number(s): B2RNE0, Q7Z326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 15, 2005
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.