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Protein

Putative protein FAM47C

Gene

FAM47C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein FAM47C
Gene namesi
Name:FAM47C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:25301. FAM47C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148924.

Polymorphism and mutation databases

BioMutaiFAM47C.
DMDMi74741513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Putative protein FAM47CPRO_0000349311Add
BLAST

Proteomic databases

EPDiQ5HY64.
PaxDbiQ5HY64.
PeptideAtlasiQ5HY64.
PRIDEiQ5HY64.

PTM databases

iPTMnetiQ5HY64.
PhosphoSiteiQ5HY64.

Expressioni

Gene expression databases

BgeeiQ5HY64.
CleanExiHS_FAM47C.
GenevisibleiQ5HY64. HS.

Structurei

3D structure databases

ProteinModelPortaliQ5HY64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM47 family.Curated

Phylogenomic databases

eggNOGiENOG410J8EG. Eukaryota.
ENOG410XRKP. LUCA.
GeneTreeiENSGT00400000022396.
HOGENOMiHOG000112475.
HOVERGENiHBG076577.
InParanoidiQ5HY64.
OMAiSSTMECV.
OrthoDBiEOG7K0ZBC.
PhylomeDBiQ5HY64.
TreeFamiTF340932.

Family and domain databases

InterProiIPR032743. FAM47.
IPR026083. FAM47C.
[Graphical view]
PANTHERiPTHR23213:SF203. PTHR23213:SF203. 4 hits.
PfamiPF14642. FAM47. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HY64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDQRPQDRP SSPGMDSTPW YCDKPPSKYF AKRKHRRLRF PPVDTQNWVF
60 70 80 90 100
VTEGMDDFRY GCQSPEDTLV CRRDEFLLPK ISLRGPQADP KSRKKKLLKK
110 120 130 140 150
AALFSKLSPA QPARKAFVEE VEAQLMTKHP LAMYPNLGED MPPDLLLQVL
160 170 180 190 200
KPLDPERKLE DAGSCEGQEK TTDEPTEPGK YPCGEFSPRP PETRVSCLPP
210 220 230 240 250
EPPKTPVSSL RPEPPETGVS HLRPQPPKTQ VSSLHLEPPE TGVSHLRPEP
260 270 280 290 300
PKTQVSSLHL EPPETGVSHL YLEPPGTGVS HLCPEPPKTR VSHLHREPPE
310 320 330 340 350
TGVPDLCLEP PKSRVSHLRP EPSETGVSHL HPEPPKTLVS SLHPEPPETG
360 370 380 390 400
VSHLCPEPPE TRVSPLRQLP PEAGVSHLCP EPPKTRVPPL RPETPKNGVS
410 420 430 440 450
PLFPEPPKTR ISNLRSEPPK IGVSHLCLEP PKTRGSHLRP EPPETGVSHL
460 470 480 490 500
RPEPPKTRVS SLHLEPPETG VSHLCPEPPE KDVSHLRPEP PDTGVSHLCP
510 520 530 540 550
EPPKTRVSHL RPEPSETGVS HLRPEPPKIL VSSLHQAPPE SSVSHLRPEP
560 570 580 590 600
PETGVSHLRP EPPKTRMYSL RPEPPDTGVS HLCPEPPKTR VSSLPPEPPE
610 620 630 640 650
TGVSHLCPEP PETRVSHLRP EPPETGVSHL RPEPPKTRMY SLRPEPPNTG
660 670 680 690 700
VSHLCPEPPK TRVSSLPPEP PETGVSHLCP EPPETRVSHL RPEPPETGVS
710 720 730 740 750
RLHPEPPKTR VSSLHAEPPE SRVSHLCPEP PETGVSHLRP EPPKPRVSSL
760 770 780 790 800
RPEPLETRVS HLRPEPPETG VSHLHPELPK PRVSSLHLEP PKTRRVSSLR
810 820 830 840 850
LEPPKTGRVS SLCPEPTKTG ASHLKELFQE GTSSTMECVS DSLQRRHTSR
860 870 880 890 900
KLRDFKWAGD LGVNEESISS LFDFTPECRA TYQDQKNKKA NECSSGLKYS
910 920 930 940 950
MELDEMDEVK FFSQEKDLDG KIQNAPNSHS AQHVKMGYGA WYLKPKLGKK
960 970 980 990 1000
LRSDEPLIDP KLVLEKPDEP DILDGLYGPI AFKDFILSKG YEMPGIIQRL
1010 1020 1030
FARRGWTYDS VKTPIQRAMQ VYKYKEDVTD ASEED
Length:1,035
Mass (Da):115,338
Last modified:February 15, 2005 - v1
Checksum:i2752692CC5AC9DE7
GO

Sequence cautioni

The sequence BAC86381.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2751P → S in BAC86381 (PubMed:14702039).Curated
Sequence conflicti482 – 4821D → N in BAC86381 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti924 – 9241N → T.
Corresponds to variant rs1995914 [ dbSNP | Ensembl ].
VAR_046358

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842568 Genomic DNA. Translation: CAI40150.1.
AK125992 mRNA. Translation: BAC86381.1. Different initiation.
CCDSiCCDS35227.1.
RefSeqiNP_001013758.1. NM_001013736.2.
UniGeneiHs.535216.

Genome annotation databases

EnsembliENST00000358047; ENSP00000367913; ENSG00000198173.
GeneIDi442444.
KEGGihsa:442444.
UCSCiuc004ddl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842568 Genomic DNA. Translation: CAI40150.1.
AK125992 mRNA. Translation: BAC86381.1. Different initiation.
CCDSiCCDS35227.1.
RefSeqiNP_001013758.1. NM_001013736.2.
UniGeneiHs.535216.

3D structure databases

ProteinModelPortaliQ5HY64.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5HY64.
PhosphoSiteiQ5HY64.

Polymorphism and mutation databases

BioMutaiFAM47C.
DMDMi74741513.

Proteomic databases

EPDiQ5HY64.
PaxDbiQ5HY64.
PeptideAtlasiQ5HY64.
PRIDEiQ5HY64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358047; ENSP00000367913; ENSG00000198173.
GeneIDi442444.
KEGGihsa:442444.
UCSCiuc004ddl.3. human.

Organism-specific databases

CTDi442444.
GeneCardsiFAM47C.
HGNCiHGNC:25301. FAM47C.
neXtProtiNX_Q5HY64.
PharmGKBiPA145148924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8EG. Eukaryota.
ENOG410XRKP. LUCA.
GeneTreeiENSGT00400000022396.
HOGENOMiHOG000112475.
HOVERGENiHBG076577.
InParanoidiQ5HY64.
OMAiSSTMECV.
OrthoDBiEOG7K0ZBC.
PhylomeDBiQ5HY64.
TreeFamiTF340932.

Miscellaneous databases

GenomeRNAii442444.
PROiQ5HY64.

Gene expression databases

BgeeiQ5HY64.
CleanExiHS_FAM47C.
GenevisibleiQ5HY64. HS.

Family and domain databases

InterProiIPR032743. FAM47.
IPR026083. FAM47C.
[Graphical view]
PANTHERiPTHR23213:SF203. PTHR23213:SF203. 4 hits.
PfamiPF14642. FAM47. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-1035.
    Tissue: Testis.

Entry informationi

Entry nameiFA47C_HUMAN
AccessioniPrimary (citable) accession number: Q5HY64
Secondary accession number(s): Q6ZU46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.